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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李宗徽 | zh_TW |
| dc.contributor.advisor | Tzong-Huei Lee | en |
| dc.contributor.author | 陳慧蓮 | zh_TW |
| dc.contributor.author | Hui-Lien Chen | en |
| dc.date.accessioned | 2023-10-03T17:20:59Z | - |
| dc.date.available | 2023-11-09 | - |
| dc.date.copyright | 2023-10-03 | - |
| dc.date.issued | 2023 | - |
| dc.date.submitted | 2023-08-08 | - |
| dc.identifier.citation | Carroll, A. R., Copp, B. R., Davis, R. A., Keyzers, R. A. & Prinsep, M. R. Marine natural products. Natural Product Reports 37, 175-223 (2020).
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Occurrence, isolation and biological activity of phytotoxic metabolites produced in vitro by Sphaeropsis sapinea, pathogenic fungus of Pinus radiata. European Journal of Plant Pathology 115, 187-193 (2006). | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/90725 | - |
| dc.description.abstract | 本研究自濱海植物防葵 (Peucedanum japonicum Thumb.) 中分離出真菌株Diaporthe ueckerae NTU1943，接著使用半淡海水馬鈴薯提取物葡萄糖培養基 (potato dextrose broth, PDB) 液態醱酵14天，以及以糙米進行固態醱酵30天，之後以乙酸乙酯進行分配萃取醱酵產物，再針對粗萃物以開放式管柱和高效液相層析儀 (HPLC) 進行分析、分離與純化，所得純質以核磁共振光譜 (NMR) 鑑定分子結構，再透過質譜 (MS)、紅外線光譜 (IR)、紫外光譜 (UV) 及旋光度 (optical rotation) 等數據佐證結構的正確性。計得到2個倍半萜 (sesquiterpenes)、1個單萜 (monoterpene)、2個苯乙烷類 (phenylethanoids)、6個δ-內酯類 (δ-lactones)、3個呫噸酮二聚物 (xanthone dimers) 和1個縮酚肽 (depsipeptide)，分別為altiloxin F (1)、altiloxin A (2)、p-menthane-1,2,4-triol (3)、phenylacetic acid (4)、tyrosol (5)、(3R)-5-hydroxymellein (6)、mellein (7)、(3R,4R)-4-hydroxymellein (8)、(3R,4S)-4-hydroxymellein (9)、(S)-8-O-methylmellein (10)、nectriapyrone (11)、diaporxanthone F (12)、dicerandrols A和B (13-14) 與fusaristatin A (15)，其中altiloxin F (1) 為未曾報導之新化合物。在抗病毒與抗菌活性測試上，顯示化合物8在4123 μM濃度下，對於貓傳染性腹膜炎病毒 (feline infectious peritonitis virus, FIPV) 具有弱的抗病毒活性；在抗水產致病菌評估中，所得純質皆無抗菌活性；化合物13在10 μM濃度下對EBV (Epstein-Barr virus) 抑制效果顯著，但同時對P3HR1細胞具有細胞毒性，且在20 μM濃度下對LPS誘導BV-2 細胞之一氧化氮 (NO) 具有明顯的抑制效果，其抑制率為113.7%，但觀察到其細胞存活率僅為9.3%，推測其NO產生的抑制效果同樣可能來自對細胞的毒殺活性。 | zh_TW |
| dc.description.abstract | In this study, a fungal strain Diaporthe ueckerae NTU1943 was isolated and identified from a littoral plant Peucedanum japonicum Thumb.. Column separation followed by HPLC purification of liquid-state and solid-state fermented products of the fungal strain was carried out, which has led to the isolation of fifteen compounds 1–15. Their structures were elucidated by spectroscopic analysis including NMR, MS, IR, UV, and optical rotational data to be two sesquiterpenes, one monoterpene, two phenylethanoids, six δ-lactones, three xanthone dimers, and one depsipeptide, and were named altiloxin F (1), altiloxin A (2), p-menthane-1,2,4-triol (3), phenylacetic acid (4), tyrosol (5), (3R)-5-hydroxymellein (6), mellein (7), (3R,4R)-4-hydroxymellein (8), (3R,4S)-4-hydroxymellein (9), (S)-8-O-methylmellein (10), nectriapyrone (11), diaporxanthone F (12), dicerandrols A and B (13 and 14), and fusaristatin A (15). Of these, 1 was a previously unreported chemical entity. Compound 8 exhibited slight antiviral activity against feline infectious peritonitis virus (FIPV) at a concentration of 4123 μM. All compounds showed no significant antibacterial activity. Dicerandrol A (13) exhibited significant Epstein-Barr virus (EBV) inhibitory activity, but it was possibly caused by its cytotoxicity in P3HR1 cells at a concentration of 10 μM. Dicerandrol A (13) showed significant NO production inhibitory activity, but it was possibly caused by its cytotoxicity in BV-2 cells at a concentration of 20 μM. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-10-03T17:20:59Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2023-10-03T17:20:59Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員會審定書 I
