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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林璧鳳 | zh_TW |
| dc.contributor.advisor | Bi-Fong Lin | en |
| dc.contributor.author | 李佩儒 | zh_TW |
| dc.contributor.author | Pei-Ru Li | en |
| dc.date.accessioned | 2024-02-22T16:16:41Z | - |
| dc.date.available | 2024-02-23 | - |
| dc.date.copyright | 2024-02-22 | - |
| dc.date.issued | 2024 | - |
| dc.date.submitted | 2024-01-28 | - |
| dc.identifier.citation | 盧頡 (2021)。母乳短鏈脂肪酸組成與異位性皮膚炎的相關性探討。國立臺灣大學生化科技學系碩士論文。
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/91695 | - |
| dc.description.abstract | 異位性皮膚炎 (atopic dermatitis, AD) 是一種常見的慢性發炎皮膚疾病，尤其在台灣AD的發病率持續上升，主要好發於嬰兒及幼童。AD所導致的皮膚乾癢、紅腫等症狀對嬰幼兒的健康產生嚴重影響。近年來，AD發病機制越來越關注到腸道微生物，特別是其代謝產物短鏈脂肪酸 (short-chain fatty acids, SCFAs)。已經有證據表明SCFAs在調節免疫反應和維護皮膚健康方面扮演關鍵角色。因此，本研究旨在探討嬰兒糞便中的短鏈脂肪酸組成，包括與異位性皮膚炎之間的相關性。本研究與台大小兒過敏門診合作，收集6個月齡的嬰兒糞便樣本，並分析AD組 (n=70) 和對照組 (Ctrl)(n=49) 嬰兒的糞便短鏈脂肪酸濃度。同時，也收集嬰兒近1個月的飲食分析表，計算其膳食纖維攝取量。首先以氣相層析-質譜 (gas chromatography-mass spectrometry, GC-MS) 建立糞便短鏈脂肪酸檢測方法，並進行確效測試。結果顯示，使用0.25% HCl ACN前處理的各個短鏈脂肪酸在檢量線濃度範圍內呈現良好的線性關係 (R2>0.99)，糞便樣品無明顯的基質效應，且具有良好的精密度及準確度，符合化學檢驗法的確效規範。依據此方法測得嬰兒糞便乙酸 (C2) 濃度為17.3-192 μmol/g、丙酸 (C3) 濃度為0.21-31 μmol/g、丁酸 (C4) 濃度為0-9 μmol/g，而戊酸與己酸則未能在糞便中檢測。與Ctrl組相比，AD組嬰兒的糞便乙酸、C2+C3+C4的濃度顯著較低，丙酸、丁酸也有較低的趨勢。另外，丙酸濃度與AD的疾病嚴重程度呈負相關。嬰兒飲食調查的結果發現，中度AD組嬰兒的膳食纖維攝取量顯著低於控制組，且膳食纖維量與AD的疾病嚴重程度呈負相關；嬰兒飲食內的膳食纖維量與糞便內乙酸、丙酸、C2+C3+C4呈正相關。此外，也有發現嬰兒飲食補充益生菌可提高糞便內丙酸、丁酸的濃度。綜上所述，罹患AD的嬰兒具有較低的糞便短鏈脂肪酸，而飲食的膳食纖維與益生菌，可能有助於提高短鏈脂肪酸濃度。 | zh_TW |
| dc.description.abstract | Atopic dermatitis (AD) is a common chronic inflammatory skin disorder, and its incidence has been steadily increasing in Taiwan, particularly among infants and young children. The symptoms of AD, such as dry and inflamed skin, can severely impact health. In recent years, research on the pathogenesis of AD has increasingly focused on the gut microbiota, specifically its metabolic products known as short-chain fatty acids (SCFAs). Evidence suggests that SCFAs are crucial in regulating immune responses and maintaining skin health. Therefore, this study aims to investigate the correlation between the composition of fecal SCFAs and atopic dermatitis in infants. This study collaborated with the Division of Pediatric Allergy of NTU hospital, collecting fecal samples from 6-month-old infants and analyzing the concentrations of SCFAs in both AD group (n=70) and control group (Ctrl) (n=49) of infants. Dietary intake data for infants were also collected to analyze their dietary fiber intake. The fecal SCFAs detection method was established using gas chromatography-mass spectrometry (GC-MS), and a validation test was conducted. The results showed that SCFAs, pretreated with 0.25% HCl ACN, exhibited good linear relationships of the calibration curves (R2>0.999), with no significant matrix effects in fecal samples. The method also demonstrated good precision and accuracy, complying with the validation guidelines. Using this method, the concentration of acetic acid (C2) in infant feces was measured to be 17.3-192 μmol/g, propionic acid (C3) ranged from 0.21-31 μmol/g, and butyric acid (C4) ranged from 0-9 μmol/g. However, valeric acid and caproic acid were not detected in feces. When compared to the control