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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/101835完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林中天 | zh_TW |
| dc.contributor.advisor | Chung-Tien Lin | en |
| dc.contributor.author | 簡瑋蝶 | zh_TW |
| dc.contributor.author | Wei-Tieh Chien | en |
| dc.date.accessioned | 2026-03-04T16:57:51Z | - |
| dc.date.available | 2026-03-05 | - |
| dc.date.copyright | 2026-03-04 | - |
| dc.date.issued | 2026 | - |
| dc.date.submitted | 2026-02-05 | - |
| dc.identifier.citation | Acland, G. M., Aguirre, G. D., Ray, J., Zhang, Q., Aleman, T. S., Cideciyan, A. V., Pearce-Kelling, S. E., Anand, V., Zeng, Y., Maguire, A. M., Jacobson, S. G., Hauswirth, W. W., & Bennett, J. (2001). Gene therapy restores vision in a canine model of childhood blindness. Nature Genetics, 28(1), 92–95. https://doi.org/10.1038/ng0501-92
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/101835 | - |
| dc.description.abstract | 漸進性視桿—視錐退化症（progressive rod-cone degeneration, PRCD）為貴賓犬中最常見的漸進性視網膜退化症（progressive retinal atrophy, PRA）類型，屬於晚發性遺傳性視網膜疾病。本研究旨在調查台灣玩具型與迷你型貴賓犬之PRCD 盛行率與突變等位基因頻率，結合完整眼科檢查與眼底攝影，探討PRCD基因型與臨床表現之關聯，並利用半自動化影像分析方法量化不同基因型犬隻的視網膜血管參數，同時建立犬隻正常參考區間。研究共收集107隻貴賓犬（玩具貴賓74隻、迷你貴賓33隻）進行眼科臨床檢查及眼底攝影，並以口腔黏膜採樣進行 PRCD基因檢測。眼底影像透過結合深度學習視神經盤定位與血管分割的半自動化分析流程，計算視網膜動脈直徑（RAD）、靜脈直徑（RVD）與動靜脈比值（AVR）。結果顯示，玩具貴賓犬之PRCD盛行率為10.8%，迷你貴賓犬為9.1%，其突變等位基因頻率分別為0.216與0.182，突變基因攜帶者（HET；G/A）在兩品種皆佔約20%。影像分析共納入366張眼底影像，取得13789筆血管直徑量測資料，最終建立198隻眼睛的代表性血管參數。PRCD突變同型合子（AFF；A/A）犬隻之RAD與RVD皆呈現明顯變細，而AVR未出現顯著差異，於未受PRCD影響犬隻也成功建立RAD、RVD 及 AVR 的正常參考區間。少數犬隻則出現基因型與眼底表現不一致之情形。總結來說，PRCD 在台灣玩具型與迷你型貴賓犬中具有相當高的遺傳負擔，約五分之一犬隻為突變基因帶因者，顯示基因篩檢對疾病預防與育種管理的重要性。PRCD 受影響犬隻出現明顯的視網膜血管變細，顯示視網膜血管直徑具有作為臨床評估視網膜退化程度之客觀輔助指標的潛力。 | zh_TW |
| dc.description.abstract | Progressive rod–cone degeneration (PRCD) is the most common form of progressive retinal atrophy (PRA) in Poodles and is classified as a late-onset inherited retinal disease. The aims of this study were to determine the prevalence and mutant allele frequency of PRCD in Toy and Miniature Poodles in Taiwan, to investigate the relationship between PRCD genotype and clinical phenotype through comprehensive ophthalmic examinations and fundus photography, and to quantitatively assess retinal vascular parameters across different PRCD genotypes using a semi-automated image analysis approach, while establishing normative reference intervals for Poodles.
A total of 107 Poodles (74 Toy Poodles and 33 Miniature Poodles) were enrolled and underwent complete ophthalmic examinations and fundus photography. PRCD genotyping was performed using buccal mucosal swab samples. Fundus images were analyzed using a semi-automated pipeline incorporating deep learning–based optic nerve head localization and retinal vessel segmentation to calculate retinal arteriolar diameter (RAD), retinal venular diameter (RVD), and arteriole-to-venule ratio (AVR). The prevalence of PRCD was 10.8% in Toy Poodles and 9.1% in Miniature Poodles, with corresponding mutant allele frequencies of 0.216 and 0.182, respectively. Heterozygous carriers (HET; G/A) accounted for approximately 20% of dogs in both breeds. A total of 366 fundus images were included for image analysis, yielding 13,789 individual vessel diameter measurements and representative vascular parameters from 198 eyes. PRCD-affected dogs (AFF; A/A) exhibited significant narrowing of both RAD and RVD compared with PRCD-unaffected dogs, whereas no significant difference in AVR was observed. Normative reference intervals for RAD, RVD, and AVR were successfully established from PRCD-unaffected dogs. A small number of dogs demonstrated discordance between genotype and funduscopic phenotype. In conclusion, PRCD represents a substantial genetic burden in Toy and Miniature Poodles in Taiwan, with approximately one-fifth of dogs being carriers, underscoring the importance of genetic screening for disease prevention and breeding management. Marked retinal vascular attenuation in PRCD-affected dogs suggests that retinal vessel diameter measurements may serve as an objective adjunctive indicator for clinical assessment of retinal degeneration. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2026-03-04T16:57:51Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2026-03-04T16:57:51Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | ACKNOWLEDGEMENT I
