請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/94723完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳漪紋 | zh_TW |
| dc.contributor.advisor | Yi-Wen Chen | en |
| dc.contributor.author | 張軒豪 | zh_TW |
| dc.contributor.author | Hsuan-Hao Chang | en |
| dc.date.accessioned | 2024-08-16T17:44:55Z | - |
| dc.date.available | 2024-08-17 | - |
| dc.date.copyright | 2024-08-16 | - |
| dc.date.issued | 2024 | - |
| dc.date.submitted | 2024-08-13 | - |
| dc.identifier.citation | 1. Albrektsson, T.O., C.B. Johansson, and L. Sennerby, Biological aspects of implant dentistry: osseointegration. Periodontol 2000, 1994. 4: p. 58-73.
2. Guo, C.Y., J.P. Matinlinna, and A.T.H. Tang, Effects of Surface Charges on Dental Implants: Past, Present, and Future. International Journal of Biomaterials, 2012. 2012: p. 1-5. 3. Zhou, A., et al., Role of Hippo-Yap Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology. Frontiers in Cell and Developmental Biology, 2020. 8. 4. Ravidà, A., et al., Diagnosis of Peri‐implant Status After Peri‐implantitis Surgical Treatment: Proposal of a New Classification. Journal of Periodontology, 2020. 91(12): p. 1553-1561. 5. Amengual‐Peñafiel, L., et al., Osteoimmunology Drives Dental Implant Osseointegration: A New Paradigm for Implant Dentistry. Japanese Dental Science Review, 2021. 57: p. 12-19. 6. Amengual-Penafiel, L., et al., Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry. Japanese Dental Science Review, 2021. 57: p. 12-19. 7. Smith, D.C., Dental implants: materials and design considerations. Int J Prosthodont, 1993. 6(2): p. 106-17. 8. Adell, R., et al., Long-term follow-up study of osseointegrated implants in the treatment of totally edentulous jaws. Int J Oral Maxillofac Implants, 1990. 5(4): p. 347-59. 9. Dewan, H., et al., Surface Characteristics of Different Zirconia Dental Implants: A Comparative Study. Journal of Pharmacy and Bioallied Sciences, 2022. 14(5): p. 260. 10. Chou, I.C., S.Y. Lee, and C.P. Jiang, Effects of Implant Neck Design on Primary Stability and Overload in a Type IV Mandibular Bone. International Journal for Numerical Methods in Biomedical Engineering, 2014. 30(11): p. 1223-1237. 11. Pirjamalineisiani, A. and M. Sarafbidabad, Comparative Stability Analysis of Two Types of CpTi and Zr-2.5% Nb Implants After Maxillofacial Surgery. Journal of Periodontology & Implant Dentistry, 2017. 8(2): p. 49-54. 12. Hakim, L.K., The Current Applications of Nano and Biomaterials in Drug Delivery of Dental Implant. BMC Oral Health, 2024. 24(1). 13. Saini, R.S., Application of Density Functional Theory for Evaluating the Mechanical Properties and Structural Stability of Dental Implant Materials. BMC Oral Health, 2023. 23(1). 14. Song, H., S.C. Jung, and B.H. Kim, Focal Adhesion of Osteoblastic Cells on Titanium Surface With Amine Functionalities Formed by Plasma Polymerization. Japanese Journal of Applied Physics, 2012. 51(8S1): p. 08HE01. 15. Goutam, M., et al., Assessment of Effect of Fluoride on Titanium Dental Implants. Journal of Pharmacy and Bioallied Sciences, 2022. 14(5): p. 220. 16. Afradh, K., et al., Evaluation of Serum Metal Ion Levels in Dental Implant Patients: A Prospective Study. Annals of Maxillofacial Surgery, 2021. 11(2): p. 261. 17. Hasan, J., et al., Preventing Peri-Implantitis: The Quest for a Next Generation of Titanium Dental Implants. Acs Biomaterials Science & Engineering, 2022. 8(11): p. 4697-4737. 18. Niinomi, M., Mechanical properties of biomedical titanium alloys. Materials Science and Engineering: A, 1998. 243(1): p. 231-236. 19. Bidez, M.W. and C.E. Misch, Force transfer in implant dentistry: basic concepts and principles. J Oral Implantol, 1992. 