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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 江建文(Kien Voon Kong) | |
dc.contributor.author | Zi-Yao Hong | en |
dc.contributor.author | 洪子堯 | zh_TW |
dc.date.accessioned | 2021-05-12T09:33:10Z | - |
dc.date.available | 2018-08-07 | |
dc.date.available | 2021-05-12T09:33:10Z | - |
dc.date.copyright | 2018-08-07 | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018-08-03 | |
dc.identifier.citation | 1. Parobek, D.; Shenoy, G.; Zhou, F.; Peng, Z.; Ward, M.; Liu, H., Synthesizing and Characterizing Graphene via Raman Spectroscopy: An Upper-Level Undergraduate Experiment That Exposes Students to Raman Spectroscopy and a 2D Nanomaterial. J. Chem. Educ. 2016, 93 (10), 1798-1803.
2. Raman Spectroscopy http://www4.ncsu.edu/~franzen/public_html/CH454/lab2/Raman_Spectroscopy.pdf. 3. McCreery, R. L., Raman spectroscopy for chemical analysis. John Wiley & Sons: 2005; Vol. 225. 4. Fleischmann, M.; Hendra, P. J.; McQuillan, A. J., Raman spectra of pyridine adsorbed at a silver electrode. Chem. Phys. Lett. 1974, 26 (2), 163-166. 5. Jeanmaire, D. L.; Van Duyne, R. P., Surface raman spectroelectrochemistry: Part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 1977, 84 (1), 1-20. 6. Albrecht, M. G.; Creighton, J. A., Anomalously intense Raman spectra of pyridine at a silver electrode. J. Am. Chem. Soc. 1977, 99 (15), 5215-5217. 7. Moskovits, M., Surface roughness and the enhanced intensity of Raman scattering by molecules adsorbed on metals. The Journal of Chemical Physics 1978, 69 (9), 4159-4161. 8. Katrin, K.; Harald, K.; Irving, I.; Ramachandra, R. D.; Michael, S. F., Surface-enhanced Raman scattering and biophysics. J. Phys.: Condens. Matter 2002, 14 (18), R597-R624. 9. Willets, K. A.; Van Duyne, R. P., Localized Surface Plasmon Resonance Spectroscopy and Sensing. Annu. Rev. Phys. Chem. 2007, 58 (1), 267-297. 10. Kleinman, S. L.; Frontiera, R. R.; Henry, A.-I.; Dieringer, J. A.; Van Duyne, R. P., Creating, characterizing, and controlling chemistry with SERS hot spots. PCCP 2013, 15 (1), 21-36. 11. Etchegoin, P. G.; Le Ru, E. C., A perspective on single molecule SERS: current status and future challenges. PCCP 2008, 10 (40), 6079-6089. 12. Lee, P. C.; Meisel, D., Adsorption and surface-enhanced Raman of dyes on silver and gold sols. J. Phys. Chem. 1982, 86 (17), 3391-3395. 13. Frens, G., Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions. Nature Physical Science 1973, 241, 20-22. 14. Nie, S.; Emory, S. R., Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering. Science 1997, 275 (5303), 1102-1106. 15. Wang, X. A.; Kong, X., Review of Recent Progress of Plasmonic Materials and Nano-Structures for Surface-Enhanced Raman Scattering. Materials 2015, 8 (6), 3024-3052. 16. Xin, S.; Hao, L., A Review: Nanofabrication of Surface-Enhanced Raman Spectroscopy (SERS) Substrates. Current Nanoscience 2016, 12 (2), 175-183. 17. De Jesús, M. A.; Giesfeldt, K. S.; Oran, J. M.; Abu-Hatab, N. A.; Lavrik, N. V.; Sepaniak, M. J., Nanofabrication of Densely Packed Metal—Polymer Arrays for Surface-Enhanced Raman Spectrometry. Appl. Spectrosc. 