請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9617
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蘇霩靄(Kua-Eyre Su) | |
dc.contributor.author | Qiao-Ting Jow | en |
dc.contributor.author | 卓巧停 | zh_TW |
dc.date.accessioned | 2021-05-20T20:31:42Z | - |
dc.date.available | 2008-09-11 | |
dc.date.available | 2021-05-20T20:31:42Z | - |
dc.date.copyright | 2008-09-11 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2008-07-30 | |
dc.identifier.citation | Auran JD, Starr MB, Jakobiec FA, 1987. Acanthamoeba keratitis. A review of the literature. Cornea 6: 2-26.
Awwad ST, Petroll WM, McCulley JP, Cavanagh HD, 2007. Updates in Acanthamoeba keratitis. Eye Contact Lens 33: 1-8. Beattie TK, Tomlinson A, McFadyen AK, Seal DV, Grimason AM, 2003. Enhanced attachment of Acanthamoeba to extended-wear silicone hydrogel contact lenses: a new risk factor for infection? Ophthalmology 110: 765–771. Bottone EJ, Madayag RM, Qureshi MN, 1992. Acanthamoeba keratitis :synergy between amebic and bacterial cocontaminants in contact lens care systems as a prelude to infection. Journal of Clinical Microbiology 30: 2447-2450. Booton GC, Kelly DJ, Chu Y-W, Chu YW, Seal DV, Houang E, Lam DSC, Byers TJ, Fuerst PA, 2002. 18S ribosomal DNA typing and tracking of Acanthamoeba species isolates from corneal scrape specimens, contact lenses, lens cases, and home water supplies of Acanthamoeba keratitis patients in Hong Kong. Journal of Clinical Microbiology 40: 1621–1625. Booton GC, Visvesvara GS, Byers TJ, Kelly DJ, Fuerst PA, 2005. Identification and distribution of Acanthamoeba species genotypes associated with nonkeratitis infections. Journal of Clinical Microbiology 43: 1689-93. Boost M, Cho P, Lai S, Sun WM, 2008. Detection of acanthamoeba in tap water and contact lens cases using polymerase chain reaction. Optometry and Vision Science : Official Publication of the American Academy of Optometry 85: 526-530. Bovee EC, 1963. Studies concerning the effects of nutrition on morphology of amoeba. II. Acanthamoeba castellani (Douglas) on abundant and starvation quantities. The American Midland Naturalist 69: 173-181. Bowers B, Korn ED , 1968. The fine structure of Acanthamoeba castellanii. I. The trophozoite. The Journal of Cell Biology 39: 95–111. Bowers B, Korn ED, 1974. Localization of lipophosphonoglycan on both sides of Acanthamoeba plasma membrane. The Journal of Cell Biology 62: 533–540. Cast RJ, Ledee DR, Fuerst PA, Byera TJ, 1996. Subfenus systematics of Acanthamoeba:Four nuclear 18S r DNA sequence types. The Journal of Eukaryotic Microbiology 43:493-504. Chang JCH, Ossoff SF, Lobe DC, Dorfman MH, Dumais CM, Qualls RG, Johnson JD, 1985. UV inactivation of pathogenic and indicator microorganisms. Applied and Environmental Microbiology 49: 1361-1365. Costas M, Griffith AJ, 1980. The suitability of starch-gel electrophoresis of esterases and acid-phosphatases for the study of Acanthamoeba taxonomy. Archiv für Protistenkunde 123: 272-279. Costas M, Griffith AJ, 1984. The esterases and acid-phosphatases of Acanthamoeba (Amoebida, Acanthamoebidae) . Protistologica 20: 27-31. Costas M, Griffith AJ, 1985. Enzyme composition and the taxonomy of Aanthamoeba. Journal of Protozoology 32: 604-607. Culbertson CG, 1971. The pathogenicity of soil amoebas. Annual Review of Microbiology 25: 231-254. Culbertson CG, Smith JW, Miner JR , 1958. Acanthamoeba