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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/98161完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 劉如熹 | zh_TW |
| dc.contributor.advisor | Ru-Shi Liu | en |
| dc.contributor.author | 劉子瑄 | zh_TW |
| dc.contributor.author | Tzu-Hsuan Liu | en |
| dc.date.accessioned | 2025-07-30T16:09:48Z | - |
| dc.date.available | 2025-07-31 | - |
| dc.date.copyright | 2025-07-30 | - |
| dc.date.issued | 2025 | - |
| dc.date.submitted | 2025-07-18 | - |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/98161 | - |
| dc.description.abstract | 近年，近紅外光材料之設計與應用日益增加，其相較紫外光與可見光，於組織內之低自發螢光、低散射及低組織吸收之特性，組織穿透能力佳，為生醫影像領域提供前景。其中以近紅外光二區(NIR-II; 900–1800 nm)材料，尤為受注目，其為影像提供優異之訊噪比與高空間解析度，為具應用潛力之螢光材料。
本研究分為兩部分，第一部分以NIR-II光源應用為核心，使用中孔洞二氧化矽限制無機螢光粉於奈米尺度，以部分反尖晶石MgGa2O4結構為發光材料，摻雜Cr3+與Ni2+離子作為發光中心，利用兩離子間之能量轉移，大幅增加能量轉換效率，故提升Ni2+離子NIR-II之內部量子效率達55.8%，NIR全區放光達79.2%。次毫米發光二極體(mini-LED)具極高亮度、長使用壽命及節省能源之特性，為高解析顯示器之熱門選項，本研究之材料發光效率佳與尺寸小之特性作為其螢光體，其對於提升mini-LED對比度具發展潛力。 第二部分以NIR-II顯影劑應用作為核心，開發奈米Gd2O3氧化物，摻雜Yb3+與Er3+離子作為發光中心。以常見之808與980 nm雷射激發，實現高量子效率之NIR-IIb與NIR-IIx放光，期望增加影像之訊噪比，並由組織穿透深度測試與體內肝臟成像，揭示此窗口卓越之穿透能力達1公分與其應用潛力。本研究亦詳細探討Yb3+-Er3+系統NIR-II範圍之詳細光學特性與材料作為核磁顯影劑之可行性。 本研究之新穎性在於結合NIR-II光源與顯影劑之材料開發，為NIR-II之應用提供嶄新選項。第一部分著重於開發具優異光學特性與高效能之奈米螢光粉材料，並首度將其應用於NIR-II次毫米發光二極體，展現潛力於生醫影像與光電元件領域。第二部分則探討鑭系氧化物作為螢光/核磁雙模式顯影劑之可行性，並由光譜分析深入研究Yb³⁺-Er³⁺系統之下轉換發光機制，以建立針對肝臟成像之顯影策略，期望提升臨床非侵入式成像之準確性與可靠性。 | zh_TW |
| dc.description.abstract | In recent years, the design and application of near-infrared (NIR) materials have garnered increasing attention. Compared to ultraviolet and visible light, NIR light offers superior tissue penetration due to its low autofluorescence, minimal scattering, and reduced absorption in biological tissues. These properties render NIR materials highly advantageous for biomedical imaging. Notably, materials operating in the near-infrared-II window (NIR-II) have emerged as promising, providing exceptional signal-to-noise ratios and high spatial resolution, thus representing a class of fluorescent probes with significant potential for biomedical applications.
