請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/16366完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 吳學良(Hsueh-Liang Wu) | |
| dc.contributor.author | Judith Exl | en |
| dc.contributor.author | 韓嫻 | zh_TW |
| dc.date.accessioned | 2021-06-07T18:11:38Z | - |
| dc.date.copyright | 2012-06-29 | |
| dc.date.issued | 2012 | |
| dc.date.submitted | 2012-06-28 | |
| dc.identifier.citation | Books:
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David Fuller, “Modelling the incentive to participate in open source biopharmaceutical innovation”. R&D MANAGEMENT, Vol. 40, 2010. Roland Andersson et al., “The Future of Pharmaceutical Innovation – Tackling the R&D Productivity Gap”. ACCENTURE, 2011. Michael R. Barnes et al., “Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery”. NATURE REVIEWS DRUG DISCOVERY, Vol. 8, 701-708, 2009. Matthia Bianchi et al., “Organisational modes for Open Innovation in the bio-pharmaceutical industry: An exploratory analysis”. TECHNOVATION Vol. 31, p. 22-33, 2011. Daren C. Brabham, “Crowdsourcing as a Model for Problem Solving”. Sage Publications: CONVERGENCE 2008. Kevin J. Boudreau, Nicola Lacetera, Karim R. Lakhani, “Parallel Search, Incentives and Problem Type: Revisiting the Competition and Innvoation Link”. Harvard Business School, Working Paper 09-041, 2008. Kevin J. Boudreau and Karim R. Lakhani, “How to Manage Outside Innovation”. MIT SLOAN MANAGEMENT REVIEW, July 1, Summer 2009. Declan Butler, “GlaxoSmithKline goes public with malaria data. Company to place structures and properties of drug leads into the public domain.” Nature Publishing Group: NATURE, Vo. 481, 237-404, January 2010. Matthew A. Cooper, “Optical biosensors in drug discovery”. NATURE REVIEWS DRUG DISCOVERY 1, 515 – 528, 2002. Daniel Cressey, “Deep future of drug discovery. For GlaxoSmithKline’s research chief Patrick Vallance, drug development unites in-house depth with external breadth.” NATURE, Vol. 471, No. 7336, 5-130, March 2011. Chris DeBresson and Fernand Amesse, “Networks of innovators: A review and introduction to the issue.” RESEARCH POLICY, Vol. 20, No. 5, 363-379, 1991. Margaret L. Eaton, “Novartis-U.C. Berkeley Research Collaboration”. Stanford: Stanford Graduate School of Business 2004. Sean Ekins and Antony J. Williams, “When companies publish large datasets: an abundance of riches or fool’s gold?” DRUG DISCOVERY TODAY, Vol. 15, No. 19/20, October 2010. Terry J. Fetterhoff and Dirk Voelkel, “Managing open innovation in biotechnology”. Arlington, VA: Industrial Research Institute 2006. David A. Fidock, “Priming the antimalarial pipeline”. Macmillan Publishers Limited: NATURE, Vol. 465, 297-298, May 2010. Mark C. Fishman and Jeffery A. Porter, “A new grammar for drug discovery”. Nature Publishing Group: NATURE, Vol. 437, Sep. 2005. Isabella Gashaw et al., “What makes a good drug target?” DRUG DISCOVERY TODAY, Vol. 16, No. 23/24, December 2011. Hans-Werner Gottinger and Celia L. Umali, “Strategic Alliances in Global Biotech Pharma Industries”. THE OPEN BUSINESS JOURNAL, Vol. 1, p. 10-24, 2008. Jeff Howe, “The power of crowdsourcing”. Condé Nast Digital: WIRED MAGAZINE, June 2006. Michael Hu et al., “The Innovation Gap in Pharmaceutical Drug Discovery & New Models for R&D Success”. Kellogg School of Management, 2007. Bethan Hughes, “Harnessing Open Innovation”. NATURE REVIEWS DRUG DISCOVERY, Vol. 8, 344-345, 2009. Dr Jackie Hunter, “Is the pharmaceutical industry open for innovation?” DRUG DISCOVERY WORLD, Fall 2010. Andrew A. King, Karim R. Lakhani, “The Contingent Effect of Absorptive Capacity: An Open Innovation Analysis. Harvard Business School, Working Paper 11-102, 2011. Joanne Kotz, “Lilly’s opening moves”. SCIENCE BUSINESS eXCHANGE, Vol. 4, No. 40, October 2011. Karim R. Lakhani, Lars Bo Jeppesen, Peter A. Lohse, Jill A. Panetta, “The Value of Openness in Scientific Problem Solving”. Harvard Business