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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張惠婷 | zh_TW |
| dc.contributor.advisor | Hui-Ting Chang | en |
| dc.contributor.author | 何語佟 | zh_TW |
| dc.contributor.author | Yu-Tung Ho | en |
| dc.date.accessioned | 2023-06-14T16:10:41Z | - |
| dc.date.available | 2026-02-07 | - |
| dc.date.copyright | 2023-06-14 | - |
| dc.date.issued | 2023 | - |
| dc.date.submitted | 2023-02-10 | - |
| dc.identifier.citation | 劉怡秀、林群雅、張銀珏、鄭森松、張上鎮 (2016) 香桂葉子精油及其成分之抗病媒蚊幼蟲活性。臺大實驗林研究報告 30(1):1-10。
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Journal of Enzyme Inhibition and Medicinal Chemistry 34(1): 279-309. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/87529 | - |
| dc.description.abstract | 貝殼杉屬 (Agathis) 植物主要分布於東南亞以及南半球，於民俗療法中具有舒緩疼痛功效，在前人研究中具有抗菌、抗真菌與抗瘧疾活性，然而其他的生物活性並無相關記載。此外，貝殼杉 (Agathis dammara) 為貝殼杉屬中少數分布於北半球的物種之一，因此本研究為探討貝殼杉是否具有其他生物活性，收集貝殼杉新鮮葉子後利用水蒸餾法 (hydrodistillation) 萃取貝殼杉葉部精油後，以氣相層析質譜儀分析精油化學成分，得知精油成分以 sesquiterpenoids 為主，依化學結構分類則以 cadinane 骨架的化合物為最多。生物活性方面，利用貝殼杉精油作為試樣測試其對黑色素生成抑制活性、黃嘌呤氧化酶抑制活性、抗病媒蚊幼蟲以及海蝦 (Artemia salina Leach) 致死試驗，在黑色素生成抑制活性探討上，包含測試酪胺酸酶抑制活性 (in vitro) 與斑馬魚 (Danio rerio) 黑色素定量試驗 (in vivo)，結果顯示貝殼杉精油可抑制酪胺酸酶作為 diphenolase 之活性，且在斑馬魚黑色素定量試驗中，於 50 μg/mL 濃度時，可以減少斑馬魚體上的黑色素；然而在黃嘌呤氧化酶試驗中，可知貝殼杉葉部精油並非有效抑制尿酸生成的抑制劑。貝殼杉精油在抗病媒蚊幼蟲試驗中，對埃及斑蚊 (Aedes aegypti) 幼蟲具有良好毒殺效果。使用海蝦作為模式生物，貝殼杉精油可有效毒殺海蝦。經過上述活性評估過後，可知貝殼杉精油作為黑色素抑制劑與天然病媒蚊殺蟲劑具開發潛力。 | zh_TW |
| dc.description.abstract | Agathis species are widely distributed around Southeast Asia and the Southern hemisphere. Traditionally, Agathis species were considered to be a remedy for aches. Besides ache treatment, Agathis species possess antibacterial, antifungal, and antimalarial activities. However, related studies for other bioactivities of the species, especially of Agathis dammara, are limited. Because of the lack of study on the bioactivities of A. dammara, this study aims to investigate the chemical composition of A. dammara leaf essential oil (ADEO) and to explore its bioactivities.
