請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/95088完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張榮珍 | zh_TW |
| dc.contributor.advisor | Jung-Chen Chang | en |
| dc.contributor.author | 林欣誼 | zh_TW |
| dc.contributor.author | Xin-Yi Lin | en |
| dc.date.accessioned | 2024-08-28T16:12:18Z | - |
| dc.date.available | 2024-08-29 | - |
| dc.date.copyright | 2024-08-28 | - |
| dc.date.issued | 2024 | - |
| dc.date.submitted | 2024-07-23 | - |
| dc.identifier.citation | 英文文獻
Areed, M. F., Amasha, M. A., Abougalala, R. A., Alkhalaf, S., & Khairy, D. (2021). Developing gamification e-quizzes based on an android app: the impact of asynchronous form. Education and Information Technologies (Dordr), 26(4), 4857-4878. https://doi.org/10.1007/s10639-021-10469-4 Aw, D. C., Tan, E. H., Chin, T. M., Lim, H. L., Lee, H. Y., & Soo, R. A. (2018). Management of epidermal growth factor receptor tyrosine kinase inhibitorrelated cutaneous and gastrointestinal toxicities. Asia-Pacific Journal of Clinical Oncology, 14(1), 23-31. https://doi.org/10.1111/ajco.12687 Badawy, S. M., Shah, R., Beg, U., & Heneghan, M. B. (2020). Habit Strength, Medication Adherence, and Habit-Based Mobile Health Interventions Across Chronic Medical Conditions: Systematic Review [Review]. Journal of Medical Internet Research, 22(4), e17883. https://doi.org/10.2196/17883 Bangor, A., Kortum, P., & Miller, J. (2009). Determining What Individual SUS Scores Mean: Adding an Adjective Rating Scale. Journal of Usability Studies, 4(3), 114-123. Bangor, A., Kortum, P. T., & Miller, J. T. (2008). An Empirical Evaluation of the System Usability Scale. International Journal of Human-Computer Interaction, 24(6), 574-594. https://doi.org/10.1080/10447310802205776 Basra, M. K. A., Fenech, R., Gatt, R. M., Salek, M. S., & Finlay, A. Y. (2008). The Dermatology Life Quality Index 1994–2007: a comprehensive review of validation data and clinical results. British Journal of Dermatology, 159(5), 997-1035. https://doi.org/10.1111/j.1365-2133.2008.08832.x Battaglin, F., Dadduzio, V., Bergamo, F., Manai, C., Schirripa, M., Lonardi, S., Zagonel, V., & Loupakis, F. (2017). Anti-EGFR monoclonal antibody panitumumab for the treatment of patients with metastatic colorectal cancer: an overview of current practice and future perspectives. Expert Opinion on Biological Therapy, 17(10), 1297-1308. https://doi.org/10.1080/14712598.2017.1356815 Bentsen, L., Hanghøj, S., Hjerming, M., Bergmann, M. B., Thycosen, M., Borup, A., Larsen, C., & Pappot, H. (2023). Development of Quality of Life in Adolescents and Young Adults With Cancer Using a Patient Support Smartphone App: Prepost Interventional Study. JMIR Cancer, 9, e49735. https://doi.org/10.2196/49735 Berns, A., Isla-Montes, J. L., Palomo-Duarte, M., & Dodero, J. M. (2016). Motivation, students' needs and learning outcomes: a hybrid game-based app for enhanced language learning. Springerplus, 5(1), 1305. https://doi.org/10.1186/s40064-016-2971-1 Bolman, C., Arwert, T. G., & Völlink, T. (2011). Adherence to prophylactic asthma medication: Habit strength and cognitions. Heart & Lung, 40(1), 63-75 https://doi.org/https://doi.org/10.1016/j.hrtlng.2010.02.003 Bonner, J. A., Harari, P. M., Giralt, J., Cohen, R. B., Jones, C. U., Sur, R. K., Raben, D., Baselga, J., Spencer, S. A., Zhu, J., Youssoufian, H., Rowinsky, E. K., & Ang, K. K. (2010). Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. The Lancet Oncology, 11(1), 21-28. https://doi.org/https://doi.org/10.1016/S1470-2045（09）70311-0 Both, H., Essink-Bot, M. L., Busschbach, J., & Nijsten, T. (2007). Critical review of generic and dermatology-specific health-related quality of life instruments. Journal of Investigate Dermatology, 127(12), 2726-2739. https://doi.org/10.1038/sj.jid.5701142 Brooke, J. (1995). SUS: A quick and dirty usability scale. Usability Evaluation in Industry, 189. Burns, R. J., Deschênes, S. S., Knäuper, B., & Schmitz, N. (2019). Habit strength as a moderator of the association between symptoms of poor mental health and unintentional non-adherence to oral hypoglycemic medication in adults with type 2 diabetes. Journal of Health Psychology, 24(3), 