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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 王兆麟 | |
dc.contributor.author | Tzu-Cheng Lin | en |
dc.contributor.author | 林子誠 | zh_TW |
dc.date.accessioned | 2021-05-20T20:32:45Z | - |
dc.date.available | 2013-08-05 | |
dc.date.available | 2021-05-20T20:32:45Z | - |
dc.date.copyright | 2008-08-05 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2008-07-31 | |
dc.identifier.citation | 1. Adams MA. Biomechanics of back pain. Acupunct Med 2004;22:178-88.
2. Adams MA, Hutton WC. The effect of fatigue on the lumbar intervertebral disc. J Bone Joint Surg Br 1983;65:199-203. 3. Adams MA, Hutton WC. The effect of posture on the fluid content of lumbar intervertebral discs. Spine 1983;8:665-71. 4. Adams MA, Hutton WC. Prolapsed intervertebral disc. A hyperflexion injury 1981 Volvo Award in Basic Science. Spine 1982;7:184-91. 5. Adams MA, McMillan DW, Green TP, et al. Sustained loading generates stress concentrations in lumbar intervertebral discs. Spine 1996;21:434-8. 6. Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine 2006;31:2151-61. 7. Antoniou J, Steffen T, Nelson F, et al. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest 1996;98:996-1003. 8. Ayotte DC, Ito K, Perren SM, et al. Direction-dependent constriction flow in a poroelastic solid: the intervertebral disc valve. J Biomech Eng 2000;122:587-93. 9. Beckstein JC, Sen S, Schaer TP, et al. Comparison of animal discs used in disc research to human lumbar disc: axial compression mechanics and glycosaminoglycan content. Spine 2008;33:E166-73. 10. Botsford DJ, Esses SI, Ogilvie-Harris DJ. In vivo diurnal variation in intervertebral disc volume and morphology. Spine 1994;19:935-40. 11. Broberg KB. Slow deformation of intervertebral discs. J Biomech 1993;26:501-12. 12. Callaghan JP, McGill SM. Intervertebral disc herniation: studies on a porcine model exposed to highly repetitive flexion/extension motion with compressive force. Clin Biomech (Bristol, Avon) 2001;16:28-37. 13. Cassidy JJ, Hiltner A, Baer E. The response of the hierarchical structure of the intervertebral disc to uniaxial compression. Journal of Materials Science: Materials in Medicine 1990;1:69-80. 14. Chen W-C, Wang J-L. The effect of intervertebral disc herniation on the disc performance and spine biomechanics. Graduate Institute of Biomedical Engineering College of Medicine and Engineering Taipei: National Taiwan University 2006:64. 15. Dath R, Ebinesan AD, Porter KM, et al. Anatomical measurements of porcine lumbar vertebrae. Clin Biomech (Bristol, Avon) 2007;22:607-13. 16. Dhillon N, Bass EC, Lotz JC. Effect of frozen storage on the creep behavior of human intervertebral discs. Spine 2001;26:883-8. 17. Ekstrom L, Kaigle A, Hult E, et al. Intervertebral disc response to cyclic loading--an animal model. Proc Inst Mech Eng [H] 1996;210:249-58. 18. Elliott DM, Sarver JJ. Young investigator award winner: validation of the mouse and rat disc as mechanical models of the human lumbar disc. Spine 2004;29:713-22. 19. Gallagher S, Marras WS, Litsky AS, et al. Torso flexion loads and the fatigue failure of human lumbosacral motion segments. Spine 2005;30:2265-73. 20. Goel VK, Monroe BT, Gilbertson LG, et al. Interlaminar shear stresses and laminae separation in a disc. Finite element analysis of the L3-L4 motion segment subjected to axial compressive loads. Spine 1995;20:689-98. 