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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 鄭宗記 | |
| dc.contributor.author | Chih-Wei Weng | en |
| dc.contributor.author | 翁志偉 | zh_TW |
| dc.date.accessioned | 2021-06-08T02:59:09Z | - |
| dc.date.copyright | 2017-08-24 | |
| dc.date.issued | 2017 | |
| dc.date.submitted | 2017-07-27 | |
| dc.identifier.citation | 1. Anson, F. C. 1976. Electroanalytical Chemistry, p. 55, ACS Audio Course Manual, American Chemical Society, Washington, D. C.
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Zanello, P. 2003. 'Inorganic Electrochemistry: Theory, Practice and Application' The Royal Society of Chemistry. 71. Zhao, T. X. 1993. Electrical impedance and haematocrit of human blood with various anticoagulants. Physiol. Meas. 14:299-307. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/20696 | - |
| dc.description.abstract | 血球容積比(Hematocrit，Hct)為一種手術和臨床診斷的關鍵判定參數，於全血領域的生物感測器上，也會高度影響血液分析裝置的分析結果。因此，本研究在網印碳電極（Screen-Printed Carbon Electrode，SPCE）的基礎上開發了一種準確且快速的Hct測定方法，藉由此新發展的檢測技術，量測系統無需新增額外的設備或量測平台，只要調整輸出的電位及建構相對應的演算法，即可將Hct對於生物感測器的干擾排除，將來還可以應用於各種全血量測的拋棄式電化學感測系統上。首先在Hct量測的研究開發上，採用電壓誘發溶血的方式，在鐵氰化物塗覆的電極上施加3.0V的直流電壓，造成電極表面的血球破裂並釋放血紅蛋白，血紅蛋白自發性地將鐵氰化物還原為亞鐵氰化物，再藉由電極氧化亞鐵氰化物獲得氧化電流量來估算Hct。線性掃描伏安法，可以在5s內測定10%至70％的Hct（r2 = 0.9907），若採用計時電流安培法於電壓在3.0 V的條件下，即可在0.8s 內完成Hct量測（r2 = 0.9833）。
更進一步，結合上述Hct的檢測方式，導入應用於一次性葡萄糖感測器的開發可以獲得準確和快速的血糖數值。這項研究的目的是開發一種補償Hct的方法，提高葡萄糖計算的準確度，使Hct對葡萄糖量測的干擾極小化。傳統上量測葡萄糖濃度的量測平均偏差與Hct呈線性相關，從Hct 9％到Hct 70％，對應的量測偏差分別從40％變化到-50％，所以，單一電壓的計時電流安培法量測葡萄糖濃度具有很高的Hct依賴性（R2 = 0.992）。本研究結果發現，3.2V的額外一組電位不僅可用於Hct檢測，而且還可用於補償Hct所造成的葡萄糖量測干擾，導入此補償邏輯後，葡萄糖量測的偏差(Bias)不再受Hct這個參數影響（R2 = 0.0705），並能夠在Hct 10％〜70％的範圍內進行量測，量測偏差控制在±10％內，此結果與傳統的計時電流法相比，大大的提高了全血葡萄糖量測的準確度。 | zh_TW |
| dc.description.abstract | Besides a crucial parameter for surgery and clinical diagnosis, hematocrit tends to affect the analytical result of point-of-care analytical devices. Therefore, an accurate and quick method for measuring hematocrit was developed on the basis of screen-printed carbon electrodes (SPCE). An impulse of 3.0V DC voltage was imposed on ferricyanide-coated SPCE to induce hemolysis, the released hemoglobin reduced the ferricyanide and generated a higher oxidation current for estimating hematocrit. Hematocrit ranging from 10 to 70% can be determined in 5s by linear sweep voltammetry (r2= 0.9907) or 0.8s by 3V of potential step voltammetry (r2 = 0.9833).
