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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/17570
Title: | 病例基底研究中風險及相對風險的估計方法 Estimating Risks and Relative Risks in Case-Base Studies |
Authors: | Tsz-Ting Chui 徐紫婷 |
Advisor: | 李文宗 |
Keyword: | 病例對照研究,條件式羅吉斯迴歸,流行病學方法,基因環境交互作用,遺傳相關分析,羅吉斯迴歸,勝算比, case-control studies,conditional logistic regression,epidemiologic methods,gene-environment interaction,genetic association studies,logistic regression,odds ratio, |
Publication Year : | 2013 |
Degree: | 博士 |
Abstract: | Both the absolute and the relative risks (RR) of disease have a crucial role to play in epidemiology. RR is often approximated by odds ratio under the rare-disease assumption in case-control study. However, such a study design does not provide an estimate for absolute risk. In this thesis, we develop a method in estimating risks and relative risks in case-base study. It contains two main themes. In the first part, we propose a logistic model for the case-base study. The model is flexible enough to admit multiple exposures in any measurements. It can be easily fitted using common statistical packages. With one additional step of simple calculations of the model parameters, one readily obtains relative and absolute risk estimates as well as their confidence intervals. The occurrences of many diseases are the interplays of genes, environments and their interactions. In the second part, we elaborate how to incorporate the assumptions of gene-environment independence and Hardy-Weinberg equilibrium into the logistic model to further improve statistical efficiency. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/17570 |
Fulltext Rights: | 未授權 |
Appears in Collections: | 流行病學與預防醫學研究所 |
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ntu-102-1.pdf Restricted Access | 355.75 kB | Adobe PDF |
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