21. Hansson TH, Keller TS, Spengler DM. Mechanical behavior of the human lumbar spine. II. Fatigue strength during dynamic compressive loading. J Orthop Res 1987;5:479-87. 22. Hilton RC, Ball J. Vertebral rim lesions in the dorsolumbar spine. Ann Rheum Dis 1984;43:302-7. 23. Jensen MC, Brant-Zawadzki MN, Obuchowski N, et al. Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med 1994;331:69-73. 24. Johannessen W, Cloyd JM, O'Connell GD, et al. Trans-endplate nucleotomy increases deformation and creep response in axial loading. Ann Biomed Eng 2006;34:687-96. 25. Johannessen W, Vresilovic EJ, Wright AC, et al. Intervertebral disc mechanics are restored following cyclic loading and unloaded recovery. Ann Biomed Eng 2004;32:70-6. 26. Keller TS, Spengler DM, Hansson TH. Mechanical behavior of the human lumbar spine. I. Creep analysis during static compressive loading. J Orthop Res 1987;5:467-78. 27. Kusaka Y, Nakajima S, Uemura O, et al. Intradiscal solid phase displacement as a determinant of the centripetal fluid shift in the loaded intervertebral disc. Spine 2001;26:E174-81. 28. Kwan M, Michael Lai W, Van Mow C. Fundamentals of fluid transport through cartilage in compression. Annals of Biomedical Engineering 1984;12:537-58. 29. Lings S, Leboeuf-Yde C. Whole-body vibration and low back pain: a systematic, critical review of the epidemiological literature 1992-1999. Int Arch Occup Environ Health 2000;73:290-7. 30. Liu YK, Njus G, Buckwalter J, et al. Fatigue response of lumbar intervertebral joints under axial cyclic loading. Spine 1983;8:857-65. 31. Luoma K, Riihimaki H, Luukkonen R, et al. Low back pain in relation to lumbar disc degeneration. Spine 2000;25:487-92. 32. MacLean JJ, Owen JP, Iatridis JC. Role of endplates in contributing to compression behaviors of motion segments and intervertebral discs. J Biomech 2007;40:55-63. 33. Malko JA, Hutton WC, Fajman WA. An in vivo magnetic resonance imaging study of changes in the volume (and fluid content) of the lumbar intervertebral discs during a simulated diurnal load cycle. Spine 1999;24:1015-22. 34. Malko JA, Hutton WC, Fajman WA. An in vivo MRI study of the changes in volume (and fluid content) of the lumbar intervertebral disc after overnight bed rest and during an 8-hour walking protocol. J Spinal Disord Tech 2002;15:157-63. 35. Masuoka K, Michalek AJ, MacLean JJ, et al. Different effects of static versus cyclic compressive loading on rat intervertebral disc height and water loss in vitro. Spine 2007;32:1974-9. 36. McLain RF, Yerby SA, Moseley TA. Comparative morphometry of L4 vertebrae: comparison of large animal models for the human lumbar spine. Spine 2002;27:E200-6. 37. McMillan DW, Garbutt G, Adams MA. Effect of sustained loading on the water content of intervertebral discs: implications for disc metabolism. Ann Rheum Dis 1996;55:880-7. 38. Moore RJ, Vernon-Roberts B, Fraser RD, et al. The origin and fate of herniated lumbar intervertebral disc tissue. Spine 1996;21:2149-55. 39. Mow VC, Kuei SC, Lai WM, et al. Biphasic creep and stress relaxation of articular cartilage in compression? Theory and experiments. J Biomech Eng 1980;102:73-84. 40. Nordin M, Frankel VH, Leger D, et al. Basic Biomechanics of the Musculoskeletal System. third ed. Baltimore: Lippincott Williams & Wilkins, 2001. 41. Osti OL, Vernon-Roberts B, Moore R, et al. Annular tears and disc degeneration in the lumbar spine. A post-mortem study of 135 discs. J Bone Joint Surg Br 1992;74:678-82. 