This study is divided into two parts. The first part focuses on the application of NIR-II light sources. Mesoporous silica is employed to confine the inorganic phosphors at the nanoscale. The luminescent material is based on a partially inverse spinel structure of MgGa₂O₄, doped with Cr³⁺ and Ni²⁺ ions as emission centers. The energy conversion efficiency is significantly enhanced through energy transfer between these two ions. As a result, the internal quantum efficiency of Ni²⁺ emission in the NIR-II region reaches 55.8%, with a total NIR emission efficiency across the full region of 79.2%. Mini-LEDs, known for their high brightness, long operational lifetime, and energy efficiency, are considered promising candidates for next-generation high-resolution displays. The developed phosphor materials, featuring high luminescence efficiency and nanoscale dimensions, are expected to improve contrast ratios and demonstrate strong potential for application in advanced mini-LED technologies. The second part of this study focuses on the application of NIR-II imaging agents, specifically developing Gd₂O₃-based nanomaterials doped with Yb³⁺ and Er³⁺ ions as luminescent centers. Under excitation by commonly used 808 nm and 980 nm lasers, high quantum efficiency emission in the NIR-IIb and NIR-IIx regions is achieved, aiming to enhance the signal-to-noise ratio (SNR) of imaging. Tissue penetration depth tests and in vivo liver imaging further demonstrate the exceptional penetration capability of this spectral window, reaching up to 1 cm, thereby highlighting its promising potential for biomedical applications. Additionally, the optical properties of the Yb³⁺–Er³⁺ system within the NIR-II range are thoroughly investigated, and the feasibility of these nanomaterials as dual-function magnetic resonance imaging (MRI) contrast agents is also explored. The novelty of this study lies in the integrated development of materials for NIR-II light sources and contrast agents, offering innovative options for NIR-II-related applications. The first part focuses on the synthesis of nanophosphor materials with excellent optical properties and high efficiency, which are applied in NIR-II mini-LEDs for the first time, demonstrating promising potential in biomedical imaging and optoelectronic devices. The second part explores the feasibility of lanthanide oxides as dual-modal contrast agents for fluorescence and magnetic resonance imaging (MRI). Through spectroscopic analysis, the downshifting luminescence mechanisms of the Yb³⁺-Er³⁺ system are thoroughly investigated to develop an imaging strategy specifically for liver diagnostics. This approach is expected to enhance the accuracy and reliability of clinical non-invasive imaging techniques. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2025-07-30T16:09:48Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2025-07-30T16:09:48Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員審定書 i
誌謝 ii 摘要 iii Abstract v 目次 vii 圖次 xii 表次 xxi 英文縮寫表 xxii 第一章、緒論 1 1.1 近紅外光與近紅外光二區 1 1.2 無機螢光粉(Inorganic phosphor) 3 1.2.1 無機螢光粉組成 3 1.2.2 主體晶格與活化劑 4 1.3 光致發光材料性能指標與機制 6 1.3.1 能量轉移(energy transfer) 7 1.3.2 下轉換、上轉換及交叉弛豫 8 1.3.3 非輻射弛豫(nonradiative relaxation/transition) 11 1.3.4淬滅效應(quenching effect) 11 1.4 紅外光二區奈米粒子應用 14 1.5本研究之近紅外光奈米材料 18 1.6第一部分：近紅外光奈米粒子應用於次毫米發光二極體 19 1.6.1近代發光二極體(Light-Emitting Diodes; LEDs) 19 1.6.1.1 次毫米發光二極體與螢光粉 19 1.6.1.2 次毫米發光二極體類型與組成 20 1.6.2 3d過渡金屬活化劑 21 1.6.3第一部份：研究動機與目的 23 1.7第二部分：近紅外光奈米粒子應用於生物顯影 