18(3): p. 264-74. 20. Kholy, K.E., et al., Investigating the Response of Human Neutrophils to Hydrophilic and Hydrophobic Micro-Rough Titanium Surfaces. Materials, 2020. 13(15): p. 3421. 21. Tanwar, N., et al., Titanium Allergy in Dentistry: A New Allergen in Rapidly Evolving Implant Dentistry. Contemporary Clinical Dentistry, 2021. 12(3): p. 317. 22. Ataya, A., et al., Titanium Exposure and Yellow Nail Syndrome. Respiratory Medicine Case Reports, 2015. 16: p. 146-147. 23. Pigatto, P.D., et al., Titanium allergy associated with dental implant failure. Clin Oral Implants Res, 2009. 20(8): p. 857. 24. Sicilia, A., et al., Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients. Clin Oral Implants Res, 2008. 19(8): p. 823-35. 25. Jung, R.E., et al., The effect of all-ceramic and porcelain-fused-to-metal restorations on marginal peri-implant soft tissue color: a randomized controlled clinical trial. The International Journal of Periodontics and Restorative Dentistry, 2008. 28(4): p. 357-365. 26. Alrababah, M.A., et al., Use of High Performance Polymers as Dental Implant Abutments and Frameworks: A Case Series Report. Journal of Prosthodontics, 2017. 28(4): p. 365-372. 27. Depprich, R., et al., Behavior of Osteoblastic Cells Cultured on Titanium and Structured Zirconia Surfaces. Head & Face Medicine, 2008. 4(1). 28. Kohal, R.J., et al., Loaded custom‐made zirconia and titanium implants show similar osseointegration: an animal experiment. Journal of periodontology, 2004. 75(9): p. 1262-1268. 29. Dubruille, J.-H., et al., Evaluation of combinations of titanium, zirconia, and alumina implants with 2 bone fillers in the dog. International Journal of Oral & Maxillofacial Implants, 1999. 14(2). 30. Scarano, A., et al., Bone response to zirconia ceramic implants: an experimental study in rabbits. Journal of Oral Implantology, 2003. 29(1): p. 8-12. 31. Depprich, R., et al., Osseointegration of zirconia implants: an SEM observation of the bone-implant interface. Head & Face Medicine, 2008. 4: p. 1-7. 32. Schultze-Mosgau, S., et al., Osseointegration of endodontic endosseous conesZirconium oxide vs titanium. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2000. 89(1): p. 91-98. 33. Buczynski, B., et al., Bacterial adhesion to zirconium surfaces. Colloids and Surfaces B: Biointerfaces, 2003. 30(1-2): p. 167-175. 34. Al-Radha, A.S.D., et al., Surface properties of titanium and zirconia dental implant materials and their effect on bacterial adhesion. Journal of dentistry, 2012. 40(2): p. 146-153. 35. De Oliveira, G.R., et al., Bacterial adhesion and colonization differences between zirconia and titanium implant abutments: an in vivo human study. Journal of periodontal & implant science, 2012. 42(6): p. 217-223. 36. Liñares, A., et al., Histological assessment of hard and soft tissues surrounding a novel ceramic implant: a pilot study in the minipig. J Clin Periodontol, 2016. 43(6): p. 538-46. 37. Sharanraj, V., et al., Zirconia: As a Biocompatible Biomaterial Used in Dental Implants. Advances in Applied Ceramics Structural Functional and Bioceramics, 2020. 120(2): p. 63-68. 38. Karaçalı, Ö., Material Fatigue Research for Zirconia Ceramic Dental Implant: A Comparative Laboratory and Simulation Study in Dentistry. Acta Physica Polonica A, 2015. 127(4): p. 1195-1198. 39. Lee, D.-J., et al., Differential healing patterns of mucosal seal on zirconia and titanium implant. Frontiers in Physiology, 2019. 10: p. 796. 40. Roehling, S., et al., Implant Supported Fixed Dental Prostheses Using a New Monotype Zirconia Implant—A Case Report. Dentistry Journal, 2015. 3(3): p. 79-92. 