請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/16225完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蘇銘嘉(Ming-Jai Su) | |
| dc.contributor.author | Chun-Yi Chen | en |
| dc.contributor.author | 陳君怡 | zh_TW |
| dc.date.accessioned | 2021-06-07T18:05:46Z | - |
| dc.date.copyright | 2012-09-18 | |
| dc.date.issued | 2012 | |
| dc.date.submitted | 2012-07-25 | |
| dc.identifier.citation | Reference:
【1】 Fondevila C, Busuttil RW, Kupiec-Weglinski JW. Hepatic ischemia/reperfusion injury – a fresh look. Exp Mol Pathol 2003;74:86–93. 【2】 Teoh NC, Farrell GC .Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection. J Gastroenterol Hepatol 2003;18:891–902 【3】 Jaeschke H, Bautista AP, Spolarics Z, Spitzer JJ. Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia. Free Radic Res Commun 1991;15:277–84. 【4】 Sindram D, Porte RJ, Hoffman MR, Bentley RC, Clavien PA. Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver. Gastroenterology 2000; 118:183–91. 【5】 Samarasinghe DA, Tapner M, Farrell GC. Role of oxidative stress in hypoxia– reoxygenation injury to cultured rat hepatic sinusoidal endothelial cells. Hepatology 2000;31:160–5. 【6】 Narci C Teoh Hepatic ischemia reperfusion injury: Contemporary perspectives on pathogenic mechanisms and basis for hepatoprotection—the good, bad and deadly. J Gastroenterol Hepatol 2011;26 Suppl. 1; 180–7. 【7】 Lentsch AB, Atsushi K, Yoshidome H, McMasters KM, Edwards MJ. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology. 2000; 32: 169–73. 【8】 Rudiger HA, Clavien PA. Tumor necrosis factor a, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver. Gastroenterology. 2002; 122: 202–10. 【9】 Teoh N, dela Pena A, Farrell G. Hepatic ischemic preconditioning in mice is associated with activation of NF-kB, p38 kinase and cell cycle entry. Hepatology. 2002; 36: 94–102. 【10】 Teoh N, Ito Y, Field J et al. Diannexin, a novel Annexin V homodimer, provides prolonged microvascular protection against warm hepatic ischemia-reperfusion injury in mice. Gastroenterology. 2007; 133: 632–46. 【11】 Teoh NC, Field J, Yu J, McCuskey RS, Farrell GC. Short-term therapy with PPARa-agonist, Wy-14643 protects murine fatty liver against ischemia reperfusion injury. Hepatology. 2010; 51: 996–1006. 【12】 Gujral JS, Bucci TJ, Farhood A, Jaeschke H. Mechanism of cell death during warm hepatic ischemia reperfusion injury in rats: apoptosis or necrosis? Hepatology. 2001; 33: 397–405. 【13】 Jaeschke H, Farhood A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am. J. Physiol. 1991; 260: G355–62. 【14】 Lentsch AB, Atsushi K, Yoshidome H, McMasters KM, Edwards MJ. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology. 2000; 32: 169–73. 【15】 Jaeschke H. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions. Am. J. Physiol. Gastrointest. Liver. Physiol. 2006; 290: G1083–8 【16】 Ozaki M, Deshpande SS, Angkeow P Bellan J, Lowenstein CJ, Dinauer MC, Goldschmidt-Clermont PJ, Irani K. Inhibition of the Rac1 GTPase protects against non-lethal ischemia/reperfusion induced necrosis and apoptosis in vivo. FASEB J. 2000; 14: 418–29. 【17】 Cutrn JC, Perrelli MG, Cavalieri B, Peralta C, Rosell Catafau J, Poli G. Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning. Free Radic Biol Med 2002;33:1200–8. 【18】 Tsukamoto H. Redox regulation of cytokine expression in Kupffer cells. Antioxid Redox Signal 2002; 4:741–8. 【19】 Lemasters JJ, Ji S, Thurman RG. Centrilobular injury following hypoxia in isolated, perfused rat liver. Science 1981; 213:661–3. 【20】 Shiratori Y, Kiriyama H, Fukushi Y, Nagura T, Takada H, Hai K, Kamii K. Modulation of ischemia reperfusion-induced hepatic injury by Kupffer cells. Dig Dis Sci 1994; 39:1265–72. 【21】 Jaeschke H. Vascular oxidant stress and hepatic ischemia/reperfusion injury. Free Radic Res Commun 1991;12–13:737-43 【22】 Liu P, McGuire GM, Fisher MA, et al. Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia. Shock 1995; 3:56-62. 