School, Working Paper 07-050, October 2006. Monika Lessl and Khusru Asadullah, “Crowd sourcing in drug discovery”. NATURE REVIEWS DRUG DISCOVERY, Vol. 10, April 2011. Monika Lessl et al., “Grants4Targets – an innovative approach to translate ideas from basic research into basic drugs”. DRUG DISCOVERY TODAY, Vol. 16, No. 7/8, April 2011. Bernard Munos, “Can open-source R&D reinvigorate drug research?” NATURE REVIEWS DRUG DISCOVERY, August 2006. Fabio Pammolli, Laura Magazzini and Massimo Riccaboni, “The productivity crisis in pharmaceutical R&D”. NATURE REVIEWS DRUG DISCOVERY, Vol. 10, 428-438, June 2011. Clare Sansom, “The power of many”. NATURE BIOTECHNOLOGY, Vol. 29, No. 3, 2011. Cormac Sheridan, “Industry continues dabbling with open innovation models”. NATURE BIOTECHNOLOGY, Vol. 29, No. 12, 2011. Sean Silverthorne, “Markets or Communities? The Best Ways to Manage Outside Innovation”, Q&A with: Karim R. Lakhani. Harvard Business School, Working Knowledge, July 20, 2009. Online Resources: “Annual Report 2009” in http://www.annualreport2009.bayer.com. Leverkusen: Bayer AG, February 26, 2010. http://www.annualreport2009.bayer.com/en/homepage.aspx (accessed June 1st, 2012) By Ben Hirschler and Kate Kelland, “Big Pharma’s stalled R&D machine” in http://in.reuters.com. London: Reuters, June 16th, 2010. http://in.reuters.com/article/2010/06/16/idINIndia-49348820100616 (accessed June 1st, 2012) “Cambridge partners with Lilly in Open Innovation Drug Discovery Platform” in https://www.enterprise.cam.ac.uk. Cambridge: University of Cambridge, 2012. https://www.enterprise.cam.ac.uk/news/2012/1/cambridge-partners-lilly-open-innovation-drug-disc/ (accessed April 26th, 2012) “Collaborative Agreement with Eli Lilly and Company for Drug Discovery” in http://www.nd.edu. South Bend, IN: University of Notre Dame. http://www.nd.edu/~crnd/Announelilillyagreement.htm (accessed April 26th, 2012) “Corporate Reporting” in http://www.gsk.com. Brentford: GlaxoSmithKline plc., January 2010. http://www.gsk.com/investors/corporate-reporting.htm (accessed June 1st, 2012) Ronald Cornet and Nicolette de Keizer, “Forty years of SNOMED: a literature review.” BioMed Central: Medical Informatics and Decision Making, 8(Suppl 1):S2, October 2008. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582789/pdf/1472-6947-8-S1-S2.pdf (accessed May 5th, 2012) “From Targets to Novel Drugs – Grants4Targets” in http://www.grants4targets.com. Leverkusen: Bayer HealthCare, 2012. http://www.grants4targets.com/scripts/pages/en/index.php (accessed April 27th, 2012) “GSK announces ‘open innovation’ strategy to help deliver new and better medicines for people living in the world’s poorest countries” in http://www.gsk.com. Brentford: GlaxoSmithKline plc., January 2010. http://www.gsk.com/media/pressreleases/2010/2010_pressrelease_10009.htm (accessed April 29th, 2012) “Lilly Reports Fourth-Quarter and Full-Year 2009 Results” in http://newsroom.lilly.com. Indianapolis: Eli Lilly and Company, Jan 28, 2010. http://newsroom.lilly.com/releasedetail.cfm?ReleaseID=441003 (accessed June 1st, 2012) “List of pharmaceutical companies” in http://en.wikipedia.org. Wikipedia: May 29, 2012. http://en.wikipedia.org/wiki/List_of_pharmaceutical_companies (accessed June 1st, 2012) “Neglected Diseases” in http://rarediseases.info.nih.gov/Resources.aspx?PageID=32. Bethesda, MD: National Institute of Health. http://rarediseases.info.nih.gov/files/Neglected_Diseases_FAQs.pdf. (accessed April 21st, 2012) “Open Innovation Drug Discovery” in https://openinnovation.lilly.com/. Indianapolis, IN: Eli Lilly & Company, 2011. (accessed April 25th, 2012) “The idea exchange at UBS” in www. managementlab.org. Woodside, CA: Management Lab 2009. http://managementlab.org/files/site/publications/labnotes/mlab-labnotes-012.pdf (accessed April 23rd, 2012). “The 10 biggest-selling drugs that are about to lose their patent” in http://www.dailyfinance.com/. New York: AOL Money & Finance 2012. http://www.dailyfinance.com/2011/02/27/top-selling-drugs-are-about-to-lose-patent-protection-ready/ (accessed April 17th, 2012) “UC, Eli Lilly partner in Phenotypic Drug Discovery Initiative” in http://www.soapboxmedia.com. Cincinnati, OH: Soapbox, August 2009. http://www.soapboxmedia.com/innovationnews/0825lilly.aspx (accessed April 26th, 2012) | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/16366 | - |
