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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳慧文 | zh_TW |
| dc.contributor.advisor | Hui-Wen Chen | en |
| dc.contributor.author | 周艾艾 | zh_TW |
| dc.contributor.author | Ai-Ai Chou | en |
| dc.date.accessioned | 2023-08-15T16:19:19Z | - |
| dc.date.available | 2023-11-09 | - |
| dc.date.copyright | 2023-08-15 | - |
| dc.date.issued | 2023 | - |
| dc.date.submitted | 2023-07-31 | - |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/88442 | - |
| dc.description.abstract | 貓冠狀病毒和鸚鵡玻那病毒皆是對伴侶動物致命的病毒。貓傳染性腹膜炎是貓冠狀病毒引起的疾病，系統性感染和抗體依賴性增強作用使此疾病更加複雜。鸚鵡玻那病毒同為棘手的疾病，會造成神經節神經炎和前胃擴張症，且會有潛伏性的感染，這兩個嚴重的疾病目前皆沒有良好的治療藥物供臨床使用。綠豆具有許多藥物活性，且綠豆種皮萃取物 (VRE) 在細胞實驗中被證實能夠抑制A型流感病毒。由於貓冠狀病毒和鸚鵡玻那病毒的治療藥物匱乏，本研究的目的為探討VRE對於這兩種病毒的抗病毒效果。結果顯示，VRE能夠抑制貓冠狀病毒所造成的細胞病變，且能減少病毒的複製以及病毒核蛋白和棘蛋白的表現。此外，VRE在病毒感染細胞之前給予可以達到較佳的抗病毒效果，且在抗體依賴性增強作用之細胞感染試驗中，VRE仍然可以有效的抑制貓冠狀病毒。VRE併用GS-441524或GC376時，能夠在低於單獨使用的劑量下清除病毒。VRE同時具有抑制鸚鵡玻那病毒的性質，在藥物作用時間點試驗中，VRE在病毒感染細胞之前先與病毒作用可以達到最好的抑制效果，且與Ribavirin併用下能夠降低病毒量。綜合以上結果，本研究揭示了VRE對於貓冠狀病毒和鸚鵡玻那病毒的抗病毒效果，且VRE具有發展成為此兩種病毒治療藥物的潛力。 | zh_TW |
| dc.description.abstract | Feline coronavirus (FCoV) and parrot bornavirus (PaBV) are pet viruses leading to high mortality diseases. Feline infectious peritonitis (FIP) is a severe illness caused by mutated FCoV, and it is complicated due to the systemic infection and antibody-dependent enhancement (ADE) phenomenon. PaBV is an intractable disease that causes ganglioneuritis and proventricular dilatation disease and also establishes latency infection. Even worse, these two viruses lack authorized treatment. Vigna radiata (L.) R. Wilczek extract (VRE) revealed several pharmacological effects and the inhibition of the influenza A virus. With the urgent need for FCoV and PaBV therapies, VRE is investigated for its antiviral ability against these two viruses. In this study, VRE inhibited the cytopathic effect caused by FCoV, inhibited viral proliferation, and reduced the expression of nucleocapsid protein and spike protein. Moreover, VRE blocked FCoV in the early and late infection stages. In the in vitro ADE infection model, VRE can also effectively block FCoV infection. Additionally, in combination treatments of VRE with the polymerase inhibitor GS-441524 or protease inhibitor GC376, FCoV was eliminated with concentrations that were lower than monotherapy. VRE also possesses anti-PaBV activity. In immunocytochemistry analysis, VRE dose-dependently decreased PaBV titer and blocked PaBV in the early stage of infection. And the combining of VRE with polymerase inhibitor Ribavirin revealed enhanced antiviral activity. To sum up, this study characterizes the antiviral property of VRE against FCoV and PaBV in vitro, and VRE possesses a therapeutic potential for FCoV and PaBV treatment. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-08-15T16:19:19Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2023-08-15T16:19:19Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | Contents