2005, 59 (12), 1501-1508. 18. Jensen, T. R.; Malinsky, M. D.; Haynes, C. L.; Van Duyne, R. P., Nanosphere Lithography: Tunable Localized Surface Plasmon Resonance Spectra of Silver Nanoparticles. The Journal of Physical Chemistry B 2000, 104 (45), 10549-10556. 19. Schmidt Michael, S.; Hübner, J.; Boisen, A., Large Area Fabrication of Leaning Silicon Nanopillars for Surface Enhanced Raman Spectroscopy. Adv. Mater. 2011, 24 (10), OP11-OP18. 20. Wu, K.; Rindzevicius, T.; Schmidt Michael, S.; Thilsted Anil, H.; Boisen, A., Optimizing silver‐capped silicon nanopillars to simultaneously realize macroscopic, practical‐level SERS signal reproducibility and high enhancement at low costs. Journal of Raman Spectroscopy 2017, 48 (12), 1808-1818. 21. Farcau, C.; Astilean, S., Mapping the SERS Efficiency and Hot-Spots Localization on Gold Film over Nanospheres Substrates. The Journal of Physical Chemistry C 2010, 114 (27), 11717-11722. 22. Sun, X.; Wang, N.; Li, H., Deep etched porous Si decorated with Au nanoparticles for surface-enhanced Raman spectroscopy (SERS). 2013; Vol. 284, p 549-555. 23. Musick, M. D.; Keating, C. D.; Lyon, L. A.; Botsko, S. L.; Peña, D. J.; Holliway, W. D.; McEvoy, T. M.; Richardson, J. N.; Natan, M. J., Metal Films Prepared by Stepwise Assembly. 2. Construction and Characterization of Colloidal Au and Ag Multilayers. Chem. Mater. 2000, 12 (10), 2869-2881. 24. Abu Hatab, N. A.; Oran, J. M.; Sepaniak, M. J., Surface-Enhanced Raman Spectroscopy Substrates Created via Electron Beam Lithography and Nanotransfer Printing. ACS Nano 2008, 2 (2), 377-385. 25. Yamakoshi, H.; Dodo, K.; Palonpon, A.; Ando, J.; Fujita, K.; Kawata, S.; Sodeoka, M., Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells. J. Am. Chem. Soc. 2012, 134 (51), 20681-20689. 26. Chen, Y.; Ren, J.-Q.; Zhang, X.-G.; Wu, D.-Y.; Shen, A.-G.; Hu, J.-M., Alkyne-Modulated Surface-Enhanced Raman Scattering-Palette for Optical Interference-Free and Multiplex Cellular Imaging. Anal. Chem. 2016, 88 (12), 6115-6119. 27. Fleming, G. D.; Golsio, I.; Aracena, A.; Celis, F.; Vera, L.; Koch, R.; Campos-Vallette, M., Theoretical surface-enhanced Raman spectra study of substituted benzenes: I. Density functional theoretical SERS modelling of benzene and benzonitrile. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2008, 71 (3), 1049-1055. 28. Halls, M. D.; Aroca, R.; Terekhov, D. S.; D'Ascanio, A.; Leznoff, C. C., Vibrational spectra of halophthalonitriles. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 1998, 54 (2), 305-317. 29. Moskovits, M.; Suh, J. S., Surface geometry change in 2-naphthoic acid adsorbed on silver. J. Phys. Chem. 1988, 92 (22), 6327-6329. 30. Lee, E.; Yi, S. S.; Kim, M. S.; Kim, K., Adsorption of aromatic nitriles on silver investigated by Raman spectroscopy. J. Mol. Struct. 1993, 298, 47-54. 31. Tripathi, A.; Emmons, E. D.; Fountain, A. W.; Guicheteau, J. A.; Moskovits, M.; Christesen, S. D., Critical Role of Adsorption Equilibria on the Determination of Surface-Enhanced Raman Enhancement. ACS Nano 2015, 9 (1), 584-593. 