observation on animal pathogenicity. Science 127: 1506. Culbertson CG, Smith JW, Cohen HK ,Miner JR , 1959. Experimental infection of mice and monkeys by Acanthamoeba. The American Journal of Pathology 35: 185–197. Cursons RT, Brown TJ, Keys EA, Moriarty KM , Till D , 1980. Immunity to pathogenic free-living amoebae: role of humoral antibody. Infection and Immunity 29: 401–407. Daggett PM, Sawyer TK, Nevad TA, 1982. Distribution and possible interrelationships of pathogenic and nonpathogenic Acanthamoeba from aquatic environments. Microbial Ecology 8: 371-386. De Jonckheere JF, 1983. Isoenzyme and total protein analysis by agarose isoelectric focusing and taxonomy of the genus Acanthamoeba. Journal of Protozoology 30: 701-706. Donzis PB, Mondino BJ, Weissman BA, Bruckner D A, 1987. Microbial contamination of contact lens care systems. American Journal of Ophthalmology 104: 325-333. Felsenstein J , 1985. Confidence limits on phylogenies: An approach using the bootstrap. Evolution 39: 783-791. Fong CF, Tseng CH, Hu FR, Wang IJ, Chen WL, Hou YC, 2004. Clinical characteristics of microbial keratitis in a university hospital in Taiwan. American journal of Ophthalmology 137: 329-36. Gast RJ, Ledee DR, Fuerst PA, Byers TJ, 1996. Subgenus systematics of Acanthamoeba: Four nuclear 18s rDNA sequence types. The Journal of Eukaryotic Microbiology 43: 498-504. Griffin JL, 1972. Temperature tolerance of pathogenic and non – pathogenic free-living amoebas. Science 277: 1174-1179. Gunderson JH, Sogin ML, 1986. Length variation in eukaryotic rRNA: small subunit r RNA from the protists Acanthamoeba castellanii and Euglena gracilis. Gene 44: 63-70. Gutell RR, 1994. Collection of small subunit (16 S and 16 S-like) ribosomal RNA structures. Nucleic Acids Research 22: 3502-3507. Hirst LW, Green WR, Merz W, Kaufmann C, Visvesvara GS, Jensen A, Howard M, 1984 Management of Acanthamoeba keratitis. A case report and review of the literature. Ophthalmology 91: 1105-11. Jakovljevich R, Talis B, 1969 Recovery of a hartmanelloid ameba in the purulent discharge from a human ear. The Journal of Protozoology 16(suppl): 36 John T, Deai D, Sahm D, 1989. Adherence of Acanthamoeba castellanii cysts and trophozoites to unworn soft contact lenses . American Journal of Ophthalmology 108: 658-664. Johnson AM, Fielke R, Christy PE, Robinson B, Baverstock PR, 1990. Small subunit ribosomal RNA evolution in the genus Acanthamoeba. Journal of General Microbiology 136: 1689-1698. Jones DB, Visvesvara GS, Rovinson NM, 1975. Acanthamoeba polyphaga keratitis and Acanthamoeba uveitis associated with fatal meningoencephalitis. Transactions of the Ophthalmological Societies of the United Kingdom 95: 221-232. Key SN 3rd, Green WR, Willaert E, Stevens AR, Key SN Jr, 1980 Keratitis due to Acanthamoeba castellani. A clinicopathologic case report. Archives of Ophthalmology 98: 475-9. Khan NA, Jarroll EL , Paget TA, 2001 Acanthamoeba can be differentiated by the polymerase chain reaction and simple plating assays. Current Microbiology 43: 204–208. Khan NA, Jarroll EL , Paget TA, 2002 Molecular and physiological differentiation between pathogenic and nonpathogenic Acanthamoeba. Current Microbiology 45: 197–202. Khan NA , 2003. Pathogenesis of Acanthamoeba infections. Microbial Pathogenesis 34: 277–285. Kimura M , 1980. A simple method for estimating evolutionary rate of base