321-326. https://doi.org/10.1177/1359105316674269 Castellanos, E., Feld, E., & Horn, L. (2017). Driven by Mutations: The Predictive Value of Mutation Subtype in EGFR-Mutated Non-Small Cell Lung Cancer. Journal of Thoracic Oncology, 12(4), 612-623. https://doi.org/10.1016/j.jtho.2016.12.014 Charles, C., Bungener, C., Razavi, D., Mateus, C., Routier, E., Lanoy, E., Verschoore, M., Robert, C., & Dauchy, S. (2016). Impact of dermatologic adverse events induced by targeted therapies on quality of life. Critical Reviews in Oncology/Hematology, 101, 158-168. https://doi.org/https://doi.org/10.1016/j.critrevonc.2016.03.003 Chen, J. Y., Liang, S. K., Chuang, T. Y., Chu, C. Y., Tu, C. H., Yeh, Y. J., Wei, Y. F., & Chen, K. Y. (2024). The impact of comorbidities, neutrophil-to-lymphocyte ratio, and drug toxicities on quality of life in lung cancer patients receiving EGFR-TKI therapy. Journal of the Formosan Medical Association, 123(2), 198-207. Cheng, C.-H., & Chen, C.-H.（2018）. Developing a Mobile APP-Supported Learning System for Evaluating Health-Related Physical Fitness Achievements of Students. Mobile Information Systems, 2018, 1-15. https://doi.org/10.1155/2018/8960968 Chou, Y. K. (2019). Actionable Gamification: Beyond Points, Badges, and Leaderboards. Packt Publishing. https://books.google.com.tw/books?id=9ZfBDwAAQBAJ Chu, C. Y., Chen, K. Y., Wen-Cheng Chang, J., Wei, Y. F., Lee, C. H., & Wang, W. M. (2017). Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitorrelated skin toxicities. Journal of the Formosan Medical Association = Taiwan yi zhi, 116(6), 413-423. https://doi.org/10.1016/j.jfma.2017.03.001 Chu, C. Y., Choi, J., Eaby-Sandy, B., Langer, C. J., & Lacouture, M. E. (2018). Osimertinib: A Novel Dermatologic Adverse Event Profile in Patients with Lung Cancer. Oncologist, 23(8), 891-899. https://doi.org/10.1634/theoncologist.2017-0582 Clabbers, J. M. K., Boers-Doets, C. B., Gelderblom, H., Stijnen, T., Lacouture, M. E., van der Hoeven, K. J. M., & Kaptein, A. A. (2016). Xerosis and pruritus as major EGFRI-associated adverse events. Support Care in Cancer, 24(2), 513-521. https://doi.org/10.1007/s00520-015-2781-y Debela, D. T., Muzazu, S. G., Heraro, K. D., Ndalama, M. T., Mesele, B. W., Haile, D. C., Kitui, S. K., & Manyazewal, T. (2021). New approaches and procedures for cancer treatment: Current perspectives. SAGE Open Medicine, 9, 20503121211034366. https://doi.org/10.1177/20503121211034366 Del Pozzo-Magana, B. R., Lazo-Langner, A., & Rieder, M. J. (2017). Health-related quality of life in children with cutaneous adverse drug reactions. Pediatric Dermatology, 34(6), e341-e342. https://doi.org/10.1111/pde.13253 Del Pozzo-Magaña, B. R., & Liy-Wong, C. (2022). Drugs and the skin: A concise review of cutaneous adverse drug reactions. British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.15490 Deterding, S., Dixon, D., Khaled, R., & Nacke, L. (2011). From game design elements to gamefulness: defining "gamification" Proceedings of the 15th International Academic MindTrek Conference: Envisioning Future Media Environments, Tampere, Finland. https://doi.org/10.1145/2181037.2181040 Du, R., Wang, X., Zhou, H., Ma, L., Larcher, L. M., Chen, C., & Wang, T. (2022). The health-related quality of life of lung cancer patients with EGFR-TKI-related skin adverse drug reactions and its relationship with coping style and selfmanagement. Support Care in Cancer, 30(12), 9889-9899. https://doi.org/10.1007/s00520-022-07451-2 Ee, R. W. X., Yap, K. Z., & Yap, K. Y. (2018). Herbopolis - A mobile serious game to educate players on herbal medicines. Complementary Therapies in Medicine, 39, 68-79. https://doi.org/10.1016/j.ctim.2018.05.004 Finlay, A. Y., & Khan, G. K. (1994). Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. Clinical and Experimental Dermatology, 19(3), 210-216. https://doi.org/10.1111/j.1365-2230.1994.tb01167.x Francisco-Aparicio, A., Gutiérrez-Vela, F. L., Isla-Montes, J. L., & Sanchez, J. L. G. (2013). Gamification: Analysis and Application. In V. M. R. Penichet, A. Peñalver, & J. A. Gallud (Eds.), New Trends in Interaction, Virtual Reality and Modeling (pp. 113-126). Springer London. https://doi.org/10.1007/978-1-4471-5445-7_9 Gandhi, M., Oishi, K., Zubal, B., & Lacouture, M. E. (2010). Unanticipated toxicities from anticancer therapies: survivors' perspectives. Support Care in Cancer, 18(11), 1461-1468. https://doi.org/10.1007/s00520-009-0769-1 Garden, B. C., Wu, S., & Lacouture, M. E. (2012). The risk of nail changes with epidermal growth factor receptor inhibitors: a systematic review of the literature and meta-analysis. Journal of the American Academy of Dermatology, 67(3), 400-408. https://doi.org/10.1016/j.jaad.2011.10.009 Ghai, A., & Tandon, U. (2023). Integrating gamification and instructional design to enhance usability of online learning. Educational and Information Technologies (Dordr), 28(2), 2187-2206. https://doi.org/10.1007/s10639-022-11202-5 Greer, J. A., Jacobs, J. M., Pensak, N., Nisotel, L. E., Fishbein, J. N., MacDonald, J. J., Ream, M. E., Walsh, E. A., Buzaglo, J., Muzikansky, A., Lennes, I. T., Safren, S. A., Pirl, W. F., & Temel, J. S. (2020). Randomized Trial of a Smartphone Mobile App to Improve Symptoms and Adherence to Oral Therapy for Cancer. Journal of the National Comprehensive Canccer Network, 18(2), 133-141. https://doi.org/10.6004/jnccn.2019.7354 Hanlon, P., Daines, L., Campbell, C., McKinstry, B., Weller, D., & Pinnock, H. (2017). Telehealth Interventions to Support Self-Management of Long-Term Conditions: A Systematic Metareview of Diabetes, Heart Failure, Asthma, Chronic Obstructive Pulmonary Disease, and Cancer. Journal of Medical Internet Research, 19(5), e172. https://doi.org/10.2196/jmir.6688 Haruna, H., Hu, X., Chu, S. K. W., Mellecker, R. R., Gabriel, G., & Ndekao, P. S. (2018). Improving Sexual Health Education Programs for Adolescent Students through Game-Based Learning and Gamification. International Journal of Environmental Research and Public Health, 15(9). https://doi.org/10.3390/ijerph15092027 He, J., Huang, Z., Han, L., Gong, Y., & Xie, C. (2021). Mechanisms and management of 3rd‑generation EGFR‑TKI resistance in advanced non‑small cell lung cancer (Review). International Journal of Oncology, 59(5). https://doi.org/10.3892/ijo.2021.5270 Henrie, C. R., Halverson, L. R., & Graham, C. R. (2015). Measuring student engagement in technology-mediated learning: A review. Computers & Education, 90, 36-53. https://doi.org/https://doi.org/10.1016/j.compedu.2015.09.005 Hirayama, K., Su, Y., Chiba, M., Izutsu, M., & Yuki, M. (2020). Relationships between quality of life and skin toxicities of epidermal growth factor receptor inhibitors in cancer patients: A literature review. Japan Journal of Nursing Science, 17(3), e12321. https://doi.org/10.1111/jjns.12321 Ho, P. H., Lin, I. C., Yang, X., Cho, Y. T., & Chu, C. Y. (2019). Using a novel scoring system for paronychia related to oncologic treatments (SPOT) for assessing paronychia severity and its correlation with pain index and quality of life. Journal of the European Academy of Dermatology and Venereology, 33(1), 204-212. https://doi.org/10.1111/jdv.15121 Hohla, F., Winder, T., Greil, R., Rick, F. G., Block, N. L., & Schally, A. V. (2014). Targeted therapy in advanced metastatic colorectal cancer: current concepts and perspectives. World Journal of Gastroenterology, 20(20), 6102-6112. https://doi.org/10.3748/wjg.v20.i20.6102 Hou, I. C., Lin, H. Y., Shen, S. H., Chang, K. J., Tai, H. C., Tsai, A. J., & Dykes, P. C. (2020). Quality of Life of Women After a First Diagnosis of Breast Cancer Using a Self-Management Support mHealth App in Taiwan: Randomized Controlled Trial. JMIR Mhealth Uhealth, 8(3), e17084. https://doi.org/10.2196/17084 Hsu, H. P., Guo, J. L., Lin, F. H., Chen, S. F., Chuang, C. P., & Huang, C. M. (2023). Effect of involvement and motivation on self-learning: Evaluating a mobile elearning program for nurses caring for women with gynecologic cancer. Nurse Education in Practice, 67, 103558. https://doi.org/10.1016/j.nepr.2023.103558 Hunicke, R., Leblanc, M., & Zubek, R. (2004). MDA: A Formal Approach to Game Design and Game Research. AAAI Workshop - Technical Report, 1. Joshi, S. S., Ortiz, S., Witherspoon, J. N., Rademaker, A., West, D. P., Anderson, R., Rosenbaum, S. E., & Lacouture, M. E. (2010). Effects