| dc.description.abstract | 近年來,製藥產業的研發生產力持續下滑;本研究藉由探討「開放式創新」與「眾包」兩種創新模式,試圖找出製藥產業如何藉此二者解決其所面臨的困境。除了介紹兩個創新模式的理論背景及定義之外,本研究以Eli Lilly、Bayer HealthCare以及GlaxoSmithKline三家藥廠的開放式創新專案作為個案研究的對象。
本研究首先查明每個專案是否具有讓開發藥物的知識在製藥產業內達到更有效率分配的潛力。接下來,本研究將一一辨識開放式專案中的成功因素,例如對外部研究員提出的挑戰之定義與溝通方式的明確性、平台的選擇、新概念對內部的營銷以及其與內部研發的整合。 此外,本研究也將探討企業在進行開放式創新的時最常遇到的挑戰,例如知識產權保護和數據的標準化,並提供一系列有助於預測或解決這些困難的建議。 綜合上述,開放式創新與眾包兩項創新模式未來可能會扮演復興藥物開發的關鍵角色,而這些模式在未來可能被應用在設計更具生產力的研發模式上。 | zh_TW |
| dc.description.abstract | This study examines current changes in the pharmaceutical industry’s innovation model. In recent years, pharmaceutical R&D productivity has been declining, forcing companies to search for new sources of innovation and cooperate with external partners. More traditional remedies to the innovation crisis include the sourcing of external knowledge through alliances, as well as partnering and licensing agreements with biotech companies. But one of the most promising novel approaches is open innovation, which allows pharmaceutical companies to exchange knowledge with external researchers without entering any form of long-term binding agreement.
This thesis employs the case study approach to examine three pharmaceutical open innovation initiatives and determine the factors that may contribute to a project’s successful implementation. Data collected concerns the objectives and implementation of each project, as well as incentive creation, IP protection mechanisms, and interaction with external researchers. Specifically, the study seeks to determine the impact of the following factors: (1) a firm’s ability to attract external knowledge, (2) the effective recombination of internal and external knowledge, (3) the appropriate choice of inbound vs. outbound open innovation models, (4) the preconditions of inbound and outbound innovation models, and finally (5) the organizational arrangements of an open innovation project. The findings indicate that successful implementation of open innovation primarily depends on a firm’s ability to identify the appropriate implementation model for its project, attract complementary external knowledge, and effectively recombine this knowledge with internal resources. Open innovation shows the potential to supplement pharmaceutical companies’ in-house drug development efforts and may contribute to resolving the industry’s innovation challenge in the future. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-07T18:11:38Z (GMT). No. of bitstreams: 1 ntu-101-R99724064-1.pdf: 3659403 bytes, checksum: b467e5933c656f4b18b7c6ab38f20666 (MD5) Previous issue date: 2012 | en |
| dc.description.tableofcontents | Contents
口試委員會審定書 ii Acknowledgments iii 摘要 (Chinese Abstract) iv Abstract v I. Introduction 1 1.1 Research and development in the pharmaceutical industry 1 1.1.2 Open innovation as a potential solution to the innovation crisis 4 1.2 Research objective 6 1.3 The structure of the thesis 7 II. Open innovation and crowdsourcing: definitions and related literature 8 2.1 Open innovation 8 2.2 Closed and open innovation concepts 9 2.2.1 Literature on open innovation in the pharmaceutical industry 11 2.3 Crowdsourcing 12 2.3.1 Literature on crowdsourcing 13 2.3.2 Literature on crowdsourcing in the pharmaceutical industry 15 2.4 Consequences of open innovation implementation for pharmaceutical companies 16 2.5 Gaps in the open innovation literature in the pharmaceutical context 17 III. Methodology 19 