【23】 Fong Y, Moldawet L, Shires GT, Lowry SF. The biological characteristics of cytokines and their implication in surgical injury. Surg Gynecol Obstet 1990; 170:363–78. 【24】 Streieter RM, Kunkel SL, Bone RC. Role of tumour necrosis factor in disease states and inflammation. Crit Care Med 1993; 21:S447–63. 【25】 Thornton AJ, Strieter RM, Lindley I, Baggiolini M, Kunkel SL. Cytokine-induced gene expression of a neutrophil chemotactic factor/IL-8 in human hepatocytes. J Immunol 1990; 144:2609–13. 【26】 Pober JS. Cytokine-mediated activation of vascular endothelium: physiology and pathology. Am J Pathol 1998; 133:426 –33. 【27】 Morariu AM, Loef BG, Aarts LP, Rietman GW, Rakhorst G, van Oeveren W, Epema AH. Dexamethasone: benefit and prejudice for patients undergoing on-pump coronary artery bypass grafting: a study on myocardial, pulmonary, renal, intestinal, and hepatic injury. Chest2005; 128:2677–87. 【28】 Chen X, Kidder LS, Schmidt AH, Lew WD. Osteogenic protein-1 induces bone formation in the presence of bacterial infection in a rat intramuscular osteoinduction model. J Orthop Trauma 2004; 18:436–42. 【29】 Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol 2003; 284:G15–26. 【30】 Lichtman SN, Lemasters JJ. Role of cytokines and cytokine-producing cells in reperfusion injury to the liver. Semin Liver Dis 1999;19:171–87 【31】 Colletti LM, Kunkel SL, Walz A, Burdick MD, Kunkel RG, Wilke CA, Strieter RM. The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat. Hepatology 1996; 23:506–14. 【32】 Shibuya H, Ohkohchi N, Tsukamoto S, Satomi S. Tumour necrosis factor-induced, superoxide-mediated neutrophil accumulation in cold ischemia/reperfusion in rat liver. Hepatology 1997; 26:113–20 【33】 Arii S, Monden K, Adachi Y, Zhang W, Higashitsuji H, Furutani M, Mise M, Fujita S, Nakamura T, Imamura M.Pathogenic role of Kupffer cell activation in the reperfusion injury of cold-preserved liver. Transplantation 1994; 58:1072–7. 【34】 Kiuchi T, Oldhafer KJ, Schlitt HJ, Nashan B, Deiwick A, Wonigeit K, Ringe B, Tanaka K, Yamaoka Y, Pichlmayr R. Background and prognostic implications of perireperfusion tissue injuries in human liver transplants: a panel histochemical study. Transplantation 1998; 66:737–47. 【35】 Shirasugi N, Wakabayashi G, Shimazu M, et al. Up-regulation of oxygen derived free radicals by interleukin-1 in hepatic ischemia/ reperfusion injury. Transplantation 1997; 64:1398–403 【36】 Shito M,Wakabayashi G,Ueda M, Shimazu M, Shirasugi N, Endo M, Mukai M, Kitajima M. Interleukin 1 receptor blockade reduces tumour necrosis factor production, tissue injury, and mortality after hepatic ischemia-reperfusion in the rat. Transplantation 1997; 63:143–8. 【37】 Anaya-Prado R, Toledo-Pereyra LH, Lentsch AB, Ward PA. Ischemia/reperfusion injury. J Surg Res2002; 105:248–58. 【38】 Cutrin, J.C., Perrelli, M.G., Cavalieri, B., Peralta, C., Rosello-Catafau, J.,Poli, G.,. Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning. Free Radical Biology and Medicine 2002; 33,1200–8 【39】 Gopalan PK,Smith CW,Lu H,Berg EL,McIntire LV,Simon SI. Neutrophil CD 18-dependent arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow can be activated through L-selectin. J Immunol 1997; 158:367–75. 【40】 Rothelin R, Dustin ML, Marlin SD, Springer TA. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 1986; 137:1270–4. 【41】 Vodovotz Y, Kim PK, Bagci EZ, Ermentrout GB, Chow CC, Bahar I, Billiar TR. Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies. Curr Mol Med 2004; 4:753–62. 【42】 Scoazec JY, Durand F, Degott C, Delautier D, Bernuau J, Belghiti J, Benhamou JP, Feldmann G. Expression of cytokine-dependent adhesion molecules in postreperfusion biopsy specimens of liver allografts. Gastroenterology 1994; 107:1094–102. 【43】 Nakano H, Kuzume M, Namatame K, Yamaguchi M, Kumada K. Efficacy of intraportal injection of anti-ICAM-1 monoclonal antibody against liver cell injury following warm ischemia in the rat. Am J Surg 1995; 170:64–6. 