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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 潘子明(Tzu-Ming Pan) | |
dc.contributor.author | Chia-Ying Chuang | en |
dc.contributor.author | 莊佳穎 | zh_TW |
dc.date.accessioned | 2021-05-20T21:32:58Z | - |
dc.date.available | 2013-08-19 | |
dc.date.available | 2021-05-20T21:32:58Z | - |
dc.date.copyright | 2010-08-19 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-08-18 | |
dc.identifier.citation | 井上清他。1994。紅麹抽出物が本態性高血圧者の血圧に及ぼす影響。医学と薬学。31: 231-240。
孔凡鐘。1996。DSM-Ⅲ-R 診斷準則手冊。合記出版社。台北。pp. 52。 玉田英明。1988。紅麴各種調味料之應用。食品及科學。July: 96-99。 白松、林向陽、阮榕生、鄭丹丹、劉玉環、何承雲。2005。γ-胺基丁酸的分布與製備。現代食品科技。21: 202-205。 江波。2008。GABA (γ-胺基丁酸) γ–一種新型的功能食品因子。中國食品學報。8 (2): 1- 4。 行政院主計處。2009。社會指標統計年報2008。pp. 54。 佐藤喜吉。1936。東洋產 Monascus 屬分類に對すゐ–考察。日農化會誌。12: 583-586。 杉下朋子。2001。注目されるGABA富化素材の開発。食品と開發。36 (6): 17-18。 岡田忠司,杉下朋子,村上太郎,村井弘道,三枝喜代,堀野俊郎,小野田明彦,梶本修身,高橋励,高橋丈夫。2000。γ-アミノ酪酸蓄積脫脂コメ胚芽の経口投与における更年期障害及び初老期精神障害に対する効果。日本食品科学工学会誌。47: 596-603。 吳政倫。2008。含 γ-胺基丁酸與血管收縮素 I 轉化酶抑制劑紅麴山藥之最適化生產與降血壓功效評估。國立台灣大學微生物與生化學研究所碩士論文。 林姿岑。2000。紅麴二級代謝產物之發酵生產研究–γ-胺基丁酸及 monacolin K。國立台灣大學農業化學研究所碩士論文。 林親錄、王婧、陳海軍。2008。γ-胺基丁酸的研究進展。現代食品科技。24 (5): 496-500。 林讚鋒。1983。紅麴菌的鑑定及實用分類法。製酒科技專論彙論。5: 104-113。 胡維恆。2003。憂鬱症、精神分裂疾病與自殺。台灣精神醫學雜誌。3 (4): 44-47。 茅原 紘與杉浦友美。2001。近年のGABA生理機能研究―脳機能改善作用,高血圧作用を中心に。食品と開発。36 (6): 4-6。 姜聖花、Mazumder T. K.、永井史郎。2001。アガリクス自己消化によるGABA高含有素材の開発。食品と開發。36 (6): 15-16。 區少梅。2002。吃 GABA 降血壓-神奇的 γ-胺基丁酸。元氣齋出版社。 許祐榮。2005。菌種、培養條件和熱處理對紅麴二次代謝產物之影響。國立海洋大學食品科學系碩士論文。 張輝、姚惠源、薑元榮。2002。富含 γ-胺基丁酸保健食品的研究與開發。食品與發酵工業。28 (9): 69-72。 張輝、徐滿英。2006。γ-胺基丁酸作用的研究進展。哈爾濱醫科大學學刊。40 (3): 267-269 陳明造、林坤炳、郭秀蘭與曾穎玉。1997。猪肉在紅麴菌、乳酸菌和酵母菌等培養液浸漬期間色澤、TBA 及VBN 的變化。中華農學會報。181: 68-75。 陳彥霖、李昭蓉、陳建州與袁國芳。1998。紅麴菌種的研究開發與應用。食品工業月刊。30: 1-10。 陳彥霖。2000。紅麴與高血壓。科學與技術。32: 54-59。 陳慶源、莊淑惠。2003。綜論紅麴產品之開發與應用。食品工業。35: 1-2。 葉伶宜。2002。紅麴菌之二次代謝產物及其分析方法簡介。食品工業。34 (11): 11-20。 楊海峰、葛竹興、鬱杰。2008。γ-胺基丁酸的急性毒性和蓄積毒性的研究。安徽農業科学。36 (13): 5464-5491。 趙健。1992。中國化學藥品大全。科學出版社。 冀林立、孟和畢力格。2007。γ-胺基丁酸的生理功能和研究進展。農產品加工學刊。12: 11-14。 澤井祐典、許斐健一、小高保喜。1999。嫌氣-好氣交互處理による茶叶のγ-アミノ酪酸量の增加。Nippon Shokuhin Kagaku Kogaku Kaishi. 46 (7): 462-466。 樽井庄一。1993。紅麴的開發與利用。食品及科學。28: 47-50。 蘇遠志、陳文亮、方鴻源、翁浩慶與王文祥。1970。紅麴菌 (Monascus anka) 之菌學研究。中國農業化學會誌。21: 63-71。 蘇遠志。1978。紅麴色素之生產研究。食品科學。5: 4-7。 蘇遠志、黃冬梨。1981。紅麴色素之動物飼養實驗。國立台灣大學農學院研究報告。21: 98-112。 蘇遠志。2001。紅麴製品應用與市場概況。生物產業。12: 68-75。 Abe, K., and Coppen, A. (1969). Personality and body composition in monozygotic twins with an affective disorder. Brit J Psychiat 115, 777-780. Alberts, A.W., Chen, J., Kuron, G., Hunt, V., Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshua, H., Harris, E., Patchett, A., Monaghan, R., Currie, S., Stapley, E., Albersschonberg, G., Hensens, O., Hirshfield, J., Hoogsteen, K., Liesch, J., Springer, J. (1980). Mevinolin-a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme-A reductase and a cholesterol-lowering agent. P Natl Acad Sci-Biol 77, 3957-3961. Aniya, Y., Ohtani, I.I., Higa, T., Miyagi, C., Gibo, H., Shimabukuro, M., Nakanishi, H., and Taira, J. (2000). Dimerumic acid as an antioxidant of the mold, Monascus anka. Free Radic Biol Med 28, 999-1004. Aoki, H., Uda, I., Tagami, K., Furuya, Y., Endo, Y., and Fujimoto, K. (2003). The production of a new tempeh-like fermented soybean containing a high level of gamma-aminobutyric acid by anaerobic incubation with Rhizopus. Biosci Biotechnol Biochem 67, 1018-1023. Balazs, R., Machiyam.Y, Hammond, B.J., Julian, T., and Richter, D. (1970). The operation of gamma-aminobutyrate bypath of tricarboxylic acid cycle in brain tissue in-vitro. Biochem J 116, 445-461. Bautista, G.M., Lugay, J.C., Cruz, L.J., and Juliano, B.O. (1964). Glutamic acid decarboxylase activity as viability index of artificially dried and stored rice. Cereal Chem 41, 188-191. Beach, S.R.H., Brody, G.H., Gunter, T.D., Packer, H., Wernett, P., and Philibert, R.A. (2010). Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. J Fam Psychol 24, 12-20. Beaulieu, C. (1993). Numerical data on neocortical neurons in adult rat, with special reference to the GABA population. Brain Research 609, 284-292. Bjork, J.M., Moeller, F.G., Kramer, G.L., Kram, M., Suris, A., Rush, A.J., and Petty, F. (2001). Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder. Psychiat Res 101, 131-136. Blanc, P.J., Loret, M.O., Santerre, A.L., Pareilleux, A., Prome, D., Prome, J.C., Laussac, J.P., and Goma, G. (1994). Pigments of Monascus. J Food Sci 59, 862-865. Borsini, F., and Meli, A. (1988). Is the forced swimming test a suitable model for revealing antidepressant activity. Psychopharmacology 94, 147-160. Bown, A.W., and Shelp, B.J. (1997). The metabolism and functions of gamma-aminobutyric acid. Plant Physiol 115, 1-5. Briones-Aranda, A., Rocha, L., and Picazo, O. (2005). Alterations in GABAergic function following forced swimming stress. Pharmacol Biochem Behav 80, 463-470. Brown, M.S., and Goldstein, J.L. (1984). How LDL receptors influence cholesterol and atherosclerosis. Sci Am 251, 58-60. Budavari, S., Maryadele, J.O., Smith, A. and Heckelman, P.E. (1989). The Merck Index 11, 2330-2331. Chen, W.P., Ho, B.Y., Lee, C.L., Lee, C.H., and Pan, T.M. (2008 a). Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet. Int J Obes (Lond) 32, 1694-1704. Chen, P.J., Hsieh, C.L., Su, K.P., Hou, Y.C., Chiang, H.M., Lin, I.H., and Sheen, L.Y. (2008 b). The antidepressant effect of Gastrodia elata Bl. on the forced-swimming test in rats. Am J Chin Med 36, 95-106. Cheng, F.-C., Kuo, J.-S., Shih, Y., Lai, J.-S., Ni, D.-R., and Chia, L.-G. (1993). Simultaneous measurement of serotonin, catecholamines and their metabolites in mouse brain homogenates by high-performance liquid chromatography with a microbore column and dual electrochemical detection. In Journal of Chromatography B: Biomedical Sciences and Applications, pp. 225-236. Christensen, H.N., Greene, A.A., Kakuda, D.K., and Macleod, C.L. (1994). Special transport and neurological significance of 2 amino-acids in a configuration conventionally designated as D. J Exp Biol 196, 297-305. Dang, H., Chen, Y., Liu, X., Wang, Q., Wang, L., Jia, W., and Wang, Y. (2009). Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry In Press, Corrected Proof. Dannlowski, U., Ohrmann, P., Konrad, C., Domschke, K., Bauer, J., Kugel, H., Hohoff, C., Schoning, S., Kersting, A., Baune, B.T., Mortensen, L. S., Arolt, V., Zwitserlood, P., Deckert, J., Heindel, W., Suslow, T. (2009). Reduced amygdala-prefrontal coupling in major depression: association with MAOA genotype and illness severity. Int J Neuropsychoph 12, 11-22. Dekloet, E.R., Rosenfeld, P., Vaneekelen, J.A.M., Sutanto, W., and Levine, S. (1988). Stress, glucocorticoids and development. Prog Brain Res 73, 101-120. Deussing, J.M. (2006). Animal models of depression. Drug Discovery Today: Disease Models 3, 375-383. Drug Topics. (2008). Top 200 generic drugs by units in 2007. http://drugtopics. modernmedicine.com/drugtopics/Top200Drugs/ArticleStandard/article/detail/491194. (Retrieved in 2008.10.23.) Duman, R.S. (2002). Synaptic plasticity and mood disorders. Mol Psychiatr 7, S29-S34. Emrich, H.M., Vonzerssen, D., Kissling, W., Moller, H.J., and Windorfer, A. (1980). Effect of sodium valproate on mania - the GABA-hypothesis of affective-disorders. Arch Psychiat Nerven 229, 1-16. Endo, A. (1979). Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J Antibiot (Tokyo) 32, 852-854. Endo, A., Hasumi, K., Nakamura, T., Kunishima, M., and Masuda, M. (1985). Dihydromonacolin L and monacolin X, new metabolites which inhibit cholesterol biosynthesis. J Antibiot (Tokyo) 38, 321-327. Fabre, C.E., Santerre, A.L., Loret, M.O., Baberian, R., Pareilleux, A., Goma, G., and Blanc, P.J. (1993). Production and food applications of the red pigments of Monascus ruber. J Food Sci 58, 1099-1102. Ford, Y.Y., Ratcliffe, R.G., and Robins, R.J. (1996). Phytohormone-induced GABA production in transformed root cultures of Datura stramonium: An in vivo N-15 NMR study. J Exp Bot 47, 811-818. Fougere, F., Lerudulier, D., and Streeter, J.G. (1991). Effects of salt stress on amino acid, organic acid, and carbohydrate composition of roots, bacteroids, and cytosol of Alfalfa (Medicago-Sativa L). Plant Physiol 96, 1228-1236. Frazer, A. (1997). Pharmacology of antidepressants. J Clin Psychopharm 17, S2-S18. Giovanni, M. (1983). Response-surface methodology and product optimization. Food Technol-Chicago 37, 41-45. Glowinsk.J, and Iversen, L.L. (1966). Regional studies of catecholamines in rat Brain .I. Disposition of [3h]Norepinephrine [3h]Dopamine and [3h]Dopa in various regions of brain. Journal of Neurochemistry 13, 655-669. Hagop, S. and Akiskal, M.D., (2005). Mood disorders: historical introduction and conceptual overview. In: Sadock, B.J. and Sadock, V.A. eds. Comprehensive Textbook of Psychiatry, Philadelphia: Lippincott Williams & Wilkins, 1284-1297. Hajjaj, H., Blanc, P.J., Groussac, E., Goma, G., Uribelarrea, J.L., and Loubiere, P. (1999). Improvement of red pigment citrinin production ratio as a function of environmental conditions by Monascus ruber. Biotechnol Bioeng 64, 497-501. Hale, A.S. (1993). New antidepressants - Use in high-risk patients. J Clin Psychiat 54, 61-70. Handoyo, T., and Morita, N. (2006). Structural and functional properties of fermented soybean (tempeh) by using Rhizopus oligosporus. Int J Food Prop 9, 347-355. Hao, R.Y., and Schmit, J.C. (1993). Cloning of the gene for glutamate-decarboxylase and its expression during conidiation in neurospora-crassa. Biochem J 293, 735-738. Herbert, P., Barros, P., Ratola, N., and Alves, A. (2000). HPLC determination of amino acids in musts and port wine using OPA/FMOC derivatives. J Food Sci 65, 1130-1133. Herman, J.P., Renda, A., and Bodie, B. (2003). Norepinephrine-gamma-aminobutyric acid (GABA) interaction in limbic stress circuits: Effects of reboxetine on GABAergic neurons. Biol Psychiat 53, 166-174. Ho, B.Y., and Pan, T.M. (2009). The Monascus metabolite monacolin K reduces tumor progression and metastasis of Lewis lung carcinoma cells. J Agric Food Chem 57, 8258-8265. Huang, Z.B., Xu, Y., Li, L.S., and Li, Y.P. (2008). Two new Monascus metabolites with strong blue fluorescence isolated from red yeast rice. J Agr Food Chem 56, 112-118. Jakobs, C., Jaeken, J., and Gibson, K.M. (1993). Inherited disorders of GABA-metabolism. J Inherit Metab Dis 16, 704-715. Jang, D.P., Lee, S.H., Park, C.W., Lee, S.Y., Kim, Y.B., and Cho, Z.H. (2009). Effects of fluoxetine on the rat brain in the forced swimming test: a [F-18]FDG micro-PET imaging study. Neurosci Lett 451, 60-64. Jeun, J., Jung, H., Kim, J.H., Kim, Y.O., Youn, S.H., and Shin, C.S. (2008). Effect of the Monascus pigment threonine derivative on regulation of the cholesterol level in mice. Food Chemistry 107, 1078-1085. Johannessen, M., Delghandi, M.P., and Moens, U. (2004). What turns CREB on? Cell Signal 16, 1211-1227. Juzlová, P., Rezanka, T., Martínková, L., and Kren, V. (1996 a). Long-chain fatty acids from Monascus purpureus. Phytochemistry 43, 151-153. Juzlová, P., Martínková, L., and Kren, V. (1996 b). Secondary metabolites of the fungus Monascus: A review. J Ind Microbiol 16, 163-170. Kalueff, A.V., and Nutt, D.J. (2007). Role of GABA in anxiety and depression. Depress Anxiety 24, 495-517. Karbon, E.W., Duman, R.S., and Enna, S.J. (1984). GABAB receptors and norepinephrine-stimulated camp production in rat-brain cortex. Brain Research 106, 327-332. Kendler, K.S., Gatz, M., Gardner, C.O., and Pedersen, N.L. (2007). Clinical indices of familial depression in the Swedish twin registry. Acta Psychiat Scand 115, 214-220. Kimura, K., Komagata, D., Murakawa, S., and Endo, A. (1990). Biosynthesis of monacolins - conversion of monacolin-J to monacolin-K (mevinolin). J Antibiot 43, 