請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/90591完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳光超 | zh_TW |
| dc.contributor.advisor | Guang-Chao Chen | en |
| dc.contributor.author | 李佳蓉 | zh_TW |
| dc.contributor.author | Chia-Jung Lee | en |
| dc.date.accessioned | 2023-10-03T16:46:10Z | - |
| dc.date.available | 2023-11-10 | - |
| dc.date.copyright | 2023-10-03 | - |
| dc.date.issued | 2023 | - |
| dc.date.submitted | 2023-08-04 | - |
| dc.identifier.citation | Ahlberg, J. and H. Glaumann (1985). "Uptake--microautophagy--and degradation of exogenous proteins by isolated rat liver lysosomes. Effects of pH, ATP, and inhibitors of proteolysis." Exp Mol Pathol 42(1): 78-88.
Ahlberg, J., L. Marzella and H. Glaumann (1982). "Uptake and degradation of proteins by isolated rat liver lysosomes. Suggestion of a microautophagic pathway of proteolysis." Lab Invest 47(6): 523-532. Aumais, J. P., J. R. Tunstead, R. S. McNeil, B. T. Schaar, S. K. McConnell, S. H. Lin, G. D. Clark and L. Y. Yu-Lee (2001). "NudC associates with Lis1 and the dynein motor at the leading pole of neurons." J Neurosci 21(24): RC187. Aumais, J. P., S. N. Williams, W. Luo, M. Nishino, K. A. Caldwell, G. A. Caldwell, S. H. Lin and L. Y. Yu-Lee (2003). "Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis." J Cell Sci 116(Pt 10): 1991-2003. Bakula, D., A. J. Mueller and T. Proikas-Cezanne (2018). "WIPI beta-propellers function as scaffolds for STK11/LKB1-AMPK and AMPK-related kinase signaling in autophagy." Autophagy 14(6): 1082-1083. Bakula, D., A. J. Muller, T. Zuleger, Z. Takacs, M. Franz-Wachtel, A. K. Thost, D. Brigger, M. P. Tschan, T. Frickey, H. Robenek, B. Macek and T. Proikas-Cezanne (2017). "WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy." Nat Commun 8: 15637. Biebl, M. M., F. Delhommel, O. Faust, K. M. Zak, G. Agam, X. Y. Guo, M. Muhlhofer, V. Dahiya, D. Hillebrand, G. M. Popowicz, M. Kampmann, D. C. Lamb, R. Rosenzweig, M. Sattler and J. Buchner (2022). "NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems." Molecular Cell 82(3): 555-+. Cappello, S., P. Monzo and R. B. Vallee (2011). "NudC is required for interkinetic nuclear migration and neuronal migration during neocortical development." Dev Biol 357(2): 326-335. Chen, Y. and D. J. Klionsky (2011). "The regulation of autophagy - unanswered questions." J Cell Sci 124(Pt 2): 161-170. Chiu, Y. H., X. Xiang, A. L. Dawe and N. R. Morris (1997). "Deletion of nudC, a nuclear migration gene of Aspergillus nidulans, causes morphological and cell wall abnormalities and is lethal." Mol Biol Cell 8(9): 1735-1749. Dooley, H. C., M. Razi, H. E. Polson, S. E. Girardin, M. I. Wilson and S. A. Tooze (2014). "WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1." Mol Cell 55(2): 238-252. Dove, S. K., R. C. Piper, R. K. McEwen, J. W. Yu, M. C. King, D. C. Hughes, J. Thuring, A. B. Holmes, F. T. Cooke, R. H. Michell, P. J. Parker and M. A. Lemmon (2004). "Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors." EMBO J 23(9): 1922-1933. Eskelinen, E. L. (2005). "Maturation of autophagic vacuoles in Mammalian cells." Autophagy 1(1): 1-10. Fader, C. M., D. G. Sanchez, M. B. Mestre and M. I. Colombo (2009). "TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways." Biochim Biophys Acta 1793(12): 1901-1916. Fracchiolla, D., C. Chang, J. H. Hurley and S. Martens (2020). "A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy." J Cell Biol 219(7). Fu, Q., W. Wang, T. Zhou and Y. Yang (2016). "Emerging roles of NudC family: from molecular regulation to clinical implications." Sci China Life Sci 59(5): 455-462. Fujita, N., T. Itoh, H. Omori, M. Fukuda, T. Noda and T. Yoshimori (2008). "The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy." Mol Biol Cell 19(5): 2092-2100. Furuta, N., N. Fujita, T. Noda, T. Yoshimori and A. Amano (2010). "Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes." Mol Biol Cell 21(6): 1001-1010. Gammoh, N. (2020). "The multifaceted functions of ATG16L1 in autophagy and related processes." J Cell Sci 133(20). Glick, D., S. Barth and K. F. Macleod (2010). "Autophagy: cellular and molecular mechanisms." J Pathol 221(1): 3-12. Hailey, D. W., A. S. Rambold, P. Satpute-Krishnan, K. Mitra, R. Sougrat, P. K. Kim and J. Lippincott-Schwartz (2010). "Mitochondria supply membranes for autophagosome biogenesis during starvation." Cell 141(4): 656-667. Hayashi-Nishino, M., N. Fujita, T. Noda, A. Yamaguchi, T. Yoshimori and A. Yamamoto (2009). "A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation." Nat Cell Biol 11(12): 1433-1437. Hayashi, T., T. Tomomizu, T. Sushida, M. Akiyama, S. I. Ei and M. Sato (2022). "Tiling mechanisms of the Drosophila compound eye through geometrical tessellation." Current Biology 32(9): 2101-+. He, C. and D. J. Klionsky (2009). "Regulation mechanisms and signaling pathways of autophagy." Annu Rev Genet 43: 67-93. Hor, C. H. H. and B. L. Tang (2019). "Beta-propeller protein-associated neurodegeneration (BPAN) as a genetically simple model of multifaceted neuropathology resulting from defects in autophagy." Rev Neurosci 30(3): 261-277. Hosokawa, N., T. Hara, T. Kaizuka, C. Kishi, A. Takamura, Y. Miura, S. Iemura, T. Natsume, K. Takehana, N. Yamada, J. L. Guan, N. Oshiro and N. Mizushima (2009). "Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy." Mol Biol Cell 20(7): 1981-1991. Itakura, E. and N. Mizushima (2010). "Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins." Autophagy 6(6): 764-776. Jager, S., C. Bucci, I. Tanida, T. Ueno, E. Kominami, P. Saftig and E. L. Eskelinen (2004). "Role for Rab7 in maturation of late autophagic vacuoles." J Cell Sci 117(Pt 20): 4837-4848. Jain, B. P. and S. Pandey (2018). "WD40 Repeat Proteins: Signalling Scaffold with Diverse Functions." Protein J 37(5): 391-406. Ji, C., H. Zhao, D. Chen, H. Zhang and Y. G. Zhao (2021). "beta-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells." Curr Biol 31(8): 1666-1677 e1666. Johnson, R. I. (2021). "Hexagonal patterning of the Drosophila eye." Dev Biol 478: 173-182. Kawabata, T. and T. Yoshimori (2016). "Beyond starvation: An update on the autophagic machinery and its functions." J Mol Cell Cardiol 95: 2-10. Kirisako, T., Y. Ichimura, H. Okada, Y. Kabeya, N. Mizushima, T. Yoshimori, M. Ohsumi, T. Takao, T. Noda and Y. Ohsumi (2000). "The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway." J Cell Biol 151(2): 263-276. Komatsu, M., S. Waguri, M. Koike, Y. S. Sou, T. Ueno, T. Hara, N. Mizushima, J. Iwata, J. Ezaki, S. Murata, J. Hamazaki, Y. Nishito, S. Iemura, T. Natsume, T. Yanagawa, J. Uwayama, E. Warabi, H. Yoshida, T. Ishii, A. Kobayashi, M. Yamamoto, Z. Yue, Y. Uchiyama, E. Kominami and K. Tanaka (2007). "Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice." Cell 131(6): 1149-1163. Koyama-Honda, I. and N. Mizushima (2022). "Transient visit of STX17 (syntaxin 17) to autophagosomes." Autophagy 18(6): 1213-1215. Krick, R., J. Tolstrup, A. Appelles, S. Henke and M. Thumm (2006). "The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy." FEBS Lett 580(19): 4632-4638. Kroemer, G., G. Marino and B. Levine (2010). "Autophagy and the integrated stress response." Mol Cell 40(2): 280-293. Li, D. and R. Roberts (2001). "WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases." Cell Mol Life Sci 58(14): 2085-2097. Marzella, L., J. Ahlberg and H. Glaumann (1981). "Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation." Virchows