of epidermal growth factor receptor inhibitor-induced dermatologic toxicities on quality of life. Cancer, 116(16), 3916-3923. https://doi.org/10.1002/cncr.25090 Jotte, R. M., & Spigel, D. R. (2015). Advances in molecular-based personalized nonsmall-cell lung cancer therapy: targeting epidermal growth factor receptor and mechanisms of resistance. Cancer Medicine, 4(11), 1621-1632. https://doi.org/10.1002/cam4.506 Keller, J. M. (1987). Development and use of the ARCS model of instructional design. Journal of instructional development, 10(3), 2-10. https://doi.org/10.1007/BF02905780 Keller, J. M. (2010). Tools to Support Motivational Design. In J. M. Keller (Ed.), Motivational Design for Learning and Performance: The ARCS Model Approach (pp. 267-295). Springer US. https://doi.org/10.1007/978-1-4419-1250-3_11 Kim, H. J., Kim, S. M., Shin, H., Jang, J. S., Kim, Y. I., & Han, D. H. (2018). A Mobile Game for Patients With Breast Cancer for Chemotherapy Self-Management and Quality-of-Life Improvement: Randomized Controlled Trial. Journal of Medical Internet Research, 20(10), e273. https://doi.org/10.2196/jmir.9559 Kozuki, T. (2016). Skin problems and EGFR-tyrosine kinase inhibitor. Japanese Journal of Clinical Oncology, 46(4), 291-298. https://doi.org/10.1093/jjco/hyv207 Krath, J., Schürmann, L., & von Korflesch, H. F. O. (2021). Revealing the theoretical basis of gamification: A systematic review and analysis of theory in research on gamification, serious games and game-based learning. Computers in Human Behavior, 125, 106963. https://doi.org/https://doi.org/10.1016/j.chb.2021.106963 Lacouture, M. E., Anadkat, M., Jatoi, A., Garawin, T., Bohac, C., & Mitchell, E. (2018). Dermatologic Toxicity Occurring During Anti-EGFR Monoclonal Inhibitor Therapy in Patients With Metastatic Colorectal Cancer: A Systematic Review. Clinical Colorectal Cancer, 17(2), 85-96. https://doi.org/10.1016/j.clcc.2017.12.004 Lacouture, M. E., Mitchell, E. P., Piperdi, B., Pillai, M. V., Shearer, H., Iannotti, N., Xu, F., & Yassine, M. (2010). Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a preEmptive Skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer. Journal of Clinical Oncology, 28(8), 1351-1357. https://doi.org/10.1200/jco.2008.21.7828 Lacouture, M. E., Sibaud, V., Gerber, P. A., van den Hurk, C., Fernandez-Penas, P., Santini, D., Jahn, F., Jordan, K., & clinicalguidelines@esmo.org, E. G. C. E. a. (2021). Prevention and management of dermatological toxicities related to anticancer agents: ESMO Clinical Practice Guidelines (☆). Annals of Oncology, 32(2), 157-170. https://doi.org/10.1016/j.annonc.2020.11.005 Landers, R. N. (2014). Developing a Theory of Gamified Learning:Linking Serious Games and Gamification of Learning. Simulation & Gaming, 45(6), 752-768. https://doi.org/10.1177/1046878114563660 Landers, R. N., Armstrong, M. B., & Collmus, A. B. (2017). How to Use Game Elements to Enhance Learning: Applications of the Theory of Gamified Learning. In M. Ma & A. Oikonomou (Eds.), Serious Games and Edutainment Applications : Volume II (pp. 457-483). Springer International Publishing. https://doi.org/10.1007/978-3-319-51645-5_21 Langenbruch, A., Radtke, M. A., Gutknecht, M., & Augustin, M. (2019). Does the Dermatology Life Quality Index (DLQI) underestimate the disease-specific burden of psoriasis patients? Journal of the European Academy of Dermatology and Venereology, 33(1), 123-127. https://doi.org/10.1111/jdv.15226 Levantini, E., Maroni, G., Del Re, M., & Tenen, D. G. (2022). EGFR signaling pathway as therapeutic target in human cancers. Seminars in Cancer Biology, 85, 253-275. https://doi.org/10.1016/j.semcancer.2022.04.002 Li, X., Zhao, L., Chen, C., Nie, J., & Jiao, B. (2022). Can EGFR be a therapeutic target in breast cancer? Biochim Biophys Acta Rev Cancer, 1877(5), 188789. https://doi.org/10.1016/j.bbcan.2022.188789 London, M., & Gallo, E. (2020). Epidermal growth factor receptor (EGFR) involvement in epithelial-derived cancers and its current antibody-based immunotherapies. Cell Biology International, 44(6), 1267-1282. https://doi.org/10.1002/cbin.11340 Loorbach, N., Peters, O., Karreman, J., & Steehouder, M. (2014). Validation