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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳振中 | zh_TW |
| dc.contributor.advisor | Jerry Chun-Chung Chan | en |
| dc.contributor.author | 林佾曇 | zh_TW |
| dc.contributor.author | Yi-Tan Lin | en |
| dc.date.accessioned | 2024-08-16T16:32:18Z | - |
| dc.date.available | 2024-08-17 | - |
| dc.date.copyright | 2024-08-16 | - |
| dc.date.issued | 2024 | - |
| dc.date.submitted | 2024-08-13 | - |
| dc.identifier.citation | (1) Meldrum, F. C.; Cölfen, H. The Many Lives of Calcium Carbonate. Nat. Chem. 2023, 15 (8), 1196–1196.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/94525 | - |
| dc.description.abstract | 製備無機連續結構的塊材是一項富有挑戰性的任務，但無機塊材的製備可能對新穎光學器件及生物材料的發展有助益。在近期的文獻報導中，有人提出了一種藉由交聯膠狀寡聚前驅物，即非晶質碳酸鈣寡聚物，來合成無機塊狀材料。延續其製備流程，我們製備了鎂穩定的非晶質碳酸鈣寡聚物，並發現其可以在三乙胺存在下藉由水進行可逆聚集。我們假設水可以改變礦物的表面性質，通過氫鍵幫助寡聚物進行聚集。為了試驗這一假設，我們引入多元醇進行寡聚物聚集的動力學研究，並利用核磁共振儀研究二元醇與寡聚物之間的交互作用，這些結果為我們的假設提供證據。藉由控制寡聚物的聚集，我們製備了具有高比表面積的中孔洞含鎂非晶質碳酸鈣塊材，並發現製程中加入水可以增加塊材的尺寸。最後，由於中孔洞含鎂非晶質塊材有作為人工骨填充物並進行局部藥物輸送的潛力，我們將其用為薑黃素的藥物載體，與非晶質碳酸鈣奈米球相比，發現其具有更延長的藥物釋放曲線。此研究有潛力推進寡聚物製作成為功能性材料。 | zh_TW |
| dc.description.abstract | Constructing inorganic monolithic materials with a continuous structure is a chal-lenging task, but the processability of these materials may allow the development of novel optical devices and biomaterials. Recently, it has been proposed a method to prepare inorganic monolithic materials through the crosslinking of a gel-like oligo-meric precursor, viz., amorphous calcium carbonate (ACC) ionic oligomers. Following Tang's protocol, we reported the synthesis of Mg-stabilized amorphous calcium car-bonate (Mg-ACC) ionic oligomers; their reversible aggregation is induced by adding water in the presence of triethylamine (TEA). We hypothesized that water modifies the surface of ionic oligomers, aiding in the aggregation of ionic oligomers through hy-drogen bond interactions. To test this hypothesis, we introduced polyols to study the kinetics of the aggregation of ionic oligomers, and the interaction between diols and ionic oligomers was studied by NMR. These results provide evidence for our hypothe-sis. By controlling the aggregation of ionic oligomers, we synthesized mesoporous monoliths with high specific surface areas, and the dimensions of the monoliths in-creased with increasing water content. Finally, the mesoporous Mg-ACC monolith, which has the potential to be applied as a bone filler for local drug delivery, was used as a curcumin carrier and exhibited a more extended release profile than ACC nano-spheres. This study has the potential to advance the processing of ionic oligomers into functional materials. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2024-08-16T16:32:18Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2024-08-16T16:32:18Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員會審定書 I
謝誌 II 中文摘要 VIII Abstract IX Abbreviations XI Contents XIII List of Figures XIX List of Tables XXIV CHAPTER 1 Introduction 1 1.1 Calcium Carbonate 1 1.1.1 Calcium Carbonate Polymorphism 1 1.1.2 Amorphous Calcium Carbonate 2 1.2 Magnesium Ions in ACC 4 1.3 Water in ACC 5 1.3.1 Structural Water 5 1.3.2 Water in ACC Formation 7 1.4 Particle Attachment 9 1.4.1 Particle Attachment in Biominerals 9 1.4.2 DLVO theory 13 1.5 Liquid-Like Mineral Precursors 15 1.5.1 Polymer Induced Liquid Precursors 16 1.5.2 Ionic Oligomers 16 1.6 ACC as Bone Substitutes 22 1.7 Curcumin 23 1.8 Motivation 24 CHAPTER 2 Materials and Method 26 2.1 Chemicals and Instruments 26 2.2 Sample Preparation 31 2.2.1 Mg-ACC Ionic Oligomers and Monolith 31 2.2.2 Optical Density 600 (OD600) Tracking of Different Mineralization Stages 33 2.2.3 Mg-ACC Aggregation Kinetics Induced by Water and Polyols 34 2.2.4 NMR Sample Preparation: Chemical Exchange Saturation