請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9181
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳玉怜(Yuh-Lien Chen) | |
dc.contributor.author | Pei-Jhen Wu | en |
dc.contributor.author | 吳珮甄 | zh_TW |
dc.date.accessioned | 2021-05-20T20:12:03Z | - |
dc.date.available | 2010-09-15 | |
dc.date.available | 2021-05-20T20:12:03Z | - |
dc.date.copyright | 2009-09-15 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-07-27 | |
dc.identifier.citation | Aggarwal BB (2000) Tumour Necrosis Factors Receptor Associated Signalling Molecules and Their Role in Activation of Apoptosis, JNK and NF-KappaB. Ann Rheum Dis 59 Suppl 1:i6-16.
Alam J, Stewart D, Touchard C, Boinapally S, Choi AM and Cook JL (1999) Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene. J Biol Chem 274:26071-26078. Aljada A, Ghanim H, Assian E and Dandona P (2002) Tumor Necrosis Factor-[Alpha ] Inhibits Insulin-Induced Increase in Endothelial Nitric Oxide Synthase and Reduces Insulin Receptor Content and Phosphorylation in Human Aortic Endothelial Cells. Metabolism 51:487-491. Bacon PA, Raza K, Banks MJ, Townend J and Kitas GD (2002) THE ROLE OF ENDOTHELIAL CELL DYSFUNCTION IN THE CARDIOVASCULAR MORTALITY OF RA. International Reviews of Immunology 21:1-17. Boyle JJ (2005) Macrophage Activation in Atherosclerosis: Pathogenesis and Pharmacology of Plaque Rupture. Curr Vasc Pharmacol 3:63-68. Cao J, Drummond G, Inoue K, Sodhi K, Li XY and Omura S (2008) Upregulation of Heme Oxygenase-1 Combined With Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats Through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress. Int J Mol Sci 9:2388-2406. Carlos TM, Dobrina A, Ross R and Harlan JM (1990) Multiple Receptors on Human Monocytes Are Involved in Adhesion to Cultured Human Endothelial Cells. J Leukoc Biol 48:451-456. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N and Williamson B (1975) An Endotoxin-Induced Serum Factor That Causes Necrosis of Tumors. Proc Natl Acad Sci U S A 72:3666-3670. Carter AM (2005) Inflammation, Thrombosis and Acute Coronary Syndromes. Diabetes and Vascular Disease Research 2:113-121. Chen JH, Wu CC, Hsiao G and Yen MH (2003) Magnolol Induces Apoptosis in Vascular Smooth Muscle. Naunyn Schmiedebergs Arch Pharmacol 368:127-133. Chen SC, Chang YL, Wang DL and Cheng JJ (2006) Herbal Remedy Magnolol Suppresses IL-6-Induced STAT3 Activation and Gene Expression in Endothelial Cells. Br J Pharmacol 148:226-232. Chen YH, Lin FY, Liu PL, Huang YT, Chiu JH, Chang YC, Man KM, Hong CY, Ho YY and Lai MT (2009) Antioxidative and Hepatoprotective Effects of Magnolol on Acetaminophen-Induced Liver Damage in Rats. Arch Pharm Res 32:221-228. Chiu JH, Wang JC, Lui WY, Wu CW and Hong CY (1999) Effect of Magnolol on in Vitro Mitochondrial Lipid Peroxidation and Isolated Cold-Preserved Warm-Reperfused Rat Livers. J Surg Res 82:11-16. Christou H, Bailey N, Kluger MS, Mitsialis SA and Kourembanas S (2005) Extracellular Acidosis Induces Heme Oxygenase-1 Expression in Vascular Smooth Muscle Cells. Am J Physiol Heart Circ Physiol 288:H2647-H2652. Deramaudt BM, Braunstein S, Remy P and Abraham NG (1998) Gene Transfer of Human Heme Oxygenase into Coronary Endothelial Cells Potentially Promotes Angiogenesis. J Cell Biochem 68:121-127. Dulak J, Deshane J, Jozkowicz A and Agarwal A (2008) Heme Oxygenase-1 and Carbon Monoxide in Vascular Pathobiology: Focus on Angiogenesis. Circulation 117:231-241. Hess S, Methe