of the Instructional Materials Motivation Survey (IMMS) in a self-directed instructional setting aimed at working with technology. British Journal of Educational Technology, 46. https://doi.org/10.1111/bjet.12138 Lozano-Lozano, M., Fernández-Lao, C., Cantarero-Villanueva, I., Noguerol, I., Álvarez-Salvago, F., Cruz-Fernández, M., Arroyo-Morales, M., & GalianoCastillo, N. (2020). A Blended Learning System to Improve Motivation, Mood State, and Satisfaction in Undergraduate Students: Randomized Controlled Trial. Journal of Medical Internet Research, 22(5), e17101. https://doi.org/10.2196/17101 Luo, Q., Zhang, Y., Wang, W., Cui, T., & Li, T. (2024). mHealth-Based Gamification Interventions Among Men Who Have Sex With Men in the HIV Prevention and Care Continuum: Systematic Review and Meta-Analysis. JMIR Mhealth Uhealth, 12, e49509. https://doi.org/10.2196/49509 Macdonald, J. B., Macdonald, B., Golitz, L. E., LoRusso, P., & Sekulic, A. (2015). Cutaneous adverse effects of targeted therapies: Part I: Inhibitors of the cellular membrane. Journal of the American Academy of Dermatology, 72(2), 203-218; quiz 219-220. https://doi.org/10.1016/j.jaad.2014.07.032 Marin-Acevedo, J. A., Pellini, B., Kimbrough, E. O., Hicks, J. K., & Chiappori, A. (2023). Treatment Strategies for Non-Small Cell Lung Cancer with Common EGFR Mutations: A Review of the History of EGFR TKIs Approval and Emerging Data. Cancers (Basel), 15(3). https://doi.org/10.3390/cancers15030629 Mazeas, A., Duclos, M., Pereira, B., & Chalabaev, A. (2022). Evaluating the Effectiveness of Gamification on Physical Activity: Systematic Review and Meta-analysis of Randomized Controlled Trials. Journal of Medical Internet Research, 24(1), e26779. https://doi.org/10.2196/26779 Miyai, K., Ito, K., Matsukuma, S., & Tsuda, H. (2020). Frequent EGFR expression/EGFR amplification and lack of activating mutation in testicular choriocarcinoma. Pathology International, 70(5), 262-269. https://doi.org/10.1111/pin.12905 Moradi-Kalbolandi, S., Hosseinzade, A., Salehi, M., Merikhian, P., & Farahmand, L. (2018). Monoclonal antibody-based therapeutics, targeting the epidermal growth factor receptor family: from herceptin to Pan HER. Journal of Pharmacy and Pharmacology, 70(7), 841-854. https://doi.org/10.1111/jphp.12911 Morrison, E. J., Novotny, P. J., Sloan, J. A., Yang, P., Patten, C. A., Ruddy, K. J., & Clark, M. M. (2017). Emotional Problems, Quality of Life, and Symptom Burden in Patients With Lung Cancer. Clinical Lung Cancer, 18(5), 497-503. https://doi.org/10.1016/j.cllc.2017.02.008 Nair, S., Bonner, J. A., & Bredel, M. (2022). EGFR Mutations in Head and Neck Squamous Cell Carcinoma. International Journal of Molecular Sciences, 23(7). https://doi.org/10.3390/ijms23073818 National Cancer Institute. (2017). Common Terminology Criteria for Adverse Events. Version 5. US Department of Health and Human Services, National Institutes of Health Retrieved from https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_5x7.pdf Nowaczyk, J., Fret, K., Kaminska-Winciorek, G., Rudnicka, L., & Czuwara, J. (2023). EGFR inhibitor-induced folliculitis decalvans: a case series and management guidelines. Anticancer Drugs. https://doi.org/10.1097/cad.0000000000001494 Oda, K., Matsuoka, Y., Funahashi, A., & Kitano, H. (2005). A comprehensive pathway map of epidermal growth factor receptor signaling. Molecular Systems Biology, 1, 2005.0010. https://doi.org/10.1038/msb4100014 Ostroff, J. S., Riley, K. E., Shen, M. J., Atkinson, T. M., Williamson, T. J., & Hamann, H. A. (2019). Lung cancer stigma and depression: Validation of the Lung Cancer Stigma Inventory. Psychooncology, 28(5), 1011-1017. https://doi.org/10.1002/pon.5033 Owczarek, W., Słowińska, M., Lesiak, A., Ciążyńska, M., Maciąg, A., Paluchowska, E., Marek-Józefowicz, L., & Czajkowski, R. (2017). The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors. Postepy Dermatologii i Alergologii, 34(5), 418-428. https://doi.org/10.5114/ada.2017.71106 Petri, G., Gresse von Wangenheim, C., & Borgatto, A. F. (2017). MEEGA+, Systematic Model to Evaluate Educational Games. In N. Lee (Ed.), Encyclopedia