41. Yamano, S., et al., The influence of different implant materials on human gingival fibroblast morphology, proliferation, and gene expression. International Journal of Oral & Maxillofacial Implants, 2011. 26(6). 42. Olmedo, D., et al., Macrophages related to dental implant failure. Implant Dentistry, 2003. 12(1): p. 75-80. 43. Akimoto, T., et al., Evaluation of corrosion resistance of implant‐use Ti‐Zr binary alloys with a range of compositions. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2018. 106(1): p. 73-79. 44. Almarghlani, A. and S. Alshali, Survival and Fracture Rates of One-Piece Zirconia Implants: A Systematic Review. Cm, 2022(24). 45. Quabius, E.S., et al., Dental Implants Stimulate Expression of Interleukin‐8 and Its Receptor in Human Blood—An <i>in Vitro</I> Approach. Journal of Biomedical Materials Research Part B Applied Biomaterials, 2012. 100B(5): p. 1283-1288. 46. Azzaldeen, A., et al., Zirconium Dental Implants and Crown for Congenitally Missing Maxillary Lateral; Clinical Case. Iosr Journal of Dental and Medical Sciences, 2017. 16(03): p. 72-77. 47. ArRejaie, A.S., et al., Clinical Performance of One‐piece Zirconia Dental Implants: A Systematic Review. Journal of Investigative and Clinical Dentistry, 2018. 10(2). 48. Haimov, E., Differences in Titanium, Titanium-Zirconium, Zirconia Implants Treatment Outcomes: A Systematic Literature Review and Meta-Analysis. Journal of Oral and Maxillofacial Research, 2023. 14(3). 49. Thoma, D.S., et al., Histological analysis of loaded zirconia and titanium dental implants: an experimental study in the dog mandible. J Clin Periodontol, 2015. 42(10): p. 967-75. 50. Jung, S., et al., Influence of Implant Material and Surface on Differentiation and Proliferation of Human Adipose-Derived Stromal Cells. International Journal of Molecular Sciences, 2018. 19(12): p. 4033. 51. Ganbold, B., et al., Osteoclastogenesis Behavior of Zirconia for Dental Implant. Materials, 2019. 12(5): p. 732. 52. Heitz‐Mayfield, L. and G.E. Salvi, Peri‐implant Mucositis. Journal of Periodontology, 2018. 89(S1). 53. Das, D. and N. Shenoy, Peri-Implant Diseases. Journal of Health and Allied Sciences Nu, 2021. 12(03): p. 223-229. 54. Rinke, S., et al., Risk Indicators for Mucositis and Peri-Implantitis: Results From a Practice-Based Cross-Sectional Study. Journal of Periodontal & Implant Science, 2020. 50(3): p. 183. 55. Berglundh, T., et al., Peri‐implant Diseases and Conditions: Consensus Report of Workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. Journal of Clinical Periodontology, 2018. 45(S20). 56. Almohandes, A., et al., Effect of Biofilm Formation on Implant Abutments With an Anti‐bacterial Coating: A Pre‐clinical in Vivo Study. Clinical Oral Implants Research, 2021. 32(6): p. 756-766. 57. Costa, F.O., et al., Peri-implant disease in subjects with and without preventive maintenance: a 5-year follow-up. J Clin Periodontol, 2012. 39(2): p. 173-81. 58. Sánchez-Martos, R., et al., The Diode Laser as Coadyuvant Therapy in the Non-Surgical Conventional Treatment of Peri-Implant Mucositis: A Systematic Review and Meta-Analysis. Journal of Clinical and Experimental Dentistry, 2020: p. e1171-e1182. 59. Wang, Q., et al., Peri‐implant Mucositis Sites With Suppuration Have Higher Microbial Risk Than Sites Without Suppuration. Journal of Periodontology, 2020. 91(10): p. 1284-1294. 60. Fernandes-Costa, A.N., et al., A Prospective Study of the Clinical Outcomes of Peri‐implant Tissues in Patients Treated for Peri‐implant Mucositis and Followed Up for 54 months. Clinical Implant Dentistry and Related Research, 2019. 21(5): p. 1099-1105. 61. Ismail, A., et al., Peri-Implantitis: A Review to Simplify a Mystifying Disease. Medical Research Archives, 2022. 10(10). 