H, Kim JO and Edelman ER (2009) NF-KappaB Activity in Endothelial Cells Is Modulated by Cell Substratum Interactions and Influences Chemokine-Mediated Adhesion of Natural Killer Cells. Cell Transplant 18:261-273. Holvoet P and Collen D (1994) Oxidized Lipoproteins in Atherosclerosis and Thrombosis. FASEB J 8:1279-1284. Huang SH, Chen Y, Tung PY, Wu JC, Chen KH, Wu JM and Wang SM (2007) Mechanisms for the Magnolol-Induced Cell Death of CGTH W-2 Thyroid Carcinoma Cells. J Cell Biochem 101:1011-1022. Huot J, Houle F, Marceau F and Landry J (1997) Oxidative Stress-Induced Actin Reorganization Mediated by the P38 Mitogen-Activated Protein Kinase/Heat Shock Protein 27 Pathway in Vascular Endothelial Cells. Circ Res 80:383-392. Ishikawa K, Navab M, Leitinger N, Fogelman AM and Lusis AJ (1997) Induction of Heme Oxygenase-1 Inhibits the Monocyte Transmigration Induced by Mildly Oxidized LDL. J Clin Invest 100:1209-1216. Jin YC, Kim KJ, Kim YM, Ha YM, Kim HJ, Yun UJ, Bae KH, Kim YS, Kang SS, Seo HG, Lee JH and Chang KC (2008) Anti-Apoptotic Effect of Magnolol in Myocardial Ischemia and Reperfusion Injury Requires Extracellular Signal-Regulated Kinase1/2 Pathways in Rat in Vivo. Exp Biol Med (Maywood ) 233:1280-1288. Kang YH and Lee SJ (2008) The Role of P38 MAPK and JNK in Arsenic Trioxide-Induced Mitochondrial Cell Death in Human Cervical Cancer Cells. J Cell Physiol 217:23-33. Karin M (1996) The Regulation of AP-1 Activity by Mitogen-Activated Protein Kinases. Philos Trans R Soc Lond B Biol Sci 351:127-134. Katori M, Buelow R, Ke B, Ma J, Coito AJ, Iyer S, Southard D, Busuttil RW and Kupiec-Weglinski JW (2002) Heme Oxygenase-1 Overexpression Protects Rat Hearts From Cold Ischemia/Reperfusion Injury Via an Antiapoptotic Pathway. Transplantation 73:287-292. Kawamura K, Ishikawa K, Wada Y, Kimura S, Matsumoto H, Kohro T, Itabe H, Kodama T and Maruyama Y (2005) Bilirubin From Heme Oxygenase-1 Attenuates Vascular Endothelial Activation and Dysfunction. Arterioscler Thromb Vasc Biol 25:155-160. Ke B, Shen XD, Melinek J, Gao F, Ritter T, Volk HD, Busuttil RW and Kupiec-Weglinski JW (2001) Heme Oxygenase-1 Gene Therapy: a Novel Immunomodulatory Approach in Liver Allograft Recipients? Transplant Proc 33:581-582. KOHCHI CHIE, INAGAWA HIRO, NISHIZAWA TAKA and SOMA GI (2009) ROS and Innate Immunity. Anticancer Research 29:817-821. Kyriakis JM and Avruch J (1996) Protein Kinase Cascades Activated by Stress and Inflammatory Cytokines. Bioessays 18:567-577. Latchman DS (2004) Protective Effect of Heat Shock Proteins in the Nervous System. Curr Neurovasc Res 1:21-27. Lavrovsky Y, Song CS, Chatterjee B and Roy AK (2000) Age-Dependent Increase of Heme Oxygenase-1 Gene Expression in the Liver Mediated by NF[Kappa]B. Mechanisms of Ageing and Development 114:49-60. Lee BC, Doo HK, Lee HJ, Jin SY, Jung JH, Hong SJ, Lee SH, Kim SD, Park JK, Leem KH and Ahn SY (2004) The Inhibitory Effects of Aqueous Extract of Magnolia Officinalis on Human Mesangial Cell Proliferation by Regulation of Platelet-Derived Growth Factor-BB and Transforming Growth Factor-Beta1 Expression. J Pharmacol Sci 94:81-85. Lee DH, Szczepanski MJ and Lee YJ (2009a) Magnolol Induces Apoptosis Via Inhibiting the EGFR/PI3K/Akt Signaling Pathway in Human Prostate Cancer Cells. J Cell Biochem 106:1113-1122. Lee J, Jung E, Park J, Jung K, Lee S, Hong S, Park J, Park E, Kim J, Park S and Park D (2005) Anti-Inflammatory Effects of Magnolol and Honokiol Are