【44】 Vollmar B, Glasz J, Menger MD, Messmer K. Leukocytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence. Surgery 1995; 117:195–200. 【45】 Yadav SS, Howell DN, Gao W, et al. L-selectin and ICAM-1 mediate reperfusion injury and neutrophil adhesion in the warm ischemic mouse liver. Am J Physiol 1998; 275:G1341–52 【46】 Toledo-Pereyra LH, Toledo AH, Walsh J, Lopez-Neblina F. Molecular signaling pathways in ischemia/reperfusion. Exp Clin Transplant 2004; 2:174–7. 【47】 Jaeschke, H., Mitchell, J.R., Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury. Biochemical and Biophysical Research Communications 1989;160, 140–7 【48】 Casillas-Ramirez A,Mosbah IB,Ramalho F,Rosello-Catafau J,Peralta C.Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation. Life Sciences 2006; 79;1881–94. 【49】 McCord JM. Oxygen-derived radicals: a link between reperfusion injury and inflammation. Fed Proc 1987; 46:2402–6. 【50】 Selzner N, Rudiger H, Graf R, Clavien PA. Protective strategies against ischemic injury of the liver. Gastroenterology 2003; 125:917–36. 【51】 Videla LA, Fernandez V. Biochemical aspects of cellular oxidative stress. Arch Biol Med Exp (Santiago) 1988; 21:85–92. 【52】 Jeon, B.R., Yeom, D.H., Lee, S.M.,. Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver. Shock 2001;15, 112–7. 【53】 Marubayashi S, Dohi K, Ochi K, Kawasaki T. Protective effects of free radical scavenger and antioxidant administration on ischemic liver cell injury. Transplant Proc 1987; 19:1327–8. 【54】 Koeppel TA, Lehmann TG, Thies JC, Gehrcke R, Gebhard MM, Herfarth C, Otto G, Post S. Impact of N-acetylcysteine on the hepatic microcirculation after orthotopic liver transplantation. Transplantation 1996; 61:1397–402 【55】 Mizoe A, Kondo S, Azuma T, Fujioka H, Tanaka K, Hashida M, Kanematsu T. Preventive effects of superoxide dismutase derivatives modified with monosaccharides on reperfusion injury in rat liver transplantation. J Surg Res 1997; 73:160–5. 【56】 Younes M, Strubelt O. The involvement of reactive oxygen species in hypoxic injury to rat liver. Res Commun Chem Pathol Pharmacol 1988;59:369–81 【57】 Marubayashi S, Dohi K, Yamada K, Kawasaki T. Changes in the levels of endogenous coenzyme Q homologs, alpha-tocopherol, and glutathione in rat liver after hepatic ischemia and reperfusion, and the effect of pretreatment with coenzyme Q10. Biochim Biophys Acta 1984; 797:1–9. 【58】 Park HH. Structural features of caspase-activating complexes. Int J Mol Sci.2012; 13: 4807–18. 【59】 Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M, Wakeham A, Khoo W, Mitchell K, El-Deiry WS, Lowe SW, Goeddel DV, Mak TW. Essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 1998; 279, 1954–8. 【60】 Rathmell, J.C.; Thompson, C.B. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell 2002; 109, S97–S107. 【61】 Strasser, A.; Jost, P.J.; Nagata, S. The many roles of FAS receptor signaling in the immune system. Immunity 2009; 30,180–92. 【62】 Kerr, J.F.; Wyllie, A.H.; Currie, A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972; 26,239–57. 【63】 Duvall, E.; Wyllie, A.H. Death and the cell. Immunol. Today 1986; 7, 115–9. 【64】 Malhi H, Guicciardi ME, Gores GJ. Hepatocyte death: a clear and present danger. Physiol. Rev. 2010; 90: 1165–94. 【65】 Rudiger HA, Clavien PA. Tumor necrosis factor a, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver. Gastroenterology. 2002; 122: 202–10 【66】 Malhi, H., Gores, G.J., Lemasters, J.J.. Apoptosis and necrosis in the liver:a tale of two deaths? Hepatology 2006; 43: S31–S44. 【67】 Yin, X.M., Ding, W.X., Death receptor activation-induced hepatocyte apoptosis and liver injury. Current Molecular Medicine 2003; 3:491–508 【68】 Ghobrial, I.M.,Witzig, T.E., Adjei, A.A.,. Targeting apoptosis pathways in cancer therapy. CA: A Cancer Journal for Clinicians 2005; 55:178–94. 