substitutions through comparative studies of nucleotide sequences. Journal of Molecular Evolution 16: 111-120. Klink F, Alizadeh H, He Y, Mellon JA, Silvany RE, McCulley JP, Niederkorn JY, 1993. The role of contact lenses, trauma, and Langerhans cells in a Chinese hamster model of Acanthamoeba keratitis. Investigative Ophthalmology & Visual Science 34: 1937-44. Ko LS, 1984. The problem of myopia in Taiwan. Korean Journal of Ophthalmology 25: 591-604 Larkn DF, 1991. Acanthamoeba keratitis. International Ophthalmology Clinics 31: 163-172. Larkin DF, Kilvington S, Easty DL, 1990. Contamination of contact lens storage cases by Acanthamoeba and bacteria. The British Journal of Ophthalmology 7: 133–135. Lindquist TD, Doughman DJ, Rubenstein JB, Moore JW, Campbell RC, 1988 Acanthamoeba-contaminated hydrogel contact lenses. Susceptibility to disinfection. Cornea 7: 300-303. Lee SM, Choi YJ, Chung DL, 1997. Contamination of Acanthamoeb in contact lens care system. Korean Journal of Ophthalmol 38:53l. Lee JJ, Hutner SH, Bovee EC, 1985. An illustrated guid to the protozoa. Society of Protozoologists Lawrene, Kansas U.S.A Maghsood AH, Sissons J, Rezaian M, Nolder D, Warhurst D, Khan NA, 2005. Acanthamoeba genotype T4 from the UK and Iran and isolation of the T2 genotype from clinical isolates. Journal of Medical Microbiology 54: 755–759. Marciano-Cabral F, Cabral G , 2003. Acanthamoeba spp.as agents of disease in humans. Clinical Microbiology Reviews 16: 273–307. Martinez AJ, 1985. Free-Living Amebas: Natural History, Prevention, Diagnosis, Pathology ,and Treatment of Disease. CRC Press, Boca Raton, Florida. Martinez AJ, 1987. Clinical manifestation of free-living amebic infection.In: Rondanelli E.G. (ed). Amphizoic amoebae : human pathology. Piccin, Padua, Italy. PP. 161-177. Martinez AJ, 1991. Infections of the central nervous system due to Acanthamoeba. Reviews of Infectious Diseases 13: S399–S402. Martinez AJ, Visvesvara GS, 1991. Laboratory diagnosis of pathogenic free-living amoebas: Naegleria, Acanthamoeba, and Leptomyxid. Clinics in Laboratory Medicine 11: 861–872. Martinez AJ & Visvesvara GS, 1997. Free-living, amphizoic and opportunistic amebas. Brain Pathology (Zurich, Switzerland) 7: 583–598. Melissa KH , Bret SB , Paul TM , Christopher PS, 2003. Identification of a new Acanthamoeba 18S r RNA gene sequence type, corresponding to the species Acanthamoeba jacobsi sawyer, nerad and visvesvara,1992 ( Lobosea : Acanthamoebidae). Acta Protozoologica 42: 325-329. Mergeryan H, 1991. The prevalence of Acanthamoeba in the human environment. Reviews of Infectious Diseases 13 Suppl 5: S390-1. Moore MB, McCulley JP, Newton C, Cobo LM, Foulks GN, O'Day DM, Johns KJ, Driebe WT, Wilson LA, Epstein RJ, et al., 1987 Acanthamoeba keratitis. A growing problem in soft and hard contact lens wearers. Ophthalmology 94: 1654-61. Khan NA, 2006. Acanthamoeba : biologyand increasing importance inhuman health. FEMS Microbiology Reviews 30 : 564–595. Neefs JM, Van de Peer YD, De Rijk P, Chapelle S, De Wachter R, 1993. Compilation of small ribosomal subunit RNA structures . Nucleic Acids Research 21: 3025-3049. Page FC, 1967a. Taxonomic criteria for limax amoebae, with descriptions of 3 new species of Hartmannella and 3 of Vahlkampfia. The Journal of Protozoology 14: 499–521. Page FC, 1967b. Re-definition of the genus Acanthamoeba with descriptions