Mediated Through Inhibition of the Downstream Pathway of MEKK-1 in NF-KappaB Activation Signaling. Planta Med 71:338-343. Lee SJ, Cho YH, Park K, Kim EJ, Kang BS, Jung KH, Kim CH, Kim WJ and Moon SK (2009b) Inhibitory Effects of the Aqueous Extract of Magnolia Officinalis on the Responses of Human Urinary Bladder Cancer 5637 Cells in Vitro and Mouse Urinary Bladder Tumors Induced by N-Butyl-N-(4-Hydroxybutyl) Nitrosamine in Vivo. Phytother Res 23:20-27. Lee SJ, Park SS, Lee US, Kim WJ and Moon SK (2008) Signaling Pathway for TNF-Alpha-Induced MMP-9 Expression: Mediation Through P38 MAP Kinase, and Inhibition by Anti-Cancer Molecule Magnolol in Human Urinary Bladder Cancer 5637 Cells. Int Immunopharmacol 8:1821-1826. Lee YK, Yuk DY, Kim TI, Kim YH, Kim KT, Kim KH, Lee BJ, Nam SY and Hong JT (2009c) Protective Effect of the Ethanol Extract of Magnolia Officinalis and 4-O-Methylhonokiol on Scopolamine-Induced Memory Impairment and the Inhibition of Acetylcholinesterase Activity. Nat Med (Tokyo) 63:274-282. Lee YM, Hsiao G, Chen HR, Chen YC, Sheu JR and Yen MH (2001) Magnolol Reduces Myocardial Ischemia/Reperfusion Injury Via Neutrophil Inhibition in Rats. Eur J Pharmacol 422:159-167. Levonen AL, Inkala M, Heikura T, Jauhiainen S, Jyrkkanen HK, Kansanen E, Maatta K, Romppanen E, Turunen P, Rutanen J and Yla-Herttuala S (2007) Nrf2 Gene Transfer Induces Antioxidant Enzymes and Suppresses Smooth Muscle Cell Growth in Vitro and Reduces Oxidative Stress in Rabbit Aorta in Vivo. Arterioscler Thromb Vasc Biol 27:741-747. Li HB, Yi X, Gao JM, Ying XX, Guan HQ and Li JC (2007) Magnolol-Induced H460 Cells Death Via Autophagy but Not Apoptosis. Arch Pharm Res 30:1566-1574. Loetscher H, Pan YC, Lahm HW, Gentz R, Brockhaus M, Tabuchi H and Lesslauer W (1990) Molecular Cloning and Expression of the Human 55 Kd Tumor Necrosis Factor Receptor. Cell 61:351-359. Ma J, Lau CK, Obed A, Dada A, Doenecke A, Fan ST, Schlitt HJ and Tsui TY (2009) A Cell Penetrating Heme Oxygenase Protein Protects Heart Graft Against Ischemia/Reperfusion Injury. Gene Ther 16:320-328. Maines MD (1997) The Heme Oxygenase System: a Regulator of Second Messenger Gases. Annu Rev Pharmacol Toxicol 37:517-554. Miralem T, Hu Z, Torno MD, Lelli KM and Maines MD (2005) Small Interference RNA-Mediated Gene Silencing of Human Biliverdin Reductase, but Not That of Heme Oxygenase-1, Attenuates Arsenite-Mediated Induction of the Oxygenase and Increases Apoptosis in 293A Kidney Cells. J Biol Chem 280:17084-17092. Ng DS and Hegele RA (1993) High-Density-Lipoprotein Cholesterol and Atherosclerosis. CMAJ 149:1807-1808. Noguchi T, Ishii K, Fukutomi H, Naguro I, Matsuzawa A, Takeda K and Ichijo H (2008) Requirement of Reactive Oxygen Species-Dependent Activation of ASK1-P38 MAPK Pathway for Extracellular ATP-Induced Apoptosis in Macrophage. J Biol Chem 283:7657-7665. Old LJ (1985) Tumor Necrosis Factor (TNF). Science 230:630-632. Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein MM, Wong J, Deshane J, Bolisetty S, Shaposhnik Z, Shih DM, Agarwal A, Lusis AJ and Araujo JA (2007) Heme Oxygenase-1 Expression in Macrophages Plays a Beneficial Role in Atherosclerosis. Circ Res 100:1703-1711. Park J, Lee J, Jung E, Park Y, Kim K, Park B, Jung K, Park E, Kim J and Park D (2004) In Vitro Antibacterial and Anti-Inflammatory Effects of Honokiol and Magnolol Against Propionibacterium Sp. European Journal of Pharmacology 496:189-195. Perrella MA and Yet SF (2003) Role of Heme Oxygenase-1 in Cardiovascular Function. Curr Pharm Des 9:2479-2487. Petrache I, Otterbein LE, Alam J, Wiegand GW and Choi AM (2000) Heme Oxygenase-1 Inhibits TNF-Alpha-Induced Apoptosis in Cultured Fibroblasts. Am J Physiol Lung Cell Mol Physiol 278:L312-L319. Pober JS and Min W (2006) Endothelial Cell Dysfunction, Injury and Death. Handb Exp Pharmacol135-156. RITOSSA P (1962) [Problems of Prophylactic Vaccinations of Infants.]