【69】 Reed, J.C,. Bcl-2 and the regulation of programmed cell death. Journal of Cell Biology 1994; 124;1–6. 【70】 Scorrano, L., Korsmeyer, S.J., Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochemical and Biophysical Research Communications 2003; 304;437–44. 【71】 Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K.J., Debatin, K.M., Krammer, P.H., Peter, M.E.,. Two CD95 (APO-1/Fas) signaling pathways. EMBO Journal 1998; 17;1675–87. 【72】 Yin, X.M., Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes. Journal of Molecular Medicine 2000;78;203–11. 【73】 Ding, W.X., Yin, X.M.,. Dissection of the multiple mechanisms of NF alpha- induced apoptosis in liver injury. Journal of Cellular and Molecular Medicine 2004; 8;445–54. 【74】 Rudiger HA, Clavien PA. Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver. Gastroenterology 2002; 122:202–10. 【75】 Natori S, Selzner M, Valentino KL, Fritz LC, Srinivasan A, Clavien PA, Gores GJ. Apoptosis of sinusoidal endothelial cells occurs during liver preservation injury by a caspase-dependent mechanism. Transplantation 1999; 68:89–96. 【76】 Cursio R, Gugenheim J, Ricci JE, Crenesse D, Rostagno P, Maulon L, Saint-Paul MC, Ferrua B,Auberger AP. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis. Faseb J 1999; 13:253–61. 【77】 Bilbao G, Contreras JL, Eckhoff DE, Mikheeva G, Krasnykh V, Douglas JT, Thomas FT, Thomas JM, Curiel DT. Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirusmediated gene transfer of the antiapoptotic Bcl-2 gene. Ann Surg 1999; 230:185–93 【78】 Gujral JS, Bucci TJ, Farhood A, Jaeschke H. Mechanism of cell death during warm hepatic ischemiareperfusion in rats: apoptosis or necrosis? Hepatology 2001; 33:397–405. 【79】 Lemasters JJV. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol 1999; 276:G1–6. 【80】 Montalvo-Jave EE,Escalante-Tattersfield T,Ortega-Salgado JA,Pina E,Geller DA Factors in the pathophysiology of the liver ischemia-reperfusion injury. J Surg Res.2008 Jun 1;147:153-9 【81】 Cursio R, Gugenheim J, Panaia-Ferrari P, Lasfar A, Tovey M, Chastanet S, Saint-Paul MC, Ferre C, Mouiel J. Improvement of normothermic rat liver ischemia/reperfusion by muramyl dipeptide. J Surg Res 1998; 80:339–44. 【82】 Czaja MJ, Xu J, Alt E. Prevention of carbon tetrachloride- induced rat liver injury by soluble tumor necrosis factor receptor. Gastroenterology 1995; 108: 1849–54 【83】 Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG,Wendel A. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am. J. Pathol. 1995; 146:1220–34. 【84】 Baker SJ, Reddy EP. Modulation of life and death by the tumor necrosis receptor superfamily. Oncogene 1998;17:3261–70. 【85】 Yamauchi N, Kuriyama H, Watanabe N, Neba H, Maeda M, Niitsu Y. Intercellular hydroxyl production induced by recombinant human TNF and its implication in the killing of tumor cells in vitro. Cancer Res. 1989; 49:1671–5. 【86】 Goosens V, Grooten J, Kurt V, Fiers W. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc. Natl Acad. Sci. USA 1995; 92:8115–19 【87】 Wanner GA, Ertel W, Muller P. Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell activation. Shock 1996; 5: 34–40 【88】 Lentsch AB,Yoshidome H,Kato A,Warner RL,Cheadle WG,Ward PA, Edwards MJ. Requirement for interleukin-12 in the pathogenesis of warm hepatic ischemia/reperfusion injury in mice. Hepatology 1999; 30:1448–53. 【89】 Toledo-Pereyra LH, Lopez-Neblina F, Toledo AH. Protein kinases in organ ischemia and reperfusion. J Invest Surg. 2008; 21:215–26. 【90】 Kaminska B. MAPK signaling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits. Biochem Biophys Acta. 2005; 1754:253–62. 【91】 Liang R, Nickkholgh A, Hoffmann K, Kern M, Schneider H, Sobirey M, et al. Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation. J Pineal Res.2009;46:8–14 【92】 Kumar S, Boehm J, Lee JC. p38 MAP Kinases: key signaling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov. 2003; 2:717–25. 【93】 Karin M. Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs. Ann Rheum Dis. 2004; 63:ii62–4. 