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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳美如(Mei-Ru Chen) | |
dc.contributor.author | Yu-Zhen Su | en |
dc.contributor.author | 蘇昱禎 | zh_TW |
dc.date.accessioned | 2021-06-08T00:10:54Z | - |
dc.date.copyright | 2013-09-24 | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013-08-06 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/17401 | - |
dc.description.abstract | Epstein-Barr virus (EBV) is an ubiquitous virus that infects most people and is the first human virus directly implicated in carcinogenesis. After the viral DNA replication and encapsidation, the nuclear egress complex composed of BFRF1 and BFLF2 can facilitate the budding of nucleocapsids through the nuclear envelope and EBV BVRF1 is recognized as a capsid-associated tegument protein that interacts with the nuclear egress complex. It is reported that BFRF1 recruits ESCRT (endosomal sorting complex required for transport) machinery to nucleus-associated membrane and induces the formation of perinuclear vesicles for promoting nuclear egress. In our previous observation, BVRF1 was co-immunoprecipitated with BFRF1 during EBV lytic cycle. In this study, the biological function and interacting protein network with nuclear egress-associated proteins were investigated. The transiently transfected Flag-BFLF2 was co-immunoprecipitated with HA-BVRF1 during EBV lytic cycle and colocalized around the nuclear rim in immunostaining. In the functional domain mapping of BFLF2, deletion of a.a. 103-149, 150-209, 209-286 or 277-318 enhanced the interaction of BFLF2 deletion mutants with HA-BVRF1. Previously, HA-BVRF1 was found co-immunoprecipitated with TSG101, a component of ESCRT machinery, in EBV reactivated cells. In this study, HA-BVRF1 and TSG101 colocalized at nuclear rim and putative EBV cytoplasmic assembly compartment in immunofluorescence assay, suggesting that BVRF1 participates in nuclear egress and maturation process of EBV through interaction with TSG101. We also established 293TetEZ cells carrying ∆BVRF1 bacmid to investigate the biological function of BVRF1 in EBV replication. Moreover, in functional domain mapping, a.a. 2-102 and a.a. 209-286 of BFLF2 was found to mediate its import into nucleus. Besides, deletion of a.a. 150-209 or a.a. 209-286 in BFLF2 influenced the vesicle formation ability of BFRF1, thereby BFRF1 accumulated as aggregates at the nuclear membrane in co-expressing cells. Overall, data here indicate multiple consequent protein-protein interactions are involved in the EBV nuclear egress process. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T00:10:54Z (GMT). No. of bitstreams: 1 ntu-102-R00445113-1.pdf: 9726309 bytes, checksum: 171bed86ca97d08c5ccaa29b6afd9252 (MD5) Previous issue date: 2013 | en |
dc.description.tableofcontents | 1. 序論 1
1.1 EB病毒(Epstein-Barr virus) 1 1.2 疱疹病毒之殼體(capsid) 4 1.3 出核過程(nuclear egress) 6 1.4 BVRF1及其同源蛋白質 9 1.5 可能與BVRF1產生交互作用之蛋白質 13 1.6 研究目的 16 2. 實驗材料與方法 17 2.1 材料 17 2.2 方法 21 3. 實驗結果 28 3.1 當EB病毒再活化時,HA-BVRF1與Flag-BFLF2蛋白質可被共同沉澱 28 3.2 HA-BVRF1與YFP-BFLF2於EB病毒活化後不同時間點之分布變化 28 3.3 BFLF2之胺基酸序列103-318影響其HA-BVRF1參與在共同免疫沉澱複合 29 體之能力 29 3.4 HA-BVRF1與Flag-BFLF2 deletion mutants於細胞內之分布變化 31 3.5 HA-BVRF1與TSG101於EB病毒在活化後不同時間點之分布變化 32 3.6 建立帶有∆BVRF1 EBV bacmid之細胞株 33 3.7 BFLF2胺基酸序列2-102與209-286影響其進入細胞核 34 3.8 BFLF2的胺基酸序列2-102對其與HA-BFRF1的交互作用為重要的 34 3.9 Flag-BFLF2 deletion mutants影響HA-BFRF1主導之液泡構造形成過程 35 4. 討論 37 4.1 HA-BVRF1與Flag-BFLF2於EB病毒溶裂期形成免疫沉澱複合體之可能意義 37 4.2 HA-BVRF1與YFP-BFLF2於NA細胞中之動態變化暗示BVRF1及BFLF 2 38 可能參與EBV核殼體出核過程 38 4.3 BFLF2的不同段結構域會調控其與BVRF1形成共同免疫沉澱複合體 39 4.4 TSG101可能參與核殼體之出核過程與成熟 40 4.5 ∆BVRF1 bacmid可能其他基因有缺陷故觀察不到外送HA-BVRF1補償的預期結果 ……………………………………………………………………………………………………………………………………….41 4.6 BFLF2的N端序列對其進入細胞核以及和BFRF1形成交互作用是重要的 42 4.7 總結 43 參考文獻 57 | |
dc.language.iso | zh-TW | |
dc.title | EB病毒出核複合體之研究 | zh_TW |
dc.title | The Study of the Nuclear Egress Complex in Epstein-Barr Virus | en |
dc.type | Thesis | |
dc.date.schoolyear | 101-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 林素芳(Su-Fang Lin),張雯(Wen Chang),李重霈(Chung-Pei Lee) | |
dc.subject.keyword | EB病毒,BVRF1,BFRF1,BFLF2,TSG101,病毒核殼體,出核過程, | zh_TW |
dc.subject.keyword | Epstein-Barr virus (EBV),BVRF1,BFRF1,BFLF2,TSG101,nucleocapsid,nuclear egress, | en |
dc.relation.page | 68 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2013-08-07 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 微生物學研究所 | zh_TW |
顯示於系所單位: | 微生物學科所 |
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