. Riv Ist Sieroter Ital 37:79-108. Ross R (1990) Mechanisms of Atherosclerosis--a Review. Adv Nephrol Necker Hosp 19:79-86. Ross R and Glomset JA (1973) Atherosclerosis and the Arterial Smooth Muscle Cell: Proliferation of Smooth Muscle Is a Key Event in the Genesis of the Lesions of Atherosclerosis. Science 180:1332-1339. Ryter SW, Alam J and Choi AM (2006) Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications. Physiol Rev 86:583-650. Sakon S, Xue X, Takekawa M, Sasazuki T, Okazaki T, Kojima Y, Piao JH, Yagita H, Okumura K, Doi T and Nakano H (2003) NF-KappaB Inhibits TNF-Induced Accumulation of ROS That Mediate Prolonged MAPK Activation and Necrotic Cell Death. EMBO J 22:3898-3909. Sawle P, Foresti R, Mann BE, Johnson TR, Green CJ and Motterlini R (2005) Carbon Monoxide-Releasing Molecules (CO-RMs) Attenuate the Inflammatory Response Elicited by Lipopolysaccharide in RAW264.7 Murine Macrophages. Br J Pharmacol 145:800-810. Seo JJ, Lee SH, Lee YS, Kwon BM, Ma Y, Hwang BY, Hong JT and Oh KW (2007) Anxiolytic-Like Effects of Obovatol Isolated From Magnolia Obovata: Involvement of GABA/Benzodiazepine Receptors Complex. Prog Neuropsychopharmacol Biol Psychiatry 31:1363-1369. Shen CC, Ni CL, Shen YC, Huang YL, Kuo CH, Wu TS and Chen CC (2009) Phenolic Constituents From the Stem Bark of Magnolia Officinalis. J Nat Prod 72:168-171. Shen Y, Pang EC, Xue CC, Zhao ZZ, Lin JG and Li CG (2008) Inhibitions of Mast Cell-Derived Histamine Release by Different Flos Magnoliae Species in Rat Peritoneal Mast Cells. Phytomedicine 15:808-814. Shen YC, Sung YJ and Chen CF (1998) Magnolol Inhibits Mac-1 (CD11b/CD18)-Dependent Neutrophil Adhesion: Relationship With Its Antioxidant Effect. Eur J Pharmacol 343:79-86. Sikorski EM, Hock T, Hill-Kapturczak N and Agarwal A (2004) The Story So Far: Molecular Regulation of the Heme Oxygenase-1 Gene in Renal Injury. Am J Physiol Renal Physiol 286:F425-F441. Steinberg D, Parthasarathy S, Carew TE, Khoo JC and Witztum JL (1989) Beyond Cholesterol. Modifications of Low-Density Lipoprotein That Increase Its Atherogenicity. N Engl J Med 320:915-924. Sue YM, Cheng CF, Chang CC, Chou Y, Chen CH and Juan SH (2009) Antioxidation and Anti-Inflammation by Haem Oxygenase-1 Contribute to Protection by Tetramethylpyrazine Against Gentamicin-Induced Apoptosis in Murine Renal Tubular Cells. Nephrol Dial Transplant 24:769-777. Torres F, Quintana J, Diaz JG, Carmona AJ and Estevez F (2008) Trifolin Acetate-Induced Cell Death in Human Leukemia Cells Is Dependent on Caspase-6 and Activates the MAPK Pathway. Apoptosis 13:716-728. Tse AK, Wan CK, Zhu GY, Shen XL, Cheung HY, Yang M and Fong WF (2007) Magnolol Suppresses NF-KappaB Activation and NF-KappaB Regulated Gene Expression Through Inhibition of IkappaB Kinase Activation. Mol Immunol 44:2647-2658. Vachharajani TJ, Work J, Issekutz AC and Granger DN (2000) Heme Oxygenase Modulates Selectin Expression in Different Regional Vascular Beds. Am J Physiol Heart Circ Physiol 278:H1613-H1617. Wajant H, Pfizenmaier K and Scheurich P (2003) Tumor Necrosis Factor Signaling. Cell Death Differ 10:45-65. Wang LJ, Lee TS, Lee FY, Pai RC and Chau LY (1998) Expression of Heme Oxygenase-1 in Atherosclerotic Lesions. Am J Pathol 152:711-720. Witztum JL and Steinberg D (1991) Role of Oxidized Low Density Lipoprotein in Atherogenesis. J Clin Invest 88:1785-1792. Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y and Koizumi S (1999) Oxidative Stress Causes Enhanced Endothelial Cell Injury in Human Heme Oxygenase-1 Deficiency. J Clin Invest 103:129-135. Yagoda N, von RM, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S and Stockwell BR (2007) RAS-RAF-MEK-Dependent Oxidative Cell Death Involving Voltage-Dependent Anion Channels. Nature 447:864-868. Yang TC, Zhang SW, Sun LN, Wang H and Ren AM (2008) Magnolol Attenuates Sepsis-Induced Gastrointestinal Dysmotility in Rats by Modulating Inflammatory Mediators. World J Gastroenterol 14:7353-7360. Zappala G and Rechler MM (2009) IGFBP-3, Hypoxia and TNF-[Alpha] Inhibit Adiponectin Transcription. Biochemical and Biophysical Research Communications 382:785-789. Zhan Y, Kim S, Izumi Y, Izumiya Y, Nakao T, Miyazaki H and Iwao H (2003) Role of JNK, P38, and ERK in Platelet-Derived Growth Factor-Induced Vascular Proliferation, Migration, and Gene Expression. Arterioscler Thromb Vasc Biol 23:795-801. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9181 | - |
dc.description.abstract | 厚朴酚是從Magnolia officinalis萃取出的化合物,長久以來被用來治療發熱、頭痛、焦慮、腹瀉及氣喘。厚朴酚已有諸多藥理應用,包括治療缺血再灌注 損傷,也發現厚朴酚具有很強的抗氧化力及抗發炎的功效。血基質氧化酶-1可以將血基質分解成一氧化碳、鐵離子及膽綠素,在細胞中有重要的抗氧化能力。血基質氧化酶藉由防止細胞凋亡保護內皮細胞,可以調節血管緊張度,抑制血管壁的發炎反應,表示血基質氧化酶-1可能具有治療心血管疾病的潛能,所以本研究目的在於探討厚朴酚對TNF-α刺激人類主動脈內皮細胞內的血基質氧化酶-1是否有調節作用,並探討其相關訊息傳遞路徑,也以Apo-E缺乏小鼠模擬動脈硬化病變模式,探討厚朴酚是否能降低TNF-α刺激Apo-E缺乏小鼠體內的氧化壓力以及對於血基質氧化酶-1的表現是否有調控的作用。實驗結果顯示:投予TNF-α可抑制人類主動脈內皮細胞中血基質氧化酶-1的表現,而先以厚朴酚處理再投予TNF-α,則可回復受到TNF-α抑制的血基質氧化酶-1表現。實驗結果也發現TNF-α刺激會增加人類主動脈內皮細胞中ERK、JNK、p38的磷酸化,以厚朴酚處理細胞,再用TNF-α刺激,則可降低受到TNF-α刺激所增加的ERK、JNK、p38的磷酸化。實驗進一步發現加入PD98059 (ERK 抑制劑) 及SP600125 (JNK 抑制劑),再加入TNF-α刺激會降低血基質氧化酶-1的表現;而加入SB203580 (p38抑制劑) 處理,再以TNF-α刺激後則有上升的趨勢。在轉錄因子部分:發現TNF-α刺激會增加人類主動脈內皮細胞中NF-κB的表現,而先以厚朴酚處理,再以TNF-α刺激則會抑制NF-κB的表現。另外以Apo-E缺乏小鼠動脈血管壁切片中發現,單獨以TNF-α刺激組,其ROS的表現量有增加的現象,而先給予厚朴酚再以TNF-α刺激組,ROS的表現量有下降的趨勢,單獨給予厚朴酚組,ROS表現量也有下降的現象。另外,在組織免疫染色部分,給予厚朴酚再受到TNF-α刺激組,其血管斑塊處的血基質氧化酶-1表現會上升。綜合上述實驗結果得知:厚朴酚會調節TNF-α所抑制血基質氧化酶-1的表現,顯示厚朴酚對動脈硬化或發炎反應的治療有很大助益。 | zh_TW |
dc.description.abstract | Magnolol, a compound extracted from Magnolia officinalis, has long been used for the treatment of fever, headache, anxiety, diarrhoea, asthma, and stroke. It also exerts antithrombotic, anti-inflammatory and analgesic effects. A number of other pharmacological effects of magnolol have also been demonstrated, including prevention of ischemic-reperfusion injury, and, most importantly, strong antioxidant activity. More recently, it has been shown to effectively prevent neointimal hyperplasia in the balloon-injured aorta of cholesterol-fed rabbits. Heme oxygenase-1 (HO-1), an enzyme degrading heme to carbon monoxide, iron, and biliverdin, has been recognized as playing a crucial role in cellular defense against stressful conditions, not only related to heme release. HO-1 protects endothelial cells from apoptosis, is involved in blood-vessel relaxation regulating vascular tone, attenuates inflammatory response in the vessel wall, and participates in blood-vessel formation by means of angiogenesis and vasculogenesis. The