【94】 LaShonda A. King A Alexander H. Toledo A Fernando A. Rivera-Chavez A Luis H. Toledo-Pereyra. Role of p38 and JNK in liver ischemia and reperfusion J Hepatobiliary Pancreat Surg 2009; 16:763–70. 【95】 Peralta C, Bartrons R, Riera L, Manzano A, Xaus C, Gelpı’ E, Rosello’ - Catafau J. Hepatic preconditioning preserves energy metabolism during sustained ischemia. Am J Physiol 2000; 279:G163-71. 【96】 Peralta C, Closa D, Xaus C, Gelpı’ E, Rosello’ -Catafau J, Hotter G. Hepatic preconditioning in rats is defined by a balance of adenosine and xanthine. Hepatology 1998; 28:768-73. 【97】 Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? Annu Rev Biochem 1998; 67:821-55. 【98】 Stein SC, Woods A, Jones NA, Davison MD, Carling D. The regulation of AMP-activated protein kinase by phosphorylation. Biochem J 2000; 345:437-43. 【99】 Kemp BE, Mitchelhill KI, Stapleton D, Michel BJ, Chen ZP, Witters LA. Dealing with energy demand: the AMP-activated protein kinase. TIPS Rev 1999; 24:22-5. 【100】 Chen ZP,Mitchelhill KI,Michell BJ,Stapleton D,Rodriguez-Crespo I,Witters LA,Power DA,Ortiz de Montellano PR,Kemp BE.AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett 1999; 443:285-9. 【101】 Vincent MF, Bontemps F, Van den Berghe G. Inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes. Biochem J 1992; 281:267-72. 【102】 Javaux F, Vincent MF, Wagner DR, Van den Berghe G. Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside.Lack of effect in rabbit cardiomyocytes and human erythrocytes,and inhibition in FTO-2B rat hepatoma cells. Biochem J 1995; 305:913-9. 【103】 Leclerc I, Kahn A, Doiron B. The 5-AMP–activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex. FEBS Lett 1998; 17:180-4. 【104】 Velasco G, Geelen MJH; Guzma’n M. Control of hepatic fatty acid oxidation by 5’-AMP-activated protein kinase involves amalonyl-CoA– dependent and a malonyl-CoA–independent mechanism. Arch Biochem Biophys 1997; 337:169-75. 【105】 Henin N, Vincent MF, Gruber HE, Van den Berghe G. Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase. FASEB J 1995; 9:541-6 【106】 Carrasco-Chaumel, E., Rosello-Catafau, J., Bartrons, R., Franco-Gou, R., Xaus, C., Casillas, A., Gelpi, E., Rodes, J., Peralta, C., Adenosine monophosphate-activated protein kinase and nitric oxide in rat steatotic liver transplantation. Journal of Hepatology 2005; 43:997–1006. 【107】 Peralta C, Bartrons R, Serafin A, Blazquez C, Guzman M, Prats N, Xaus C, Cutillas B, Gelpi E, Rosello-Catafau J. Adenosine monophosphate-activated protein kinase mediates the protective effects of ischemic preconditioning on hepatic ischemia-reperfusion injury in the rat. Hepatology. 2001Dec; 34:1164-73. 【108】 Darnell JE Jr. STATs and gene regulation. Science 1997; 277:1630-5. 【109】 Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264:1415-21. 【110】 Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, et al. STAT3 deletion during hematopoiesis causes Crohn’s disease-like pathogenesis and lethal ity: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci USA 2003; 100:1879–84. 【111】 Ke B, Shen XD, Ji H, Kamo N, Gao F, Freitas MC, Busuttil RW, Kupiec-Weglinski JW. HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: regulation of TLR4 innate responses through PI3K/PTEN signaling.J Hepatol. 2012; 56:359-66. 【112】 Cressman DE, Diamond RH, Taub R. Rapid activation of the Stat3 transcription complex in liver regeneration. Hepatology 1995; 21:1443-9. 【113】 Diehl AM, Rai R. Review: regulation of liver regeneration by pro-inflammatory cytokines. J Gastroenterol Hepatol 1996; 11:466-70. 【114】 Shen Y, Devgan G, Darnell JE Jr, Bromberg JF. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc Natl Acad Sci USA 2001; 98:1543-8. 【115】 Cross, T.G., Scheel-Toellner, D., Henriquez, N.V., Deacon, E., Salmon, M.,Lord, J.M., Serine/threonine protein kinases and apoptosis. Experimental Cell Research 2000; 256:34–41. 