of three species. The Journal of Protozoology 14: 709–724. Page FC, 1988. A New Key to Fresh Water and Soil Amoebae. Freshwater Biological Association Scientific Publications, Cumbria, UK. Saitou N , Nei M, 1987. The neighbor-joining method: A new method for reconstructing phylogenetic trees. Molecular Biology and Evolution 4:406-425. Sawyer T, 1971. Acanthamoeba griffini a new species of marine amoeba. The Journal of Protozoology 18: 650–654. Schroeder JM, Booton GC, Hay J, Niszl IA, Seal DV, Markus MB, Fuerst PA , Byers TJ, 2001. Use of subgenic 18S ribosomal DNA PCR and sequencing for genus and genotype identification of Acanthamoebae from humans with keratitis and from sewage sludge. Journal of Clinical Microbiology 39: 1903–1911. Schuster FL, Visvesvara GS, 2004. Free-living amoebae as opportunistic and nonopportunistic pathogens of humans and animals. International Journal for Parasitology 34: 1001–1027. Seal D, Stapleton F, Dart J, 1992. Possible environmental sources of Acanthamoeba spp in contact lens wearers. The British Journal of Ophthalmology 76: 424-427. Singh BN , Das SR, 1970. Studies on pathogenic and nonpathogenic small free-living amoebae and the bearing of nuclear division on the classification of the order Amoebida. Philosophical Transactions of the Royal Society of London.Series A: Mathematical and Physical Sciences 259: 435–476. Stehr-Green JK, Baily TM, Visvesvara GS, 1989. The epidemiology of Acanthamoeba keratitis in the United States. American Journal of Ophthalmology 107: 331–336. Stothard DR, Schroeder-Diedrich JM, Awwad MH, Gast RJ, Ledee DR, Rodriguez-Zaragoza S, Dean CL, Fuerst PA, Byers TJ, 1998. The evolutionary history of the genus Acanthamoeba and the identification of eight new 18S rRNA gene sequence types. The Journal of Eukaryotic Microbiology 45: 45-54. Tamura K, Dudley J, Nei M, Kumar S , 2007. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Molecular Biology and Evolution 10.1093/molbev/msm092. Visvesvara GS, Balamuth W, 1975. Comparative studies on related free-living and pathogenic amoebae with special reference to Acanthamoeba. The Journal of Protozoology 22: 245-256. Visvesvara GS, Martinez AJ, Schuster FL, Leitch GJ, Wallace SV, Sawyer TK Anderson M, 1990. Leptomyxid ameba, a new agent of amebic meningoencephalitis in humans and animals. Journal of Clinical Microbiology 28: 2750–2756. Visvesvara GS , 1991. Classification of Acanthamoeba. Reviews of Infectious Diseases 13: 369–372. Zhang Y, Sun X, Wang Z, Li R, Luo S, Jin X, Deng S, Chen W, 2004. Identification of 18S Ribosomal DNA Genotype of Acanthamoeba from Patients with Keratitis in North China Invest. Investigative ophthalmology & visual science 45: 1904-1907. 李清真, 1994. 大台北地區公共場所盥洗台伺機性阿米巴—棘阿米巴類之調查研究. 國立台灣大學醫學院微生物研究所寄生蟲學組碩士論文。 丘子宏、曾錦華、包麗菊、黃宏仁, 1987. 配戴隱形眼鏡之問題分析.中華民國眼科醫學會會刊。 26:88-91. 林思源、周文穎、林隆光、潘玟利、施永豐, 2001. 台灣學生隱形眼鏡配戴之狀態-十年之變遷。 中華民國眼科醫學會雜誌 43:320-325. 林耕國、侯鈞賀、楊孟玲、李建興, 2005. 隱形眼鏡。 中華民國眼科醫學會雜誌 44:272-276. 黃國銅, 1994. 針對台北地區土壤及淡水內自由生活性阿米巴之研究。 國立台灣大學醫學院微生物研究所寄生蟲學組碩士論文。 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9617 | - |
dc.description.abstract | 棘阿米巴 ( Acanthamoeba spp. ) 為營自由生活之阿米巴原蟲,分布的環境範圍極廣。水、土壤和空氣都可以發現他們的蹤跡。具有致病性之棘阿米巴蟲株會造成極嚴重的棘阿米巴角膜炎、肉芽腫性阿米巴腦炎及其他器官感染。本實驗收集了197組隱形眼鏡配戴者盥洗台及清潔保養液之檢體作棘阿米巴之培養。此外,也收集了台大醫院自2006年9月~2008年6月,從患者角膜刮取物所分離出來之棘阿米巴原蟲。所得蟲株並進行18S rRNA基因序列分析以確定其基因型。我們從盥洗台分離出17株棘阿米巴,從病人角膜刮取物分離出7株棘阿米巴;隱形眼鏡盒、生理食鹽水、隱形眼鏡清潔保養液及拋棄式隱形眼鏡則皆未培養出棘阿米巴原蟲。 18S rRNA 基因分型之結果顯示:19株屬T4型,3株為T3型,而2株為T6型。我們所分離出來之棘阿米巴大多屬於T4型,此點與國外研究之結果一致的。 | zh_TW |
