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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳昭岑(Chao-Tsen Chen) | |
dc.contributor.author | Visgola Yang-Hao Yeh | en |
dc.contributor.author | 葉暘皓 | zh_TW |
dc.date.accessioned | 2021-05-20T20:01:40Z | - |
dc.date.available | 2012-10-28 | |
dc.date.available | 2021-05-20T20:01:40Z | - |
dc.date.copyright | 2009-10-28 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-10-26 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/8805 | - |
dc.description.abstract | 端粒在多數癌症細胞當中因具有過度表現的端粒酶而受到延長,因此成為染色體上的重要腫瘤標的。文獻中設計配體穩定端粒形成四股結構,造成端粒酶功能受抑制而限制腫瘤成長。其中配體BMVC具有辨識腫瘤並穩定端粒鳥嘌呤四股結構的作用及其螢光特性,本論文在結構上積極地引入具有光激活的端粒傷害分子片段,使在顯影出癌細胞的位置同時也伴隨有毒殺癌細胞的潛力。在文獻報導中得知, BMVC一側的吡啶陽離子與四股結構平行股上的胸腺嘧啶T17距離3.75 Å,並發生 | zh_TW |
dc.description.abstract | Telomeres, an important tumor chromosomal target, are enlogated by overexpressed telomerase in most tumor cell. Researchers have attempted to design and synthesize G-4 ligands to stabilize telomeric G-quadruplex aiming for telomerase inhibition as a potential anti-tumor route. Taking advantages of the strong binding of BMVC with telomeres as well as its fluorescent sensing, we decided toreplace one of the pyridinium ring with a photoactive thymine in order to damage the telomere G-quardruplex. The reported simulation result indicates that one pyridinium arm of BMVC showed tightly | en |
dc.description.provenance | Made available in DSpace on 2021-05-20T20:01:40Z (GMT). No. of bitstreams: 1 ntu-98-R96223121-1.pdf: 18047944 bytes, checksum: 95ced7eb14402aca444164cd06948a61 (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | 目錄 I
圖目錄 III 表目錄 VII 中文摘要 VIII Abstract X 第一章 簡介 1 前言 1 1.1淺談腫瘤標的與標靶藥物設計 1 1.2重要的廣現性腫瘤標的:端粒與端粒酶 3 1.2.1染色體複製機制與端粒及端粒酶作用 3 1.2.2維持端粒的穩定:屏蔽蛋白群(Shelterins) 7 1.2.3與眾不同的結構標的:端粒的鳥嘌呤四股結構的多樣性 8 1.3潛在抑制端粒酶與抑癌化合物 12 1.3.1具顯影及抑癌作用的咔唑衍生物BMVC 17 1.4癌症化學治療與光化學 20 1.4.1光動力治療(Photodynamic Therapy) 22 1.4.2 〔2+2〕環化加成(Cycloaddition) 23 1.4.3 染色體內質性光化學傷害(Intrinsic Photodamage) 26 第二章 TMPC與MTMPC設計動機與合成 34 前言 34 2.1 DNA傷害分子及端粒標的分子設計 34 2.2 目標分子TMPC與MTMPC設計與合成 37 2.2.1 預期目標與設計基礎 38 2.2.2 逆合成分析與實驗合成路徑選擇 40 2.2.3 目標化合物TMPC及MTMPC的合成 42 第三章 結果與討論 48 3.1 TMPC與MTMPC的光物理表現與DNA作用後的吸收及螢光結果 48 3.2 TMPC與MTMPC與DNA膠體電泳 53 3.3 TMPC與MTMPC對Hum24的辨識結合能力 60 3.4 TMPC與MTMPC對端粒酶的抑制能力 63 3.5 TMPC與MTMPC與端粒片段的光產物 66 第四章 總結 75 實驗部分 77 一、一般敘述 77 二、實驗步驟及光譜數據 79 參考文獻 88 | |
dc.language.iso | zh-TW | |
dc.title | 腫瘤尋標感測暨光激活端粒毒殺潛質分子開發 | zh_TW |
dc.title | Tumor Targeting Molecular Sensor and Therapeutic Potential of Photoinduced DNA Damage | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 張大釗(Ta-Chau Chang),賴秉杉(Ping-Shan LAI) | |
dc.subject.keyword | 腫瘤尋標,分子感測,胸腺嘧啶雙體,DNA傷害,端粒, | zh_TW |
dc.subject.keyword | Tumor Targeting,Molecular Sensor,Thmine dimer,DNA Damage,Telomere, | en |
dc.relation.page | 104 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2009-10-26 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 化學研究所 | zh_TW |
顯示於系所單位: | 化學系 |
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