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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林致廷 | zh_TW |
| dc.contributor.advisor | Chih-Ting Lin | en |
| dc.contributor.author | 滑凱茵 | zh_TW |
| dc.contributor.author | Hoi-Yan Wat | en |
| dc.date.accessioned | 2024-08-01T16:14:36Z | - |
| dc.date.available | 2024-08-02 | - |
| dc.date.copyright | 2024-08-01 | - |
| dc.date.issued | 2024 | - |
| dc.date.submitted | 2024-07-29 | - |
| dc.identifier.citation | [1] Xu, J., Murphy., S.L., Kochanek, K.D., Arias E. (2022). Mortality in the United States, 2021.NCHS Data Brief, (456), 1-8.
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Rapid and low-cost, and disposable electrical sensor using an extended gate field-effect transistor for cardiac troponin I detection. Biomedical Engineering Letters, 12(2), 197–203. [17] Chou, J., & Weng, C. (2001). Sensitivity and hysteresis effect in Al2O3 gate pH-ISFET. Materials Chemistry and Physics, 71(2), 120–124. [18] Ryu, S., Lee, S., Sohn, Y., Son, W., & Choi, S. (2012). Characteristics of Al2O3 gate pH-ISFET difference of thermal annealing temperature. Biomedical Engineering: Applications, Basis and Communications, 24(2), 117–121. [19] Bousse, L., Mostarshed, S., van der Schoot, B., & de Rooij, N.F. (1994). Comparison of the hysteresis of Ta2O5 and Si3N4 pH-sensing insulators. Sensors and Actuators. B, Chemical, 17(2), 157–164. [20] Chen, M., Jin, Y., Qu, X., Jin, Q., & Zhao, J. (2014). Electrochemical impedance spectroscopy study of Ta2O5 based EIOS pH sensors in acid environment. Sensors and Actuators. B, Chemical, 192, 399–405. [21] Yusof, K.A., Noh, N.I., Herman, S.H., Abdullah, A.Z., Zolkapli, M., & Abdullah, W.F. (2013). pH sensing characteristics of silicon nitride thin film and silicon nitride-based ISFET sensor. 2013 IEEE 4th Control and System Graduate Research Colloquium, 132-135. [22] Lai, C., Lue C., Yang C., and Jao J., Modifications on pH sensitivity of Si3N4 membrane by CF4 plasma and rapid thermal annealing for ISFET/REFET applications. 2006 International Conference on Solid State Devices and Materials, 11-15. [23] Yao, P., Chiang, J., & Lee, M. (2014). Application of sol–gel TiO2 film for an extended-gate H+ ion-sensitive field-effect transistor. Solid State Sciences, 28, 47–54. [24] Huang, Y.-J., Lin, C.-C., Huang, J.-C., Hsieh, C.-H., Wen, C.-H., Chen, T.-T., Jeng, L.-S., Yang, C.-K., Yang, J.-H., Tsui, F., Liu, Y.-S., Liu, S., & Chen, M. (2015). 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Fabrication of high-performance dual-gate ISFET PH sensors using In2O3 nano-channel, Current Research in Biotechnology, 6, 100149. [30] Srikanya, D., Bhat, A.M. and Sahu, C. (2023). Design and analysis of high-performance double-gate ZnO nano-structured thin-film ISFET for pH sensing applications, Microelectronics Journal, 137, 105811. [30] Chiang, J., Jan, S., Chou, J., & Chen, Y. (2001). Study on the temperature effect, hysteresis and drift of pH-ISFET devices based on amorphous tungsten oxide. Sensors and Actuators. B, Chemical, 76(1–3), 624–628. [31] Fathil, M., Arshad, M. M., Gopinath, S. C., Hashim, U., Adzhri, R., Ayub, R., Ruslinda, A., MN, M. N., Azman, A., Zaki, M., & Tang, T. (2015). Diagnostics on acute myocardial infarction: Cardiac troponin biomarkers. Biosensors & Bioelectronics/Biosensors & Bioelectronics (Online), 70, 209–220. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/93460 | - |
| dc.description.abstract | 隨著全球各國陸續進入高齡化的社會，醫療問題顯得日益重要，根據多項研究指出，心血管疾病佔據所有疾病死因之冠，如急性心肌梗塞等都是人類健康的一大威脅。
因此，本篇論文主要探討如何製作出一個有良好穩定度，精確又能快速檢驗的生物感測器。我們將從半導體元件設計為核心，採用不同結構、不同面積、並進一步針對感測膜材料進行談討。再者，我們使用表面改質的方法，使表面種上抗體，使元件能有效檢測出抗原的濃度。接著，進行選擇比測試，說明元件具有的專一性吸附的特性。最後進行穩定度測試，驗證何種感測膜能夠有最少的時間飄移，以減少元件所造成的誤差。 在這篇論文中，我們驗證了多種大小、不同材料的元件，得到Al2O3有良好的穩定性，同時最大面積的Al2O3感測膜靈敏度甚至能夠達到50.4 mV/decade 的Troponin I量測。若未來能進一步結合大數據的資料及AI模型的訓練，將能夠有效解決時間飄移的問題，使臨床上有更穩定的表現，實現快速，精準的醫療檢測器。 | zh_TW |
| dc.description.abstract | As global populations continue to age, healthcare issues become increasingly important. Numerous studies have identified cardiovascular diseases as the leading cause of mortality, presenting significant threats to human health, including acute myocardial infarction.
