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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 丁詩同 | zh_TW |
| dc.contributor.advisor | Shih-Torng Ding | en |
| dc.contributor.author | 邱于珍 | zh_TW |
| dc.contributor.author | Yu-Chen Chiu | en |
| dc.date.accessioned | 2025-09-09T16:09:57Z | - |
| dc.date.available | 2025-09-10 | - |
| dc.date.copyright | 2025-09-09 | - |
| dc.date.issued | 2025 | - |
| dc.date.submitted | 2025-08-04 | - |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/99364 | - |
| dc.description.abstract | 抗生素抗藥性（AMR）為影響防疫一體（One Health）架構之重要議題。本報告視產食動物之抗生素使用為人為因素，以全面的觀點探討其傳播抗生素抗藥性之可能性。研究方法包括分析法國、日本及台灣之產食動物抗生素使用習慣及實地樣本之抗藥性分析。結果顯示相較於日本及台灣，法國具有較強力度之法規及較少之抗生素使用。相似趨勢亦發現於廢水宏基因體定序分析，與日本及台灣之集群相比，法國樣本之集群表現出較為獨立之趨勢。依據前述之研究結果，同時擁有β-內醯胺類抗生素及多黏菌素抗性之抗藥性基因被提議作為追溯產食動物抗藥性來源之指標基因。抗生素敏感性試驗更進一步的被用於探討產食動物相關樣品分離出之菌株抗藥性機制。自法國肉牛農場採集之動物及環境樣本篩選分離出之革蘭氏陰性菌菌株用於探討以質體為媒介之抗藥性傳播，而自日本蔬菜農場採集之含產食動物糞便肥料樣本篩選分離出之革蘭氏陽性菌菌株則被用於探討其可能之β-內醯胺類抗生素抗藥性。ESKAPEE病原體所屬之菌屬在抗藥性傳播中可能扮演的生態棲位也同時於本研究中探討。產食動物抗生素使用及抗生素抗藥性之間存在由多樣因子構成之關聯，現今之相關研究因而有所侷限，多元之研究方法因此被建議使用以彌補研究之不足。本報告提議以功能性宏基因體定序分析作為填補現今產食動物抗生素抗藥性研究缺口之方法，從而連接防疫一體及全球意識，提升抗生素抗藥性監測效能。整體而言，本研究提供關於產食動物抗生素抗藥性的全面見解，旨在守護所有生物與環境的健康與福祉，並為未來抗生素抗藥性提供可能之研究方向。 | zh_TW |
| dc.description.abstract | Antimicrobial resistance (AMR) is a serious concern that affects the One Health sectors. This report examines antibiotic use in food-producing animals as an anthropogenic factor, identifying its potential contribution to resistance spread by analyzing antibiotic use patterns and real-life sample resistance profiling in France, Japan, and Taiwan to provide a comprehensive perspective. The results indicated stricter policies and lower levels of antibiotic use in France compared to Japan and Taiwan. Similar trends were discovered in the wastewater metagenomic analyses, with samples from France forming more distinct clusters than the other two countries. Genes resistant to both beta-lactam and polymyxin are proposed as potential markers to track animal-originated sources. Phenotypic profiling was further performed to explore strain-specific, animal-originated resistance mechanisms by identifying plasmid-mediated resistance in Gram-negative isolates from France and possible beta-lactam resistance in Gram-positive isolates from Japan, alongside the consideration of possible ecological roles played by ESKAPEE-associated genera in resistance dissemination. The relationship between food-producing animal antibiotic practices and AMR is shaped by complex factors, which pose limitations for current studies. A multi-method approach is therefore recommended to complement existing constraints. Functional metagenomics is proposed as a potential solution to address current gaps in food-producing animals’ AMR research to bridge One Health and global efforts toward improved AMR surveillance. Overall, this study provides insights about AMR related to food-producing animals with the aim of protecting the health and welfare of all living beings, and offers possible directions for future AMR research. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2025-09-09T16:09:57Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2025-09-09T16:09:57Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | Acknowledgement i