1621-1622. Kohama, Y., Matsumoto, S., Mimura, T., Tanabe, N., Inada, A., and Nakanishi, T. (1987). Isolation and identification of hypotensive principles in red-mold rice. Chem Pharm Bull (Tokyo) 35, 2484-2489. Komatsuzaki, N., Tsukahara, K., Toyoshima, H., Suzuki, T., Shimizu, N., and Kimura, T. (2007). Effect of soaking and gaseous treatment on GABA content in germinated brown rice. Journal of Food Engineering 78, 556-560. Komatsuzaki, N., Tsukahara, K., Toyoshima, H., Suzuki, T., Shimizu, N., and Kimura, T. (2007). Effect of soaking and gaseous treatment on GABA content in germinated brown rice. Journal of Food Engineering 78, 556-560. Kono, I., and Himeno, K. (2000). Changes in gamma-aminobutyric acid content during beni-koji making. Biosci Biotech Bioch 64, 617-619. Krogsgaardlarsen, P., Frolund, B., Jorgensen, F.S., and Schousboe, A. (1994). GABAA receptor agonists, partial agonists, and antagonists - design and therapeutic prospects. J Med Chem 37, 2489-2505. Kubicek, C.P., Hampel, W., and Rohr, M. (1979). Manganese deficiency leads to elevated amino-acid pools in citric-acid accumulating Aspergillus niger. Arch Microbiol 123, 73-79. Kumar, S., and Punekar, N.S. (1997). The metabolism of 4-aminobutyrate (GABA) in fungi. Mycological Research 101, 403-409. Lakshman, P.L.N., Toyokawa, Y., Toyama, H., Taira, T., and Yasuda, M. (2010). Purification and characterisation of two extracellular acid proteinases from Monascus pilosus. Food Chemistry 121, 1216-1224. Lee, C.L., Wang, J.J., and Pan, T.M. (2006). Synchronous analysis method for detection of citrinin and the lactone and acid forms of monacolin K in red mold rice. J AOAC Int 89, 669-677. Lee, C.L., Chen, W.P., Wang, J.J., and Pan, T.M. (2007a). A simple and rapid approach for removing citrinin while retaining monacolin K in red mold rice. J Agric Food Chem 55, 11101-11108. Lee, C.L., Hung, H.K., Wang, J.J., and Pan, T.M. (2007b). Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition. J Agric Food Chem 55, 6493-6502. Lee, C.L., Hung, H.K., Wang, J.J., and Pan, T.M. (2007c). Red mold dioscorea has greater hypolipidemic and antiatherosclerotic effect than traditional red mold rice and unfermented dioscorea in hamsters. J Agric Food Chem 55, 7162-7169. Lee, C.L., Kuo, T.F., Wang, J.J., and Pan, T.M. (2007d). Red mold rice ameliorates impairment of memory and learning ability in intracerebroventricular amyloid beta-infused rat by repressing amyloid beta accumulation. J Neurosci Res 85, 3171-3182. Lee, C.L., Kuo, T.F., Wu, C.L., Wang, J.J., and Pan, T.M. (2010). Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer's risk factors and amyloid beta expression in hyperlipidemic Abeta40-infused rats. J Agric Food Chem 58, 2230-2238. Lee, B.J., Kim, J. S., Kang, Y.M., Lim, J.H., Kim, Y.M., Lee, M. S., Jeong, M.H., Ahn, C.B., and Je, J.Y. (2010). Antioxidant activity and γ-aminobutyric acid (GABA) content in sea tangle fermented by Lactobacillus brevis BJ20 isolated from traditional fermented foods. Food Chemistry 122, 271-276. Lopez-Rubalcava, C., and Lucki, I. (2000). Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test. Neuropsychopharmacol 22, 191-199. Lucki, I. (1997). The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behav Pharmacol 8, 523-532. Manji, H.K., Drevets, W.C., and Charney, D.S. (2001). The cellular neurobiology of depression. Nat Med 7, 541-547. Maras, B., Sweeney, G., Barra, D., Bossa, F., and John, R.A. (1992). The amino-acid-sequence of glutamate-decarboxylase from Escherichia coli - Evolutionary relationship between mammalian and bacterial enzymes. Eur J Biochem 204, 93-98. McCann, S.M., Vijayan, E., Negro-Vilar, A., Mizunuma, H., and Mangat, H. (1984). Gamma aminobutyric acid (GABA), a modulator of anterior pituitary hormone secretion by hypothalamic and pituitary action. Psychoneuroendocrino 9, 97-106. Mckinney, W.T., and Bunney, W.E. (1969). Animal model of depression I. Review