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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 翁啟惠(Chi-Huey Wong) | |
| dc.contributor.author | Bin-Ling Tsai | en |
| dc.contributor.author | 蔡秉霖 | zh_TW |
| dc.date.accessioned | 2021-05-20T20:22:32Z | - |
| dc.date.available | 2012-02-10 | |
| dc.date.available | 2021-05-20T20:22:32Z | - |
| dc.date.copyright | 2009-02-10 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-01-21 | |
| dc.identifier.citation | 1.Dwek, R. A.. Chem. Rev. 1996, 96, 683.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9436 | - |
| dc.description.abstract | 醣類是組成細胞的四種基本成分之一，含量豐富且以多樣化形式存在於生物高分子中。癌細胞與正常細胞相比較下，在某些醣分子上的結構或量的層級上有不同表現。醣蛋白和醣脂質在醣化過程中，分子的不正常改變常會造成腫瘤的惡化。
路易士X二聚體與KH-1為大腸癌的細胞膜上顯著表現的兩種抗原分子，這兩種抗原分子大量的表現也與癌症的惡化前兆有關。所以路易士X二聚體與KH-1抗原分子可以用來發展疫苗或是用於醣晶片上作癌症的診斷。然而在鑑定和純化腫瘤細胞上的醣類抗原分子是非常困難，因此有機合成在醣生物學的研究上扮演重要的角色。在此篇論文中成功利用本實驗室所發展的一鍋化合成法來合成出三醣的路易士Ｘ、六醣的路易士X二聚體與七醣KH-1腫瘤抗原分子的類似物。 | zh_TW |
| dc.description.abstract | Among four major classes of macro-biomolecules-nucleic acids, proteins, lipids, and carbohydrates-carbohydrates are the least studied and understood.Carbohydrates and their conjugates are abundantly expressed on the out-surfaces of prokaryotic and eukaryotic cells and involved in various biological event. Especially, the surface of cancer cells frequently display glycans at different levels or with fundamentally different structures in comparison with that of normal cells, including the progression of tumor cell metastasis.
Dimeric Lewis X and KH-1 are two tumor-associated antigens. These antigens are considered as the marker for malignancy and pre-malignancies involving colonic adenocarcinoma. Lewis X dimmer and KH-1 tumor associated antigens can be used to develop carbohydrate-based anticancer vaccines and carbohydrate microarray in diagnosis. However, the structure identification and isolation of homogeneous carbohydrate-based tumor antigen is very difficult, organic synthesis play an important role in glycobiology research. Finally, one-pot strategy was successfully developed to synthesis Lewis X monomer, Lewis X dimer hexasaccharide and KH-1 heptasaccharide analogues. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-20T20:22:32Z (GMT). No. of bitstreams: 1 ntu-98-R95223083-1.pdf: 1872581 bytes, checksum: 3d0fa35f16419d8e998ce09ed062ff38 (MD5) Previous issue date: 2009 | en |
| dc.description.tableofcontents | 謝誌 i
中文摘要 iii 英文摘要 iv 縮寫表 v 目錄 vi 第一章 緒論 01 第一節 寡糖的化學合成 04 第二節 一鍋化合成法 07 第三節 腫瘤細胞表面醣分子抗原 13 第二章 路易士Ｘ二聚體與KH-1寡醣分子之化學合成回顧 17 第一節 路易士Ｘ二聚體寡糖合成回顧 17 第二節 KH-1寡糖合成回顧 26 第三章 結果與討論 32 第一節 路易士X二聚體與KH-1之逆合成分析 32 第二節 路易士X二聚體與KH-1之合成流程 34 參考文獻 47 附錄 材料與實驗步驟 50 | |
| dc.language.iso | zh-TW | |
| dc.title | 合成路易士X二聚體與KH-1抗原分子 | zh_TW |
| dc.title | Synthesis of dimeric LeX and KH-1 antigens | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 吳宗益(Chung-Yi Wu) | |
| dc.contributor.oralexamcommittee | 林俊宏,鄭偉杰 | |
| dc.subject.keyword | 醣合成,一鍋化,腫瘤抗原,路易士X二聚體,KH-1, | zh_TW |
| dc.subject.keyword | carbohydrate synthesis,one-pot,cancer antigen,dimer Lex,KH-1, | en |
| dc.relation.page | 63 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2009-01-21 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 化學研究所 | zh_TW |
| 顯示於系所單位： | 化學系 | |
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