請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/10504完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 潘子明 | |
| dc.contributor.author | Shang-Ping Chang | en |
| dc.contributor.author | 張尚平 | zh_TW |
| dc.date.accessioned | 2021-05-20T21:34:48Z | - |
| dc.date.available | 2011-08-18 | |
| dc.date.available | 2021-05-20T21:34:48Z | - |
| dc.date.copyright | 2010-08-18 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-08-16 | |
| dc.identifier.citation | 王馨世。1999。女性生殖生理與內分泌學。合記圖書出版社。台北，台灣，中華民國。
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/10504 | - |
| dc.description.abstract | 本實驗利用切除卵巢鼠作為模擬停經後婦女的動物模式，分別利用不同劑量的山藥與紅麴山藥，及以大豆異黃酮做為正控制組分別餵食大鼠，觀察大鼠骨質的變化情況。Citrinin、monacolin K、monascin 及 ankaflavinc 的濃度分別為4.63 ppm、104.8 ppm、369 ppm、602.8 ppm。山藥及紅麴山藥不含異黃酮類及木質酚類植物雌激素，但皆含薯蕷皂苷配基 (diosgenin)，在紅麴山藥及山藥的含量分別為 1.36 mg/g 及 0.68 mg/g。進行手術前後利用微型電腦斷層儀 (microcomputed tomography, micro-CT) 及雙能量 X 射線吸收儀 (dual energy x-ray absorptiometry, DEXA) 測定骨質狀況，結果顯示手術前各組骨質無明顯的差異，手術三個月後即誘導出骨質疏鬆症。接下來餵食樣品四週後，由 micro-CT 影像定量結果可知，各組的骨質狀況相對於 OVX 組皆有改善，尤以餵食紅麴山藥組 I. RMD 2X、II. RMD 2X、II. RMD 2X 最為顯著。餵食大豆異黃酮組 (ISO) 之骨鹼性磷酸酶 (bone alkaline phosphatase, bone-ALP) 活性有較高的趨勢，而本實驗餵食的樣本 (山藥與紅麴山藥) 對於大鼠之活性無顯著的影響。由骨鈣素濃度測定結果可知，除了 I. dioscorea 1X 組之外，其餘各組之骨質合成作用相對於 OVX 組皆有改善。右股骨進行 micro-CT 3 D 影像分析結果中，觀察出試驗組各組與 OVX 組比較，骨質皆有正向的改善，尤以 ISO、I. RMD 2X、II. RMD 2X 三組改善最為顯著。右股骨遠端骨小樑定量的結果中，餵食異黃酮組與餵食兩倍劑量的紅麴山藥組，骨質相較於 OVX 組有改善的趨勢，其中骨小樑厚度之分析結果具有顯著差異。在肝、腎血清指標及染色切片的安全性評估中，除了因切除卵巢引起的脂肪堆積，造成少數輕微至中度脂肪肝的情況之外，其他指標與檢驗皆為正常。 | zh_TW |
| dc.description.abstract | This experiment established the ovariectomized rat model of postmenopausal osteoporosis and used different dosage of dioscorea and red mold dioscorea as well as soy isoflavone as positive control to study the changing in rats’ bones.The concentrations of citrinin, monacolin K, monascin, and ankaflavinc in red mold dioscorea were 4.63 ppm, 104.8 ppm, 369 ppm, and 602.8 ppm, respectively. No phytoestrogens were found in neither red mold dioscorea nor dioscorea, except for diosgenin. The concentrations of diosgenin in red mold dioscorea and dioscorea were 1.36 mg/g and 0.68 mg/g, respectively. Before and after operation, micro-CT (microcomputed tomography) and DEXA (dual energy x-ray absorptiometry) were used to measure the bone mass condition. Resluts showed that bone conditions had no significant difference among groups before operation and osteoporosis was induced after operation for three months. After feeding sampes for four weeks, the bone mass conditions of each group were improved in comparison with OVX group by the quantification of micro-CT images. I. RMD 2X、II. RMD 2X、II. RMD 2X these three groups showed