Transfer (CEST) 36 2.2.5 NMR Sample Preparation: 37 2.2.6 Aggregation Kinetics Among Mg-ACC, Mg-ACC TEA, Mg-ACC water, Mg-ACC TEA-water 38 2.2.7 Preparation of Amorphous Calcium Phosphate (ACP) and Amorphous Magnesium Phosphate (AMP) Ionic Oligomers and Study of Aggregation Kinetics 40 2.2.8 Preparation of Mg-ACC Monolith with Different Water Content in the Process 41 2.2.9 Preparation of ACC Nanospheres 42 2.2.10 Loading Curcumin into Mg-ACC Monolith and ACC Nanospheres 43 2.2.11 Release Profile of Curcumin 44 2.3 Sample Characterization 46 2.3.1 Inductively Coupled Plasma Mass Spectroscopy (ICP-MS) 46 2.3.2 Dynamic Light Scattering (DLS) 48 2.3.3 Zeta Potential 49 2.3.4 Fourier Transform Infrared Spectroscopy (FT-IR) 50 2.3.5 Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) 51 2.3.6 Scanning Electron Microscopy (SEM) 52 2.3.7 Transmission Electron Microscope (TEM) 53 2.3.8 UV-vis Spectroscopy 54 2.3.9 Specific Surface Area and Porosimetry Analyzer 55 2.4 Solution State Nuclear Magnetic Resonance (NMR) 57 2.4.1 Larmor Frequency 57 2.4.2 Spin Lattice Relaxation 57 2.4.3 Spin Spin Relaxation 59 2.4.4 Estimation of Correlation Time from Relaxation Data 61 2.4.5 Diffusion Ordered Spectroscopy (DOSY) 61 2.4.6 Chemical Exchange Saturation Transfer (CEST) 63 CHAPTER 3 Mg-ACC Monolith and Aggregation of Ionic Oligomers Induced by Water 65 3.1 Characterization of Mg-ACC Monolith 65 3.1.1 ICP-MS 65 3.1.2 FT-IR 66 3.1.3 TGA and DSC 67 3.1.4 SEM 69 3.2 Gel-Like Ionic Oligomers Induced by Water 70 3.2.1 CEST: Nanodroplet Property of Mg-ACC Ionic Oligomers 75 3.3 Roles of Water in Aggregation of Mg-ACC Ionic Oligomers 77 3.3.1 Different Amount of Water 78 3.3.2 Double Hydrogen Bond Donor 79 3.3.3 Length of Diols 81 3.4 Role of TEA 84 3.5 Attraction between Like-charged Particles 87 3.6 NMR Study: Interfacial Interactions between Propanediols, TEA, Chloroform and Ionic Oligomers 89 3.6.1 Concept 89 3.6.2 Rotational Correlation Time 91 3.7 Aggregation of ACC, AMC, ACP and AMP Ionic Oligomers 96 3.8 Summary 99 CHAPTER 4 Mesoporous Mg-ACC Monolith and Its Application as Curcumin Carrier 101 4.1 Mesoporous Mg-ACC Monoliths 101 4.1.1 Effect of Water to the Dimension of Monolith 101 4.1.2 Pore Analysis 102 4.2 Loading and Release of Curcumin 107 4.3 Summary 113 CHAPTER 5 Conclusions and Outlook 115 5.1 Conclusion 115 5.2 Outlook 116 References 118 Appendix A Mg Content in Mg-ACC Monoliths with Different Mg mol% in Mother Liquid 131 Appendix B Effects of Dielectric Constant 132 Appendix C Karl-Fischer Titration 135 Appendix D Other NMR Results 138 D.1 1H Direct Excitation NMR Spectrum 138 D.2 Chemical Shift 139 D.3 Diffusion Coefficient 140 Appendix E Calculation of Rotational Correlation Time from Relaxation Data 145 Appendix F DLS Results of Other Ionic Oligomers 147 Appendix G Calibration Curves of Curcumin 148 | - |
| dc.language.iso | en | - |
| dc.title | 藉由水誘導含鎂非晶質碳酸鈣寡聚物粒子聚集的機制探討及應用 | zh_TW |
| dc.title | Mechanistic Study of Particle Attachment of Mg-Stabilized Amorphous Calcium Carbonate Ionic Oligomers Induced by Water and Its Applications | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 112-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 余慈顏;鍾博文 | zh_TW |
| dc.contributor.oralexamcommittee | Tsyr-Yan Yu;Po-Wen Chung | en |
| dc.subject.keyword | 含鎂非晶質碳酸鈣,離子寡聚物,塊材,水,溶膠凝膠法,中孔洞,藥物載體, | zh_TW |
| dc.subject.keyword | magnesium amorphous calcium carbonate,ionic oligomers,monolith,water,sol-gel process,mesoporous,drug carrier, | en |
| dc.relation.page | 148 | - |
| dc.identifier.doi | 10.6342/NTU202404043 | - |
| dc.rights.note | 未授權 | - |
| dc.date.accepted | 2024-08-14 | - |
| dc.contributor.author-college | 理學院 | - |
| dc.contributor.author-dept | 化學系 | - |
| 顯示於系所單位： | 化學系 | |
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