Furthermore, accurate and quick disposable sensor for both glucose and hematocrit (Hct) was also developed. The aim of this study was to develop a method for glucose calculation with improved accuracy using the Hct compensation method that minimizes the effects of Hct on glucose measurements. Typically, simple chronoamperometry with one potential step is used to measure glucose concentrations. The mean biases of glucose measurements were linearly correlated with Hcts from 9% to 70% and the deviations ranged from 40% to -50%. The result indicated that simple chronoamperometry method for glucose measurements were highly Hct dependent (R2 = 0.992). The present study showed that an additional potential step of 3.2V not only can be used for Hct detection but also applied for interference compensation of glucose measurement. After compensation, the biases of glucose measurements of proposed method were Hct independent (R2 = 0.0705) and is consequently capable of operating acceptably in a wide Hct range of 10% ~ 70% with biases in ± 10% which has improved the accuracy of glucose measurements as compared with the existing chronoamperometry method. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T02:59:09Z (GMT). No. of bitstreams: 1 ntu-106-D99631006-1.pdf: 3047597 bytes, checksum: 01127bfac8139d022dc7c2e8351e910d (MD5) Previous issue date: 2017 | en |
| dc.description.tableofcontents | 誌 謝 ii
中文摘要 iii Abstract iv 目錄 vi 圖目錄 x 表目錄 xii 第一章 前言 1 第二章 文獻探討 3 2.1糖尿病 3 2.2 血糖監控系統 5 2.2.1市場重要性及變化 5 2.2.2 生物感測器 8 2.2.3 血糖感測器的發展 8 2.2.4 血糖感測器問題及干擾 11 2.3血球容積比 12 2.3.1血球容積比干擾原理及對血糖量測的影響 13 2.3.2 血球容積量測及補償血糖方式 14 2.3.3 破血球量測血球容積 15 2.4 電化學分析技術 16 2.4.1循環伏安法 16 2.4.2線性掃描技術 18 2.4.3計時電流法 19 第三章 實驗材料與方法 20 3.1實驗藥品與儀器設備 20 3.1.1試劑藥品 20 3.1.2儀器設備 21 3.2電化學式血球容積比量測方式的建置與開發 22 3.2.1單一使用可拋棄網印碳電極的製作 22 3.2.2膜電極的製作 23 3.2.3電壓誘導的溶血研究 23 3.2.3.1量測主原理及線性掃描伏安法可行性確認 23 3.2.3.2血液樣品製備 25 3.2.3.3循環伏安法於電壓誘導的溶血機制 25 3.2.3.4定電壓搭配等張/非等張溶液探討電壓誘導溶血的機制 26 3.2.4 電化學式血球容積比量測方式的建立 27 3.2.4.1電子顯微鏡確認膜電極外觀 27 3.2.4.2 線性掃描伏安法於血球容積比量測 27 3.2.4.3計量安培法於血球容積比量測 28 3.2.4.4主要干擾物於血球容積比量測系統的研究 28 3.3 血球容積比量測方式應用於血糖感測及其補償的建置與開發 29 3.3.1葡萄糖感測試片的製作 29 3.3.2血液樣品製備 29 3.3.3 血球容積比對血糖量測的影響 30 3.3.3.1原理 30 3.3.3.2供電模式 31 3.3.3.3計算基準 32 3.3.4 補償後血糖量測受血球容積比影響的程度研究 32 3.3.5干擾物程度評估 32 第四章 結果與討論 34 4.1電壓誘導溶血的研究 34 4.1.1線性掃描伏安法分析動力學表現 34 4.1.2電壓施加後紅血球破壞狀態 37 4.1.3循環伏安法於電壓誘導的溶血機制探討 38 4.1.4定電壓搭配等張/非等張溶液探討電壓誘導溶血的機制 41 4.1.5 電化學式血球容積比量測方式的建立 44 4.1.5.1電子顯微鏡確認膜電極外觀 44 4.1.5.2 線性掃描伏安法量測血球容積比 45 4.1.5.3計量安培法於1.5V量測血球容積比 46 4.1.5.4計量安培於3.0V量測血球容積比 48 4.1.5.5 干擾物於血球容積比量測系統的研究 51 4.2 血球容積比量測方式應用於血糖感測及其補償的建置與開發 52 4.2.1 血球容積比對血糖量測的影響 52 4.2.2 血球容積比補償對血糖量測的影響 54 4.2.3可能干擾物質的評估 56 第五章 結論 57 參考文獻 58 個人簡歷 68 | |
| dc.language.iso | zh-TW | |
| dc.subject | 血糖 | zh_TW |
| dc.subject | 血液容積比 | zh_TW |
| dc.subject | 溶血反應 | zh_TW |
| dc.subject | 網印碳電極 | zh_TW |
| dc.subject | 可拋棄式 | zh_TW |
| dc.subject | glucose sensor | en |
| dc.subject | disposable | en |
| dc.subject | Screen printed carbon electrodes (SPCE) | en |
| dc.subject | Hematocrit | en |
| dc.title | 電壓誘導溶血應用於血糖量測系統之血球容積比誤差補償校正 | zh_TW |
| dc.title | Glucose Monitoring System with Hematocrit Error Compensation Based on Voltage-Induced Hemolysis | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 105-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 陳力騏,陳林祈,謝博全,吳靖宙 | |
| dc.subject.keyword | 血液容積比,溶血反應,網印碳電極,可拋棄式,血糖, | zh_TW |
| dc.subject.keyword | Hematocrit,Screen printed carbon electrodes (SPCE),disposable,glucose sensor, | en |
| dc.relation.page | 68 | |
| dc.identifier.doi | 10.6342/NTU201702178 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2017-07-28 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 生物產業機電工程學研究所 | zh_TW |
| 顯示於系所單位： | 生物機電工程學系 | |
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