In the first part of the study, the chemical composition of ADEO was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). The results showed that the major constituents of ADEO were sesquiterpenoids characterized by the cadinene skeleton. To investigate bioactivities of ADEO, four activities, including antimelanogenic effect, xanthine oxidase inhibitory activity, mosquito larvicidal activity, and brine shrimp (Artemia salina Leach) lethality, were analyzed. In the antimelanogenic effect evaluation, both in vitro and in vivo assays were carried out. According to the result from in vitro assay, ADEO could inhibit tyrosinase activity when the substrate was 3,4-dihydroxyphenylalanine (L-DOPA). Furthermore, ADEO displayed antimelanogenic effect because ADEO could reduce zebrafish (Danio rerio) pigmentation at the concentration of 50 μg/mL. As for assessments of mosquito larvicidal activity and brine shrimp lethality, ADEO could work effectively against Aedes aegypti larvae and brine shrimp. However, ADEO cannot present xanthine oxidase inhibitory activity in the xanthine oxidase inhibition assay. According to these findings, ADEO could have a potential to be a natural whitening agent and a mosquito larvicide. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-06-14T16:10:41Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2023-06-14T16:10:41Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 謝 誌 I
摘 要 II Abstract III 目 錄 IV 表目錄 VI 圖目錄 VII 壹、前 言 1 貳、文獻回顧 3 一、黑色素生成與其抑制機制 3 (一)、酪胺酸酶於黑色素生合成之作用機制 3 (二)、黑色素生合成途徑 4 (三)、黑色素生合成訊息傳遞途徑 8 (四)、黑色素生合成之抑制機制 9 二、斑馬魚的發育及作為模式生物的優勢 10 (一)、斑馬魚胚發育 11 (二)、斑馬魚的黑色素細胞 11 (三)、斑馬魚作為模式生物優勢 12 三、植物天然物抑制黑色素生成之成分 12 (一)、植物天然物抑制黑色素生成功效 12 (二)、天然物成分抑制黑色素生成功效 14 四、貝殼杉屬植物天然物成分及生物活性 15 (一)、貝殼杉屬植物天然物成分 16 (二)、貝殼杉屬植物天然物生物活性 18 參、材料與方法 19 一、試驗試材 19 (一)、試材 19 (二)、試驗藥品與溶劑 19 二、試驗方法 20 (一)、貝殼杉葉部精油萃取 20 (二)、精油成分分析 20 (三)、酪胺酸酶活性抑制試驗 21 (四)、斑馬魚試驗 22 (五)、黃嘌呤氧化酶活性抑制試驗 23 (六)、抗病媒蚊試驗 23 (七)、海蝦致死試驗 24 (八)、統計方法 24 肆、結果與討論 25 一、貝殼杉葉部精油含量與成分分析 25 (一)、貝殼杉葉部精油氣相層析-質譜儀分析 25 (二)、貝殼杉葉部精油主要成分鑑定 31 (三)、貝殼杉葉部精油其他成分鑑定 37 二、貝殼杉葉部精油之抑制黑色素生成活性評估 53 (一)、貝殼杉葉部精油對蕈類酪胺酸酶抑制活性 53 (二)、貝殼杉葉部精油抑制斑馬魚黑色素生成之活性 60 三、貝殼杉葉部精油對黃嘌呤氧化酶之抑制活性 65 四、貝殼杉葉部精油之抗病媒蚊幼蟲活性 66 五、貝殼杉精油對海蝦致死活性評估 71 伍、結論 75 陸、參考文獻 76 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 黑色素抑制活性 | zh_TW |
| dc.subject | 貝殼杉 | zh_TW |
| dc.subject | 植物天然物 | zh_TW |
| dc.subject | 斑馬魚 | zh_TW |
| dc.subject | 埃及斑蚊 | zh_TW |
| dc.subject | 海蝦致死活性 | zh_TW |
| dc.subject | zebrafish (Danio rerio) | en |
| dc.subject | Agathis dammara | en |
| dc.subject | antimelanogenic effect | en |
| dc.subject | brine shrimp lethality activity | en |
| dc.subject | Aedes aegypti | en |
| dc.subject | plant natural product | en |
| dc.title | 貝殼杉葉部精油之化學成分與生物活性研究 | zh_TW |
| dc.title | Studies on Chemical Constituents and Bioactivities of Agathis dammara Leaf Essential Oil | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 111-1 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 劉逸軒;張美鈴 | zh_TW |
| dc.contributor.oralexamcommittee | I-Hsuan Liu;Mei-Ling Chang | en |
| dc.subject.keyword | 貝殼杉,植物天然物,斑馬魚,埃及斑蚊,海蝦致死活性,黑色素抑制活性, | zh_TW |
| dc.subject.keyword | Agathis dammara,plant natural product,zebrafish (Danio rerio),Aedes aegypti,brine shrimp lethality activity,antimelanogenic effect, | en |
| dc.relation.page | 85 | - |
| dc.identifier.doi | 10.6342/NTU202300349 | - |
| dc.rights.note | 未授權 | - |
| dc.date.accepted | 2023-02-13 | - |
| dc.contributor.author-college | 生物資源暨農學院 | - |
| dc.contributor.author-dept | 森林環境暨資源學系 | - |
| 顯示於系所單位： | 森林環境暨資源學系 | |
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