26 1.7.1近紅外光螢光生物顯影(bioimaging) 26 1.7.1.1生物組織光學窗口 27 1.7.1.2水分子與光學影像 30 1.7.2 多模式顯影 33 1.7.3 常見近紅外光螢光顯影材料 34 1.7.3.1稀土發光材料 36 1.7.3.2 鑭系元素光學性質 39 1.7.3.3 鑭系紅外光螢光奈米材料 39 1.7.4 磁振造影 42 1.7.4.1自旋-晶格弛豫(Spin-lattice relaxation) 43 1.7.4.2自旋-自旋弛豫(Spin-spin relaxation) 45 1.7.4.3弛緩率(Relaxivity) 47 1.7.5 磁振造影顯影劑(MRI contrast agent) 48 1.7.5.1含釓顯影劑 48 1.7.5.2含釓顯影劑弛豫效應 50 1.7.5.3含釓顯影劑毒性 51 1.7.6溶膠-凝膠製程原理 51 1.7.6.1溶膠與凝膠 52 1.7.6.2檸檬酸溶膠-凝膠法 55 1.7.7 第二部分：研究動機與目的 57 第二章、實驗步驟與儀器分析原理 60 2.1 化學藥品 60 2.2 第一部分：實驗步驟 62 2.2.1中孔洞二氧化矽奈米粒子(MSN)之合成 62 2.2.2 MGOCN@MSN之合成 62 2.3 第二部分：實驗步驟 63 2.3.1 GOYE奈米粒子之合成 63 2.3.2 GOYE奈米粒子之APTES修飾 63 2.3.3細胞培養 64 2.3.4細胞存活率測試 64 2.3.5溶血反應測試 65 2.3.6樣品組織穿透度量測 66 2.3.7皮下/尾靜脈注射小鼠980 nm紅外光顯影。 66 2.4 儀器原理 68 2.4.1 粉末X射線繞射儀(Powder X-ray diffractometer; PXRD) 68 2.4.2 掃描式顯微鏡(Scanning electron microscope; SEM) 72 2.4.3 穿透式電子顯微鏡(Transmission Electron Microscopy; TEM) 75 2.4.4 能量色散X-射線光譜(Energy-dispersive X-ray spectroscopy; EDS) 80 2.4.5 光激發光譜儀(Photoluminescence spectrometer; PL) 82 2.4.6 變溫光激發螢光光譜(Temperature-dependent photoluminescence) 85 2.4.7絕對量子產率光譜儀(Absolute photoluminescence quantum yield spectrometer) 85 2.4.8 紫外光/可見光光譜儀(UV-vis absorption spectrometer) 87 2.4.9 X射線吸收光譜(X-ray absorption Spectrum; XAS) 90 2.4.10連續波電子順磁共振波譜儀(Continuous-Wave Electron Paramagnetic Resonance; CW-EPR) 94 2.4.11比表面積及孔徑分析儀(Surface area and porosity analysis) 97 2.4.12動態光散射與電泳光散射法(Dynamic light scattering and Electrophoretic light scattering; DLS and ELS) 100 2.4.13臨床磁振造影儀(Preclinical magnetic resonance imaging) 103 2.4.14 深冷相機 104 第三章、結果與討論 106 3.1第一部分：高量子效率之部分反尖晶石結構MgGa2O4:Cr3+,Ni2+中孔洞二氧化矽奈米螢光粉(MGOCN@MSN)應用於紅外光二區次毫米發光二極體 106 3.1.1中孔洞二氧化矽奈米粒子(MSN)之結構與形貌鑑定 106 3.1.2 MGOCN@MSN之結構與形貌鑑定 109 3.1.3 MGOCN@MSN螢光性質之探討 115 3.1.4 MGOCN@MSN之Cr3+-Ni2+能量轉移機制 121 3.1.5 MGOCN@MSN之變溫與變壓光譜 125 3.1.6 MGOCN@MSN次毫米發光二極體之元件測試 129 3.2第二部分：鑭系奈米粒子Gd2O3:Yb3+,Er3+ (GOYE)作為近紅外光二區螢光/磁振雙模式顯影劑之影像與光學性質探討 132 3.2.1 GOYE之形貌與結構鑑定 132 3.2.2 GOYE螢光光譜分析 139 3.2.3 GOYE之Yb3+-Er3+能量轉移機制 147 3.2.4 GOYE變溫光譜 151 3.2.5 GOYE@APTES之形貌鑑定 155 3.2.6 GOYE@APTES之生物相容性 157 3.2.7 GOYE@APTES顯影劑之NIR-II螢光與磁振影像 160 第四章、結論 177 第五章、參考文獻 179 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 奈米螢光粉 | zh_TW |
| dc.subject | 近紅外光二區 | zh_TW |
| dc.subject | 次毫米發光二極體 | zh_TW |
| dc.subject | 鑭系奈米粒子 | zh_TW |
| dc.subject | 顯影劑 | zh_TW |
| dc.subject | 螢光成像 | zh_TW |
| dc.subject | mini-LED | en |
| dc.subject | nanophosphor | en |
| dc.subject | fluorescence imaging | en |
| dc.subject | contrast agent | en |
| dc.subject | rare-earth nanoparticle | en |
| dc.subject | near-infrared II | en |
| dc.title | 應用於光源與顯影之近紅外光二區奈米材料 | zh_TW |
| dc.title | Near-Infrared II Nanomaterials for Light Sources and Contrast Agent Development | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 113-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 江建文;蘇昭瑾;葉晨聖;詹明賢 | zh_TW |
| dc.contributor.oralexamcommittee | Kien-Voon Kong;Chao-Chin Su ;Chen-Sheng Yeh;Ming-Hsien Chan | en |
| dc.subject.keyword | 奈米螢光粉,近紅外光二區,次毫米發光二極體,鑭系奈米粒子,顯影劑,螢光成像, | zh_TW |
| dc.subject.keyword | nanophosphor,near-infrared II,mini-LED,rare-earth nanoparticle,contrast agent,fluorescence imaging, | en |
| dc.relation.page | 199 | - |
| dc.identifier.doi | 10.6342/NTU202501356 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2025-07-21 | - |
| dc.contributor.author-college | 理學院 | - |
| dc.contributor.author-dept | 化學系 | - |
| dc.date.embargo-lift | 2026-07-31 | - |
| 顯示於系所單位： | 化學系 | |
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