32. Green, M.; Liu, F. M., SERS Substrates Fabricated by Island Lithography: The Silver/Pyridine System. The Journal of Physical Chemistry B 2003, 107 (47), 13015-13021. 33. Wang, L.; Sun, Y.; Li, Z., Dependence of Raman intensity on the surface coverage of silver nanocubes in SERS active monolayers. Appl. Surf. Sci. 2015, 325, 242-250. 34. Lim, J. K.; Joo, S.-W.; Shin, K. S., Concentration dependent Raman study of 1,4-diethynylbenzene on gold nanoparticle surfaces. Vib. Spectrosc 2007, 43 (2), 330-334. 35. Wu, K.; Rindzevicius, T.; Schmidt, M. S.; Mogensen, K. B.; Hakonen, A.; Boisen, A., Wafer-Scale Leaning Silver Nanopillars for Molecular Detection at Ultra-Low Concentrations. The Journal of Physical Chemistry C 2015, 119 (4), 2053-2062. 36. Jansen, H.; Boer, M. d.; Legtenberg, R.; Elwenspoek, M., The black silicon method: a universal method for determining the parameter setting of a fluorine-based reactive ion etcher in deep silicon trench etching with profile control. Journal of Micromechanics and Microengineering 1995, 5 (2), 115-120. 37. Gu, Y.; Zhang, L.; Yang, J. K. W.; Yeo, S. P.; Qiu, C.-W., Color generation via subwavelength plasmonic nanostructures. Nanoscale 2015, 7 (15), 6409-6419. 38. Park, W., Optical interactions in plasmonic nanostructures. Nano Convergence 2014, 1 (1), 1-27. 39. Kahraman, M.; Mullen Emma, R.; Korkmaz, A.; Wachsmann-Hogiu, S., Fundamentals and applications of SERS-based bioanalytical sensing. In Nanophotonics, 2017; Vol. 6, pp 831-852. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/handle/123456789/1138 | - |
dc.description.abstract | 在1800 cm-1到2500 cm-1的區域是比較不會受到來自醣類,蛋白質等生物分子干擾的區域,然而許多具有參鍵的分子在這個位置則是有明顯的訊號,因此本論文選擇幾個具有CC三鍵或是CN三鍵的分子來做測試,分別為benzonitrile, 4-iodophthalonitrile, (triphenylsilyl)acetylene, 1,2-bis(triphenylsilyl)acetylene,並且測量他們的訊號是否在這個區域,並且在確認了他們在這個區域有SERS(Surface Enhancement Raman Spectroscopy,SERS)訊號之後,更進一步地把溶液進行稀釋,得到強度對溶液的關係圖,這些圖也符合常見的SERS訊號對濃度作圖所得到的吸附曲線。並且也透過測試他們在鍍金SERS基質上的作用力來評估他們做為發訊分子的可行性。
除了找尋在1800 cm-1到2500 cm-1波長範圍有訊號的適當的分子以外,具有靈敏度,再現性等特性的SERS基質在感測應用上也是很重要的一環,因此本論文也試著以無遮罩反應式離子蝕刻(maskless reactive ion etching, maskless RIE)製程來製造SERS基質,因為最終的SERS基質是先透過RIE製程,接著再用電子束蒸鍍的方式鍍上金,因此調整RIE參數像是蝕刻氣體流速比例,蝕刻功率對於製造出可以產生SERS訊號的奈米結構是相當關鍵的,並且所產生的奈米結構可以透過掃描式電子顯微鏡 (scanning electron microscopy, SEM) 影像來確認。最後,我們從自製晶片對於分子訊號的測試顯示了我們成功地製造出具有SERS活性的基質。 | zh_TW |
dc.description.abstract | The spectral region in 1800~2500 cm-1 is well-known for the absence of interference signal from biomolecules such as proteins or carbohydrates. However, molecules with triple bond have signal in this region. So we choose molecules containing CC and CN triple bond that is, benzonitrile, 4-iodophthalonitrile, (triphenylsilyl)acetylene, 1,2-bis(triphenylsilyl)acetylene to test their signal intensity and position. Their signals on the gold chip upon serial dilution also behave like typical adsorption isotherm. Affinity on gold coated SERS substrate is also tested to evaluate the feasibility of using them as reporter molecules.
