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標題: | 通過表面化學進行功能性材料排列控制及其分析應用 Functional Material Alignment Controls for Analytical Applications Through Surface Chemistry |
作者: | 張鐘云 Chung-Yun Chang |
指導教授: | 廖尉斯 Wei-Ssu Laio |
關鍵字: | 液晶,液晶微陣列,空間控制技術, Liquid crystal,Liquid crystal microdroplet array,spatially-controlled molecular patterning technique, |
出版年 : | 2024 |
學位: | 博士 |
摘要: | 液晶分子是一種雙折射物質具有特殊的光學信號,常被作為感測器的訊號材料。常見的液晶感測系統在製備與偵測有些缺點仍須克服,如液晶-固相界面系統其製備過程複雜且耗時、液晶-水溶液界面系統使用銅網固定液晶分子的區域,使得液晶分子與銅網之間產生作用力產生亮的光學信號,造成訊號辨別的誤差,液晶液滴系統無法精確控制液晶液滴的位置與大小且液晶的訊號會因批次的變化而改變,這些缺點造成液晶檢測系統有較差的再現性與定量性。
空間控制技術是一種的常見的表面化學技術,可以將分子定向排列成特定的圖案或結構。本研究利用空間控制分子圖案化技術,將氧離子電漿活化後的PDMS印章與修飾N,N-dimethyl-N-octadecyl(3-aminopropyl) trimethoxysilyl chloride (DMOAP) 分子的玻璃基材表面接觸,讓印章與玻璃表面進行空間控制技術後將印章移除,讓玻璃表面產生與印章圖案相對應的分子圖案。液晶是一種功能性材料,其會因為自身的排列變化產生特殊的光學信號。我們將液晶分子沉積在分子圖案化後的玻璃表面,可以得到大面積的液晶微液滴陣列。液晶微液滴陣列可以藉由空間控制分子圖案化技術控制液晶液滴的大小與位置,提供液晶分子檢測一個高重複性且易定量的檢測陣列。液晶微液滴陣列應用於檢測水溶液中的汞離子 (Hg2+) ,其偵測極限為50 nM,低於傳統銅網液晶檢測系統的偵測極限200倍。液晶微液滴陣列提高液晶檢測系統的穩定性與降低檢測的極限。此外,3D 列印設計的多重檢測盒,可以將摻雜不同的分子探針的液晶微液滴陣列應用於同時檢測多種金屬離子 (Hg2+、Al3+、Fe3+) 和溶液酸鹼值。透過設計的排列方式可以將液晶分子的光學訊號轉換為數字顯示。液晶微液滴陣列應用在真實水樣檢測中有高的回收率(100%)。通過空間控制分子圖案化技術,可以實現具有靈活尺寸且均勻液晶微滴陣列的製備,並且比其他文獻的液晶感測器設計具有更大的檢測應用潛力。 Liquid crystal (LC) molecules, used as signal materials in sensors due to their unique optical signals, suffer drawbacks in common sensing systems. The LC-solid phase interface system involves complex and time-consuming preparation, while the LC-water solution interface, using copper mesh to fix LC molecules, creates forces causing bright optical signals and signal identification errors. Moreover, the LC droplet system lacks precise control over droplet position and size, leading to signal variation due to batch changes. These limitations result in reduced reproducibility and quantification in LC detection systems. In this study, we presented a spatially-controlled molecular patterning technique to prepare LC microdroplet arrays on glass substrates. This technique utilizes an oxygen plasma activated PDMS stamp to remove the pre-coated dimethyloctadecyl 3-(trimethoxysilyl) propyl ammonium chloride (DMOAP) molecules from glass substrates, producing a surface with complementary patterns and specific hydrophobicity. When LC molecules are introduced onto this produced molecular pattern, a LC microdroplet array with uniform droplet size and positional order is formed. By using the LC microdroplet array doped with a Hg2+ selective ligand, the lowest detectable concentration of Hg2+ is 200-fold lower than that of conventional LC-based sensors. In addition, multiplexed detection of Hg2+, Al3+, Fe3+ and pH value in real water samples with a high recovery rate (~100%) was demonstrated by using the LC microdroplet arrays doped with different molecular probes. Due to the specific arrangement of the LC microdroplet arrays, the collected optical signal of LC microarrays can be transformed into numerical symbols. The developed spatially controlled molecular patterning technique could be used to prepare highly uniform LC microdroplet arrays with consistent optical signals, providing a simple method to prepare the LC-based sensing platforms with improved sensing performance. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/91604 |
DOI: | 10.6342/NTU202400124 |
全文授權: | 未授權 |
顯示於系所單位: | 化學系 |
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