purpose of this study was aimed to examine the effects of TNF-a on HO-1 expression in HAECs, and the effect of magnolol as a potential therapeutic agent, and the mechanisms involved in the effects of magnolol or TNF-a on HO-1 expression. In the present study, TNF-α treatment reduced HO-1 expression in HAECs as well as in Apo-E deficient mice. Magnolol increased the expression of HO-1 in TNF-α-treated HAECs. Phosphorylation studies of ERK1/2, JNK, and p38, three subgroups of mitogen-activated protein kinases (MAPKs) demonstrated that magnolol suppressed TNF-α-induced ERK1/2, JNK, and p38 phosphorylation. In the transcription level, magnolol suppressed TNF-a-treated NF-кB expression. In addition, magnolol effectively attenuated TNF-a-induced ROS production in Apo-E deficient mice. These results suggest that magnolol has a therapeutic potential in cardiovascular diseases through the upregulation of HO-1 expression. | en |
dc.description.provenance | Made available in DSpace on 2021-05-20T20:12:03Z (GMT). No. of bitstreams: 1 ntu-98-R96446006-1.pdf: 4314471 bytes, checksum: c584570ba26ed930e925025564436596 (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | 誌謝---------------------------------------------------------------------------------------------- i
中文摘要---------------------------------------------------------------------------------------- ii 英文摘要---------------------------------------------------------------------------------------- iii 壹、緒論---------------------------------------------------------------------------------------- 1 一、動脈硬化 (atherosclerosis) 與內皮細胞的關係----------------------------- 1 二、動脈硬化與腫瘤壞死因子的關係---------------------------------------------- 3 三、動脈硬化和mitogen activated protein kinases (MAPKs) 的關係--------- 3 四、動脈硬化與轉錄因子的關係--------------------------------------------------- 4 五、血基質氧化酶-1 (heme oxygenase-1, HO-1) ------------------------------- 4 六、厚朴酚------------------------------------------------------------------------------- 7 七、研究動機---------------------------------------------------------------------------- 9 貳、實驗材料---------------------------------------------------------------------------------- 10 叁、實驗方法---------------------------------------------------------------------------------- 18 肆、實驗結果---------------------------------------------------------------------------------- 27 伍、結論與討論------------------------------------------------------------------------------- 31 陸、附圖---------------------------------------------------------------------------------------- 35 柒、參考資料--------------------------------------------------------------------------------- 45 | |
dc.language.iso | zh-TW | |
dc.title | 厚朴酚增加TNF-α處理之內皮細胞與Apo-E缺乏小鼠動脈的heme oxygenase-1表現 | zh_TW |
dc.title | Magnolol increases the expression of heme oxygenase-1 in tumor necrosis factor-α-treated endothelial cells and aortas of Apo-E deficient mice | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 王淑美(Seu-Mei Wang),姜安娜(An-Na Chiang),陳永祥(Yung-Hsiang Chen) | |
dc.subject.keyword | 腫瘤壞死因子,人類主動脈內皮細胞,厚朴酚,血基質氧化酶,-1, | zh_TW |
dc.subject.keyword | TNF-α,HAECs,magnolol,heme oxygenase-1, | en |
dc.relation.page | 58 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2009-07-27 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 解剖學暨生物細胞學研究所 | zh_TW |
顯示於系所單位: | 解剖學暨細胞生物學科所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-98-1.pdf | 4.21 MB | Adobe PDF | 檢視/開啟 |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。