【116】 Brar, B.K., Stephanou, A., Pennica, D., Latchman, D.S.,CT-1 mediated cardioprotection against ischaemic re-oxygenation injury is mediated by PI3 kinase. Akt and MEK1/2 pathways. Cytokine 2001; 16:93–6. 【117】 Buehler, A., Martire, A., Strohm, C., Wolfram, S., Fernandez, B., Palmen, M.,Wehrens, X.H.,Doevendans, P.A., Franz,W.M., Schaper,W., Zimmermann, R.,Angiogenesis-independent cardioprotection in FGF-1 transgenic mice. Cardiovascular Research.2002 ; 55 :768–77. 【118】 Yamashita, K., Kajstura, J., Discher, D.J., Wasserlauf, B.J., Bishopric, N.H., Anversa, P.,Webster, K.A.,Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circulation Research. 2001; 88:609–14. 【119】 Hausenloy, D.J., Yellon, D.M.,. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovascular Research. 2004; 61:448–60. 【120】 Cardone, M.H., Roy, N., Stennicke, H.R., Salvesen, G.S., Franke, T.F.,Stanbridge, E., Frisch, S., Reed, J.C., Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282 :1318–21. 【121】 Russo A, Longo R, Vanella A. Antioxidant activity of propolis: Role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002;73:S21-9 【122】 Gokalp O, Uz E, Cicek E, Yilmaz HR, Ozer MK, Altunbas A, Ozcelik N. Ameliorating role of caffeic acid phenethyl ester (CAPE) against isoniazid-induced oxidative damage in red blood cells. Mol Cell Biochem 2006; 290:55-9 【123】 Michaluart P,Masferrer JL,Carothers AM,Subbaramaiah K,Zweifel BS,Koboldt C,Mestre JR,Grunberger D,Sacks PG,Tanabe T,Dannenberg AJ. Inhibitory effects of caffeic acid phenethyl ester on the activity and expres sion of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 1999; 59:2347-52 【124】 Natarajan K,Singh S,Burke TR Jr,Grunberger D,Aggarwal BB. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc Natl Acad Sci USA 1996;93:9090-5 【125】 Ates B,Dogru MI,Gul M, Erdogan A, Dogru AK, Yilmaz I, Yurekli M, Esrefoglu M. Protective role of caffeic acid phenethyl ester in the liver of rats exposed to cold stress. Fundam Clin Pharmacol 2006; 20:283-9. 【126】 Kimura Y, Okuda H, Okuda T, Hatano T, Agata I, and Arichi S. Studies on the activities of tannins and related compounds from medicinal plants and drugs. VII. Effects of extracts of leaves of Artemisia species, and caffeic acid and chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil. Chem Pharm Bull (Tokyo) 1985;33:2028–34 【127】 Sud’ina GF, Mirzoeva OK, Pushkareva MA, Korshunova GA, Sumbatyan NV, and Varfolomeev SD. Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett 1993; 329: 21–4. 【128】 Irmak MK,Koltuksuz U,Kutlu NO,Yağmurca M,Ozyurt H,Karaman A,Akyol O.The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with alpha-tocopherol in rat kidneys. Urol Res 2001; 29:190-3 【129】 Ozyurt H,Irmak MK, Akyol O, Soğut S.Caffeic acid phenethyl ester changes the indices of oxidative stress in serum of rats with renal ischemia-reperfusion injury. Cell Biochem Funct 2001;19:259-63 【130】 Koltuksuz U, Ozen S, Uz E, Aydinc M, Karaman A, Gultek A, Akyol O, Gursoy MH, Aydin E. Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats. J Pediatr Surg 1999; 1434-58. 【131】 Khan M,Elango C,Ansari MA,Singh I,Singh AK. Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J Neurochem 2007;102:365-77 【132】 Tan J,Ma Z,Han L,Du R,Zhao L,Wei X,Hou D,Johnstone BH,Farlow MR,Du Y. Caffeic acid phenethyl ester possesses potent cardioprotective effects in a rabbit model of acute myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2005;289:H2265-71 【133】 Saavedra-Lopes M, Ramalho FS, Ramalho LN,Andrade-Silva A,Martinelli AL,Jordao AA Jr,Castro-e-Silva O,Zucoloto S. The Protective Effect of CAPE on Hepatic Ischemia/Reperfusion Injury in Rats. Journal of Surgical Research 2008;150:271–7 【134】 Weng YC, Chiu HL, Lin YC, Chi TC, Kuo YH, Su MJ. Antihyperglycemic effect of a caffeamide derivative, KS370G, in normal and diabetic mice. J Agric Food Chem. 2010; 58:10033-8. 