of evidence - implications for research. Arch Gen Psychiat 21, 240-248. Narayan, V.S., and Nair, P.M. (1990). Metabolism, enzymology and possible roles of 4-aminobutyrate in higher-plants. Phytochemistry 29, 367-375. Nestler, E.J., Barrot, M., DiLeone, R.J., Eisch, A.J., Gold, S.J., and Monteggia, L.M. (2002). Neurobiology of depression. Neuron 34, 13-25. Nomura, M., Kimoto, H., Someya, Y., Furukawa, S., and Suzuki, I. (1998). Production of gamma-aminobutyric acid by cheese starters during cheese ripening. J Dairy Sci 81, 1486-1491. Nozaki, H., Date, S., Kondo, H., Kiyohara, H., Takaoka, D., Tada, T., and Nakayama, M. (1991). Ankalactone, a new alpha, beta-unsaturated gamma-lactone from Monascus anka. Agr Biol Chem Tokyo 55, 899-900. Oh, S.H., and Oh, C.H. (2003). Brown rice extracts with enhanced levels of GABA stimulate immune cells. Food Sci Biotechnol 12, 248-252. Oh, S.H., Soh, J.R., and Cha, Y.S. (2003). Germinated brown rice extract shows a nutraceutical effect in the recovery of chronic alcohol-related symptoms. J Med Food 6, 115-121. Okada, T., Sugishita, T., Murakami, T., Murai, H., Saikusa, T., Horino, T., Onoda, A., Kajimoto, O., Takahashi, R., and Takahashi, T. (2000). Effect of the defatted rice germ enriched with GABA for sleeplessness, depression, autonomic disorder by oral administration. J Jpn Soc Food Sci 47, 596-603. Olsen, R.W., DeLorey, T. M. (1999). GABA and glycine. In Siegel, G. J., Agranoff, B. W., Albers, R.W., et al., eds. Basic neurochemistry, sixth ed. Philadelphia: Lippincott-Raven, 335-346. Olsen, R.W. (2002). GABA. In Davis, K. L. and Coyle, J. T., eds. Neuropsychopharmacology: The fifth generation of progress. Philadelphia: Lippincott Williams & Wilkins, 159-167. Othmer, E. and Othmer, S. C. (1994). The clinical interview using DSM-IV. America Psychiatric Press, 116-117. Ozawa, H., and Rasenick, M.M. (1991). Chronic electroconvulsive treatment augments coupling of the Gtp-binding protein-Gs to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs. Journal of Neurochemistry 56, 330-338. Petty, F. (1995). GABA and mood disorders: a brief review and hypothesis. Journal of Affective Disorders 34, 275-281. Petty, F., and Sherman, A.D. (1981). Gabaergic modulation of learned helplessness. Pharmacology Biochemistry and Behavior 15, 567-570. Petty, F., Kramer, G.L., Moeller, M. and Jordan, S. (1993) In vivo modulation of serotonin release in frontal neocortex. Society for Neuroscience Annual Meeting, Washington, DC, November 7-12. Popoli, M., Brunello, N., Perez, J., and Racagni, G. (2000). Second messenger-regulated protein kinases in the brain: Their functional role and the action of antidepressant drugs. Journal of Neurochemistry 74, 21-33. Porsolt, R.D., Lepichon, M., and Jalfre, M. (1977). Depression - new animal-model sensitive to antidepressant treatments. Nature 266, 730-732. Ramputh, A.L., and Bown, A.W. (1996). Rapid gamma-aminobutyric acid synthesis and the inhibition of the growth and development of oblique-banded leaf-roller larvae. Plant Physiol 111, 1349-1352. Rasheva, T., Kujumdzieva, A., and Hallet, J.N. (1997). Lipid production by Monascus purpureus albino strain. J Biotechnol 56, 217-224. Reed, L.J. (1950). The occurrence of gamma-aminobutyric acid in yeast extract - Its isolation and identification. J Biol Chem 183, 451-458. Reid, I., Forbes, N., Stewart, C., and Matthews, K. (1997). Chronic mild stress and depressive disorder: a useful new model? Psychopharmacology 134, 365-367. Sachar, E.J., and Baron, M. (1979). Biology of affective disorders. Annu Rev Neurosci 2, 505-518. Sanacora, G., Mason, G.F., Rothman, D.L., and Krystal, J.H. (2002). Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. Am J Psychiat 159, 663-665. Schofield, P.R., Darlison, M.G., Fujita, N., Burt, D.R., Stephenson, F.A., Rodriguez, H., Rhee, L.M., Ramachandran, J., Reale, V., Glencorse, T.A., Seeburg, P.H. and Barnard, E.A. (1987). Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature 328, 221-227. Schousboe, A., and Waagepetersen, H.S. (2009). Gamma-aminobutyric acid (GABA). In Encyclopedia of Neuroscience, R.S. Larry, ed. (Oxford, Academic Press), pp. 511-515. Schwacke, R., Grallath, S., Breitkreuz, K.E., Stransky, E., Stransky, H., Frommer, W.B., and Rentsch, D. (1999). LeProT1, a transporter for proline, glycine betaine, and gamma-amino butyric acid in tomato pollen. Plant Cell 11, 377-391. Sheline, Y.I. (2000). 3D MRI studies of neuroanatomic changes in unipolar major depression: The role of stress and medical comorbidity. Biol Psychiat 48, 791-800. Shelp, B.J., Bown, A.W., and McLean, M.D. (1999). Metabolism and functions of gamma-aminobutyric acid. Trends Plant Sci 4, 446-452. Sherman, A.D., and Petty, F. (1982). Additivity of neurochemical changes in learned helplessness and imipramine. Behav Neural Biol 35, 344-353. Shiah, I.S., and Yatham, L.N. (1998). GABA function in mood disorders: An update and critical review. Life Sciences 63, 1289-1303. Shih, R.A., Belmonte, P.L., and Zandi, P.P. (2004). A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. Int Rev Psychiatr 16, 260-283. Su, N.W., Lin, Y.L., Lee, M.H., and Ho, C.Y. (2005). Ankaflavin from Monascus-fermented red rice exhibits selective cytotoxic effect and induces cell death on Hep G2 cells. J Agr Food Chem 53, 1949-1954. Su, Y.C., Wang, J.J., Lin, T.T., and Pan, T.M. (2003). Production of the secondary metabolites gamma-aminobutyric acid and monacolin K by Monascus. J Ind Microbiol Biotechnol 30, 41-46. Sun, T.S., Zhao, S.P., Wang, H.K., Cai, C.K., Chen, Y.F., and Zhang, H.P. (2009). ACE-inhibitory activity and gamma-aminobutyric acid content of fermented skim milk by Lactobacillus helveticus isolated from Xinjiang koumiss in China. Eur Food Res Technol 228, 607-612. Suzdak, P.D., and Gianutsos, G. (1985). Differential coupling of GABAA and GABAB receptors to the noradrenergic system. Journal of Neural Transmission 62, 77-89. Taira, J., Miyagi, C., and Aniya, Y. (2002). Dimerumic acid as an antioxidant from the mold, Monascus anka: the inhibition mechanisms against lipid peroxidation and hemeprotein-mediated oxidation. Biochem Pharmacol 63, 1019-1026. Tillakaratne, N.J.K., Medina-Kauwe, L., and Gibson, K.M. (1995). Gamma-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues. Comp Biochem Physiol A Physiology 112, 247-263. Tiraboschi, E., Tardito, D., Kasahara, J., Moraschi, S., Pruneri, P., Gennarelli, M., Racagni, G., and Popoli, M. (2004). Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades. Neuropsychopharmacol 29, 1831-1840. Tsai, R.L., Ho, B.Y., and Pan, T.M. (2009). Red mold rice mitigates oral carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-induced oral carcinogenesis in Hamster. Evid Based Complement Alternat Med. Tzeng, D.S., Chien, C.C., Lung, F.W., and Yang, C.Y. (2009). MAOA Gene polymorphisms and response to mirtazapine in major depression. Hum Psychopharm Clin 24, 293-300. Ueno, H. (2000). Enzymatic and structural aspects on glutamate decarboxylase. J Mol Catal B-Enzym 10, 67-79. Vaz, S.H., Cristóvão-Ferreira, S., Ribeiro, J.A., and Sebastião, A.M. (2008). Brain-derived neurotrophic factor inhibits GABA uptake by the rat hippocampal nerve terminals. Brain Research 1219, 19-25. Wada, M., Kido, H., Ohyama, K., Ichibangase, T., Kishikawa, N., Ohba, Y., Nakashima, M.N., Kuroda, N., and Nakashima, K. (2007). Chemiluminescent screening of quenching effects of natural colorants against reactive oxygen species: Evaluation of grape seed, monascus, gardenia and red radish extracts as multi-functional food additives. Food Chemistry 101, 980-986. Wang, J.J., Lee, C.L., and Pan, T.M. (2003a). Improvement of monacolin K, gamma-aminobutyric acid and citrinin production ratio as a function of environmental conditions of Monascus purpureus NTU 601. J Ind Microbiol