Arch B Cell Pathol Incl Mol Pathol 36(2-3): 219-234. Massey, A., R. Kiffin and A. M. Cuervo (2004). "Pathophysiology of chaperone-mediated autophagy." Int J Biochem Cell Biol 36(12): 2420-2434. Mauvezin, C., C. Ayala, C. R. Braden, J. Kim and T. P. Neufeld (2014). "Assays to monitor autophagy in Drosophila." Methods 68(1): 134-139. Mehrpour, M., A. Esclatine, I. Beau and P. Codogno (2010). "Overview of macroautophagy regulation in mammalian cells." Cell Res 20(7): 748-762. Mijaljica, D., M. Prescott and R. J. Devenish (2011). "Microautophagy in mammalian cells: revisiting a 40-year-old conundrum." Autophagy 7(7): 673-682. Mizushima, N. (2010). "The role of the Atg1/ULK1 complex in autophagy regulation." Curr Opin Cell Biol 22(2): 132-139. Mizushima, N., A. Kuma, Y. Kobayashi, A. Yamamoto, M. Matsubae, T. Takao, T. Natsume, Y. Ohsumi and T. Yoshimori (2003). "Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate." J Cell Sci 116(Pt 9): 1679-1688. Mizushima, N., A. Yamamoto, M. Hatano, Y. Kobayashi, Y. Kabeya, K. Suzuki, T. Tokuhisa, Y. Ohsumi and T. Yoshimori (2001). "Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells." J Cell Biol 152(4): 657-668. Morris, S. M., P. Anaya, X. Xiang, N. R. Morris, G. S. May and L. Yu-Lee (1997). "A prolactin-inducible T cell gene product is structurally similar to the Aspergillus nidulans nuclear movement protein NUDC." Mol Endocrinol 11(2): 229-236. Noda, T., N. Fujita and T. Yoshimori (2009). "The late stages of autophagy: how does the end begin?" Cell Death Differ 16(7): 984-990. Osmani, A. H., S. A. Osmani and N. R. Morris (1990). "The molecular cloning and identification of a gene product specifically required for nuclear movement in Aspergillus nidulans." J Cell Biol 111(2): 543-551. Pankiv, S., T. H. Clausen, T. Lamark, A. Brech, J. A. Bruun, H. Outzen, A. Overvatn, G. Bjorkoy and T. Johansen (2007). "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy." J Biol Chem 282(33): 24131-24145. Parzych, K. R. and D. J. Klionsky (2014). "An overview of autophagy: morphology, mechanism, and regulation." Antioxid Redox Signal 20(3): 460-473. Polson, H. E., J. de Lartigue, D. J. Rigden, M. Reedijk, S. Urbe, M. J. Clague and S. A. Tooze (2010). "Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation." Autophagy 6(4): 506-522. Proikas-Cezanne, T., Z. Takacs, P. Donnes and O. Kohlbacher (2015). "WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome." J Cell Sci 128(2): 207-217. Proikas-Cezanne, T., S. Waddell, A. Gaugel, T. Frickey, A. Lupas and A. Nordheim (2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy." Oncogene 23(58): 9314-9325. Puri, C., M. Vicinanza, A. Ashkenazi, M. J. Gratian, Q. Zhang, C. F. Bento, M. Renna, F. M. Menzies and D. C. Rubinsztein (2018). "The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A." Dev Cell 45(1): 114-131 e118. Ravikumar, B., K. Moreau, L. Jahreiss, C. Puri and D. C. Rubinsztein (2010). "Plasma membrane contributes to the formation of pre-autophagosomal structures." Nat Cell Biol 12(8): 747-757. Sarkar, S., B. Ravikumar, R. A. Floto and D. C. Rubinsztein (2009). "Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies." Cell Death Differ 16(1): 46-56. Shpilka, T., H. Weidberg, S. Pietrokovski and Z. Elazar (2011). "Atg8: an autophagy-related ubiquitin-like protein family." Genome Biol 12(7): 226. Takeshige, K., M. Baba, S. Tsuboi, T. Noda and Y. Ohsumi (1992). "Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction." J Cell Biol 119(2): 301-311. Vergne, I., E. Roberts, R. A. Elmaoued, V. Tosch, M. A. Delgado, T. Proikas-Cezanne, J. Laporte and V. Deretic (2009). "Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy." EMBO