of Computer Graphics and Games (pp. 1-7). Springer International Publishing. https://doi.org/10.1007/978-3-319-08234-9_214-1 Polit, D. F., & Beck, C. T. (2006). The content validity index: are you sure you know what's being reported? Critique and recommendations. Research in Nursing & Health, 29(5), 489-497. https://doi.org/10.1002/nur.20147 Polit, D. F., Beck, C. T., & Owen, S. V. (2007). Is the CVI an acceptable indicator of content validity? Appraisal and recommendations. Research in Nursing & Health, 30(4), 459-467. https://doi.org/10.1002/nur.20199 Qian, M., & Clark, K. R. (2016). Game-based Learning and 21st century skills: A review of recent research. Computers in Human Behavior, 63, 50-58. https://doi.org/https://doi.org/10.1016/j.chb.2016.05.023 Rencz, F., Gulácsi, L., Péntek, M., Poór, A. K., Sárdy, M., Holló, P., Szegedi, A., Remenyik, É., & Brodszky, V. (2018). Proposal of a new scoring formula for the Dermatology Life Quality Index in psoriasis. Brtish Journal of Dermatology, 179(5), 1102-1108. https://doi.org/10.1111/bjd.16927 Rencz, F., Poór, A. K., Péntek, M., Holló, P., Kárpáti, S., Gulácsi, L., Szegedi, A., Remenyik, É., Hidvégi, B., Herszényi, K., Jókai, H., Beretzky, Z., & Brodszky, V. (2018). A detailed analysis of 'not relevant' responses on the DLQI in psoriasis: potential biases in treatment decisions. Journal of the European Academy of Dermatology and Venereology, 32(5), 783-790. https://doi.org/10.1111/jdv.14676 Robson, K., Plangger, K., Kietzmann, J. H., McCarthy, I., & Pitt, L. (2015). Is it all a game? Understanding the principles of gamification. Business Horizons, 58(4), 411-420. https://doi.org/https://doi.org/10.1016/j.bushor.2015.03.006 Rolnick, S. J., Pawloski, P. A., Hedblom, B. D., Asche, S. E., & Bruzek, R. J. (2013). Patient characteristics associated with medication adherence. Clinical Medicine & Research, 11(2), 54-65. https://doi.org/10.3121/cmr.2013.1113 Rosen, A. C., Case, E. C., Dusza, S. W., Balagula, Y., Gordon, J., West, D. P., & Lacouture, M. E. (2013). Impact of Dermatologic Adverse Events on Quality of Life in 283 Cancer Patients: A Questionnaire Study in a Dermatology Referral Clinic. American Journal of Clinical Dermatology, 14(4), 327-333. https://doi.org/10.1007/s40257-013-0021-0 Sardi, L., Idri, A., & Fernández-Alemán, J. L. (2017). A systematic review of gamification in e-Health. Journal of Biomedical Informatics, 71, 31-48. https://doi.org/10.1016/j.jbi.2017.05.011 Sasaki, T., Hiroki, K., & Yamashita, Y. (2013). The role of epidermal growth factor receptor in cancer metastasis and microenvironment. Biomed Research International, 2013, 546318. https://doi.org/10.1155/2013/546318 Seinsche, J., de Bruin, E. D., Saibene, E., Rizzo, F., Carpinella, I., Ferrarin, M., Moza, S., Ritter, T., & Giannouli, E. (2023). A Newly Developed Exergame-Based Telerehabilitation System for Older Adults: Usability and Technology Acceptance Study. JMIR Human Factors, 10, e48845. https://doi.org/10.2196/48845 Siegel, R. L., Miller, K. D., Fuchs, H. E., & Jemal, A. (2022). Cancer statistics, 2022. CA: A Cancer Journal for Clinicians, 72(1), 7-33. https://doi.org/10.3322/caac.21708 Sotos-Martínez, V. J., Tortosa-Martínez, J., Baena-Morales, S., & Ferriz-Valero, A. (2023). Boosting Student's Motivation through Gamification in Physical Education. Behavioral Sciences (Basel), 13(2). https://doi.org/10.3390/bs13020165 Szabó, Á ., Brodszky, V., & Rencz, F. (2022). A comparative study on the measurement properties of Dermatology Life Quality Index (DLQI), DLQI‐Relevant and Skindex‐16*. British Journal of Dermatology, 186(3), 485-495. https://doi.org/10.1111/bjd.20765 Taghipour, E., Vizeshfar, F., & Zarifsanaiey, N. (2023). The effect of gamification-based training on the knowledge, attitudes, and academic achievement of male adolescents in preventing substance and internet addiction. BMC Medical Education, 23(1), 860. https://doi.org/10.1186/s12909-023-04858-1 Tan, C. S., Kumarakulasinghe, N. B., Huang, Y. Q., Ang, Y. L. E., Choo, J. R., Goh, B. C., & Soo, R. A. (2018). Third generation EGFR TKIs: current data and future directions. Molecular Cancer, 17(1), 29. https://doi.org/10.1186/s12943-018-0778-0 Twiss, J., Meads, D. M., Preston, E. P., Crawford, S. R., & McKenna, S. P. (2012). Can we rely on the Dermatology Life Quality Index as a measure of the impact of psoriasis or atopic dermatitis? Journal of Investigative Dermatology, 132(1), 76-84. https://doi.org/10.1038/jid.2011.238 Vigarios, E., Epstein, J. B., & Sibaud, V. (2017). Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors. Support Care in Cancer, 25(5), 1713-1739. https://doi.org/10.1007/s00520-017-3629-4 Wang, T. F., Huang, R. C., Yang, S. C., Chou, C., & Chen, L. C. (2020). Evaluating the Effects of a Mobile Health App on Reducing Patient Care Needs and Improving Quality of Life After Oral Cancer Surgery: Quasiexperimental Study. JMIR Mhealth and Uhealth, 8(7), e18132. https://doi.org/10.2196/18132 Wang, Y.-F., Hsu, Y.-F., & Fang, K. (2022). The key elements of gamification in corporate training – The Delphi method. Entertainment Computing, 40, 100463. https://doi.org/https://doi.org/10.1016/j.entcom.2021.100463 Wang, Y., Lei, T., & Liu, X. (2020). Chinese System Usability Scale: Translation, Revision, Psychological Measurement. International Journal of Human–Computer Interaction, 36(10), 953-963. https://doi.org/10.1080/10447318.2019.1700644 Weigandt, W. A., Schardt, Y., Bruch, A., Herr, R., Goebeler, M., Benecke, J., & Schmieder, A. (2023). Impact of an eHealth Smartphone App on Quality of Life and Clinical Outcome of Patients With Hand and Foot Eczema: Prospective Randomized Controlled Intervention Study. JMIR Mhealth and Uhealth, 11, e38506. https://doi.org/10.2196/38506 World Health Organization. (2022). Cancer. World Health Organization Retrieved from https://www.who.int/news-room/fact-sheets/detail/cancer Wu, J., Markova, A., & Lacouture, M. E. (2019). Dermatologic Adverse Events from Cancer Treatments. In N. H. Shear & R. P. Dodiuk-Gad (Eds.), Advances in Diagnosis and Managment of Cutaneous Adverse Drug Reactions (pp. 131-174). Adis Singapore. https://doi.org/https://doi.org/10.1007/978-981-13-1489-6 Xie, Z., Liu, K., Or, C., Chen, J., Yan, M., & Wang, H. (2020). An examination of the socio-demographic correlates of patient adherence to self-management behaviors and the mediating roles of health attitudes and self-efficacy among patients with coexisting type 2 diabetes and hypertension. BMC Public Health, 20(1), 1227. https://doi.org/10.1186/s12889-020-09274-4 中文文獻 張黎露、朱家瑜、姜紹青、許麗珠、黃國埕、周文珊、張美娟、侯秀香（2015）‧標靶治療藥品之皮膚毒性預防及照護指引‧腫瘤護理雜誌，15，47-80. https://doi.org/10.3966/168395442015121503005 衛生福利部國民健康署（2022，12 月）‧中華民國 109 年癌症登記報告。https://www.hpa.gov.tw/File/Attach/16434/File_21196.pdf | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/95088 | - |
| dc.description.abstract | 背景：病人服用表皮生長因子受體（Epidermal growth factor receptor; EGFR）標靶藥物時常出現皮膚藥物不良反應（Cutaneous Adverse Drug Reactions，CADR），缺乏皮膚照護知識可能使 CADR 加重，導致癌症患者預後與生活品質惡化。近年來遊戲化電子醫療照護被發現可提升民眾健康促進行為，卻較少研究探討遊戲衛教應用於提升癌症患者皮膚自我照護的效果。
目的：探討行動衛教程式（mobile application，APP）結合遊戲化教學，是否能提升服用 EGFR 標靶藥物病人對 CADR 的自我照護知識、技能與學習動機之成效。 研究方法：採隨機分派雙組前後測設計，2024 年 2 月至 5 月於北部某醫學中心腫瘤醫學部與皮膚部收案。邀請服用 EGFR 標靶藥物之病人，使用研究者設計之APP 進行為期 4 週的介入，實驗組接受遊戲衛教，對照組則僅接受文字衛教。分別在 Day1、Day15 與 Day30 填答結構性問卷，內容包含人口學資料、CADR 知識、學習動機、照護措施遵從性、程式可用性、有趣性與生活品質。 結果：共 82 位服用 EGFR 標靶藥物之患者隨機分派至實驗組與對照組，兩組於Day15 及 Day30 的知識得分均比 Day1 有顯著進步（p< .001），且實驗組得分明顯高於對照組（p< .001）。Day30 時，兩組的照護遵從度皆有顯著進步（p< .001），且實驗組的遵從度優於對照組（p= .037）。兩組生活品質並未隨時間進展有顯著進步，亦無組間差異。實驗組的 APP 使用時長（p= .001）與有趣性評分（p= .008）均明顯高於對照組。患者若能經常使用此遊戲化教學 APP 便有機會提升其 CADR 知識與照護遵從性，而學習動機、遊戲有趣性與系統可用性將影響患者使用 APP 的時長。 結論：皮膚不良反應是 EGFR 標靶藥物使用者需要長期面對的問題，應用行動遊戲 APP 進行患者衛教於本研究被證實是可行的策略，建議可於患者第一次服藥前進行介入，幫助患者提早了解與藥物相關的皮膚不良反應與學習居家自我照護。 | zh_TW |
| dc.description.abstract | Background: Patients taking Epidermal Growth Factor Receptor (EGFR) targeted therapies often experience Cutaneous Adverse Drug Reactions (CADR). A lack of skin care knowledge may exacerbate CADR, leading to a deteriorated prognosis and quality of life in cancer patients. In recent years, gamified digital healthcare has been found to improve public health-promoting behaviors. However, there is limited research on the application of gamified health education to enhance skin self-care among cancer patients.