This paper addresses the development of a stable, precise, and rapid biosensor. It focuses on semiconductor device design, exploring various structures and areas, and deep into discussions regarding sensing membrane materials. Additionally, surface modification techniques are employed to immobilize antibodies on the surface, enabling effective detection of antigen concentrations. Subsequent selectivity tests demonstrate the specificity of the device. Finally, stability tests are conducted to discover which sensing membrane exhibits minimal drift over time. Through this study, we validate multiple devices of varying sizes and materials, identifying Al2O3 exhibited excellent sensitivity and stability. Furthermore, the largest area Al2O3 sensing membrane demonstrates a sensitivity of up to 50.4 mV/decade for Troponin I measurement. We hope to have the integration of big data and AI model training in future research holds promise for effectively addressing drift issues, leading to more stable performance in clinical settings and facilitating rapid and accurate medical diagnostics. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2024-08-01T16:14:36Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2024-08-01T16:14:36Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員會審定書 i
致謝 ii 摘要 iii Abstract iv Table of Contents vi List of Figures viii List of Tables xii Chapter 1 Preamble 1 1.1 Motivation 1 1.2 Objective 2 1.3 Thesis structure 3 1.4 Research Questions and Hypotheses 4 Chapter 2 Introduction 6 2.1 Introduction of Ion-Sensitive Field-Effect Transistors (ISFET) structure 6 2.3 Extended-Gate Ion-Sensitive Field-Effect Transistors (EG-ISFET) 12 2.4 ISFET Usage 13 2.5 Design Improvement 14 2.6 Non ideal effect 16 2.7 Target Biomarker and detection range for myocardial infarction 16 Chapter 3 Experiment Design and Procedure 18 3.1 Extend-Gate ISFET design and fabrication 18 3.2 Process Flow after chip out 24 3.3 Post Processing 25 3.4 Wire Bonding and Package 33 3.5 Surface Modification 35 Chapter 4 Result and Discussion 39 4.1 ISFET measurement system 39 4.2 pH measurement 40 4.3 Threshold voltage and voltage sensitivity 41 4.4 Drift effect 42 4.5 Performance of ISFETs – pH measurement 43 4.6 Drifting issue of ISFET 57 4.7 Troponin Measurement 60 Chapter 5 Conclusion and Future Work 68 5.1 Conclusion 68 5.2 Future Work 69 References 71 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 心肌鈣蛋白I感測器 | zh_TW |
| dc.subject | 離子敏感型場效電晶體 | zh_TW |
| dc.subject | 感測膜材料對ISFET性能影響 | zh_TW |
| dc.subject | 感測膜面積研究 | zh_TW |
| dc.subject | 表面改質 | zh_TW |
| dc.subject | Ion-sensitive field-effect transistor | en |
| dc.subject | Area impact on ISFET performance | en |
| dc.subject | Troponin I sensor | en |
| dc.subject | Surface modification | en |
| dc.subject | Sensing membrane material effects on ISFET | en |
| dc.title | 離子敏感型場效電晶體設計於Troponin I感測之研究 | zh_TW |
| dc.title | An Implementation of Ion Sensitive Field Effect Transistors for Troponin I Detection | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 112-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 張子璿;黃建璋 | zh_TW |
| dc.contributor.oralexamcommittee | Tzu-Hsuan Chang;Jian-Jang Huang | en |
| dc.subject.keyword | 離子敏感型場效電晶體,心肌鈣蛋白I感測器,感測膜面積研究,感測膜材料對ISFET性能影響,表面改質, | zh_TW |
| dc.subject.keyword | Ion-sensitive field-effect transistor,Troponin I sensor,Area impact on ISFET performance,Sensing membrane material effects on ISFET,Surface modification, | en |
| dc.relation.page | 74 | - |
| dc.identifier.doi | 10.6342/NTU202402246 | - |
| dc.rights.note | 未授權 | - |
| dc.date.accepted | 2024-07-30 | - |
| dc.contributor.author-college | 重點科技研究學院 | - |
| dc.contributor.author-dept | 元件材料與異質整合學位學程 | - |
| 顯示於系所單位： | 元件材料與異質整合學位學程 | |
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