Biotechnol 30, 669-676. Wang, J.J., and Pan, T.M. (2003b). Effect of red mold rice supplements on serum and egg yolk cholesterol levels of laying hens. J Agric Food Chem 51, 4824-4829. Wang, J.J., Pan, T.M., Shieh, M.J., and Hsu, C.C. (2006). Effect of red mold rice supplements on serum and meat cholesterol levels of broilers chicken. Appl Microbiol Biotechnol 71, 812-818. Wang, Y.Z., Ju, X.L., and Zhou, Y.G. (2005). The variability of citrinin production in Monascus type cultures. Food Microbiol 22, 145-148. Wang, H. F., Tsai, Y. S., Lin, M. L., and Ou, A. S. (2006). Comparison of bioactive components in GABA tea and green tea produced in Taiwan. Food Chem 96, 648-653. Wells, B. G., DiPiro, J.T., Schwinghammer, T.L. and DiPiro, C.V. (2008). Major depressive disorder. In Broen, M. and Naglieri, C., eds. Pharmacotherapy Handbook 7th. America: McGraw-Hill, 778-798. Wong, C.G., Bottiglieri, T., and Snead, O.C., 3rd (2003). GABA, gamma-hydroxybutyric acid, and neurological disease. Ann Neurol 54 Suppl 6, S3-12. Wong, H.C., and Bau, Y.S. (1977). Pigmentation and antibacterial activity of fast neutron-ray and X-ray-induced strains of Monascus purpureus went. Plant Physiol 60, 578-581. Wong, H.C., and Koehler, P.E. (1981). Production and isolation of an antibiotic from Monascus purpureus and its relationship to pigment production. J Food Sci 46, 589-592. World Health Organization. (2008). The global burden of disease: 2004 update. Switzerland, 44-51. World Health Organization. (2010). Depression. http://www.who.int/mental_health/management/depression/definition/en/ Wu, C.L., Lee, C.L., and Pan, T.M. (2009). Red mold dioscorea has a greater antihypertensive effect than traditional red mold rice in spontaneously hypertensive rats. J Agric Food Chem 57, 5035-5041. Yokoyama, S., Hiramatsu, J., and Hayakawa, K. (2002). Production of gamma-aminobutyric acid from alcohol distillery lees by Lactobacillus brevis IFO-12005. J Biosci Bioeng 93, 95-97. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/10481 | - |
dc.description.abstract | 憂鬱症為主要最常見的神經失調疾病,包括心情及認知能力的改變,及經常有死亡或自殺念頭。現今臨床的治療藥物並不適用於所有患者且會產生副作用,因此尋找具抗憂鬱功效且低副作用的物質為極具價值性的研究方向。γ-胺基丁酸 (γ-aminobutyric acid, GABA) 是一重要的神經傳導物質,且具有許多生理活性,如降血壓、利尿及改善焦慮、憂鬱等情緒相關疾病,在此研究中,利用紅麴探討在不同培養基質及培養條件 (培養時間、pH 值、溫度及接種量) 對 GABA 生成的影響;另一方面,利用強迫游泳動物試驗 (forced swimming test, FST) 評估富含 GABA 的紅麴發酵產物其抗憂鬱功效。利用反應曲面法探討 GABA 最適生成條件,當米糠添加比例為 77.3%、培養基起始 pH 值 6.3 及麩胺酸鈉濃度 122.6 mM 時,發酵 7 天後,GABA 從原本 40 mg/L 提升至 350 mg/L,每克 GABA 生產成本為新台幣 8.5 元。另一方面,在強迫游泳短期試驗顯示,GABA為紅麴發酵產物中主要具抗憂鬱功效之物質;而長期試驗中,紅麴發酵產物比同劑量之 GABA 具更好的抗憂鬱潛力,效果類似於 fluoxetine (臨床抗憂鬱藥劑)。於腦組之中,GABA 能提升杏仁核及海馬迴中正腎上腺素、多巴胺與血清素含量;除此之外,紅麴發酵產物更能減緩杏仁核及海馬迴多巴胺的消耗。因此,富含 GABA 之紅麴發酵產物具有低基質成本與抗憂鬱功效等市場潛力。 | zh_TW |
dc.description.abstract | Depression is a disorder characterized by a broad range of symptoms, including altered mood and cognitive functions, and recurrent thoughts of death or suicide. The pharmacotherapy used in clinic today is not suitable for all patients and causes certain side-effects. Thus, looking for alternative treatments with antidepressant effect and minimal side-effect is important. γ-Aminobutyric acid (GABA) is a key compound of the major neurotransmitters. It also has several physiological functions, not hypotensive and diuretic effects, but related to anxiety, depression and numerous mood disorders. In this study, various cultivation substrates and culture conditions (cultural time, pH value, temperature and inoculum volume) were selected to investigate the effect on GABA production by Monascus sp. Moreover, the forced swimming test (FST) of animal model was used to evaluate the antidepressant effect of GABA-rich Monascus submerged fermented product (MSF). To explore the GABA optimal culture conditions, response surface methodology experiment was used. When 77.3% rice bran was used as a substrate which initial pH value and monosodium glutamate concentration were 