中文摘要 I Abstract II Contents IV List of figures VII List of tables VIII Chapter 1 Introduction 1 1.1. Characteristic of feline coronavirus 1 1.2. Feline infectious peritonitis (FIP) 2 1.3. Treatment and control of FIP 3 1.4. Characteristics of parrot bornavirus 4 1.5. Avian bornaviral ganglioneuritis and proventricular dilatation 5 1.6. Treatment and control of parrot bornavirus 6 1.7. Application of mung bean seed coat 7 1.8. The objectives of this study 8 Chapter 2 Materials and methods 9 2.1. Compounds 9 2.2. Cell culture 10 2.3. Viruses 11 2.4. Cytotoxicity test 12 2.5. Cytopathic effect reduction test 13 2.6. Plaque assay 15 2.7. Western blotting analysis 16 2.8. VRE antiviral activity against FIPV 17 2.9. Quantitative RT-PCR (qRT-PCR) for FIPV 18 2.10. Time-of-addition assay of VRE against FIPV 20 2.11. VRE antiviral activity assay under in vitro ADE infection 22 2.12. FIPV penetration inhibition test 23 2.13. Spike protein inhibition test 24 2.14. Combinational use of compounds against FIPV 25 2.15. Immunocytochemical (ICC) staining 27 2.16. Quantitative RT-PCR (qRT-PCR) for PaBV 28 2.17. Antiviral activity against PaBV 29 2.18. Infection state assays of PaBV 29 2.19. Combinational use of compounds against PaBV 31 2.20. Statistical analyses 32 Chapter 3 Results 33 3.1 Profile of Vigna Radiata extract (VRE) 33 3.2 Cytotoxicity of VRE 33 3.3 Dose-dependent anti-FIPV activity of VRE 33 3.4 Cytopathic effect reduction activity of VRE 34 3.5 VRE anti-FIPV activity in different infection states 35 3.6 VRE anti-FIPV activity at different time-of-addition 36 3.7 VRE anti-FIPV activity in in vitro ADE model 36 3.8 Inhibitory effect of VRE on FIPV penetration 37 3.9 Inhibitory effect of VRE on FIPV spike protein 37 3.10 Combinational use of VRE and GS-441524 in FIPV-infected cells 38 3.11 Combinational use of VRE and GC376 in FIPV-infected cells 39 3.12 Anti-PaBV activity of VRE 39 3.13 VRE anti-PaBV activity in different infection states 40 3.14 Combinational use of VRE and Ribavirin in PaBV-infected cells 41 Chapter 4 Discussion 42 Chapter 5 Figures and tables 48 Chapter 6 References 81 | - |
| dc.language.iso | en | - |
| dc.subject | 抗病毒藥物 | zh_TW |
| dc.subject | 綠豆種皮萃取物 | zh_TW |
| dc.subject | 貓冠狀病毒 | zh_TW |
| dc.subject | 鸚鵡玻那病毒 | zh_TW |
| dc.subject | Parrot bornavirus | en |
| dc.subject | Feline coronavirus | en |
| dc.subject | Vigna Radiata seed coat extract | en |
| dc.subject | antivirals | en |
| dc.title | 綠豆種皮萃取物對貓冠狀病毒及鸚鵡玻那病毒之抗病毒研究 | zh_TW |
| dc.title | Antiviral Activity of Vigna Radiata Extract Against Feline Coronavirus and Parrot Bornavirus | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 111-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 張惠雯;張晏禎;林中惠 | zh_TW |
| dc.contributor.oralexamcommittee | Hui-Wen Chang;Yen-Chen Chang;Chung-Hui Lin | en |
| dc.subject.keyword | 貓冠狀病毒,鸚鵡玻那病毒,綠豆種皮萃取物,抗病毒藥物, | zh_TW |
| dc.subject.keyword | Feline coronavirus,Parrot bornavirus,Vigna Radiata seed coat extract,antivirals, | en |
| dc.relation.page | 91 | - |
| dc.identifier.doi | 10.6342/NTU202302219 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2023-08-02 | - |
| dc.contributor.author-college | 生物資源暨農學院 | - |
| dc.contributor.author-dept | 獸醫學系 | - |
| 顯示於系所單位： | 獸醫學系 | |
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