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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林靖愉 | zh_TW |
| dc.contributor.advisor | Ching-Yu Lin | en |
| dc.contributor.author | 洪子涵 | zh_TW |
| dc.contributor.author | Tzu-Han Hung | en |
| dc.date.accessioned | 2023-09-22T16:15:02Z | - |
| dc.date.available | 2023-11-09 | - |
| dc.date.copyright | 2023-09-22 | - |
| dc.date.issued | 2023 | - |
| dc.date.submitted | 2023-08-07 | - |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/89818 | - |
| dc.description.abstract | 研究背景與目的：全氟辛烷磺酸（PFOS）是一種人工化學物質，目前被廣泛用於工業及商業產品。根據研究，PFOS已經被釋放至環境中，並能在環境造成持久性汙染，在人體血清也可以檢測到PFOS。流行病學研究顯示，PFOS暴露和一些不良健康效應相關，例如：體內脂質失去平衡、引起代謝症候群等，然而現在針對PFOS暴露導致體內脂質的影響資訊仍有限。因此這個研究的目的為利用脂質體學方法，探討大鼠暴露PFOS之後器官內的脂質體變化。
研究材料與方法：實驗以18隻雄性大鼠作為模型，每日分別以管餵暴露0、5、10毫克／千克體重的劑量，連續暴露21天後犧牲大鼠，採集心臟、肺臟、肝臟、腎臟、胰臟及睪丸樣本，再進行高解析核磁共振儀分析。核磁共振圖譜會經過圖譜前處理並進行單變量和多變量分析，最後進行數據及生物資訊的解釋。 研究結果與討論：在器官重量變化的分析結果，肝臟重量/體重有顯著變化。而PCA和PLS-DA結果顯示相較於其他器官，肝臟和腎臟有較多的脂質變化，包含膽固醇、飽和及不飽和脂肪酸、三酸甘油酯、甘油酯、鞘磷脂、磷脂醯膽鹼和磷脂醯乙醇胺。這些脂質變化可能與肝臟脂質累積、非酒精性脂肪肝、胰島素阻抗、細胞膜功能變化和慢性腎臟疾病有關。睪丸、心臟、肺臟中的脂質變化可能分別導致精子細胞膜功能干擾、心血管疾病和肺部損傷。而胰臟則無觀察到顯著的脂質變化。 結論：總而言之，這個研究使用脂質體學方法揭示了PFOS暴露後脂質在各器官內的變化，並認為肝臟和腎臟是主要的目標器官。另外PFOS造成的脂質的改變也和代謝疾病有潛在的關聯，特別是非酒精性脂肪肝和慢性腎臟疾病。 | zh_TW |
| dc.description.abstract | Introduction: Perfluorooctane sulfonate (PFOS) is an artificial chemical and has been extensively used in commercial and industrial products. PFOS has been released to the environment widely and been persistent in the environment. It has also been detected in human serum. Epidemiological studies showed that PFOS exposure is related to several adverse health effects, such as lipid disturbances and metabolic syndromes. However, the lipid events of PFOS exposure are still unclear.
Materials and methods: The study aims to identify the organ-specific lipidome changes in Sprague-Dawley rats after PFOS exposure with lipidomic approach. Eighteen male Sprague-Dawley rats were treated with PFOS in 0, 5, and 10 mg/kg body weight/day by gavage. After 21 days continuously exposure, the heart, lung, liver, kidney, pancreas and testis were collected and extracted followed by high resolution nuclear magnetic resonance analysis. Univariate and multivariate analysis were conducted after spectral pretreatment followed by data interpretation. Results and discussions: The results presented the liver/body weight ratio had a significant change. The results of PCA and PLS-DA analysis showed the liver and kidney had greater lipid changes, including cholesterol, saturated and unsaturated fatty acids, triglyceride, glycerides, sphingomyelin, phosphatidylcholine, and phosphatidylethanolamine. These findings were potentially correlated with hepatic lipid accumulation, non-alcoholic fatty liver disease (NAFLD), insulin resistance, alterations in cell membrane, and chronic kidney disease (CKD). The lipid changes in the testis, heart, and lung may lead to the interference in the functions of sperm membrane, cardiovascular disease, and the lung injury, respectively. There was no significant lipid alteration observed in the pancreas. Conclusion: The lipidomic approach revealed lipid changes after PFOS exposure, whereas the result suggested the liver and kidney are the target organs. The lipid alterations indicate that there are potential association between PFOS and metabolic diseases, especially NAFLD and CKD. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-09-22T16:15:02Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2023-09-22T16:15:02Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員會審定書 i
謝辭 ii 摘要 iii Abstract iv I. Introduction 1 1-1 Perfluorooctanesulfonic Acid 1 1-2 Lipidomics 3 1-3 Study aims 5 II. Materials and methods 6 2-1 Experimental framework 6 2-2 Animal experiment and sample collection 7 2-3 Measurement of lipid profiles in organs by 1H NMR spectroscopy 7 2-3-1 Sample preparation 7 2-3-2 Lipid profiles collection 8 2-3-3 Spectral processing 9 2-3-4 Peak identification 9 2-4 Statistical analysis 9 III. Results 12 3-1 Changes in the weights of SD rats 12 3-2 Lipid profiling in SD rats by 1H NMR spectroscopy 12 3-3 Association between PFOS exposure and lipid responses in the organs 13 3-4 Selective lipid significant changes in the organs after PFOS exposure 14 IV. Discussion 16 4-1 The impact of PFOS exposure on the liver 16 4-1-1 Lipid accumulation and non-alcoholic fatty liver disease 17 4-1-2 Insulin resistance 18 4-1-3 Alteration in the structure and functions of cell membrane 19 4-2 The impact of PFOS exposure on the kidney 19 4-2-1 Chronic kidney disease 20 4-2-2 Alteration in the functions of cell membrane 22 4-2-3 The comparison between the significant lipid changes in the liver and kidney 22 4-3 The impact of PFOS exposure on the testis, heart, and lung 23 4-3-1 Testicular membrane disturbances 23 4-3-2 Cardiovascular disease 23 4-3-3 Lung injury 24 4-4 The strengths and limitations 24 V. Conclusions and future works 26 References 28 | - |
| dc.language.iso | en | - |
| dc.title | 應用核磁共振儀探討大鼠暴露全氟辛烷磺酸之多器官脂質反應研究 | zh_TW |
| dc.title | Lipid Responses to Perfluorooctanesulfonic Acid Exposure in Multiple Organs of Rats using Nuclear Magnetic Resonance | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 111-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 陳保中;羅宇軒;李昇翰 | zh_TW |
| dc.contributor.oralexamcommittee | Pau-Chung Chen;Yu-Syuan Luo;Sheng-Han Lee | en |
| dc.subject.keyword | 全氟辛烷磺酸,脂質體學,核磁共振儀,多器官毒性, | zh_TW |
| dc.subject.keyword | Perfluorooctane sulfonate,Lipidomics,Nuclear magnetic resonance,multiple organ toxicity, | en |
| dc.relation.page | 77 | - |
| dc.identifier.doi | 10.6342/NTU202303298 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2023-08-08 | - |
| dc.contributor.author-college | 公共衛生學院 | - |
| dc.contributor.author-dept | 環境與職業健康科學研究所 | - |
| 顯示於系所單位： | 環境與職業健康科學研究所 | |
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