6.3 and 122.6 mM respectively, the GABA increased from 40 mg/L to 350 mg/L in day 7. The cost of GABA was NT $8.5 per gram. On the other hand, the FST data shows that GABA may be the major compound in MSF to provide antidepressant-like effect in short-term test. In long-term test, the MSF had more antidepressant potential than GABA to reduce the immobility time, and as well as fluoxetine (a clinical prescription) in FST. In brain tissue, GABA provide a high potential to recovered the concentration of norepinephrine, dopamine and serotonin in hippocampus and amygdala. However, MSF also can reduce the consumption of dopamine in hippocampus and amygdala. Thus, MSF which with high GABA level has more potential in low production cost and antidepressant-like effect. | en |
dc.description.provenance | Made available in DSpace on 2021-05-20T21:32:58Z (GMT). No. of bitstreams: 1 ntu-99-R97b47106-1.pdf: 3585430 bytes, checksum: 7e507ee79d8fcb7564411df3a7535b95 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 縮寫表 i
摘要 iii 圖目錄 vii 表目錄 ix 第一章 文獻回顧 1 第一節 紅麴菌 1 1. 古今歷史記載 1 2. 紅麴菌之特性 2 3. 紅麴之高價值代謝產物 5 第二節 γ-胺基丁酸 (GABA) 12 1. GABA 之特性 12 2. GABA 的代謝途徑 12 3. GABA 的生產 18 4. GABA 產品的拓展與演進 19 5. GABA 的作用機制 20 6. GABA 的生理功能 23 7. 安全性 23 第三節 憂鬱症 (Depression) 24 1. 憂鬱症盛行趨勢 24 2. 憂鬱症的診斷 27 3. 憂鬱症病理 28 4. 憂鬱症的藥物治療 30 5. 憂鬱症的動物模式 33 6. 憂鬱症與 GABA 之關係 34 第二章 研究動機與目的 37 第三章 材料與方法 39 第一節 儀器設備 39 第二節 藥品 40 第三節 紅麴菌菌株來源、培養方法 42 第四節 紅麴菌液態發酵方法與條件 42 第五節 紅麴菌固態發酵方法與條件 43 第六節 發酵槽控制條件與樣品製備 44 第七節 紅麴中代謝產物之分析方法 44 第八節 以反應曲面法探討 GABA 最適培養條件之設計 46 第九節 紅麴發酵產物抗憂鬱功效性評估試驗 (強迫游泳) 48 第十節 大鼠腦組織單胺濃度及其代謝產物分析 53 第四章 結果與討論 55 第一節 GABA 生產菌株之挑選 55 第二節 培養條件對 GABA 生成之影響 58 第三節 以反應曲面法 (response surface methodology, RSM) 探討紅麴生產 GABA 最適培養條件 73 第四節 抗憂鬱評估-強迫游泳試驗 81 第五章 結論 100 參考文獻 104 附錄 121 圖目錄 圖 1-1 紅麴菌之生活史 4 圖 1-2 GABA與其他相關代謝路徑 13 圖 1-3 生物及非生物性壓力對 GABA 細胞內與細胞間的調節 15 圖 1-4 真菌無性生活史中各階段 GABA 代謝產物及酵素表現 17 圖 1-5 GABA突觸概要 22 圖 1-6 十大高負擔疾病 2004 年排名及 2030 年預估排名 25 圖 2 研究大綱 38 圖 3 動物實驗流程 49 圖 4-1 不同紅麴菌株之 γ-胺基丁酸生成曲線 57 圖 4-2-1 味精濃度對 M. purpureus BCRC 31499 γ-胺基丁酸生成之影響 59 圖 4-2-2 米的種類對 M. purpureus BCRC 31499 生成 γ-胺基丁酸之影響 60 圖 4-2-3 培養基質於液態發酵對 γ-胺基丁酸生成之影響 62 圖 4-2-4 與米等比例混合之農業副產品對生產 γ-胺基丁酸之影響 62 圖 4-2-5 米糠添加量對固態發酵的影響 65 圖 4-2-6 培養基質於固態發酵對生產 γ-胺基丁酸之影響 66 圖 4-2-7 不同培養條件對M. purpureus BCRC 31499 生成 γ-胺基丁酸之影響 70 圖 4-2-8 米糠添加量對液態發酵的影響 72 圖 4-3-1 米糠添加比例與 MSG 濃度對 γ-胺基丁酸生成量之反應曲面圖 75 圖 4-3-2 Monascus purpureus BCRC 31499 於發酵槽培養之 γ-胺基丁酸生成曲線 80 圖 4-4-1 試驗中體重之變化 82 圖 4-4-2 試驗中攝食量之變化 83 圖 4-4-3 紅麴發酵產物在短期試驗中對強迫游泳不活動時間之影響 85 圖 4-4-4 紅麴發酵產物在長期試驗中對強迫游泳之不活動時間影響 86 圖 4-4-5 單胺物質標準品之層析圖譜 88 圖 4-4-6 紅麴發酵產物與 GABA 對大腦不同區域多巴胺代謝速率之影響 93 圖 4-4-7 紅麴發酵產物與 GABA 對大腦不同區域血清素代謝速率之影響 94 圖 4-4-8 不同實驗組別之肝、腎臟組織切片 99 表目錄 表 1-1 依國家收入分組之全球疾病負擔造成因素 (2004) 26 表 1-2 美國 2007 年零售市場常見抗憂鬱劑處方用藥統計 31 表 1-3 抗憂鬱藥物副作用比較 32 表 1-4 GABA 在情緒疾病生理學的功能與在情緒穩定劑、抗憂鬱藥劑及電痙攣療法產生的機制 36 表 2-1 固態發酵之三因子-三階層之中心旋轉組合設計 47 表 2-2 動物分組與劑量設計 51 表 4-2 M. purpureus BCRC 31499 以固態發酵或液態發酵生產 γ-胺基丁酸的基質成本之比較 68 表 4-3-1 反應曲面法之三因子-三階層條件 74 表 4-3-2 三因子-三階層之中心旋轉組合設計 76 表 4-3-3 變異數迴歸分析 77 表 4-3-4 生產 γ-胺基丁酸基質成本之比較 79 表 4-4-1 紅麴發酵產物對不同腦區正腎上腺素含量之影響 89 表 4-4-2 紅麴發酵產物對不同腦區多巴胺含量之影響 90 表 4-4-3 紅麴發酵產物對不同腦區血清素含量之影響 91 表 4-4-4 紅麴發酵產物與 γ-胺基丁酸對不同腦區單胺物質含量之影響 95 表 4-4-5 紅麴發酵產物對 SD 大鼠血清中 AST、ALT、BUN 及 creatinine 之影響 97 表 4-4-6紅麴發酵產物對 SD 大鼠血清中電解質之影響 98 | |
dc.language.iso | zh-TW | |
dc.title | 富含γ-胺基丁酸之紅麴發酵產物最適生產條件與其抗憂鬱功效評估 | zh_TW |
dc.title | Study on the optimal culture condition and evaluation of the antidepressant effect of the GABA-rich Monascus-fermented product | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 蘇遠志,黃健雄,邱秋霞,蔡宗佑 | |
dc.subject.keyword | 紅麴,γ-胺基丁酸,成本,強迫游泳試驗,抗憂鬱, | zh_TW |
dc.subject.keyword | Monascus,GABA,cost,forced swimming test,antidepressant, | en |
dc.relation.page | 121 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2010-08-18 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 微生物與生化學研究所 | zh_TW |
顯示於系所單位: | 微生物學科所 |
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