42. Palmer EI, Lotz JC. The compressive creep properties of normal and degenerated murine intervertebral discs. J Orthop Res 2004;22:164-9. 43. Rajasekaran S, Babu JN, Arun R, et al. ISSLS prize winner: A study of diffusion in human lumbar discs: a serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs. Spine 2004;29:2654-67. 44. shen C-L. Practical Anatomy. third ed. Taipei: Farseeing Publishing CO., Ltd, 2002. 45. Soltz MA, Ateshian GA. Experimental verification and theoretical prediction of cartilage interstitial fluid pressurization at an impermeable contact interface in confined compression. J Biomech 1998;31:927-34. 46. Urban JP, McMullin JF. Swelling pressure of the lumbar intervertebral discs: influence of age, spinal level, composition, and degeneration. Spine 1988;13:179-87. 47. van der Veen AJ, Mullender M, Smit TH, et al. Flow-related mechanics of the intervertebral disc: the validity of an in vitro model. Spine 2005;30:E534-9. 48. van der Veen AJ, van Dieen JH, Nadort A, et al. Intervertebral disc recovery after dynamic or static loading in vitro: is there a role for the endplate? J Biomech 2007;40:2230-5. 49. Videman T, Nurminen M. The occurrence of anular tears and their relation to lifetime back pain history: a cadaveric study using barium sulfate discography. Spine 2004;29:2668-76. 50. Vresilovic EJ, Johannessen W, Elliott DM. Disc mechanics with trans-endplate partial nucleotomy are not fully restored following cyclic compressive loading and unloaded recovery. J Biomech Eng 2006;128:823-9. 51. Wilke HJ, Neef P, Caimi M, et al. New in vivo measurements of pressures in the intervertebral disc in daily life. Spine 1999;24:755-62. 52. Wu T-K, Wang J-L. The Effect of Fatigue Loading and Rest on The Shock Attenuation of Intervertebral Disc. Graduate Institute of Biomedical Engineering College of Medicine and Engineering Taipei: National Taiwan University 2007:46. 53. Yoshizawa H, O'Brien JP, Smith WT, et al. The neuropathology of intervertebral discs removed for low-back pain. J Pathol 1980;132:95-104. 54. Yu CY, Tsai KH, Hu WP, et al. Geometric and morphological changes of the intervertebral disc under fatigue testing. Clin Biomech (Bristol, Avon) 2003;18:S3-9. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9636 | - |
dc.description.abstract | 目的:探討疲勞負載次數與休息對椎間盤流變性質的影響。
背景:疲勞負載是引發下背痛的主要因子之一,並且影響椎間盤水分的含量及黏彈性行為的表現。文獻上指出,長期的疲勞負載會造成椎間盤力學性質改變,推測是椎間盤微結構破壞而改變椎間盤水分進出情形。然而,實際機制仍有待詳盡地探討,因此探討疲勞負載與休息對椎間盤流變性質的影響,有助於了解因疲勞負載所引起的脊椎病變機制。 材料與方法:使用六個月大的豬隻腰椎運動單元作為試樣(L1-L2,L3-L4,共十副),每副試樣在疲勞負載前先經過一次潛變測試,於食鹽水中休息24小時後,依序進行「疲勞負載-休息-潛變測試-休息」的實驗流程,五次循環後即完成一組實驗。潛變測試時間為1小時,負載力量為420N;疲勞負載的大小為190至590N (平均為420N),頻率為5Hz。五次疲勞負載時間依序為0.5、1、2、3、4小時(次數:9,000、18,000、36,000、54,000、72,000次);休息時,將試樣浸泡於生理食鹽水溶液中24小時。以線性位移計量測計錄試樣於潛變測試中的高度改變,擷取頻率為2Hz,並使用雙相(固液相)線性模型對椎間盤於潛變期間的高度變化量進行聚合模數(HA,類似材料之楊氏係數)、滲透性(k)的擬合。實驗結束後,將椎間盤沿著中央冠狀面及矢狀面切半觀察內部結構改變。 結果:椎間盤高度在承受0.5小時(9000次)的疲勞負載後所下降的高度並無法藉由浸泡24小時食鹽水溶液完全回復,且隨著疲勞負載時間的增加,無法回復的高度量愈多。椎間盤在承受10.5小時的疲勞負載後,聚合模數並無顯著性的改變,滲透性則會隨著疲勞負載時間增加而明顯地下降,直到疲勞負載時間達到3小時以上才不再降低。實驗後從椎間盤的橫剖面可發現靠近椎間核內側的椎間環有明顯的扭曲變形現象,有些甚致產生斷裂。 結論:椎間盤因為疲勞負載所流失的水分無法藉由浸泡生理24小時食鹽水的過程中完全回復。隨著疲勞負載時間的增加,椎間盤的滲透性會明顯地下降,聚合模數則無顯著性改變。椎間盤受到10.5小時的疲勞負載後,內側椎間環產生扭曲或斷裂,但外側椎間環並沒有出現肉眼可觀察到的損傷。 | zh_TW |
dc.description.abstract | Objective: To evaluate the effect of the duration of fatigue loading and the rest on the rheological properties of healthy porcine intervertebral disc.
