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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9892完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 賈景山 | |
| dc.contributor.author | Ying-Che Huang | en |
| dc.contributor.author | 黃英哲 | zh_TW |
| dc.date.accessioned | 2021-05-20T20:47:46Z | - |
| dc.date.available | 2016-10-03 | |
| dc.date.available | 2021-05-20T20:47:46Z | - |
| dc.date.copyright | 2011-10-03 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-08-08 | |
| dc.identifier.citation | 行政院農業委員會農業藥物毒物試驗所自行研究期末報告書，民國96年。
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9892 | - |
| dc.description.abstract | 大豆發酵產物和調控腸道菌相分布具有免疫調節的功能而達到減緩發炎反應的功能，然而還沒有研究指出腸道菌相與發酵產物之間的關係。本實驗研究目的為藉建立三種動物模式：異位性皮膚炎模式、耳朵腫脹過敏模式、腸道炎模式來探討餵食大豆發酵食品(SCLFP)是否可藉由改變腸道微生物菌相而改善過敏及腸道發炎疾病。(1)異位性皮膚炎模式：在老鼠背部皮膚以雞卵蛋白及金黃色葡萄球菌外毒素貼皮致敏，可觀察到皮膚的浸潤淋巴結中Th2相關的IL-4和Th17相關IL-17A、IL-17F表現有上升，且腸道Lactobacillus數量下降，且背部皮膚外觀有發炎反應，而經餵食SCLFP後，腸道內的Lactobacillus有顯著增加的趨勢，皮膚的浸潤淋巴結中抗發炎細胞激素IL-10和Th1相關的IFN-γ表現則有上升的現象，IL-4和IL-17A、IL-17F表現則有下降現象，並看到外觀觀察皮膚發炎有改善的現象。(2)耳朵腫脹過敏模式：以雞卵蛋白皮下注射於老鼠耳朵致敏，建立耳朵腫脹的遲發型過敏模式，經餵食SCLFP之後，腸道內的Lactobacillus有增加的趨勢，而腸繫膜淋巴結中IL-10表現則有上升的現象。(3)腸道炎模式：在老鼠日常飲用水中加入右旋糖酐硫酸酯鈉(Dextran sulphate sodium, DSS)引發腸道發炎，建立腸道炎模式，結果發現，餵食右旋糖酐硫酸酯鈉後，體重有下降，且大腸有發炎的症狀，腸道中Lactobacillus、Clostridium、SFB、Bifidobacterium數量有下降，Enterobacterium、Bacteroides數量有上升的情形，經餵食SCLFP之後，腸道內的Lactobacillus則有顯著回升的趨勢，脾臟因發炎而重量增加現象有明顯降低，而體重與疾病活性指數則無明顯差異。因此餵食SCLFP，可能透過調節腸道中菌叢分布並增加Lactobacillus數量，達到調節免疫的功能，進而降低過敏及腸道發炎的症狀。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-05-20T20:47:46Z (GMT). No. of bitstreams: 1 ntu-100-R98450013-1.pdf: 2180340 bytes, checksum: 2ae28ebf1e2314f6e903933095f4a0d4 (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | 第一章 文獻回顧 1
第一節 腸道概論 1 第二節 人體腸道菌叢 2 第三節 食品調節腸道菌相及免疫調節機能 3 第四節 啤酒酵母(Saccharomyces cerevisiae) 6 第五節 豆類發酵食品 7 第六節 實驗動物模式介紹 7 第七節 研究動機與目的 10 第二章 材料與方法 11 第一節 實驗動物小鼠 11 第二節 啤酒酵母菌豆類發酵產物(SCLFP)的製備 11 第三節 小鼠食道插管餵食 11 第四節 異位性皮膚炎(Atopic dermatitis, AD)模式建立 11 第五節 耳朵腫脹過敏試驗(mouse ear swelling test, MEST) 模式建立 12 第六節 DSS誘導腸炎模式(DSS-induced colitis)建立 12 第七節 組織與檢體收集 12 第八節 細菌核酸萃取(bacterial DNA extraction) 13 第九節 組織核酸萃取(tissue RNA extraction) 14 第十節 聚合酶連鎖反應(polymerase chain reaction, PCR) 14 第十一節 即時定量聚合酶連鎖反應(real-time PCR) 14 第十二節 組織化學染色(H&E stain) 15 第十三節 統計分析 15 第三章 實驗結果 16 第一部分 異位性皮膚炎小鼠模式(atopic dermatitis, AD) 16 第一節 異位性皮膚炎小鼠腸道菌量 16 第二節 異位性皮膚炎小鼠浸潤淋巴結細胞激素表現 16 第三節 異位性皮膚炎小鼠外觀症狀 17 第二部分小鼠耳朵腫脹過敏模式(mouse ear swelling test, MEST) 17 第一節 小鼠耳朵腫脹過敏模式腸道菌量 17 第二節 小鼠耳朵腫脹過敏模式腸繫膜淋巴結OVA專一性IL-10細胞激素表現 17 第三部分 DSS誘導小鼠腸炎模式(DSS-induced colitis) 18 第一節 DSS誘導小鼠腸炎模式腸道菌量 18 第二節 DSS誘導小鼠腸炎模式疾病活性指數 18 第三節 DSS誘導小鼠腸炎模式體重 18 第四節 DSS誘導小鼠腸炎模式脾臟重量 19 第五節 DSS誘導小鼠腸炎模式腸道長度 19 第四章 討論 20 第一節：異位性皮膚炎老鼠模式(Atopic dermatitis,AD) 20 第二節：小鼠耳朵腫脹試驗(mouse ear swelling test, MEST) 24 第三節：DSS誘導腸炎老鼠模式(DSS-induced colitis) 24 第五章 參考文獻……………………………………………………………...………29 | |
| dc.language.iso | zh-TW | |
| dc.title | 酵母菌豆類發酵食品對於小鼠腸道菌相分佈及細胞激素分泌的調節功能 | zh_TW |
| dc.title | The Regulatory Effect of Legume-Based Fermented Product by
Saccharomyces cerevisiae on Intestinal Flora Population and Cytokine Production in Mice | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 王莉芳,陳俊任 | |
| dc.subject.keyword | 發酵豆類食品,腸道菌相,BALB/c,細胞激素, | zh_TW |
| dc.subject.keyword | SCLFP,gut flora,BALB/c,cytokine, | en |
| dc.relation.page | 55 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2011-08-08 | |
| dc.contributor.author-college | 牙醫專業學院 | zh_TW |
| dc.contributor.author-dept | 口腔生物科學研究所 | zh_TW |
| 顯示於系所單位： | 口腔生物科學研究所 | |
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