62. Umar, M.S., et al., Peri Implantitis- A Narrative Review. Ip International Journal of Periodontology and Implantology, 2022. 6(4): p. 204-211. 63. Khoury, F., et al., Surgical treatment of peri-implantitis - Consensus report of working group 4. Int Dent J, 2019. 69 Suppl 2(Suppl 2): p. 18-22. 64. Herrera, D., et al., Prevention and treatment of peri‐implant diseases—The EFP S3 level clinical practice guideline. Journal of Clinical Periodontology, 2023. 50: p. 4-76. 65. Wang, C.W., et al., Laser-assisted regenerative surgical therapy for peri-implantitis: A randomized controlled clinical trial. J Periodontol, 2021. 92(3): p. 378-388. 66. Ikeda, S., et al., Dietary Restriction Impairs Neutrophil Exudation by Reducing CD11b/CD18 Expression and Chemokine Production. Archives of Surgery, 2001. 136(3): p. 297. 67. Jaillon, S., et al., Neutrophils in Innate and Adaptive Immunity. Seminars in Immunopathology, 2013. 35(4): p. 377-394. 68. Güncü, G.N., et al., Myeloperoxidase as a measure of polymorphonuclear leukocyte response in inflammatory status around immediately and delayed loaded dental implants: a randomized controlled clinical trial. Clinical implant dentistry and related research, 2008. 10(1): p. 30-39. 69. Oshrain, H.I., B. Telsey, and I.D. Mandel, Neutrophil Chemotaxis in Refractory Cases of Periodontitis. Journal of Clinical Periodontology, 1987. 14(1): p. 52-55. 70. Liu, L., et al., BCG Immunotherapy Inhibits Cancer Progression by Promoting the M1 Macrophage Differentiation of THP‑1 Cells via the Rb/E2f1 Pathway in Cervical Carcinoma. Oncology Reports, 2021. 46(5). 71. Tang, D., et al., SRplot: A free online platform for data visualization and graphing. PLoS One, 2023. 18(11): p. e0294236. 72. Wang, L.T., et al., Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1beta in Klebsiella-mediated acute respiratory distress syndrome. Thorax, 2022. 73. Tanaka, R., et al., Preparation of fibrin hydrogels to promote the recruitment of anti-inflammatory macrophages. Acta biomaterialia, 2019. 89: p. 152-165. 74. Ye, Q., et al., Subcutaneous inflammatory reaction to a synthetic auditory ossicle (Bioceram®) in rats. Acta oto-laryngologica, 1999. 119(1): p. 83-88. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/94723 | - |
| dc.description.abstract | 在現今的牙醫學，植牙治療已經被證明為可預期性高且經得起長久時間考驗的治療方式。而其中最常使用的植體材料則是鈦金屬或其合金，目前被認定為治療的首選。但是近年來，隨著材料科技的進步，二氧化鋯漸漸有越來越多被用來取代鈦金屬成為牙科植體的材料，因其與鈦金屬相比，有接近之骨整合能力，但有更好的美觀性。在植體使用長時間後，有可能會發生植體周圍黏膜炎甚至引發植體周圍炎的情形，此類疾病皆與植體周圍的軟組織免疫反應有相當大的關聯性。但現有文獻關於軟組織免疫能力多半僅侷限在鈦金屬，關於二氧化鋯植體的軟組織免疫反應研究甚少。此研究主要以小鼠為實驗動物，在上顎分別置入鈦植體與二氧化鋯植體。於手術一週後，取下植體周圍軟組織，進行免疫染色並使用流式細胞儀分析，探討不同材料之植體周圍軟組織免疫反應之差異。
結果顯示，無論是多型核中性白血球之浸潤量，或是巨噬細胞分化之情形，均顯示在二氧化鋯組別中有抑制發炎反應之結果。因實驗組數及條件之限制，對於此結果應謹慎看待，但此研究仍然顯示二氧化鋯植體在臨床應用上，除了美觀上之巨大優勢之外，更好的生物相容性、較低的發炎反應或許將為牙科植體學帶來更多的臨床解決方案。 | zh_TW |
| dc.description.abstract | In contemporary dentistry, implant therapy has been established as a highly predictable and long-lasting treatment modality. The most commonly used implant materials are titanium and its alloys, which are currently considered the gold standard in treatment. However, recent advancements in material science have led to the increasing use of zirconia as an alternative to titanium for dental implants. Zirconia offers comparable osseointegration capabilities to titanium while providing superior esthetic outcomes. Over time, the occurrence of peri-implant mucositis and peri-implantitis has been observed, conditions that are closely related to the immune response of the peri-implant soft tissue. However, existing literature on soft tissue immune response predominantly focuses on titanium implants, with limited studies addressing the immune response to zirconia implants.
