請用此 Handle URI 來引用此文件：
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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 王兆麟 | zh_TW |
| dc.contributor.advisor | Jaw-Lin Wang | en |
| dc.contributor.author | 簡于涵 | zh_TW |
| dc.contributor.author | Yu-Han Chien | en |
| dc.date.accessioned | 2025-09-10T16:35:44Z | - |
| dc.date.available | 2025-09-11 | - |
| dc.date.copyright | 2025-09-10 | - |
| dc.date.issued | 2025 | - |
| dc.date.submitted | 2025-07-16 | - |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/99537 | - |
| dc.description.abstract | 隨者人口高齡化，現在的患有神經退化性疾病的患者也隨之增多，為社會與家庭帶來沉重的負擔。而這些疾病的成因大多與腦中蛋白質沉積有關，像Tau、Aβ，或是α-syn等。已有研究證實大腦可以透過膠淋巴系統循環清除這些腦部生理代謝廢物，且已有許多研究正在探討該如何促進膠淋巴系統循環，包括藥物治療、侵入性、非侵入性刺激，以及自主運動等方式。
而目前尚未有非侵入性的低強度超音波刺激研究，故本研究觀察了不同心律是否會影響腦脊髓液擴散至腦中的速率，以了解心律對膠淋巴系統循環的影響，並探討小鼠進行低強度超音波刺激後，是否可以促進腦脊髓液流入。 我們在研究中證實了不同的心律將影響腦脊髓液流入腦實質的速度，當心律越快時，腦脊髓液流入的速度就越快；心律越慢時，流入的速度則越慢，而小鼠經過低強度超音波刺激後，其腦脊髓液流入的速度也得到了顯著性的改善。 藉由本研究證實，膠淋巴系統循環與心律兩者之間呈現正向關係。未來若將低強度超音波刺激應用於臨床，其刺激能量該如何界定，仍須抱持著謹慎的態度進行探討。總體而言，此次的研究結果表明，低強度超音波刺激具有治療神經退化性疾病的潛能。 | zh_TW |
| dc.description.abstract | Neurodegenerative diseases are increasingly prevalent with aging populations, largely due to the accumulation of misfolded proteins such as Tau, beta-amyloid, and alpha-synuclein. Recent studies have proven that the brain can clean metabolic waste through the glymphatic system. Various methods have been explored to enhance glymphatic circulation,
However, there is no research on non-invasive low-intensity ultrasound stimulation. In this study, we observe whether different heart rate will affect the rate of CSF diffusion into the brain, and to explore whether low-intensity ultrasound stimulation of mice can promote CSF influx. Results showed that heart rate will affect the rate of CSF influx into brain; faster heart rates, the faster the CSF flows in, while slower heart rates have the opposite effect. After low-intensity ultrasound stimulation of mice, the speed of CSF influx was significantly improved. This study confirmed that there is a positive relationship between the lymphatic system circulation and heart rate. While these findings suggest the therapeutic potential of ultrasound in treating neurodegenerative diseases, further studies are required to determine its clinical applicability and safety. Overall, the results of this study suggest that low-intensity ultrasound stimulation has the potential to treat neurodegenerative diseases. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2025-09-10T16:35:44Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2025-09-10T16:35:44Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員審定書 i
致謝 ii 中文摘要 iv Abstract v 目次 vi 圖次 viii 表次 x 第一章 緒論 1 1.1 神經退化性疾病 1 1.2 膠淋巴系統 2 1.3 膠淋巴系統中的關鍵蛋白 4 1.3.1 AQP4水通道（Aquaporin-4 Water Channel） 4 1.3.2星狀細胞（Astrocytes） 5 1.3.3 小膠質細胞（Microglia） 6 1.4 現今治療方式及研究 7 1.5 研究目的與重要性 8 1.6 超音波參數定義 9 第二章 材料與方法 11 2.1研究方法 11 2.2 不同心律小鼠實驗 11 2.2.1 心律藥物濃度控制 12 2.2.2 實驗操作步驟 12 2.2.3 腦組織切片樣本製備 13 2.2.4 螢光顯微鏡拍攝參數 15 2.2.5 螢光分析參數 16 2.4 超音波刺激系統 17 2.4.1 刺激設備與探頭 17 2.4.1.1訊號產生器（Functiongenerator） 17 2.4.1.2功率放大器（Amplifier） 18 2.4.1.3 陶瓷壓電片（PZT-Probe） 18 2.4.2 刺激系統能量量測 19 2.4.3 刺激系統升溫量測 20 第三章 實驗結果 22 第四章 討論 24 4.1心律小鼠實驗結果與討論 24 4.1.1小鼠模型心律異常緩慢 24 4.1.2 心律小鼠與CSF滲透率 24 4.1.3 低強度超音波刺激與CSF滲透率 25 第五章 結論與未來展望 27 第六章 參考文獻 28 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 心律 | zh_TW |
| dc.subject | 膠淋巴系統 | zh_TW |
| dc.subject | 低強度超音波 | zh_TW |
| dc.subject | low-intensity ultrasound | en |
| dc.subject | Glymphatic system | en |
| dc.subject | heart rate | en |
| dc.title | 探討心律對腦脊髓液滲透率的影響 | zh_TW |
| dc.title | Investigation of Heart Rate on CSF Influx | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 113-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 陳文翔;陳志成;蕭仲凱 | zh_TW |
| dc.contributor.oralexamcommittee | Wen-shiang Chen;Chih-Cheng Chen;Jong-Kai Hsiao | en |
| dc.subject.keyword | 膠淋巴系統,心律,低強度超音波, | zh_TW |
| dc.subject.keyword | Glymphatic system,heart rate,low-intensity ultrasound, | en |
| dc.relation.page | 36 | - |
| dc.identifier.doi | 10.6342/NTU202501609 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2025-07-18 | - |
| dc.contributor.author-college | 工學院 | - |
| dc.contributor.author-dept | 醫學工程學系 | - |
| dc.date.embargo-lift | 2030-07-07 | - |
| 顯示於系所單位： | 醫學工程學研究所 | |
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