Aim: This study aimed to investigate the efficacy of a mobile application (APP) combined with gamified instruction in enhancing the knowledge, skills, and learning motivation of patients receiving EGFR-targeted therapies in the self-care of CADR. Methods: A randomized two-group pretest-posttest design was employed, with data collection from February to May 2024 in the oncology and dermatology departments of a medical center in northern Taiwan. Patients taking EGFR-targeted therapies were invited to participate in a 4-week intervention using a researcher-designed APP. The experimental group received gamified health education via APP, while the control group received text-based health education via APP. Structured questionnaires were administered on Day 1, Day 15, and Day 30, covering demographic data, CADR knowledge, learning motivation, adherence to care measures, program usability, enjoyment, and quality of life. Results: Eighty-two patients taking EGFR-targeted therapies were randomly assigned to the experimental and control groups. Both groups showed significant improvement in knowledge scores on Day 15 and Day 30 compared to Day 1 (p < .001), with the experimental group scoring significantly higher than the control group (p < .001). On Day 30, both groups demonstrated significant improvement in adherence to self-care measures (p < .001), with the experimental group outperforming the control group (p = .037). There was no significant improvement in quality of life for either group nor was there a difference between groups. The experimental group had significantly higher APP usage time (p = .001) and enjoyment ratings (p = .008) than the control group. Frequent use of this gamified instructional APP has the potential to enhance CADR knowledge and adherence to care measures. Learning motivation, enjoyment, and system usability will influence patients' duration of app usage. Conclusions: CADRs are a long-term issue for users of EGFR-targeted therapies. This study confirms that using a mobile gamified APP for patient education is feasible. It is recommended to implement this intervention before the patient's first use of EGFRtargeted drugs to help them understand drug-related skin adverse reactions and learn self-care at home. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2024-08-28T16:12:18Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2024-08-28T16:12:18Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 致謝 I
中文摘要 II 英文摘要 III 目次 V 圖次 VII 表次 VII 第一章 緒論 1 第一節 研究背景 1 第二節 研究動機 3 第三節 研究目的 4 第四節 名詞定義及解釋 5 第二章 文獻查證 6 第一節 表皮生長因子受體標靶藥物介紹 6 第二節 EGFR 標靶藥物之常見皮膚不良反應與照護 8 第三節 遊戲式學習與遊戲化相關理論 16 第四節 行動遊戲程式應用於健康衛生教育 19 第三章 研究方法 21 第一節 研究設計與流程 21 第二節 研究對象與取樣方法 23 第三節 研究工具與信效度檢定 24 第四節 資料收集過程 35 第五節 資料處理與分析 37 第六節 研究倫理考量 38 第四章 研究結果 39 第一節 研究對象基本資料與屬性分析 41 第二節 衛教遊戲 APP 介入對各結果變項之成效 45 第三節 影響研究對象自我照護知能之因子 61 第四節 研究對象的 APP 使用行為分析 66 第五章 討論 77 第一節 行動衛教遊戲於照護知能的成效 77 第二節 行動衛教遊戲於學習動機的成效 80 第三節 行動衛教遊戲於生活品質的成效 81 第六章 結論 84 參考文獻 86 附錄 97 附錄一 專家效度問卷 97 附錄二 第一次問卷 104 附錄三 第二次問卷 109 附錄四 第三次問卷 115 附錄五 倫理委員會核准函 120 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 皮膚藥物不良反應 | zh_TW |
| dc.subject | 自我照護知能 | zh_TW |
| dc.subject | 行動遊戲衛教 | zh_TW |
| dc.subject | 表皮生長因子受體 | zh_TW |
| dc.subject | Cutaneous Adverse Drug Reactions | en |
| dc.subject | Mobile Gamified Health Education | en |
| dc.subject | Self-Care Competence | en |
| dc.subject | Epidermal Growth Factor Receptor | en |
| dc.title | 行動遊戲衛教於提升標靶藥物使用者皮膚自我照護之成效 | zh_TW |
| dc.title | The Efficacy of Applying Mobile Healthcare Education Game to Improve Cutaneous Self-care for Patients Receiving Targeted Therapy | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 112-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 朱家瑜;林家齊 | zh_TW |
| dc.contributor.oralexamcommittee | Chia-Yu Chu;Chia-Chi Lin | en |
| dc.subject.keyword | 表皮生長因子受體,皮膚藥物不良反應,自我照護知能,行動遊戲衛教, | zh_TW |
| dc.subject.keyword | Epidermal Growth Factor Receptor,Cutaneous Adverse Drug Reactions,Self-Care Competence,Mobile Gamified Health Education, | en |
| dc.relation.page | 120 | - |
| dc.identifier.doi | 10.6342/NTU202402158 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2024-07-26 | - |
| dc.contributor.author-college | 醫學院 | - |
| dc.contributor.author-dept | 護理學研究所 | - |
| dc.date.embargo-lift | 2027-07-23 | - |
| 顯示於系所單位： | 護理學系所 | |
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