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標題: | 食道癌手術Ivor Lewis vs Mckeown存活率分析 : 統合分析與臨床試驗計畫書 Ivor Lewis vs Mckeown esophagectomy: a meta-analysis of survival and protocol |
作者: | 林晶晶 Ching-Ching Lin |
指導教授: | 李章銘 Jang-Ming Lee |
關鍵字: | 食道,總生存期, esophageal, Ivor Lewis, Mckeown, overall survival, |
出版年 : | 2023 |
學位: | 碩士 |
摘要: | 背景:
食道癌 (EC) 現在是影響男性的第 7 大最常見癌症,也是影響全球女性的第 13 大最常見癌症。 它是癌症相關死亡的第六大常見原因。 鱗狀細胞癌 (SCC) 佔全世界食道癌病例的 88%。 五年生存率在 15% 到 25% 之間。 (Sabra et al., 2020) 手術仍然是晚期食道癌的主要治療方法,目前常見的食道切除術有兩種:Ivor Lewis 和 McKeown。 然而,目前仍不確定 Ivor Lewis 或 McKeown 是否與更好的總生存率有關。 本統合分析的目的是總結 Ivor Lewis 和 McKeown 之間總生存率比較的最新證據,並計劃確認食道癌手術治療臨床試驗的最新存活率。 方法: 首先包括並審查了十項研究。 有五項非隨機、回溯性臨床試驗符合統合分析條件。 所有關於一年存活率的研究和可比較的數據都可以匯集起來進行進一步的定量統合分析。 結果: 完成了十項研究的初步審查和納入。使用五項非隨機、回溯性臨床試驗進行統合分析。 為了進一步定量統合分析,合併所有針對一年存活率和可比較數據的研究。此外,Ivor Lewis 和 McKeown 的一年存活率相似。 臨床試驗: 我們計劃進行臨床試驗,以確認 Ivor Lewis vs Mckeown 食道切除術的總體存活率和長期健康相關質量。 Background: Esophageal cancer (EC) is currently the seventh most prevalent cancer in males and the thirteenth most prevalent cancer in women worldwide. It ranks as the sixth most frequent reason for cancer-related fatalities. Around the world, squamous cell carcinoma (SCC) makes up up to 88% of cases of esophageal cancer. The five-year survival rate ranges from 15 to 25%. (Sabra et al., 2020) Advanced esophageal cancer is still mostly treated surgically. There are now two common esophagectomies: Ivor Lewis and McKeown. Ivor Lewis or McKeown may be linked to a higher overall survival rate, however this is not yet clear. This meta-analysis's objective is to compile the most recent information on the overall survival rates of Ivor Lewis and McKeown in comparison, and it also intends to validate the most recent survival rate information from clinical trials for surgically treating esophageal cancer. Materials and methods: We did a methodical search of three electronic databases: Web of Science, Embase, and PubMed. The overall survival rate after one year is the main outcome. The secondary endpoint is pulmonary complication. Selected papers with acceptable clinical and methodological uniformity were subjected to a meta-analysis. Results: The initial review and inclusion of ten studies was done. For the meta-analysis, five nonrandomized clinical trials were accepted. For further quantitative synthesis, all studies for the one-year overall survival rate and comparable data might be combined. Additionally, the one-year survival rates of Ivor Lewis and McKeown are comparable. Protocol design: We plan to implement the Ivor Lewis vs. Mckeown esophagectomy overall survival rate and long-term health-related quality, we want to carry out the clinical trial. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/89647 |
DOI: | 10.6342/NTU202301885 |
全文授權: | 未授權 |
顯示於系所單位: | 臨床醫學研究所 |
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