J 28(15): 2244-2258. Vicencio, J. M., C. Ortiz, A. Criollo, A. W. Jones, O. Kepp, L. Galluzzi, N. Joza, I. Vitale, E. Morselli, M. Tailler, M. Castedo, M. C. Maiuri, J. Molgo, G. Szabadkai, S. Lavandero and G. Kroemer (2009). "The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1." Cell Death Differ 16(7): 1006-1017. Vincent, O., L. Anton-Esteban, M. Bueno-Arribas, A. Tornero-Ecija, M. A. Navas and R. Escalante (2021). "The WIPI Gene Family and Neurodegenerative Diseases: Insights From Yeast and Dictyostelium Models." Front Cell Dev Biol 9: 737071. Wang, L., D. J. Klionsky and H. M. Shen (2023). "The emerging mechanisms and functions of microautophagy." Nat Rev Mol Cell Biol 24(3): 186-203. Wang, Y. T., T. Y. Liu, C. H. Shen, S. Y. Lin, C. C. Hung, L. C. Hsu and G. C. Chen (2022). "K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy." Cell Rep 38(8): 110354. Wong, A. S., Z. H. Cheung and N. Y. Ip (2011). "Molecular machinery of macroautophagy and its deregulation in diseases." Biochim Biophys Acta 1812(11): 1490-1497. Wynshaw-Boris, A. and M. J. Gambello (2001). "LIS1 and dynein motor function in neuronal migration and development." Genes Dev 15(6): 639-651. Xiang, X., A. H. Osmani, S. A. Osmani, M. Xin and N. R. Morris (1995). "NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration." Mol Biol Cell 6(3): 297-310. Yang, X. F., C. J. Wu, S. McLaughlin, A. Chillemi, K. S. Wang, C. Canning, E. P. Alyea, P. Kantoff, R. J. Soiffer, G. Dranoff and J. Ritz (2001). "CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia." Proc Natl Acad Sci U S A 98(13): 7492-7497. Yang, Y., X. Yan, Y. Cai, Y. Lu, J. Si and T. Zhou (2010). "NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90." Proc Natl Acad Sci U S A 107(8): 3499-3504. Yang, Z. and D. J. Klionsky (2010). "Mammalian autophagy: core molecular machinery and signaling regulation." Curr Opin Cell Biol 22(2): 124-131. Yla-Anttila, P., H. Vihinen, E. Jokitalo and E. L. Eskelinen (2009). "3D tomography reveals connections between the phagophore and endoplasmic reticulum." Autophagy 5(8): 1180-1185. Yorimitsu, T. and D. J. Klionsky (2005). "Autophagy: molecular machinery for self-eating." Cell Death Differ 12 Suppl 2(Suppl 2): 1542-1552. Yoshii, S. R. and N. Mizushima (2017). "Monitoring and Measuring Autophagy." Int J Mol Sci 18(9). Zhang, H., F. Wu, X. Wang, H. Du, X. Wang and H. Zhang (2013). "The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway." Autophagy 9(12): 1965-1974. Zheng, M., T. Cierpicki, A. J. Burdette, D. Utepbergenov, P. L. Janczyk, U. Derewenda, P. T. Stukenberg, K. A. Caldwell and Z. S. Derewenda (2011). "Structural features and chaperone activity of the NudC protein family." J Mol Biol 409(5): 722-741. Zhou, T., W. Zimmerman, X. Liu and R. L. Erikson (2006). "A mammalian NudC-like protein essential for dynein stability and cell viability." Proc Natl Acad Sci U S A 103(24): 9039-9044. Zhu, X. J., X. Liu, Q. Jin, Y. Cai, Y. Yang and T. Zhou (2010). "The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability." J Biol Chem 285(39): 29903-29910. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/90591 | - |
| dc.description.abstract | 細胞自噬 (Autophagy) 是真核生物體內一種降解受損胞器和物質的過程，透過細胞自噬可以維持細胞恆定並且可以透過回收降解物質幫助細胞度過逆境。在細胞自噬的過程中，受損的胞器與物質會被雙層膜構造的細胞自噬小體所包裹，細胞自噬小體會再和溶酶體融合形成自噬溶小體，接著所包裹的胞器與物質會被溶酶體帶來的酸性酵素所降解。核遷移蛋白C (NudC)已知在有絲分裂和細胞質分裂中扮演重要的角色，除此之外，已經有其他文獻發現NudC突變會降低細胞自噬小體和內噬體進行反向運輸時的速率，但對於NudC在細胞自噬中的功能仍不清楚。近來我們透過將果蠅以及哺乳類細胞中弱化NudC，發現在飢餓引發細胞自噬的狀況下會使Microtubule-associated proteins 1A/1B light chain 3A (LC3)的數量下降，也會妨礙細胞自噬的進行。此外也發現NudC是因不同刺激引發細胞自噬時的廣泛調控因子。另一方面，目前已知有一部分的WD重複結構域磷酸肌醇相互作用蛋白(WIPI)成員會和NudC有交互作用，我們發現當在細胞中弱化NudC時會使WIPI2的數量降低。我們還有在果蠅的不同組織中弱化NudC，發現眼睛會有縮小以及翅膀會有萎縮的表徵。未來我們將會進一部探討NudC詳細於細胞自噬中的功能，以及了解NudC對於WIPI 蛋白於細胞自噬中的影響。 | zh_TW |