摘要 ii Abstract iii Nomenclature iv Chapter 1 Introduction 1 1.1. Global Threat of Antimicrobial Resistance (AMR) 1 1.2. One Health Framework and AMR Dissemination 1 1.3. Concern of AMR in Food-Producing Animals 2 1.4. Surveillance of AMR 3 1.5. Case Selection: France, Japan, and Taiwan 4 1.6. Study Objective and Scope 5 Chapter 2 Food-Producing Animal Antibiotic Use in France, Japan, and Taiwan 6 2.1. Policies Regarding Antibiotics in Animal Feed 6 2.2. Authorized Antibiotic Products 9 2.3. Food-Producing Animal Antibiotic Sales 12 2.4. Quantifying the Impact of Antibiotic Use on AMR 15 Chapter 3 Metagenomic Profiling of the Resistome in Wastewater from France, Japan, and Taiwan 19 3.1. Comparative Resistome Structure Based on ARG Abundance 20 3.2. Potential Signatures of Food-Producing Animal Contribution to the Wastewater Resistome 22 3.3. Prevalence of ESKAPEE Pathogen-Associated Genera 24 Chapter 4 Phenotypic Characterization of Antibiotic Resistance in Animal-Associated Bacteria 27 4.1. Resistance in Gram-Negative Bacteria from France 28 4.2. Resistance in Gram-Positive Bacteria from Japan 39 Chapter 5 Conclusion and Discussion 41 5.1. Human: Decision Maker for Anthropogenic Factors 41 5.2. Environment: Wastewater Samples as Surveillance Model 42 5.3. Animal: Phenotypic Profiling of Originated Strains 45 5.4. Solution: Functional Metagenomics as One Health Gap-Filler 47 5.5. Conclusion 50 References 51 Appendix 58 | - |
| dc.language.iso | en | - |
| dc.subject | 抗生素抗藥性 | zh_TW |
| dc.subject | 防疫一體 | zh_TW |
| dc.subject | 產食動物 | zh_TW |
| dc.subject | 人為因素 | zh_TW |
| dc.subject | 宏基因體 | zh_TW |
| dc.subject | 抗生素敏感性試驗 | zh_TW |
| dc.subject | Food-Producing Animals | en |
| dc.subject | One Health | en |
| dc.subject | Antibiotic Susceptibility Testing | en |
| dc.subject | Antimicrobial Resistance (AMR) | en |
| dc.subject | Anthropogenic Factors | en |
| dc.subject | Metagenomics | en |
| dc.title | 產食動物抗生素抗藥性：法國、日本及台灣之防疫一體分析 | zh_TW |
| dc.title | Antibiotic Resistance in Food-Producing Animals: A One Health Analysis Across France, Japan, and Taiwan | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 113-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | Christophe Dagot;王如邦 | zh_TW |
| dc.contributor.oralexamcommittee | Christophe Dagot;Reuben Wang | en |
| dc.subject.keyword | 抗生素抗藥性,防疫一體,產食動物,人為因素,宏基因體,抗生素敏感性試驗, | zh_TW |
| dc.subject.keyword | Antimicrobial Resistance (AMR),One Health,Food-Producing Animals,Anthropogenic Factors,Metagenomics,Antibiotic Susceptibility Testing, | en |
| dc.relation.page | 77 | - |
| dc.identifier.doi | 10.6342/NTU202503336 | - |
| dc.rights.note | 同意授權(全球公開) | - |
| dc.date.accepted | 2025-08-05 | - |
| dc.contributor.author-college | 醫學院 | - |
| dc.contributor.author-dept | 國際三校農業生技與健康醫療碩士學位學程 | - |
| dc.date.embargo-lift | 2025-09-10 | - |
| 顯示於系所單位： | 國際三校農業生技與健康醫療碩士學位學程 | |
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