remarkable improvement.The bone-ALP (bone alkaline phosphatase) activity was higher in the soy isoflavone feeded group (ISO) and other experimental groups feeded red mold dioscorea and dioscorea showed no significant influence in bone-ALP activity. In the analyzing results of osteocalcin concetrations, each group had better bone-formation condition than OVX group, except for I. dioscorea 1X. With micro-CT 3 D images each experimental group has positive changes of bone mass condition in comparison with OVX group, especially ISO、I. RMD 2X、II. RMD 2X these three groups. By the quantification of right distall femurs’ trabecular bones, ISO、I. RMD 2X、II. RMD 2X theses groups showed positive changes of bone mass condition in comparison with OVX group and showed statistically significance in the analyzing results of trabecular thickness. As to iver and kidney index in serum and histopathological examination, every index and examination were normal except for a few slight to moderate fatty change in livers causing by ovariectomized-induced fatty accumulation. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-20T21:34:48Z (GMT). No. of bitstreams: 1 ntu-99-R96b47110-1.pdf: 3361969 bytes, checksum: a407c43768ddf00c3d77227cdffe59c2 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 目錄
縮寫表 i 中文摘要 iii Abstract iv 表目錄 ix 圖目錄 x 第壹章 文獻回顧 1 一、紅麴特性簡 1 二、紅麴生產之二次代謝物及其功效 3 (一) 色素 3 (三) 膽固醇合成抑制劑 (monacolins) 5 (四) 降血壓物質 (GABA) 9 (五) 防癌物質 9 (六) 降血糖物質 9 (七) 麥角固醇 9 (八) 抗氧化物質-Dimerumic acid 10 (九) 長鏈脂肪酸之產生 10 (十) 抗疲勞功效 10 (十一) 護肝功能 11 (十二) 促進骨骼成長 11 三、山藥及其生理效用 12 (一) 山藥分佈 13 (二) 山藥種類 13 (三) 山藥成分 15 (四) 山藥之保健作用 16 四、紅麴以山藥作發酵基質之差異化與複合性功效 21 五、人體骨骼、組成及代謝之簡介 21 (一) 骨骼的組成 21 (二) 骨骼的代謝 22 (三) 營養對骨骼代謝的影響 23 (四) 雌激素對骨骼的影響 24 (一) 植物雌激素之種類與來源 27 (二) 植物雌激素之生理功能 35 第貳章 研究動機與目的 39 第參章 材料與方法 42 一、菌株之培養 42 (一) 試驗菌株： 42 (二) 培養基組成 42 二、儀器 43 (ㄧ) 固態培養相關設備 43 (二) 萃取及分析相關設備 43 (三) 骨質密度測定相關設備 43 三、藥品 44 (一) 標準品 44 (二) 培養基 44 (三) 其餘藥品、溶劑皆為試藥級 44 四、固態培養方法與條件 44 (一) 種菌之培養 44 (二) 固態培養 44 五、Monacolin K、monascin、ankaflavinc、citrinin 與植物雌激素分析方式 46 (一) Monacolin K、monascin、ankaflavinc 與 citrinin 分析方式 46 (二) 植物雌激素分析方式………………………………………………….48 六、紅麴山藥改善骨質疏鬆之評估 50 (一) 實驗動物之飼養 50 (二) 試驗物質與餵食劑量訂定 50 (三) 實驗動物之分組 53 (四) 骨質疏鬆模式大鼠之誘導 55 (五) 飼料之製備 55 (六) 骨質密度之測度 58 (七) 動物犧牲、採血及肝臟病理切片鏡檢 58 (八) 血液骨質生化指標 (biomarker) 之測定 59 七、生物統計分析方法 60 第肆章 結果與討論 61 一、Citrinin、Monacolin K、monascin、ankaflavinc 與植物雌激素之分析 61 (一) 紅麴山藥中 citrinin 含量之分析 61 (二) Monacolin K、monascin 及 ankaflavinc 之分析.................................68 (三) 山藥與紅麴山藥之植物雌激素分析 73 二、動物攝食量以及體重紀錄 90 三、雙能量 X 射線吸收儀 (dual energy x-ray absorptiometry, DEXA) 93 四、微型電腦斷層儀之骨質分析 97 (一) 餵食前骨質疏鬆動物模式之誘導 97 (二) 餵食樣品四週後骨質變化情況 104 五、血清骨質代謝指標分析 108 (一) 骨鹼性磷酸酶 (bone alkaline phosphatase, bone-ALP) 108 (二) 骨鈣素 (osteocalcin) 110 六、微型電腦斷層儀之股骨骨質分析 112 (一) 影像分析 112 (二) 右股骨遠端骨小樑定量 114 七、肝腎指數與病理切片分析 116 (一) 血清肝腎指數分析 116 (二) 肝、腎切片鏡檢 119 第伍章 結論 121 一、Citrinin、monacolin K、monascin、ankaflavinc與植物雌激素之分析 121 二、餵食樣品前後骨質的變化情況 121 三、未來展望 122 表目錄 表 2-1、根據山藥有效劑量定出餵食劑量 51 表 2-2、根據 diosgenin 有效劑量定出餵食劑量 52 表 2-3、各組飼料組成 57 表 4-1、Citrinin 標準品之 HPLC 分析結果 62 表 4-2、紅麴山藥樣品中 citrinin 之 HPLC 分析結果 63 表 4-3、Daidzein, genistein 及 formononetin 標準品之 HPLC 分析結果 74 表 4-4、Secoisolariciresinol 不同濃度標準品之 HPLC 分析結果 80 表 4-5、Diosgenin 不同濃度標準品之 HPLC 分析結果 84 表 4-6、紅麴山藥、山藥樣品中diosgenin 之 HPLC 分析結果 85 表 4-7、切除卵巢前之 micro-CT 影像定量 100 表 4-8、切除卵巢三個月後之 micro-CT 影像定量 103 表 4-9、餵食四週後之 micro-CT 影像定量 107 表 4-7、骨小樑定量 115 表 4-8、血清肝指數 117 表 4-9、血清腎指數 118 圖目錄 圖 1-2、紅麴色素之結構 4 圖 1-3、3-Hydroxy-3-methylglutaryl CoA (HMG-CoA) 還原酶路徑 8 圖 1-4、控制破骨細胞與造骨細胞的賀爾蒙 25 圖 1-5、雌激素缺乏對骨質流失之影響 26 圖 1-6、黃豆中異黃酮的化學構造 29 圖 1-7、哺乳動物及植物中木質酚的化學構造 31 圖 1-8、苜蓿中兩種香豆素 coumestrol 與 4’-methoxycoumestrol 的結構 33 圖 1-9、雌激素 (estrogen) 與薯蕷皂苷配基 (diosgenin) 的化學構造 34 圖 2-1、本研究大綱與流程 41 圖 3-1、實驗動物分組 54 圖 4-1、Citrinin 之 HPLC 檢量曲線 64 圖 4-2、Citrinin 不同濃度標準品、紅麴山藥樣品之 HPLC 圖譜 67 圖 4-3、 Monacolin K、monascin 及 ankaflavinc 標準品、紅麴山藥樣品之 HPLC 圖譜 69 圖 4-4、Monacolin K 之 檢量曲線 70 圖 4-5、Monascin 之 檢量曲線 71 圖 4-6、Ankaflavinc 之 檢量曲線 72 圖 4-7、Daidzein, genistein 及 formononetin 標準品、山藥樣品、紅麴山藥樣品之 HPLC 圖譜 76 圖 4-8、Genistein、daidzein、山藥樣品、紅麴山藥樣品全波段光譜 77 圖 4-9、Secoisolariciresinol標準品、山藥及紅麴山藥樣品HPLC 圖譜 81 圖 4-10、Diosgenin 之檢量曲線 86 圖 4-11、Diosgenin標準品、紅麴山藥、山藥樣品之HPLC 圖譜 88 圖 4-12、Diosgenin 標準品，紅麴山藥樣品及山藥樣品之全波段圖譜 89 圖 4-13、大鼠之平均體重 91 圖 4-14、大鼠之平均攝食量 92 圖 4-15、大鼠餵食前之髖關節骨密度 94 圖 4-16、大鼠餵食前股骨遠端骨密度 95 圖 4-17、大鼠餵食前之脛骨近端骨密度 96 圖 4-18、切除卵巢前大鼠之膝關節橫截面骨質狀況 98 圖 4-19、切除卵巢前大鼠之股骨遠端與脛骨近端縱切面骨質狀況 99 圖 4-20、切除卵巢三個月後大鼠之膝關節橫截面骨質狀況 101 圖 4-21、切除卵巢三個月後大鼠之股骨遠端與脛骨近端縱切面骨質狀況 102 圖 4-22、餵食樣品四週後大鼠之膝關節橫截面骨質狀況 105 圖 4-23、餵食樣品四週後大鼠之股骨遠端與脛骨近端縱切面骨質狀況 106 圖 4-24、大鼠血清中骨鹼性磷酸酶之活性 109 圖 4-25、大鼠血清中骨鈣素之濃度 111 圖 4-26、大鼠之股骨遠端之 micro-CT 3 D 影像分析 113 | |
| dc.language.iso | zh-TW | |
| dc.title | 利用切除卵巢鼠之動物模式探討紅麴山藥對於停經後骨質疏鬆症之影響 | zh_TW |
| dc.title | Study on Monascus-fermented dioscorea in ovariectomized rat model of postmenopausal osteoporosis | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蔡敬民,蘇遠志,黃健雄,蔡宗佑 | |
| dc.subject.keyword | 切除卵巢鼠,骨質疏鬆症,植物雌激素,紅麴山藥,微型電腦斷層儀,雙能量 X 射線吸收儀, | zh_TW |
| dc.subject.keyword | ovariectomized rat,osteoporosis,phytoestrogen,red mold dioscorea,micro-CT,DEXA, | en |
| dc.relation.page | 138 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2010-08-17 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 微生物與生化學研究所 | zh_TW |
| 顯示於系所單位： | 微生物學科所 | |
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