group, infants in the AD group had significantly lower concentration of acetic acid, C2+C3+C4, and a trend of lower propionic acid and butyric acid in feces. Furthermore, there was a negative correlation between propionic acid and the severity of AD. Dietary analysis showed that those with moderate AD had significantly lower dietary fiber intake, and dietary fiber intake was negatively correlated with the severity of AD. The amount of dietary fiber was positively correlated with fecal acetic acid, propionic acid, and C2+C3+C4 concentration. Additionally, it was observed that supplementing infants' diets with probiotics increased fecal propionic acid and butyric acid concentration. In summary, infants with AD had lower fecal SCFAs levels. Dietary fiber and probiotics in their diets may help increase SCFAs concentration. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2024-02-22T16:16:41Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2024-02-22T16:16:41Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員會審定書 I
誌謝 II 摘要 III ABSTRACT IV 目次 VI 圖次 IX 表次 X 縮寫對照表 XI 第一章 緒論 1 第一節 文獻回顧 1 一、 異位性皮膚炎 1 (一) 異位性皮膚炎流行病學 1 (二) 異位性皮膚炎與過敏疾病 1 (三) 異位性皮膚炎症狀及診斷 2 (四) 異位性皮膚炎成因 3 (五) 異位性皮膚炎的病理機制 4 (六) 兒童與成人異位性皮膚炎 5 (七) 異位性皮膚炎的治療 6 二、 糞便的組成 7 (一) 糞便微生物 7 (二) 糞便蛋白質或含氮物質 7 (三) 糞便碳水化合物或纖維 8 (四) 糞便脂質 8 三、 短鏈脂肪酸 9 (一) 腸道短鏈脂肪酸的分佈 9 (二) 飲食與短鏈脂肪酸 9 (三) 短鏈脂肪酸的生成途徑 10 (四) 腸道短鏈脂肪酸的吸收 11 (五) 短鏈脂肪酸的受體 12 (六) 短鏈脂肪酸的作用 13 (七) 短鏈脂肪酸與免疫細胞 15 (八) 短鏈脂肪酸組成與疾病 16 四、 膳食纖維 20 (一) 定義與種類 20 (二) 膳食纖維對於腸道微生物之影響 20 (三) 膳食纖維對於免疫之影響 21 第二節 研究動機與目的 22 第二章 嬰兒糞便短鏈脂肪酸檢測方法的建立與確效 23 第一節 前言 23 第二節 材料與方法 24 【儀器/耗材】 24 【標準品/藥品】 24 【方法】 25 一、 分析條件設定 25 二、 方法確效測試 26 第三節 結果 29 一、 分析條件設定 29 1. 選擇配製溶液 29 2. 標準品與內標準品配製 30 3. 氣相層析儀-質譜儀設置參數 31 二、 方法確效測試 34 1. 短鏈脂肪酸之檢量線線性評估 34 2. 檢測結果專一性評估 35 3. GC-MS之檢測極限和定量極限 37 4. 檢測結果準確度評估 37 5. 檢測結果精密度評估 40 第三章 嬰兒糞便短鏈脂肪酸組成與異位性皮膚炎的相關性 41 第一節 前言 41 第二節 材料與方法 42 一、 研究對象與實驗流程 42 二、 嬰兒糞便收集與短鏈脂肪酸分析 42 1. 糞便檢體收集和保存 43 2. 糞便樣品前處理 43 3. 氣相層析儀-質譜儀設置條件 43 三、 嬰兒飲食分析表 43 四、 統計分析 43 第三節 結果 44 一、 異位性皮膚炎的嬰兒糞便短鏈脂肪酸組成 44 二、 嬰兒異位性皮膚炎嚴重程度與糞便短鏈脂肪酸的含量之相關性 47 三、 嬰兒異位性皮膚炎的膳食纖維的攝取量 48 四、 嬰兒膳食纖維攝取量與糞便短鏈脂肪酸之相關性 50 五、 補充益生菌與罹患異位性皮膚炎對嬰兒糞便短鏈脂肪酸濃度的影響 51 第四章 綜合討論與結論 52 第一節 綜合討論 52 一、 嬰兒糞便短鏈脂肪酸檢測方法建立 52 二、 嬰兒糞便短鏈脂肪酸與異位性皮膚炎之相關性 53 三、 嬰兒膳食纖維攝取量與異位性皮膚炎之相關性 54 四、 嬰兒膳食纖維攝取量與糞便短鏈脂肪酸之相關性 55 五、 補充益生菌與罹患異位性皮膚炎對嬰兒糞便短鏈脂肪酸濃度的影響 55 六、 實驗限制 56 第二節 結論 57 參考文獻 58 附錄 71 | - |
| dc.language.iso | zh_TW | - |
| dc.title | 嬰兒糞便的短鏈脂肪酸組成與異位性皮膚炎之相關性 | zh_TW |
| dc.title | The correlation between the fecal short-chain fatty acids composition and atopic dermatitis in infants | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 112-1 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 江伯倫;王麗潔;蘇南維;江孟燦 | zh_TW |
| dc.contributor.oralexamcommittee | Bor-Luen Chiang;Li-Chieh Wang;Nan-Wei SU;Meng-Tsan Chiang | en |
| dc.subject.keyword | 異位性皮膚炎,短鏈脂肪酸,膳食纖維,糞便,飲食, | zh_TW |
| dc.subject.keyword | atopic dermatitis,short-chain fatty acids,dietary fiber,feces,diet, | en |
| dc.relation.page | 74 | - |
| dc.identifier.doi | 10.6342/NTU202400145 | - |
| dc.rights.note | 未授權 | - |
| dc.date.accepted | 2024-01-30 | - |
| dc.contributor.author-college | 生命科學院 | - |
| dc.contributor.author-dept | 生化科技學系 | - |
| 顯示於系所單位： | 生化科技學系 | |
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