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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 曹建和 | |
| dc.contributor.author | Ming-Huang Chen | en |
| dc.contributor.author | 陳明煌 | zh_TW |
| dc.date.accessioned | 2021-06-08T01:40:57Z | - |
| dc.date.copyright | 2016-10-05 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-08-18 | |
| dc.identifier.citation | References
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/18965 | - |
| dc.description.abstract | The phospholipid coated microbubbles are widely used for ultrasound contrast imaging. The quality of imaging strongly depends on the resonance frequency of bubbles. When the transmitted frequency matches the resonance frequency of a contrast agent, conditions are optimal for producing higher scattering, which has been demonstrated to improve the contrast to tissue ratio (CTR). Therefore, a significant factor in ultrasound contrast imaging is knowledge of the resonance frequencies of bubbles. Usually, the natural frequency of a bubble is inversely proportional to its radius. However, in previous studies showed if a bubble size is smaller than 10 μm and its encapsulating material has high viscosity, its resonance frequency is very different from its natural frequency due to the high viscous damping coefficient. In order to research how the resonance frequencies of bubbles are affected by viscous damping over the whole range of microbubble sizes accompanied by the acoustic pressure increasing, we simulate the bubble dynamic oscillation for sizes varying between 1 to 4 μm with the Marmottant model. It showed the pressure-dependent resonance only occurred in bubble sizes larger than Rm (the bubble size at the maximal resonance frequency), and on the opposite side, at bubble sizes smaller than Rm it does not appear. While a bubble size that is smaller than Rm, and which has a larger and flatter spectrum without thresholding effect. The bubbles cease to resonate due to total damping larger than square root of 2. The understanding of the influence of shell parameters on the resonance frequency of lipid coated bubbles, which may aid to optimize pulse echoes for ultrasound contrast imaging.
Second harmonic imaging is the principle technique used in the ultrasound contrast agent diagnosis. Quality of second harmonic images is limited by CTR. Techniques for improving the generation of the contrast harmonic are helpful in increasing the CTR of contrast images. Therefore, this study proposed the effects of the compressible shell on the second harmonic response due to ultrasonic excitation. Recent studies show that the ultrasound contrast agent with phospholipid shell may have compression-only behavior, which may improve the generation of harmonic responses due to the compressibility of shell. Analytical simulations were performed for understanding the influence of the compression-only behavior on the generation of second harmonic. A CER (Compression to Expansion Ratio) index is proposed to quantify the degree of the nonlinearity of microbubbles. Effects of the shell viscosity, shell elasticity and the derivative of shell elasticity on the generation of microbubble second harmonic are presented using the analytical solutions of the bubble dynamic equation. It is shown that the derivative of the effective shell elasticity is positively correlated with CER and SCS (Scattering Cross-Section) of second harmonic, and the CER provides a common ground for gauging the effect of different shell parameters on ultrasound contrast agent harmonic generation. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T01:40:57Z (GMT). No. of bitstreams: 1 ntu-105-F95921050-1.pdf: 2646672 bytes, checksum: c27d14223b1f72786b85572668aa4cf2 (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | Contents
口試委員會審定書 i 誌謝 ii 中文摘要 iii Abstract v Contents vii List of Figures x List of Tables xv Chapter 1 Introduction 1 1.1 Ultrasound contrast imaging 1 1.2 Resonance of ultrasound contrast agents 1 1.3 Motivation 2 1.4 Research objectives 4 1.5 Organization 5 Chapter 2 Background and Theory 6 2.1 Medical diagnostic ultrasound 6 2.2 Contrast agents microbubbles 7 2.2.1 Evolution of contrast agents 9 2.2.2 Contrast imaging 11 2.2.3 The importance of resonant frequency for contrast imaging 14 2.3 Dynamic bubbles 16 2.3.1 Dynamics of coated Bubbles 16 2.3.2 Marmottant model 20 2.3.2.1 Compression-only behavior 22 2.4 Nonlinear dynamic of lipid-coated bubbles 27 2.4.1 Skewing behavior 29 2.4.2 Pressure-dependent resonance 32 2.4.3 Thresholding behavior 34 2.5 Weakly nonlinear analysis 40 2.6 Simulation method 45 Chapter 3 Resonance Frequency of Phospholipid Shelled Microbubbles for Nonlinear Oscillations: Effect of shell viscosity 49 3.1 Introduction 49 3.2 Effects of damping on resonance frequency 53 3.3 Effect of bubble radius on the resonance frequency 57 3.4 Effect of shell viscosity on the resonance frequency 61 3.5 Effect of shell viscosity on the pressure-dependent resonance 74 3.6 Limitation of simulation model 93 Chapter 4 Effects of Phospholipid Shell on the Generation of Second Harmonic of Ultrasound Contrast Agent Microbubble 94 4.1 Introduction 94 4.2 Quantifying compression-only behavior by CER (Compression to Expansion Ratio) 96 4.3 Shell parameter effect 100 4.3.1 Effects of shell viscosity 101 4.3.2 Effects of effective shell elasticity 103 4.3.3 Effects of derivative of shell elasticity 105 Chapter 5 Conclusion 112 References 115 | |
| dc.language.iso | en | |
| dc.subject | 氣泡動態模型 | zh_TW |
| dc.subject | 磷脂包覆之微氣泡 | zh_TW |
| dc.subject | 共振頻率 | zh_TW |
| dc.subject | 超音波對比劑成像 | zh_TW |
| dc.subject | Phospholipid-coated microbubble | en |
| dc.subject | Ultrasound contrast imaging | en |
| dc.subject | Resonance frequency | en |
| dc.subject | Compression-only | en |
| dc.subject | Bubble dynamic model | en |
| dc.title | 超音波對比劑聲學反應之優化 | zh_TW |
| dc.title | The Optimization of the Acoustic Response of Ultrasound Contrast Agents | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 羅孟宗,林文澧,林祐霆,曹勝凱 | |
| dc.subject.keyword | 磷脂包覆之微氣泡,氣泡動態模型,共振頻率,超音波對比劑成像, | zh_TW |
| dc.subject.keyword | Phospholipid-coated microbubble,Bubble dynamic model,Compression-only,Resonance frequency,Ultrasound contrast imaging, | en |
| dc.relation.page | 123 | |
| dc.identifier.doi | 10.6342/NTU201603288 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2016-08-20 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
| 顯示於系所單位： | 生醫電子與資訊學研究所 | |
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| ntu-105-1.pdf 未授權公開取用 | 2.58 MB | Adobe PDF |
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