Summary of Background Data: Fatigue loading can induce the low back pain by altering the water content and viscoelastic behaviors of the intervertebral disc. Long term fatigue loading was suspected to result in changes of material properties due to the irreversible failure. However, the mechanical properties of disc fluid flow (i.e., the rheology) within the disc have not been fully discussed yet. The understanding of effect of fatigue loading and rest on the disc rheological properties can be beneficial to delineate the mechanism of fatigue loading induced spinal disorders. Methods: Ten porcine lumbar motion segments (L1-L2,L3-L4) without posterior elements were applied with fatigue loading (190~590N) at 5 Hz for 0.5, 1, 2, 3, and 4 hours (9,000, 18,000, 36,000, 54,000, 72,000 cycles), respectively. A creep test using 420 N was applied after a 24 hours saline immersion post fatigue loading. The axial deformation during creep phase was curve-fitted with linear biphasic model to obtain the aggregate modulus (HA) and permeability coefficient (k). After the fatigue loading, the disc was sectioned along sagittal and coronal plane to find the structure changes of anulus fibrosus and nucleus pulposus. The paired-t test was performed to evaluate the change of disc height, HA, and k after a series of fatigue loading and 24 hours rest. Results: The height of intervertebral disc was not recovered by a 24 hours rest after fatigue loading. The permeability decreased significantly with the duration of fatigue loading, while the aggregate modulus remained the same. The ruptured inner fibrosus were found after fatigue loading. Conclusion: A 24 hours rest is not able to fully restore the fluid loss during fatigue loading. The increase of duration of the fatigue loading reduces the disc permeability and damages the structure of inner anular fibrosus. | en |
dc.description.provenance | Made available in DSpace on 2021-05-20T20:32:45Z (GMT). No. of bitstreams: 1 ntu-97-R95548008-1.pdf: 1679269 bytes, checksum: 08aedd7c79dea067a4f3b5572f434cb2 (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 論文口試委員審定書 i
誌謝 ii 中文摘要 iii 英文摘要 v 第一章 前言 1 1-1 脊椎的基本構造 1 1-2 脊椎盤的基本構造及功能 1 1-3 椎間盤水分對其生物力學影響之分析 3 1-4 椎間盤之潛變生物力學測試 5 1-5 疲勞負載與休息對椎間盤性能影響 6 1-6 實驗目的與假設 9 第二章 實驗設備 11 2-1 連續式衝擊測試平台(Continuous Impact Testing Apparatus) 11 2-2 衝擊錘(Impactor) 12 2-3 撞擊承受器(Impounder) 12 2-4 往復式衝擊模組(Cyclic Loading) 13 2-5 線性位移計(Linear variable differential transformer) 14 2-6 一維測力元(1-D Load Cell ) 14 2-7 訊號量測及控制系統 15 第三章 材料與方法 18 3-1 試樣準備 18 3-2 實驗方法 19 3-2-1 實驗流程 19 3-2-2 載荷狀況 21 3-3 數學模型及統計分析 21 第四章 結果 24 4-1 椎間盤高度變化及參數定義 24 4-2 椎間盤初始高度(H0)與疲勞負載後之高度(H1) 26 4-3 預壓負載下降高度(hpre) 26 4-4 瞬時負載下降高度(hins)及瞬時剛性係數(Sins) 27 4-5 潛變測試下高度下降(hcreep)及其應變(strain) 29 4-6 聚合模數(Aggregate Modulus, HA)與滲透係數(Permeability, k) 31 4-7 椎間盤切面觀察 32 第五章 討論 34 5-1 椎間盤內含水量之討論 34 5-2 潛變測試之材料參數討論 35 5-3 疲勞負載對椎間環破壞 36 5-4 實驗限制 37 第六章 結論與未來展望 39 6-1 結論 39 6-2 未來展望 39 文獻參考 40 | |
dc.language.iso | zh-TW | |
dc.title | 疲勞負載與休息對椎間盤流變性質的影響 | zh_TW |
dc.title | Effect of Fatigue and Rest on the Rheological Properties of Intact Intervertebral Disc | en |
dc.type | Thesis | |
dc.date.schoolyear | 96-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 林晉,莊仕勇,趙振綱,蘇芳慶 | |
dc.subject.keyword | 椎間盤,疲勞負載,潛變測試,滲透性,聚合模數, | zh_TW |
dc.subject.keyword | disc,fatigue,creep test,permeability,aggregate modulus, | en |
dc.relation.page | 43 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2008-07-31 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
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