dc.description.abstract | Acanthamoeba is a free-living protozoan genus found in a wide variety of natural habitats, including water, soil, and air. Pathogenic isolates of Acanthamoeba are medically relevant as the causative agent of sight-threatening Acanthamoeba keratitis (AK), serious infections of other organs, and fatal granulomatous amebic encephalitis. A total of 197 sets of contact lens care system and bathroom basin samples from contact lense users were cultured for the isolation of Acanthamoeba. In addition, Acanthamoeba isolates obtained, between September 2006 till June 2008, from cornea scraping of patients suspected of amebic kerattitis were also included in this study. Genotype of the isolates were identified by 18S rRNA gene sequence analysis. We obtained 17 Acanthamoeba isolates from bathroom basin of contact lens users and 7 isolates from patients with keratitis in National Taiwan University Hospital. Acanthamoeba was not detected in contact lens box, normal saline, contact lens care fluid and disposable contact lenses. Among the 24 isolates, 19 were identified as Rns genotype T4 , 3 were Rns genotype T3 and 2 Rns genotype T6. Thus most Acanthamoeba strain isolated from home water supplies of contact lens users and patients with keratitis in National Taiwan University Hospital belong to Rns genotype T4, which agree with findings of similar studies abroad. | en |
dc.description.provenance | Made available in DSpace on 2021-05-20T20:31:42Z (GMT). No. of bitstreams: 1 ntu-97-R94445205-1.pdf: 595236 bytes, checksum: 648d4cdff0c2b6aab53ba14a0db41c27 (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 第一章 前言 1
第二章 材料與方法 8 一、 採檢對象 8 二、 採檢方法 8 三、 檢體之培養 8 四、 核苷酸粹取及聚合酶反應 9 五、 DNA定序及親緣分析 10 第三章 結果 11 一、 棘阿米巴之培養 11 二、 DNA定序及親緣分析 11 第四章 討論 13 參考文獻 15 圖表說明 27 圖一.棘阿米巴之生活史 27 圖二.棘阿米巴Rns中之十二個高度可變區 expansion segment之 分布圖 28 圖三.ASA.S1在Rns中所在的區域 29 圖四.棘阿米巴之營養體在100倍放大倍率下所觀察到的形態 30 圖五.棘阿米巴之囊體在100倍放大倍率下所觀察到的形態 31 圖六.油鏡下所觀察到棘阿米巴營養體之形態 32 圖七.油鏡下所觀察到棘阿米巴囊體之形態 33 圖八.Amplify ASA.S1其電泳所在位置 34 圖九.neighbor-joining distance tree based on partial 18S rDNA sequences 35 圖十.parsimony tree based on partial 18SrDNA sequences 37 圖十一.利用Clustal W將所得之T3 、T4 型棘阿米巴之ASA.S1 Acanthamoeba-specfic amplimer S1 region核酸序列與已知的DF3 diagnostic fragment 3 核酸序列比對 39 表一.棘阿米巴之基因型與引起人類疾病,如角膜炎及肉芽腫性腦膜炎之相關聯性 41 表二.本研究參考之Rns核酸序列及GeneBank accession numbers 42 表三. 本研究參考之DF3核酸序列及Gene Bank accession numbers 43 表四.本研究分離所得之棘米阿米巴蟲株之核酸序列比對結果 44 附錄 45 | |
dc.language.iso | zh-TW | |
dc.title | 隱形眼鏡配戴者其盥洗台及清潔保養液之棘阿米巴分離及基因分型 | zh_TW |
dc.title | 18S Ribosomal DNA Typing of Acanthamoeba Species Isolates from Contact Lens Care System and Bathroom Basin of Contact Lens Wearers | en |
dc.type | Thesis | |
dc.date.schoolyear | 96-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 薛博仁(Po-Ren Hsueh) | |
dc.contributor.oralexamcommittee | 林大盛,杜文圓 | |
dc.subject.keyword | 棘阿米巴, | zh_TW |
dc.subject.keyword | Acanthamoeba spp, | en |
dc.relation.page | 25 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2008-07-31 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 微生物學研究所 | zh_TW |
顯示於系所單位: | 微生物學科所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-97-1.pdf | 581.29 kB | Adobe PDF | 檢視/開啟 |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。