| dc.description.abstract | Autophagy is a conserved process in eukaryotes by which the intracellular materials are degraded for recycling. Autophagy is important for maintaining cellular homeostasis and recycling cytosolic materials in response to various stress stimulation. During autophagy, the cargo is engulfed into double-membrane structures called autophagosomes, followed by fusing with lysosome to form autolysosomes. The cargo in autolysosomes then degraded by various acidic enzyme in lysosomes. Nuclear migration protein C (NudC) plays an essential role in mitosis and cytokinesis. Although NudC mutants have been implicated reducing the velocity of autophagosomes and late endosomes retrograde transport, the function of NudC in autophagy remains unclear. Recently, we observed that knockdown of NudC results in the reduction of LC3 puncta formation and impaired autophagic flux in both Drosophila larval fat bodies and mammalian cells under starvation conditions. Moreover, our results indicate that NudC is a general regulator of autophagy in reponse to various stresses stimulation. The WIPI members have been reported to interact with NudC. In this study, we found that the number of WIPI1 and WIPI2 decreased in NudC knockdown cells. Furthermore, we investigated the developmental function of NudC by crossing dNudC-RNAi with various drivers in Drosophila and found that dNudC knockdown cause small eye and aberrant wing phenotypes. In the future, we will investigate the molecular function of NudC in autophagy and explore the relationship between NudC and WIPI proteins in autophagy. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-10-03T16:46:10Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2023-10-03T16:46:10Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 中文摘要 i
Abstract ii Content iv Chapter 1. Introduction 1 1. Autophagy 1 1.1 Overview of Autophagy 1 1.2 The Machinery of Autophagy 2 (1) Induction 2 (2) Nucleation and Elongation 3 (3) Degradation 4 2. NudC 4 3. WIPI proteins 6 Chapter 2. Material and Methods 9 Chapter 3. Results 14 Drosophila NudC depletion impairs starvation-induced autophagy. 14 NudC depletion impairs starvation-induced autophagy. 15 NudC is a general regulator of autophagy. 16 NudC interacts with WIPI1, WIPI2, and WIPI4. 17 NudC depletion reduces WIPI1 and WIPI2 puncta formation. 18 Phenotypes of Drosophila NudC knockdown flies 19 Chapter 4. Discussion 21 References 28 Figures 36 | - |
| dc.language.iso | en | - |
| dc.subject | 細胞自噬 | zh_TW |
| dc.subject | NudC | zh_TW |
| dc.subject | 果蠅 | zh_TW |
| dc.subject | WIPI | zh_TW |
| dc.subject | Autophagy | en |
| dc.subject | WIPI proteins | en |
| dc.subject | NudC | en |
| dc.subject | Drosophila | en |
| dc.title | 探討 NudC 調控細胞自噬的分子機制 | zh_TW |
| dc.title | Exploring the functional roles of NudC in autophagy | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 111-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 姚季光;王婉菁;廖永豐 | zh_TW |
| dc.contributor.oralexamcommittee | Chi-Kuang Yao;Won-Jing Wang;Yung-Feng Liao | en |
| dc.subject.keyword | 細胞自噬,果蠅,NudC,WIPI, | zh_TW |
| dc.subject.keyword | Autophagy,Drosophila,NudC,WIPI proteins, | en |
| dc.relation.page | 53 | - |
| dc.identifier.doi | 10.6342/NTU202301996 | - |
| dc.rights.note | 同意授權(全球公開) | - |
| dc.date.accepted | 2023-08-08 | - |
| dc.contributor.author-college | 生命科學院 | - |
| dc.contributor.author-dept | 生化科學研究所 | - |
| dc.date.embargo-lift | 2025-09-01 | - |
| 顯示於系所單位： | 生化科學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-111-2.pdf | 3.51 MB | Adobe PDF | 檢視/開啟 |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。