【135】 Weng YC, Chuang CF, Chuang ST, Chiu HL, Kuo YH, Su MJ. KS370G, a synthetic caffeamide derivative, improves left ventricular hypertrophy and function in pressure-overload mice heart. Eur J Pharmacol. 2012; 684:108-15. 【136】 Lentsch AB, Yoshidome H, Cheadle WG, Miller FN, Edwards MJ: Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and KC. Hepatology 1998; 27:1172-7. 【137】 Haga S, Terui K, Zhang HQ, Enosawa S, Ogawa W, Inoue H, Okuyama T, Takeda K,Akira S,Ogino T,Irani K,Ozaki M. Stat3 protects against Fas-induced liver injury by redox-dependent and –independent mechanisms. J. Clin. Invest. 2003;112:989–98 【138】 Hattori, R., N. Maulik, H. Otani, L. Zhu, G. Cordis, R.M. Engelman, M.A. Siddiqui, and D.K. Das. Role of STAT3 in ischemic preconditioning. J. Mol. Cell. Cardiol. 2001; 33:1929–36. 【139】 Smith, R.M., N. Suleman, L. Lacerda, L.H. Opie, S. Akira, K.R. Chien, and M.N. Sack..Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning. Cardiovasc. Res. 2004; 63:611–6. 【140】 Uz E,Soğut S,Sahin S,Var A,Ozyurt H,Gulec M,Akyol O. The protective role of caffeic acid phenethyl ester (CAPE) on testicular tissue after testicular torsion and detorsion. World J Urol 2002; 20:264-70 【141】 Ilhan A,Koltuksuz U,Ozen S,Uz E,Ciralik H,Akyol O.The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia/reperfusion injury in rabbits. Eur J Cardiothorac Surg 1999; 16:458-63 【142】 Kim AH, Khursigara G, Sun X, Franke TF, Chao MV. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 2001; 21: 893–901. 【143】 Carini, R., Albano, E.,. Recent insights on the mechanisms of liver preconditioning. Gastroenterology 2003; 125:1480–91. 【144】 Matsui T,Tao J,del Monte F,Lee KH,Li L,Picard M,Force TL,Franke TF,Hajjar RJ,Rosenzweig A. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 2001; 104: 330–5. 【145】 Fujio Y, Nguyen T,Wencker D, Kitsis RN,Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia reperfusion injury in mouse heart. Circulation 2000; 101: 660–7. 【146】 Hong F, Nguyen VA, Shen X, Kunos G, Gao B. Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration. Biochem Biophys Res Commun 2000; 279: 974–9 【147】 Yoshinari D,Takeyoshi I,Kobayashi M,Koyama T,Iijima K,Ohwada S,Matsumoto K,Morishita Y.Effects of a p38 mitogen-activated protein kinase inhibitor as an additive to University of Wisconsin solution on reperfusion injury in liver transplantation. Transplantation.2001; 72:22–7 【148】 Fan C, Zwacka RM, Engelhardt JF. Therapeutic approaches for ischemia/reperfusion injury in the liver. J Mol Med 1999; 77:577-92 【149】 Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: The control of NF-κB activity. Annu Rev Immunol 2000; 18:621-3 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/16225 | - |
| dc.description.abstract | 背景:在肝臟手術或是進行肝臟移植時，肝臟缺血再灌流是一個不可避免的傷害，並且因而造成肝臟本身功能不正常抑或是失去功能。到目前為止，並沒有一個主要的療法。目前，據我們所知，給予Caffeic acid phenyl ester (CAPE)在肝臟缺血再灌流的傷害中，可以發現改善肝臟組織的傷害以及肝指數，KS-370G本身是一個caffeamide的衍生物，結構類似Caffeic acid phenyl ester (CAPE)，但是在肝臟的作用，目前仍一無所知，故本篇研究目的在於評估KS-370G 是否能夠改善肝臟缺血再灌流所造成的肝功能損傷。
方法:我們在ICR小鼠在肝臟缺血前15分鐘，並且以尾靜脈注射方式注入1 mg/kg的劑量，之後再進行70%肝臟缺血約1個小時，接著實行3小時的再灌流。 結果: 經過肝臟再灌流3小時後，蒐集肝臟組織以及血液去評估KS-370G的保護作用。我們發現KS-370G 可以改善肝臟缺血再灌流引起肝功能不良的情形。並且肝臟再灌流3小時後，KS-370G 藉由活化PI3K-Akt路徑去誘導Bcl-2和Bcl-xl的活化並且同時抑制Bax的蛋白表現，若在給予KS-370G時，同時投予LY294002 (PI3K的抑制劑)時，會抑制KS-370G 對於肝臟損傷的保護程度以及增加細胞凋亡(apoptosis)的作用。此外，KS-370G 可以減少TNFα以及P38蛋白磷酸化並且同時也可以增加STAT和AMPK的活化。 結論: KS-370G 在肝臟缺血再灌流是具有保護作用，且歸功於活化細胞存活路徑PI3K-Akt路徑進而去抑制細胞凋亡作用，並且本身也有藉由抑制TNF-α和P38蛋白磷酸化的情形達到抗發炎的作用，以及(或)活化AMPK的作用。 | zh_TW |
| dc.description.abstract | Purpose:
