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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9918完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 江俊斌 | |
| dc.contributor.author | Chia-Chuan Chang | en |
| dc.contributor.author | 張家銓 | zh_TW |
| dc.date.accessioned | 2021-05-20T20:49:23Z | - |
| dc.date.available | 2009-08-14 | |
| dc.date.available | 2021-05-20T20:49:23Z | - |
| dc.date.copyright | 2008-08-14 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-06-27 | |
| dc.identifier.citation | Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J. Human ICE/CED-3 Protease Nomenclature. Cell 1996;87: 171-172.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9918 | - |
| dc.description.abstract | 背景: 細胞凋亡抑制蛋白1 (cIAP-1)的過度表現，已經在不同的人類癌症中被發現，且和腫瘤的大小，淋巴結的轉移，腫瘤分期，復發和預後等有關。
方法: 在本研究中，我們利用免疫組織化學染色法，探討cIAP-1蛋白質在73例口腔鱗狀細胞癌（OSCC），76例口腔上皮變異（OED；23例輕度，34例中度，19例重度上皮變異），31例正常口腔黏膜（NOM）之表現。計算cIAP-1在OSCC、OED、和NOM細胞質的染色強度(staining intensity, SI)和染色指標(labeling indices, LIs，定義為在所有細胞中陽性染色細胞的百分比)並比較組間差異。利用統計分析OSCCs細胞質LIs和臨床參數或存活率間的關連性。 結果: 結果顯示平均細胞質cIAP-1 LIs從NOM (23±22%)， 經OED (50±25%) 至OSCC 樣本 (73±17%)，呈統計上有意義增加 (NOM v.s. OED or OSCC, P=0.000; OED v.s. OSCC, P=0.000)。平均細胞質cIAP-1 LIs和OSCCs和局部淋巴轉移(P=0.000)，和較高的臨床分期(P=0.045)有明顯相關。 結論: 我們的結果顯示，cIAP-1廣泛地表現在正常的、變異的與惡性的口腔上皮細胞之細胞質中。而cIAP-1在細胞質的表現從NOM至OED至OSCC有顯著的增加。量測OSCC樣本細胞質cIAP-1的表現，也許可預測口腔癌的進程、復發和預後。 關鍵字: 細胞凋亡抑制蛋白1，口腔癌，口腔癌前病變 | zh_TW |
| dc.description.abstract | Background: Overexpression of cellular inhibitor of apoptosis protein 1 (cIAP-1) has been demonstrated in a variety of human cancers and found to be associated with the lymph node metastasis, clinical stage, recurrence, or prognosis of these cancers.
Methods: In this study, we examined the expression of cIAP-1 protein in 73 specimens of oral squamous cell carcinoma (OSCC), 76 specimens of oral epithelial dysplasia (OED), and 31 specimens of normal oral mucosa (NOM) by immunohistochemistry. The cytoplasmic cIAP-1 labeling indices (LIs) in OSCC, OED, and NOM samples were calculated and compared between groups. The correlation between the cytoplasmic cIAP-1 LI in OSCCs and clinicopathological parameters or survival of OSCC patients was analyzed statistically. Results: The mean cytoplasmic cIAP-1 LIs increased significantly from NOM (23 ± 22%) through OED (50 ± 25%) to OSCC samples (73 ± 17%) (P = 0.000). A significant correlation was found between the higher mean cytoplasmic cIAP-1 LIs and OSCCs with positive lymph node metastasis (P = 0.000) or more advanced clinical stages (P=0.045). Conclusion: Our results suggest that the increased expression of cIAP-1 is an early event in oral carcinogenesis and the cIAP-1 may be a biomarker for OSCCs. Measuring the amount of cytoplasmic cIAP-1 expression in OSCC samples may predict the oral cancer progression in Taiwan. Key words: cellular inhibitor of apoptosis protein 1, oral cancer, oral precancer | en |
| dc.description.provenance | Made available in DSpace on 2021-05-20T20:49:23Z (GMT). No. of bitstreams: 1 ntu-97-R95422001-1.pdf: 1099851 bytes, checksum: 4e8ab802b32c2a4d3b8d4996259e2f32 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 目 錄
口試委員會審定書 謝誌 中文摘要 7 Abstract 8 Introduction 9 Background 11 Purposes of this study 13 Literature Review 14 Part 1: Introduction of oral squamous cell carcinoma 14 Epidemiology in the world 14 Epidemiology in Taiwan 14 Etiology 15 Clinical presentation 17 Histologic features 18 Grading of oral squamous cell carcinoma 19 Our previous studies on oral cancers 19 Part 2: IAP family proteins 20 Structure 21 Gene locationa 23 Part 3: Associated proteins—Caspase 23 Structure 23 Caspase activation pathway 24 i. The Mitochondrial Pathway of Caspase Activation 25 ii. The Death Receptor Pathway of Caspase Activation 25 iii. Convergence Point and Cross-Talk 25 Part 4: Associated proteins—Smac/DIABLO 26 Part 5: Associated proteins—HtrA2 26 Part 6: Mechanisms of IAPs-mediated inhibition of apoptosis 27 Caspase inhibition 27 Signal transduction pathways 27 Ubiquitylation 28 Part 7: Regulation of IAPs 28 Part 8: The emerging role of IAPs in cancers 31 Part 9: IAPs as therapeutic targets 32 Antisense Oligonucleotides 32 Small molecule 33 Part 10: cIAP-1 expression in normal tissue 33 Part 11: cIAP-1 expression in cancers 34 Part 12: cIAP-1 expression in OSCC 37 Materials and Methods Part 1: Patients and specimens 39 Part 2: Immunohistochemical staining for cIAP-1 40 Part 3: Statistical analysis 41 Results Part 1: Expression of cIAP-1 and mean LIs for OSCC, OED, and NOM samples 43 Part 2: Correlation between the mean cIAP-1 LI in OSCCs and clinicopathological parameters of OSCC patients 43 Part 3: Correlation between the mean cIAP-1 LI in OSCCs and oral habitsof OSCC patients 43 Part 4: Correlation between cytoplasmic cIAP-1 LI in OSCCs and survival of OSCC patients 44 Discussion 45 Conclusions 49 References 50 Tables 60 Figures 64 Tables Table 1. The mean cIAP-1 labeling indices (LI) in normal oral mucosa (NOM), oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC) samples 60 Table 2. Correlation between cytoplasmic cIAP-1 labeling indices (LI) in OSCC samples and clinicopathological parameters of OSCC patients 61 Table 3. Correlation between cytoplasmic cIAP-1 labeling indices (LI) in OSCC samples and oral habits (OH) of OSCC patients 62 Table 4. Univariate and multivariate survival analyses of cIAP-1 LI and clinicopathological parameters in 73 patients with OSCC by Cox proportional hazard regression model 63 Figures Figure 1. Immunohistochemical staining for cIAP-1 64 Figure 2. Kaplan–Meier survival curves of 73 patients with oral SCC followed completed or more than 5 years 68 | |
| dc.language.iso | en | |
| dc.title | 細胞凋亡抑制蛋白1於口腔鱗狀細胞癌與口腔癌前病變之表現 | zh_TW |
| dc.title | Expression of cellular inhibitor of apoptosis protein 1 in oral squamous cell carcinomas and precancerous lesions | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 關學婉,張龍昌 | |
| dc.subject.keyword | 細胞凋亡抑制蛋白1,口腔癌,口腔癌前病變, | zh_TW |
| dc.subject.keyword | cellular inhibitor of apoptosis protein 1,oral cancer,oral precancer, | en |
| dc.relation.page | 69 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2008-06-27 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床牙醫學研究所 | |
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