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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 嚴震東 | |
dc.contributor.author | Ying Wang | en |
dc.contributor.author | 王楹 | zh_TW |
dc.date.accessioned | 2021-05-20T20:06:27Z | - |
dc.date.available | 2014-08-14 | |
dc.date.available | 2021-05-20T20:06:27Z | - |
dc.date.copyright | 2009-08-14 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-08-11 | |
dc.identifier.citation | Ahissar E, Sosnik R, Haidarliu S (2000) Transformation from temporal to rate coding in a somatosensory thalamocortical pathway. Nature 406:302-306.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9008 | - |
dc.description.abstract | 前人研究顯示大鼠視丘後內側核(POm)會受到未定核(ZI)持續且有力的抑制性調控,因此ZI移除後,才能見到POm神經元對輕觸鬍鬚之刺激產生明顯的反應。本研究目的是檢視ZI被毀壞後,POm調控傷害性傳入訊息的能力。首先利用神經追蹤劑檢視ZI投射至POm的確切區域。而後在ZI經過毀壞的實驗動物上,以16通道-密西根電極進行單一神經元紀錄。本實驗在ZI毀壞同側之POm紀錄到了42顆神經元,在ZI毀壞側之對側與未經手術的動物紀錄了81顆神經元,比較這些神經元對於傷害性機械刺激與熱痛刺激的反應。研究結果顯示:1)ZI被毀壞後,POm中對傷害性刺激有反應的神經元數目顯著高於對照組;2)藉由ZI的調控,POm可能為一傳遞傷害性刺激訊息的區域。本實驗藉由ZI移除的處理,揭開了隱藏於POm傳遞傷害性訊息之能力。然此能力在正常動物中的重要性仍需進一步的研究與探討。 | zh_TW |
dc.description.abstract | The posterior medial nucleus (POm) is tonically inhibited by Zona Incerta (ZI), so that robust vibrissae evoked responses are revealed after ZI inactivation. The present study was to examine the capability of the POm neurons in processing nociceptive information after removal of ZI inhibition. Incerto-POm terminal zones were delineated by anterograde tracing of Biotinylated Dextran Amine. For electrophysiological studies, unilateral ZI lesion was made by micro-injection of kainic acid into the facial region of ZI. Seven days after lesion, single-unit recordings were made with a 16-channel Michigan probe. Responses to noxious mechanical and thermal stimuli were compared among 42 POm neurons in ZI lesioned sides versus 81 neurons in non-lesioned side and na | en |
dc.description.provenance | Made available in DSpace on 2021-05-20T20:06:27Z (GMT). No. of bitstreams: 1 ntu-98-R94b41006-1.pdf: 10921371 bytes, checksum: 0c10ff7ba291b8a00a6285f7460bf884 (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | Table of Contents
1. 中文摘要 3 2. ABSTRACT 4 3. INTRODUCTION 5 3.1. FUNCTIONAL ROLES OF THE POM 6 3.2. INHIBITION CONTROL FROM THE ZI 7 3.3. GOAL OF THE STUDY 8 4. MATERIALS AND METHODS 10 4.1. EXPERIMENT 1. ANTEROGRADE TRACING STUDY 10 4.1.1. Surgery preparation 10 4.1.2. Injections of bi-directional tracer 10 4.1.3. Fixation and immunohistochemistry 11 4.1.4. Data analysis 12 4.2. EXPERIMENT 2. ELECTROPHYSIOLOGICAL EXPERIMENTS 12 4.2.1. Kainic acid lesion 12 4.2.2. Surgery preparation 13 4.2.3. Extracellulary single-unit recording 13 4.2.4. Data acquisition and analysis 15 4.2.5. Histology 17 4.2.6. Immunohistochemistry for parvalbumin 17 5. RESULT 19 5.1. I ANTEROGRADE TRACING STUDY 19 5.1.1. Electrophysiological identification of ZI 19 5.1.2. B. BDA injection in the ZI 20 5.2. II. ELECTROPHYSIOLOGICAL EXPERIMENTS 21 5.2.1. Lesion of ZI 22 5.2.2. Response of POm and VP neurons to mechanical stimulation 22 5.2.3. Response of POm and VP neurons to contact thermal stimulation 25 5.2.4. Cell locations 26 6. DISCUSSION 27 6.1. INCERTO-THALAMIC TERMINAL FIELD 27 6.2. NOCICEPTIVE FUNCTION OF POM 28 6.3. HYPOTHESES FOR ZI MODULATION 31 7. REFERENCES 33 8. TABLES AND FIGURES 36 | |
dc.language.iso | en | |
dc.title | 大鼠未定核對視丘後內側核傳遞傷害性傳入訊息之調控 | zh_TW |
dc.title | Zona Incerta modulation of posterior medial nucleus processing of nociceptive information in the rat | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 黃基礎,閔明源,廖佳琦 | |
dc.subject.keyword | 未定核,視丘後內側核, | zh_TW |
dc.subject.keyword | Zona Incerta,posterior medial nucleus, | en |
dc.relation.page | 62 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2009-08-12 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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