Hepatic ischemia-reperfusion injury is an unavoidable consequence which leads to primary liver dysfunction and organ failure during liver surgery and transplantation. There are at present no targets treatments against liver I/R damage. Recently，caffeic acid phenyl ester (CAPE) evidently attenuates hepatic ischemia-reperfusion injury via decreasing histological damage score and the serum transaminase levels. The structure of KS-370G, a caffeamide derivative, is similar to CAPE. However, the effect of KS-370G on liver has not been studied. We aimed to study whether KS-370G could alleviate hepatic ischemia-reperfusion damage in livers from normal mice. Materials and Methods: We performed a 70% liver-ischemia (60 min) reperfusion model in ICR male mice. KS-370G was given at15 min (1 mg/kg, i.v.) before ischemia and the following 3 h reperfusion. Results: Liver tissues and blood were sampled at 3 h after reperfusion for detection of the protection efficacy of KS-370G. KS-370G strikingly ameliorated the deterioration of liver function in the mice after ischemia-reperfusion injury. PI3K-Akt pathway was activated at 3h after reperfusion. Besides, KS-370G conspicuously down-regulated Bax and accompanied with up-regulated Bcl-2 and Bcl-xl. Treatment with specific PI3k inhibitor LY294002 deteriorated I/R injury and elevated apoptotic effect despite KS-370G treatment. Moreover, KS-370G suppressed the increase in TNFα and phosphorylated p38 protein expression and increased STAT3 and AMPK phosphorylation. Conclusion In conclusion, KS-370G alleviates ischemia-reperfusion injury in liver by activation of cell survival PI3K-Akt signaling pathway to down-regulate apoptosis effect and anti-inflammatory effect by inhibition P38 activation and TNF-alpha production and/or activation of AMPK. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-07T18:05:46Z (GMT). No. of bitstreams: 1 ntu-101-R99443011-1.pdf: 1133394 bytes, checksum: 1250b6b2ee809d43166b7a520b1c58c8 (MD5) Previous issue date: 2012 | en |
| dc.description.tableofcontents | 口試委員審定書 i
誌謝 ii Abbreviations iii Abstract (Chinese) vi Abstract (English) vii Chapter 1 Introduction 1. Introduction 1 2. Phases of warm ischemia reperfusion injury 2 3. Kupffer cells 3 4. Cytokines 4 5. Neutrophils 5 6. Reactive oxygen species (ROS) 7 7. Cell death in I/R injury 8 8. Liver damage induced by tumor necrosis factor-alpha 11 9. Liver damage induced by p38 12 10. The role of AMPK in liver ischemia reperfusion injury 13 11. The role of STAT3 in liver ischemia reperfusion injury 14 12. PI3K-Akt pathway 15 13. CAPE and KS-370G 16 14. Aim 18 Chapter2: Materials and methods 19 Chapter3: Results 1. Effect of KS-370G on liver function of I/R mice 23 2. KS-370G promotes PI3K/Akt pathway in liver of I/R mice 24 3. KS-370G reduces liver apoptosis in I/R mice via activating PI3K/Akt pathway 24 4. KS-370G down-regulated P38 activity in liver of I/R mice 25 5. KS-370G down-regulated TNF-α expression in liver of I/R mice 26 6. KS-370G increased AMPK phosphorylation in liver of I/R mice 26 7. KS-370G increased STAT3 phosphorylation in liver of I/R mice 26 Result figures 28 Chapter 4: Discussion 38 Chapter 5: Limitations and Perspective 43 References 45 | |
| dc.language.iso | en | |
| dc.subject | 細胞凋亡 | zh_TW |
| dc.subject | PI3K-Akt | zh_TW |
| dc.subject | caffeamide | zh_TW |
| dc.subject | 肝臟缺血再灌流的損傷 | zh_TW |
| dc.subject | apoptosis | en |
| dc.subject | PI3K-Akt | en |
| dc.subject | caffeamide | en |
| dc.subject | hepatic ischemia-reperfusion injury | en |
| dc.title | KS-370G 對於ICR小鼠肝臟缺血再灌流的保護作用 | zh_TW |
| dc.title | KS-370G Alleviates Hepatic Ischemia/Reperfusion Injury in ICR mice | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 100-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 顏茂雄(Mao-Hsiung YEN),吳錦楨(Chin-Chen WU) | |
| dc.subject.keyword | PI3K-Akt,caffeamide,肝臟缺血再灌流的損傷,細胞凋亡, | zh_TW |
| dc.subject.keyword | PI3K-Akt,caffeamide,hepatic ischemia-reperfusion injury,apoptosis, | en |
| dc.relation.page | 67 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2012-07-25 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 藥理學研究所 | zh_TW |
| 顯示於系所單位： | 藥理學科所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-101-1.pdf 未授權公開取用 | 1.11 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。