誌謝 II 中文摘要 III 英文摘要 IV 目錄 VI 圖目錄 IX 表目錄 XII 縮寫表 XIII 第一章 緒論與研究目的 1 第二章 文獻回顧 5 2.1 防葵 (Peucedanum japonicum Thumb.) 內生菌Diaporthe ueckerae之介紹 5 2.2 間座殼菌屬 (Diaporthe spp.) 真菌成分之文獻回顧 5 第三章 實驗結果 52 3.1 真菌株活性評估初步篩選 52 3.2 真菌種親緣關係 53 3.3 真菌液態醱酵萃取液分離流程 54 3.4 真菌固態醱酵萃取分離流程 56 3.5 天然物結構解析 58 3.5.1 Altiloxin F (1) 之結構解析 58 3.5.2 Altiloxin A (2) 之結構解析 67 3.5.3 p-Menthane-1,2,4-triol (3) 之結構解析 77 3.5.4 Phenylacetic acid (4) 之結構解析 82 3.5.5 Tyrosol (5) 之結構解析 88 3.5.6 (3R)-5-Hydroxymellein (6) 之結構解析 92 3.5.7 Mellein (7) 之結構解析 102 3.5.8 (3R,4R)-4-Hydroxymellein (8) 之結構解析 108 3.5.9 (3R,4S)-4-Hydroxymellein (9) 之結構解析 118 3.5.10 (S)-8-O-Methylmellein (10) 之結構解析 128 3.5.11 Nectriapyrone (11) 之結構解析 138 3.5.12 Diaporxanthone F (12) 之結構解析 144 3.5.13 Dicerandrol A (13) 之結構解析 152 3.5.14 Dicerandrol B (14) 之結構解析 158 3.5.15 Fusaristatin A (15) 之結構解析 168 3.6 各成分之物理數據 181 3.7 化合物活性平台測試 186 3.7.1 抗貓冠狀病毒實驗結果 186 3.7.2 抗第四型人類疱疹病毒實驗結果 189 3.7.3 一氧化氮抑制與細胞存活率之實驗結果 190 3.7.4 抗水產致病菌實驗結果 192 第四章 實驗部分 194 4.1 儀器設備與試劑 194 4.1.1 化合物之物理性質測定儀器 194 4.1.2 管柱層析膠體 194 4.1.3 試劑耗材與溶劑 194 4.1.4 真菌培養基 195 4.1.5 細菌培養基 195 4.2 實驗材料 195 4.2.1 真菌菌株分離與篩選 195 4.2.2 菌種分子鑑定 195 4.3 真菌培養與成分分離 198 4.3.1 培養基配置 198 4.3.2 真菌菌種保存 198 4.3.3 真菌液態醱酵萃取液 198 4.3.4 真菌液態醱酵萃取液之成分分離與純化 198 4.3.5 真菌固態醱酵萃取液 201 4.3.6 真菌固態醱酵萃取液之成分分離與純化 201 4.4 抗貓冠狀病毒活性篩選 202 4.5 抗第四型人類疱疹病毒活性評估 203 4.6 抗發炎活性評估 203 4.6.1 細胞培養 203 4.6.2 MTT assay 203 4.6.3 Griess reagent assay 204 4.7 抗水產致病菌活性評估 205 4.7.1 細菌培養基 205 4.7.2 檢測原理 205 4.7.3 測試菌種 205 4.7.4 實驗步驟 205 第五章 討論 207 第六章 參考文獻 210 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | Diaporthe ueckerae | zh_TW |
| dc.subject | 貓傳染性腹膜炎病毒 | zh_TW |
| dc.subject | altiloxin F | zh_TW |
| dc.subject | 人類第四型疱疹病毒 | zh_TW |
| dc.subject | 抗發炎 | zh_TW |
| dc.subject | altiloxin F | en |
| dc.subject | feline infectious peritonitis virus | en |
| dc.subject | Epstein-Barr virus | en |
| dc.subject | Diaporthe ueckerae | en |
| dc.subject | anti-inflammatory | en |
| dc.title | 防葵衍生真菌株Diaporthe ueckerae NTU1943之成分研究 | zh_TW |
| dc.title | Chemical Constituents from a Peucedanum japonicum Thumb.-derived Fungal Strain Diaporthe ueckerae NTU1943 | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 111-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 李慶國;陳日榮;陳慧文;蕭哲志 | zh_TW |
| dc.contributor.oralexamcommittee | Ching-Kuo Lee;Jih-Jung Chen;Hui-Wen Chen;George Hsiao | en |
| dc.subject.keyword | Diaporthe ueckerae,altiloxin F,貓傳染性腹膜炎病毒,人類第四型疱疹病毒,抗發炎, | zh_TW |
| dc.subject.keyword | Diaporthe ueckerae,altiloxin F,feline infectious peritonitis virus,Epstein-Barr virus,anti-inflammatory, | en |
| dc.relation.page | 221 | - |
| dc.identifier.doi | 10.6342/NTU202303090 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2023-08-09 | - |
| dc.contributor.author-college | 生命科學院 | - |
| dc.contributor.author-dept | 漁業科學研究所 | - |
| dc.date.embargo-lift | 2028-08-05 | - |
| 顯示於系所單位： | 漁業科學研究所 | |
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