This study primarily utilized a murine model, with titanium and zirconia implants placed in the maxilla. One week post-surgery, peri-implant soft tissues were harvested, subjected to immunohistochemical staining, and analyzed using flow cytometry to investigate the differences in immune responses of peri-implant soft tissues associated with different implant materials. The results demonstrated that zirconia implants exhibited a suppressed inflammatory response, as evidenced by reduced infiltration of polymorphonuclear neutrophils and a distinct pattern of macrophage differentiation. Due to the limitations in sample size and experimental conditions, these findings should be interpreted with caution. Nevertheless, this study suggests that zirconia implants, beyond their significant esthetic advantages, may offer better biocompatibility and reduced inflammatory responses, potentially providing new clinical solutions in the field of dental implantology. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2024-08-16T17:44:55Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2024-08-16T17:44:55Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 目次
誌謝 ii 中文摘要 iii ABSTRACT iv 目次 vi 圖次 viii 表次 xii 1. Introduction 1 1.1 Implant dentistry 1 1.1.1 Osseointegration 1 1.1.2 Implant materials 2 1.1.3 Ti implants 2 1.1.4 Zr implants 3 1.1.5 Soft tissue and immune response to Ti and Zr implants 6 1.2 Peri-implant diseases 7 1.2.1 Peri-implantitis 7 1.2.2 Current concepts and modalities in the treatment of peri-implantitis 8 1.3 Myeloid cell-mediated innate immunity in implant response 9 1.3.1 Polymorphonuclear neutrophils (PMNs) 9 1.3.2 Macrophages 10 2. Research Motivation and Research Purposes 14 3. Materials and Methods 15 3.1 Surgical Procedures 15 3.1.1 Murine Model for Implant Placement 15 3.1.2 Isolation and Processing of Gingival and Peri-Implant Mucosal Tissues 23 3.2 In vivo assessment of Myeloid cell activation 24 3.2.1 Bioinformatics analysis 24 3.2.2 Staining protocol and flow cytometry analysis 25 3.3 Statistical analysis 25 4. Results 26 4.1 Transcriptomic comparison of immune responses in peri-implant tissues: Ti vs. Zr implants 26 4.2 Myeloid cell-mediated immune response in peri-implant tissues: Ti vs. Zr implants 36 4.3 PMN responses to Ti vs. Zr implants 48 4.4 MΦ responses to Ti vs. Zr implants 55 5. Discussion 69 5.1 Myeloid cell-mediated immune response in different materials of Ti and Zr implant 69 5.2 The utilization of the mice model 71 5.3 Limitations of our study 73 5.4 Future perspectives 74 Reference: 77 | - |
| dc.language.iso | en | - |
| dc.title | 利用動物試驗評估鈦植體與氧化鋯植體誘導之軟組織免疫反應 | zh_TW |
| dc.title | investigation of soft tissue immune response triggered by titanium and zirconia implants in an animal model | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 112-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 王麗姿;郭瑋庭 | zh_TW |
| dc.contributor.oralexamcommittee | Li-Tzu Wang;Wei-Ting Kuo | en |
| dc.subject.keyword | 鈦植體,氧化鋯植體,軟組織免疫, | zh_TW |
| dc.subject.keyword | zirconia implant,titanium implant,soft tissue immune, | en |
| dc.relation.page | 82 | - |
| dc.identifier.doi | 10.6342/NTU202404286 | - |
| dc.rights.note | 同意授權(全球公開) | - |
| dc.date.accepted | 2024-08-13 | - |
| dc.contributor.author-college | 醫學院 | - |
| dc.contributor.author-dept | 臨床牙醫學研究所 | - |
| 顯示於系所單位： | 臨床牙醫學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-112-2.pdf | 29.05 MB | Adobe PDF | 檢視/開啟 |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。