中文摘要 II ABSTRACT IV TABLE OF CONTENTS VI LIST OF FIGURES X LIST OF TABLES XII TABLE OF ABBREVIATIONS XIII CHAPTER 1. INTRODUCTION 1 1.1 BACKGROUND 1 1.2 PURPOSE OF THE STUDY 3 CHAPTER 2. LITERATURE REVIEW 4 2.1 INTRODUCTION OF CANINE FUNDUS 4 2.2 OVERVIEW OF PRA AND PRCD 7 2.3 MANAGEMENT OF PRA 11 CHAPTER 3. MATERIAL AND METHODS 15 3.1 ANIMALS 15 3.2 CLINICAL EXAMINATION 15 3.2.1. Photopic and scotopic menace responses 15 3.2.2. Palpebral reflex 16 3.2.3. Dazzle reflex 16 3.2.4. Direct and indirect pupillary light reflex (PLR) 17 3.2.5. Chromatic pupillary light reflex (cPLR) 17 3.2.6. Tonometry and pupil dilation 18 3.2.7. Slit lamp biomicroscopy 19 3.2.8. Fundus examination and recording 19 3.3 DNA TESTING 19 3.3.1. DNA extraction and quantification 19 3.3.2. DNA amplification 20 3.3.3. DNA sequencing and analysis 21 3.4 IMAGE ANALYSIS 21 3.4.1. Measurement of optic nerve head (ONH) diameter 21 3.4.2. Measurement of retinal vessel diameter 23 3.4.3. Exclusion criteria for image analysis 24 3.5 OPTICAL COHERENCE TOMOGRAPHY (OCT) 27 3.6 STATISTICAL ANALYSIS 27 CHAPTER 4. RESULTS 29 4.1 CHARACTERIZATION OF STUDY POPULATION 29 4.2 DNA TESTING 30 4.3 IMAGE ANALYSIS 32 4.3.1. Performance of the YOLO-based ONH Detection Model 32 4.3.2. Comparison of retinal vascular parameters among genotypes 32 4.3.3. Evaluation of age effect 35 4.3.4. Comparison between PRCD-unaffected and AFF 35 4.3.5. Breed differences within PRCD-free dogs 36 4.3.6. Establishment of reference intervals 37 4.4 CLINICAL FINDINGS 39 4.4.1. Ocular and funduscopic observations 39 4.4.2. Fundus abnormalities in AFF dogs 41 4.4.3. Neuro-ophthalmic abnormalities in AFF dogs 42 4.4.4. Correlation between genotype and phenotype 44 4.4.5. Association of cataract and PRCD 45 CHAPTER 5. DISCUSSION 46 5.1 COMPARISON OF RETINAL VASCULAR PARAMETERS BETWEEN GENOTYPES 46 5.2 ESTABLISHMENT OF NORMATIVE REFERENCE INTERVALS 47 5.3 GENOTYPE-PHENOTYPE DISCORDANCE 49 5.4 RESULTS OF CLINICAL SIGNS 51 5.5 COMPARISON OF PRCD PREVALENCE AND MUTANT ALLELE FREQUENCY 52 CHAPTER 6. LIMITATIONS 55 CHAPTER 7. CONCLUSIONS 57 REFERENCES 59 APPENDIX A 70 APPENDIX B 74 APPENDIX C 78 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 漸進性視網膜萎縮症 | - |
| dc.subject | 漸進性視桿—視錐退化症 | - |
| dc.subject | 基因測試 | - |
| dc.subject | 視網膜血管直徑 | - |
| dc.subject | 眼底影像 | - |
| dc.subject | progressive retinal atrophy | - |
| dc.subject | progressive rod-cone degeneration | - |
| dc.subject | gene testing | - |
| dc.subject | retinal blood vessel diameters | - |
| dc.subject | fundus imaging | - |
| dc.title | 正常與漸進性視網膜萎縮症貴賓犬之視網膜形態、 基因檢測及眼底影像半自動化分析之探討 | zh_TW |
| dc.title | Investigations of Retinal Morphology, Gene Testing and Semiautomated Analysis of Fundus Images in Poodles with or without Progressive Retinal Atrophy | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 114-1 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 林荀龍;廖泰慶;周呈霙;陳達慶 | zh_TW |
| dc.contributor.oralexamcommittee | Shiun-Long Lin;Tai-Chiang Liao;Cheng-Ying Chou;Ta-Ching Chen | en |
| dc.subject.keyword | 漸進性視網膜萎縮症,漸進性視桿—視錐退化症基因測試視網膜血管直徑眼底影像 | zh_TW |
| dc.subject.keyword | progressive retinal atrophy,progressive rod-cone degenerationgene testingretinal blood vessel diametersfundus imaging | en |
| dc.relation.page | 88 | - |
| dc.identifier.doi | 10.6342/NTU202600646 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2026-02-09 | - |
| dc.contributor.author-college | 生物資源暨農學院 | - |
| dc.contributor.author-dept | 臨床動物醫學研究所 | - |
| dc.date.embargo-lift | 2026-03-05 | - |
| 顯示於系所單位： | 臨床動物醫學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-114-1.pdf 授權僅限NTU校內IP使用（校園外請利用VPN校外連線服務） | 2.34 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。