請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/20232完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林璧鳳(Bi-Fong Lin) | |
| dc.contributor.author | Yu-Qing Ye | en |
| dc.contributor.author | 葉雨晴 | zh_TW |
| dc.date.accessioned | 2021-06-08T02:42:49Z | - |
| dc.date.copyright | 2021-01-07 | |
| dc.date.issued | 2020 | |
| dc.date.submitted | 2020-12-28 | |
| dc.identifier.citation | 辜祥霖 (2016)，不同葉酸含量對高油飲食小鼠腎臟的影響，國立臺灣大學生化科技學系 碩士論文
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/20232 | - |
| dc.description.abstract | 台灣末期腎臟病疾病盛行率為全球第一，已知過重及肥胖所造成的代謝異常如高血糖、高血脂會增加腎病變的風險。因此，本研究欲探討代田菌 (Lactobacillus casei Shirota, LcS) 的補充對高油高糖致肥胖的Vhlh基因缺失小鼠脂質代謝的影響。實驗一先以自發性腎炎致腎癌之Vhlhdel/del小鼠，將離乳後5週齡開始以管餵方式補充LcS，觀察生命期，結果發現LcS可以顯著延長Vhlhdel/del小鼠生命期。實驗二以高油高糖飲食致肥胖Vhlh+/del小鼠，探討補充LcS對醣類與脂質代謝及免疫調節的影響。結果顯示，餵飼LcS8週後能顯著降低小鼠體重，延緩血糖的上升並減緩胰島素阻抗。肝臟三酸甘油酯及膽固醇在高油高糖飲食下顯著增加，補充LcS可顯著降低肝臟總膽固醇含量。補充LcS對盲腸及糞便的指標菌門的結果，高油高糖飲食顯著降低盲腸的厚壁菌門及擬桿菌門，補充LcS有降低厚壁菌門並提升擬桿菌門的趨勢；糞便中擬桿菌門相對量達顯著差異，而有降低厚壁菌門與擬桿菌門比例的趨勢。指標菌屬評估，高油高糖飲食糞便中乳酸菌屬有降低趨勢，LcS補充增加盲腸及糞便中乳酸菌屬量，WT小鼠糞便達顯著差異；高油高糖飲食降低盲腸及糞便中比菲德氏菌屬，LcS補充可回升比菲德氏菌屬數量，也在糞便達顯著差異。腸道免疫細胞群結果顯示PP中，LcS補充可顯著增加脾臟中CD4+ T細胞比例。細胞激素方面，高油高糖飲食促進MLN及脾臟細胞IL-6分泌以及PP的TNF-α的分泌。補充LcS降低脾臟IL-6的分泌。高油高糖飲食顯著降低IL-10的分泌，補充LcS有增加Vhlh+/del小鼠調節型細胞激素IL-10生成的趨勢，同時降低IL-4的產生。綜上所述，補充LcS對於高油高糖飲食致肥胖之Vhlh+/del小鼠，能有效改善其血糖及脂質代謝，並調節體內免疫反應，可能有助延緩慢性腎炎致腎癌Vhlhdel/del小鼠生命期。 | zh_TW |
| dc.description.abstract | The incidence of kidney cancer is increasing by approximately 2% per year. The prevalence of end-stage renal disease in Taiwan ranks the first place in the world. This increasing incidence is thought to be partly due to an increased prevalence of obesity, which may cause metabolic abnormalities like hyperglycemia and dyslipidaemia, the risk factors of nephropathy. This study aimed to investigate the effects of Lactobacillus casei strain Shirota (LcS) on lipid metabolism and rephropathy. The experiment 1 demonstrated that oral administration of LcS improved the life span of Vhlhdel/del mice. To investigate whether LcS may favourably affect metabolic abnormalities in obese Vhlh+/del mice. Herein, high-fat-sucrose diet (HFS)-induced obese mice were supplemented with oral administration of LcS for 48 weeks. The result showed that the body weight of Vhlh+/del mice significantly decreased, fasting serum glucose level and insulin resistance were improved compared to the HFS group. Furthermore, the gut microbiota in fecal and cecum contents from mice fed high-fat-sucrose diet exhibit significantly reduced the population of Firmicutes and Bacteroidetes compared to the that of control diet group. Probiotic LcS increased Bacteroidetes, decreased Firmicutes in both on fecal and cecum. Lactobacillus and Bifidobacterium significantly decreased in the HFS diet group. LcS supplement elevated the population of Lactobacillus and Bifidobacterium in fecal significantly, and also increased Lactobacillus in cecum in Vhlh+/del mice. In addition, after long-term induced by HFS diet which in turn triggers chronic low-grade inflammation, results of immune cells population and secreting cytokines showed that the proinflammatory cytokine IL-6 increased in mesenteric lymph nodes (MLN) and spleen in the HFS group. LcS group significantly decreased on IL-6 in spleen compared to the HFS group. The HFS diet also decreased regulatory cytokine IL-10 in MLN and spleen, which increased with LcS supplement. And declined IL-4 effectively after LcS supplement in spleen. In conclusion, LcS as a probiotic supplement, greatly improve the carbohydrate and lipid metabolism, gut microbiota, immune responses affected by the HFS diet. And LcS supplement also may improved the life span of Vhlhdel/del mice. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T02:42:49Z (GMT). No. of bitstreams: 1 U0001-1609202012501700.pdf: 13258779 bytes, checksum: c0196c1bd31091d7e528b2d6c8aed748 (MD5) Previous issue date: 2020 | en |
| dc.description.tableofcontents | 目錄 摘要 I Abstract II 目錄 IV 表目錄 VII 圖目錄 VIII 縮寫對照表 X 第一章 序論 1 第一節 文獻回顧 1 一、 腸道共生菌 1 (一) 腸道共生菌組成 1 (二) 飲食對腸道菌的作用 2 (三) 腸道共生菌與肥胖 3 (四) 腎炎與腸道共生菌 4 二、 肥胖 4 (一) 肥胖與胰島素抗性 5 (二) 肥胖與發炎反應 5 (三) 肥胖與慢性腎臟疾病 6 三、 腸道免疫系統 8 (一) 腸道免疫系統的組成 8 (二) 腸道免疫與腸道共生菌 8 四、 益生菌與免疫調節 10 (一) 益生菌 10 (二) 代田菌 (Lactobacillus casei Shirota, LcS) 11 五、 VHL基因 12 (一) VHL基因與亮細胞腎癌 (clear cell renal cell carcinoma) 12 (二) VHL基因與肝損傷 13 第二節 研究動機與目的 14 第二章 實驗設計與材料方法 15 一、 實驗材料製備及動物飼養 15 (一) 乳酸菌活化、保存與菌數檢測 15 (二) 實驗動物繁殖 15 二、 實驗設計與分組 17 實驗一 LcS對Vhlh基因缺失小鼠生命期之影響 17 實驗二 LcS對高油高糖飲食WT及 Vhlh基因部分缺失小鼠之影響 18 三、 組織分析 20 (一) 血清樣本分析 20 (二) 肝臟脂質萃取與含量分析 21 (三) 組織切片染色 21 四、 腸道指標菌群分析 22 五、 免疫指標分析 25 (一) 免疫細胞分離與培養 25 (二) 免疫細胞表型分析 26 六、 統計分析 29 第三章 結果與討論 30 實驗一 LcS對Vhlh基因缺失小鼠生命期之影響 30 實驗二 LcS對高油高糖飲食致肥胖WT及Vhlh+/del小鼠之影響 31 一、 LcS補充對高油高糖飲食致肥胖之WT及Vhlh+/del小鼠生長情形及攝食量之影響 31 二、 LcS補充對高油高糖飲食致肥胖之WT及Vhlh+/del小鼠禁食血糖之影響 33 三、 LcS補充對高油高糖飲食誘致肥胖之WT及Vhlh+/del小鼠禁食血清胰島素及胰島素抗性之影響 35 四、 LcS補充對高油高糖飲食致肥胖之WT及Vhlh+/del小鼠組織重之影響 36 五、 LcS補充對高油高糖飲食致肥胖之WT及Vhlh+/del小鼠血清脂質之影響 37 六、 LcS補充對高油高糖飲食致肥胖之WT及Vhlh+/del小鼠肝臟脂質之影響 38 七、 LcS補充對高油高糖飲食致肥胖之WT及Vhlh+/del小鼠肝臟脂肪之影響 39 八、 LcS補充對高油高糖飲食致肥胖之WT及Vhlh+/del小鼠肝臟細胞損傷之影響 40 九、 LcS補充對高油高糖飲食致肥胖之WT及Vhlh+/del小鼠腸道中指標菌群之影響 40 (一) 盲腸指標菌門：厚壁菌門、擬桿菌門 41 (二) 糞便指標菌門：厚壁菌門、擬桿菌門 42 (三) 盲腸和糞便指標菌屬：乳酸菌屬 43 (四) 盲腸和糞便指標菌屬：比菲德氏菌屬 44 (五) 盲腸微生物消長分析 45 十、 LcS補充對高油高糖飲食致肥胖之WT及Vhlh+/del小鼠腸道及脾臟中調節型T細胞之影響 46 十一、 LcS補充對高油高糖飲食致肥胖之WT及Vhlh+/del小鼠腸道免疫細胞及脾臟細胞分泌細胞激素之影響 48 第四章 綜合討論與結論 55 第一節 綜合討論 55 一、 高油高糖飲食對小鼠腎臟損傷的影響 55 二、 益生菌LcS對高油高糖飲食小鼠血清生化的影響 56 三、 益生菌LcS對高油高糖飲食小鼠肝臟脂質堆積及損傷的影響 57 四、 益生菌LcS對高油高糖飲食小鼠腸道菌群的影響 57 五、 益生菌LcS對高油高糖飲食小鼠腸道免疫的影響 60 第二節 結論 64 參考文獻 65 附錄 76 | |
| dc.language.iso | zh-TW | |
| dc.title | 益生菌 Lactobacillus casei Shirota 與高油高糖飲食對 Vhlh 基因缺失小鼠脂質代謝與免疫反應之影響 | zh_TW |
| dc.title | Effects of probiotic Lactobacillus casei Shirota and high-fat-sucrose diet on lipid metabolism and immune responses in Vhlh gene defect mice | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 109-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 徐沺(Tien Hsu),林金源(Jin-Yuarn Lin),江孟燦(Meng-Tsan Chiang),鄭光成(Kuan-Chen Cheng) | |
| dc.subject.keyword | 代田菌,黏膜免疫系統,肥胖,腸道菌群, | zh_TW |
| dc.subject.keyword | Lactobacillus casei strain Shirota,obesity,mucosal immune system,gut microbiota, | en |
| dc.relation.page | 80 | |
| dc.identifier.doi | 10.6342/NTU202004212 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2020-12-29 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科技學系 | zh_TW |
| 顯示於系所單位： | 生化科技學系 | |
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