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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳小梨 | zh_TW |
| dc.contributor.advisor | Show-li Chen | en |
| dc.contributor.author | 黃健庭 | zh_TW |
| dc.contributor.author | Chien-Ting Huang | en |
| dc.date.accessioned | 2025-09-22T16:10:19Z | - |
| dc.date.available | 2025-09-23 | - |
| dc.date.copyright | 2025-09-22 | - |
| dc.date.issued | 2025 | - |
| dc.date.submitted | 2025-07-31 | - |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/99966 | - |
| dc.description.abstract | 核受體交互蛋白（NRIP）為一多功能蛋白，於骨骼肌與脊髓中均有表現，參與神經肌肉接點（NMJ）穩定維持。肌肉來源的NRIP功能已有相關研究，但神經元來源NRIP（mnNRIP）的生理角色仍未釐清。本研究目的為探討mnNRIP對NMJ穩定與神經再生之貢獻。我們利用運動神經元專一性NRIP剔除小鼠（mnKO）模型，分析其脊髓中運動神經元形態、NMJ結構、運動行為與坐骨神經損傷後的再生狀態。結果發現，mnKO小鼠脊髓中大型膽鹼能神經元明顯減少，但其NMJ結構、肌纖維類型及運動功能與野生型無顯著差異。坐骨神經損傷後14天，mnKO與對照組皆展現類似的NMJ再生能力。值得注意的是，mnKO小鼠在未受傷對側肢體出現提早去神經化現象，顯示mnNRIP可能於壓力狀態下支持雙側NMJ的穩定性。總結而言，mnNRIP雖非維持NMJ結構及再生所必需，但可能參與運動神經元存活及傷後跨側神經反應之調控。 | zh_TW |
| dc.description.abstract | NRIP is a multifunctional protein expressed in muscle and spinal cord, implicated in neuromuscular junction (NMJ) maintenance. While muscle-derived NRIP supports NMJ stability, its motor neuron-derived counterpart (mnNRIP) is less studied. We aimed to determine the physiological function of mnNRIP in NMJ homeostasis and regeneration. By generating mnNRIP knockout (mnKO) mice, we examined motor neuron morphology, NMJ structure, behavioral performance, and regenerative capacity following sciatic nerve injury. mnKO mice exhibited reduced numbers of large spinal cholinergic neurons but displayed no significant changes in NMJ architecture, muscle fiber composition, or motor behavior. At 14 days after nerve injury, both mnKO and wild-type mice showed comparable NMJ regeneration. Unexpectedly, mnKO mice exhibited early signs of NMJ denervation in the contralateral, uninjured limb. These results indicate that mnNRIP is not essential for NMJ regeneration or structure under normal conditions but may play a role in supporting bilateral NMJ integrity under stress. Thus, mnNRIP contributes to motor neuron maintenance and may regulate trans-neural responses to injury. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2025-09-22T16:10:19Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2025-09-22T16:10:19Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員會審定書 I
致謝 II 中文摘要 IV Abstract V 目次 VI Chapter 1. Introduction 1 1.1 The nuclear receptor interaction protein (NRIP) 1 1.2 The physiology of neuromuscular junction (NMJ) 2 1.3 The development of NMJ and AChR cluster formation 3 1.4 The NRIP at the neuromuscular junction 5 1.5 The retrograde effect at the neuromuscular junction 6 1.6 The role of motor neuron-derived postsynaptic components 7 1.7 The role of NMJ components in regeneration after peripheral nerve injury 8 1.8 The aim of this study 8 Chapter 2. Materials and Methods 10 2.1 Mice 10 2.2 Mice spinal cord and muscles preparation 10 2.3 Immunofluorescent staining of motor neurons 11 2.4 Immunofluorescent staining of NMJ and muscle fibers 12 2.5 Behavioral analysis 15 2.6 Sciatic nerve crush injury 16 Chapter 3. Results 18 3.1 Reduced large cholinergic and NRIP-expressing neurons in NRIP mnKO mice 18 3.2 Comparable neuromuscular junction (NMJ) structure between WT and mnKO mice 20 3.3 Comparable muscle fiber types distribution in WT and mnKO mice. 21 3.4 Insignificant difference on motor function and behavior between WT and mnKO mice. 22 3.5 Completely Denervation After Sciatic Nerve Crush Injury 22 3.6 Comparable NMJ Regeneration Status 14 Days Post Injured 24 Chapter 4. Discussion 26 4.1 MN-NRIP is dispensable for NMJ function but involved in MN development in the spinal cord. 26 4.2 mnNRIP is dispensable for unilateral NMJ regeneration after sciatic nerve injury. 30 4.3 mnNRIP KO accelerates contralateral NMJ denervation after unilateral injury. 32 Chapter 5. Figures 35 Chapter 6. Supplementary information 44 Chapter 8. Appendix 47 Chapter 9. Reference 50 | - |
| dc.language.iso | en | - |
| dc.subject | 核受體交互蛋白（NRIP） | zh_TW |
| dc.subject | 神經肌肉接點（NMJ） | zh_TW |
| dc.subject | 背側膽鹼能神經元 | zh_TW |
| dc.subject | 坐骨神經損傷 | zh_TW |
| dc.subject | NMJ再生 | zh_TW |
| dc.subject | 去神經化 | zh_TW |
| dc.subject | 雙側神經調控 | zh_TW |
| dc.subject | Bilateral neuromuscular regulation | en |
| dc.subject | Sciatic nerve injury | en |
| dc.subject | Regeneration | en |
| dc.subject | Neurodegeneration | en |
| dc.subject | NRIP | en |
| dc.subject | NMJ | en |
| dc.subject | Motor neurons | en |
| dc.title | 運動神經元NRIP對運動神經及肌肉的影響 | zh_TW |
| dc.title | The Effect of mnNRIP on Motor Neuron and Muscle | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 113-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.coadvisor | 楊宏志 | zh_TW |
| dc.contributor.coadvisor | Hung-Chih Yang | en |
| dc.contributor.oralexamcommittee | 黃祥博;曹友平;陳伯翰 | zh_TW |
| dc.contributor.oralexamcommittee | Hsiang-Po Huang;Yeou-Ping Tsao;Po-Han Chen | en |
| dc.subject.keyword | 核受體交互蛋白（NRIP）,神經肌肉接點（NMJ）,背側膽鹼能神經元,坐骨神經損傷,NMJ再生,去神經化,雙側神經調控, | zh_TW |
| dc.subject.keyword | NRIP,NMJ,Motor neurons,Sciatic nerve injury,Regeneration,Bilateral neuromuscular regulation,Neurodegeneration, | en |
| dc.relation.page | 66 | - |
| dc.identifier.doi | 10.6342/NTU202503096 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2025-07-31 | - |
| dc.contributor.author-college | 醫學院 | - |
| dc.contributor.author-dept | 微生物學研究所 | - |
| dc.date.embargo-lift | 2027-12-31 | - |
| 顯示於系所單位： | 微生物學科所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-113-2.pdf 未授權公開取用 | 1.94 MB | Adobe PDF | 檢視/開啟 |
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