In addition to looking for appropriate molecules with signal in the 1800~2500 cm-1, SERS substrate with good sensitivity, reproducibility is also a desirable goal for sensing applications. We try to fabricate SERS substrate by a maskless reactive ion etching (RIE) process. Because SERS substrate is fabricated through the RIE procedure followed by e-beam evaporation of Au, it is crucial to adjust the RIE parameters (etching gas ratio, etching power) to get a nanostructure suitable for SERS signal generation, and the fabricated nanostructure could be identified through scanning electron microscopy images of fabricated substrates. Finally, SERS signals of the molecules on the in-house fabricated substrates demonstrate that we successfully fabricate a SERS substrate through a simple maskless process. | en |
dc.description.provenance | Made available in DSpace on 2021-05-12T09:33:10Z (GMT). No. of bitstreams: 1 ntu-107-R05223178-1.pdf: 2292985 bytes, checksum: 777a5c6c4643724e016160abd82bda65 (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 致謝 I
摘要 II ABSTRACT III 目錄 IV 圖目錄 VII 表目錄 XI 第一章 緒論 1 1.1拉曼光譜(Raman spectroscopy) 1 1.1.1拉曼(Raman scattering)的發展與特性 1 1.1.2拉曼(Raman scattering)和雷利散射(Rayleigh scattering)的理論模型 3 1.2表面增強拉曼散射(Surface-Enhanced Raman Scattering, SERS)的發展與原理 5 1.2.1電磁增強效應(Electromagnetic Field Enhancement) 5 1.2.2 化學增強效應(Chemical Enhancement) 7 1.3 SERS的基質(SERS substrate) 9 1.3.1奈米顆粒膠體溶液 9 1.3.2固體SERS基質 10 1.3.2.1微影法(lithography-based method) 10 1.3.2.2非微影法(non-lithography-based method) 12 1.4 研究動機 14 第二章 實驗方法 15 2.1 化學藥品 15 2.2 儀器 16 2.2.1 拉曼光譜儀 (Raman Microscope) 16 2.2.2 掃描式電子顯微鏡 (Scanning Electron Microscope, SEM) 16 2.2.3 反應式離子蝕刻機 (Reactive Ion Etching System) 16 2.2.4 氧電漿清洗機(O2 plasma cleaner) 17 2.2.5 電子束蒸鍍機 (Electron Beam Evaporator) 17 2.2.6 精密晶圓切割機 (Precision Dicing Saw) 17 2.3 實驗步驟 18 2.3.1 拉曼和SERS的測量 18 2.3.1.1 Benzonitrile SERS的測量 18 2.3.1.2 4-Iodophthalonitrile SERS的測量 18 2.3.1.3 (Triphenylsilyl)acetylene SERS的測量 18 2.3.1.4 1,2-Bis(Triphenylsilyl)acetylene SERS的測量 19 2.3.2 晶片製作 20 第三章 結果與討論 21 3.1分子光譜討論 21 3.1.1 Benzonitrile的光譜討論 23 3.1.2 4-Iodophthalonitrile的光譜討論 25 3.1.3 (Triphenylsilyl)acetylene的光譜討論 30 3.1.4 1,2-Bis(triphenylsilyl)acetylene的光譜討論 33 3.2晶片製作 36 3.3自製SERS基質的訊號測試 44 3.3.1 Benzonitrile在自製SERS基質的訊號測試 44 3.3.2 4-Iodophthalonitrile在自製SERS基質的訊號測試 45 3.3.3 (Triphenylsilyl)acetylene在自製SERS基質的訊號測試 47 3.3.4 1,2-Bis(triphenylsilyl)acetylene在自製SERS基質的訊號測試 48 第四章 結論 49 第五章 參考文獻 50 | |
dc.language.iso | zh-TW | |
dc.title | 利用表面增強拉曼光譜法基質在不受光譜干擾的區域對分子進行研究 | zh_TW |
dc.title | Study of Molecules in Optical Interference-Free Spectra Region with Fabricated SERS Substrate | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 游景晴(Ching-Ching Yu),郭俊宏(Chun-Hong Kuo) | |
dc.subject.keyword | 不受生物分子訊號干擾的光譜區域,表面增強拉曼光譜基質, | zh_TW |
dc.subject.keyword | Spectral region free from biomolecules signals,Surface Enhanced Raman Spectroscopy(SERS), | en |
dc.relation.page | 52 | |
dc.identifier.doi | 10.6342/NTU201802323 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2018-08-03 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 化學研究所 | zh_TW |
顯示於系所單位: | 化學系 |
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