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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 吳文超 | zh_TW |
| dc.contributor.advisor | Wen-Chau Wu | en |
| dc.contributor.author | 陳昌民 | zh_TW |
| dc.contributor.author | Chang-Min Chen | en |
| dc.date.accessioned | 2023-09-07T17:16:32Z | - |
| dc.date.available | 2023-11-09 | - |
| dc.date.copyright | 2023-09-07 | - |
| dc.date.issued | 2023 | - |
| dc.date.submitted | 2023-07-31 | - |
| dc.identifier.citation | A. Alhowimel, M. AlOtaibi, K. Radford, and N. Coulson. Psychosocial factors associated with change in pain and disability outcomes in chronic low back pain patients treated by physiotherapist: a systematic review. SAGE open medicine, 6:2050312118757387, 2018.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/89500 | - |
| dc.description.abstract | 本研究旨在使用靜息狀態 (Resting State) 下的功能連結 (Functional Connectivity, FC) 進行探索性分析，研究慢性下背痛患者的靜息狀態功能連接及其與疼痛相關失能之間的關係。我們的結果顯示，與對照組 (n = 26) 相比，患者組 (n = 26) 在多個腦區與預設模式網絡的 FC 下降。特別的是，我們發現在右羅蘭氏腦溝區 (right Rolandic operculum)，FC 與 Oswestry 失能指數呈負相關 (r = -0.616，p <0.001)，顯示情緒處理和疼痛知覺之間的相互作用。此外，以網路為基礎的關連分析並未發現跨網路 FC 的組間差異，似乎暗示 CLBP 對 FC 的影響比較具有區域性，並且在我們的研究群體中尚未達到網絡層面。 | zh_TW |
| dc.description.abstract | This study conducted an exploratory analysis of resting-state functional connectivity (FC) and its association with pain-related disability in patients with chronic low back pain (CLBP). Our results showed that as compared with the control group (n = 26), the patient group (n = 26) had decreased FC with the default mode network in multiple brain regions. Specifically, the right Rolandic operculum was identified, where FC was negatively correlated with the Oswestry disability index (r = -0.616, p < 0.001), suggesting the interplay between emotion processing and pain perception. Moreover, our results revealed no significant group-difference in cross-network FC between the entire networks, suggesting the impact of CLBP on FC is relatively regional and has not reached the network level in our study cohort. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-09-07T17:16:32Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2023-09-07T17:16:32Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | Verification Letter from the Oral Examination Committee i
Acknowledgements ii 摘要 iv Abstract v Contents vi List of Figures ix List of Tables x Denotation xi Chapter 1 Introduction 1 1.1 Chronic low back pain 1 1.2 Resting-state functional connectivity 1 1.3 Altered functional connectivity in chronic pain 2 1.4 Aim of the present study 3 Chapter 2 Materials and methods 5 2.1 Participants and MR data 5 2.2 fMRI data processing 5 2.3 Clinical assessment 6 2.4 Multilevel functional connectivity mapping and analysis 7 2.4.1 Voxel-level mapping and analysis 7 2.4.2 Network-level mapping and analysis 7 2.4.3 Correlation between functional connectivity and symptoms 8 2.4.4 Functional characterization of the abnormal brain region 8 Chapter 3 Results 9 3.1 Demographics 9 3.2 Altered functional connectivity to DMN 10 3.2.1 Cluster of voxels functional connectivity changes 10 3.2.2 Correlation between functional connectivity and symptoms 10 3.3 Cross-network effect on functional connectivity 12 3.4 Functional characteristics of the right Rolandic operculum 16 Chapter 4 Discussion 18 4.1 Anticorrelation between DMN and right Rolandic operculum 18 4.2 Anticorrelation between DMN and right uncinate fasciculus 20 4.3 Intact connectivity between networks 21 4.4 Limitations 22 Chapter 5 Conclusion 24 References 25 Appendix A — Voxel based morphometry for right uncinate fasciculus 35 A.1 Voxel-based morphometry analysis 36 A.2 Decreased white matter in right uncinate fasciculus 36 Appendix B — Functional connectivity between right Rolandic operculum and auditory network 38 B.1 Smoothing effect on the functional connectivity 38 B.2 Neurobiological relevance of the functional connectivity 39 B.2.1 Auditory network had functional connectivity to the right Rolandic operculum substantially higher than the background regions 39 B.2.2 Auditory network and the right Rolandic operculum had distinct functional connectivity to DMN 41 B.2.3 Conclusion 43 | - |
| dc.language.iso | en | - |
| dc.subject | 功能性連結 | zh_TW |
| dc.subject | 慢性下背痛 | zh_TW |
| dc.subject | 靜息態 | zh_TW |
| dc.subject | 功能性磁振造影 | zh_TW |
| dc.subject | 情緒 | zh_TW |
| dc.subject | functional connectivity | en |
| dc.subject | resting state | en |
| dc.subject | functional magnetic resonance imaging | en |
| dc.subject | chronic low back pain | en |
| dc.subject | emotion | en |
| dc.title | 探討靜息態下慢性下背痛患者的情緒相關腦功連結變化與臨床症狀之關係 | zh_TW |
| dc.title | Altered emotional resting-state functional connectivity in patients with chronic low back pain and its association with clinical symptoms | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 111-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 趙啟超;王淑芬 | zh_TW |
| dc.contributor.oralexamcommittee | Chi-Chao Chao;Shwu-Fen Wang | en |
| dc.subject.keyword | 慢性下背痛,靜息態,功能性磁振造影,功能性連結,情緒, | zh_TW |
| dc.subject.keyword | chronic low back pain,resting state,functional magnetic resonance imaging,functional connectivity,emotion, | en |
| dc.relation.page | 44 | - |
| dc.identifier.doi | 10.6342/NTU202301915 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2023-08-01 | - |
| dc.contributor.author-college | 醫學院 | - |
| dc.contributor.author-dept | 醫療器材與醫學影像研究所 | - |
| dc.date.embargo-lift | 2028-07-30 | - |
| 顯示於系所單位： | 醫療器材與醫學影像研究所 | |
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