3.1 Case selection criteria 23 IV. Open innovation in the pharmaceutical industry 25 4.1 Ways to implement open innovation 26 4.2 Viability of open innovation in peripheral areas vs. core strategic areas 29 4.3 Implementation Schemes 31 4.4 Creating incentives for external researchers 35 4.5 Assessing the practicality of open innovation in the pharmaceutical industry 37 V. Cases of open innovation in pharmaceutical companies: Eli Lilly, Bayer HealthCare and GlaxoSmithKline 39 5.1 Eli Lilly and Company 41 5.1.1 Open innovation at Eli Lilly 41 5.1.2 Eli Lilly’s Open Innovation Drug Discovery platform 42 5.1.3 Participating in Lilly’s OIDD program – evaluation of compounds and further collaboration 43 5.1.4 IP protection mechanisms of the OIDD initiative 45 5.1.5 Scope of the OIDD project and strategic fit with Eli Lilly’s existent drug development focus areas 47 5.1.6 Incentives for external researchers to participate in the OIDD platform 50 5.1.7 Preliminary evaluation of the OIDD platform’s performance 50 5.2 Bayer HealthCare Pharmaceuticals 53 5.2.1 Open innovation at Bayer HealthCare 53 5.2.2 Bayer Healthcare’s Grants4Targets program 54 5.2.3 Participating in Bayer Healthcare’s Grants4Targets program – submission of proposals 54 5.2.4 Scope of the Grants4Targets project and strategic fit with Bayer Healthcare’s existent drug development focus areas 57 5.2.5 Incentives for external researchers to participate in the Grants4Targets program 58 5.2.6 Preliminary evaluation of the Grants4Targets project’s performance 59 5.3 GlaxoSmithKline plc 62 5.3.1 Open Innovation at GlaxoSmithKline 62 5.3.2 GSK’s “Open Lab” program 63 5.3.3 GSK’s open innovation approach to malaria drug discovery 64 5.3.4 Scope of the Open Lab project and strategic fit with GSK’s R&D focus areas 66 5.3.5 Incentives for external researchers to participate in GSK’s open innovation program 67 5.3.6 Preliminary evaluation of the Open Lab’s performance 67 5.4 Differences in the objectives, implementation and management of Eli Lilly’s, Bayer Healthcare’s and GSK’s open innovation projects 69 5.5 Evaluation 71 5.5.1 The scope of outside ideas 71 5.5.2 The added value of idea recombination 73 5.5.3 Innovation strategy 76 5.5.4 Implementation of open innovation 77 5.5.5 Organizational arrangements 79 VI. Prerequisites for the successful implementation of open innovation projects and potential challenges 82 6.1 Identifying the determinants of a successful open innovation project 82 6.2 Fundamental challenges to open innovation in the pharmaceutical industry 84 6.2.1 Intellectual Property management in open source collaboration and open innovation 85 6.2.2 Balancing internal R&D and external knowledge in open innovation 87 6.2.3 The challenge of organizing and standardizing public-domain data – issues raised in the wake of GSK’s malaria data release 89 VII. Limitations of this study and recommendations for further research 92 VIII. Conclusion 94 References 96 | |
| dc.language.iso | en | |
| dc.subject | 製藥產業 | zh_TW |
| dc.subject | 眾包 | zh_TW |
| dc.subject | 開放式創新 | zh_TW |
| dc.subject | open innovation | en |
| dc.subject | pharmaceutical industry | en |
| dc.subject | crowdsourcing | en |
| dc.title | 企業眾包專案的成功因素 - 以三家藥廠為例 | zh_TW |
| dc.title | What makes crowdsourcing projects successful? Case studies of three pharmaceutical companies | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 100-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李振宇(Cheng-Yu Lee),鮑慧文(Huei-Wen Pao) | |
| dc.subject.keyword | 製藥產業,開放式創新,眾包, | zh_TW |
| dc.subject.keyword | pharmaceutical industry,open innovation,crowdsourcing, | en |
| dc.relation.page | 100 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2012-06-29 | |
| dc.contributor.author-college | 管理學院 | zh_TW |
| dc.contributor.author-dept | 國際企業學研究所 | zh_TW |
| 顯示於系所單位: | 國際企業學系 | |
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