請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/87519完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 劉浩澧 | zh_TW |
| dc.contributor.advisor | Hao-Li Liu | en |
| dc.contributor.author | 趙天易 | zh_TW |
| dc.contributor.author | Tian-Yi Chao | en |
| dc.date.accessioned | 2023-06-14T16:07:21Z | - |
| dc.date.available | 2026-02-08 | - |
| dc.date.copyright | 2023-06-14 | - |
| dc.date.issued | 2023 | - |
| dc.date.submitted | 2023-02-10 | - |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/87519 | - |
| dc.description.abstract | 聚焦式超音波是一種很有前途的腦部疾病治療方法，近年來越來越多的治療計劃需要透過實時的模擬來滿足，以協助臨床醫生做出治療計畫，因此快速且準確的模擬出超音波聲場聚焦分布成為一個重要課題。在我們的研究中，我們提出一種高計算效率的方式來模擬非均勻介質組織下的三維經顱聚焦式超音波聲場聚焦分布。我們將角譜法加入角度權重來模擬經顱聚焦分布的結果，並根據文獻中壓克力材料的設置來驗證本論文方法的精確度，最後透過真實離體顱骨比較模擬數據和測量數據之間的聲場聚焦分布差異。該模擬還與正在進行的臨床測試分析結合，以提供完整的治療計劃。我們開發的角譜法具有快速的計算能力，可以達到半實時的速度計算三維壓力場，範圍覆蓋整個顱內。在壓克力場域中模擬及量測的結果在位置差異上以及穿透率差異上分別小於0.5mm和5%。經顱實驗測量結果（5個真實顱骨中的129個位置）與本論文方法的模擬在相關度R2為 0.7233，平均位置差異為 2.424mm，正規化均方根誤差為 0.1390，根據上述的結果，本論文提出的方法對於經顱聚焦超音波治療的治療計劃具有顯著的效益。 | zh_TW |
| dc.description.abstract | Focused ultrasound is a promising methodology for the therapy of brain diseases. Nowadays, more and more demand has been requested to fulfill the need of delivering real-time treatment planning in order to assist treatment decision-making for clinicians. Rapid and accurate simulation of the ultrasound pressure becomes an important issue. In this study, we proposed the use of a high computational efficiency strategy to simulate a 3D transcranial focused ultrasound beam under heterogenetic tissue conditions. Angular Spectrum Method(ASM) algorithm was Improved by angle weight to simulate the transcranial focal beam deposition. The precision of the algorithm was calibrated via the PE material in vitro setting and then compared the pressure discrepancy between simulated and measured data through a trans-human-cadaver sample setup. The simulation also incorporates the analysis of ongoing clinical testing to provide treatment planning information. The developed ASM algorithm provided the efficient computational capability to calculate a 3D pressure field with a semi-real-time scale with the range to cover the entire brain cavity. The position discrepancy and magnitude between the simulated and measured PE in vitro phantoms were less than 0.5 mm and 5%, respectively. The correlation between the comparison of transcranial measurements (129 positions contributed from 5 human cadavers) as well as the ASM estimations was R2= 0.7233 , the position discrepancy was 2.424mm and NRMS error was 0.1390. This high computing efficient algorithm implementation may provide benefits to improve the treatment planning quality of the current transcranial focused ultrasound treatment. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-06-14T16:07:21Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2023-06-14T16:07:21Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 致謝i
摘要ii Abstract iii 目錄iv 圖目錄vii 表目錄x 第一章緒論1 1.1 聚焦超音波. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.2 聚焦式超音波腦部應用. . . . . . . . . . . . . . . . . . . . . . . . . 3 1.3 療程規劃及聲場分佈模擬. . . . . . . . . . . . . . . . . . . . . . . . 4 1.3.1 均勻介質超音波模擬. . . . . . . . . . . . . . . . . . . . . . . . 4 1.3.2 非均勻介質超音波模擬. . . . . . . . . . . . . . . . . . . . . . . 5 1.4 穿顱聚焦式超音波模擬. . . . . . . . . . . . . . . . . . . . . . . . . 10 1.5 研究目的. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 第二章研究方法15 2.1 理論. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.1.1 雷利-薩瑪菲爾德繞射積分式(Rayleigh-Sommerfeld diffraction integral) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.1.2 傳統角譜法(Traditional angular spectrum method) . . . . . . . . . 16 2.1.3 混合角譜法(Hybrid angular spectrum method) . . . . . . . . . . . 17 2.2 非均質角譜法(Heterogeneous angular spectrum method) . . . . . . . 20 2.2.1 非均質角譜法於角度加權改良. . . . . . . . . . . . . . . . . . . 23 2.3 數值方法細節. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 2.3.1 模擬設備. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 2.3.2 前處理細節. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 2.3.3 數值方法細節. . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 2.3.4 後處理細節. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 2.4 實驗架構及驗證方法. . . . . . . . . . . . . . . . . . . . . . . . . . 30 2.4.1 壓克力場域. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 2.4.2 水場域及顱骨場域. . . . . . . . . . . . . . . . . . . . . . . . . . 31 第三章結果與討論38 3.1 實驗目的. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 3.2 壓克力場域結果分析. . . . . . . . . . . . . . . . . . . . . . . . . . 38 3.3 水場域及顱骨場域結果分析. . . . . . . . . . . . . . . . . . . . . . 41 3.3.1 水場域結果分析. . . . . . . . . . . . . . . . . . . . . . . . . . . 41 3.3.2 顱骨場域結果. . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 3.3.3 顱骨場域穿透率結果分析. . . . . . . . . . . . . . . . . . . . . . 55 3.3.4 顱骨場域位置結果分析. . . . . . . . . . . . . . . . . . . . . . . 61 3.3.5 顱骨場域聚焦分布結果分析. . . . . . . . . . . . . . . . . . . . 62 3.3.6 實驗誤差討論. . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 第四章結論及未來展望65 4.1 結論. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 4.2 未來展望. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66 參考文獻68 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 超音波治療 | zh_TW |
| dc.subject | 聚焦式超音波聲場模擬 | zh_TW |
| dc.subject | 角譜法 | zh_TW |
| dc.subject | Focused ultrasound simulation | en |
| dc.subject | Ultrasonic therapy | en |
| dc.subject | Angular spectrum method | en |
| dc.title | 非均質角譜法於穿顱聚焦式超音波之模擬 | zh_TW |
| dc.title | Heterogeneous Angular Spectrum Method for Trans-Skull Focused Ultrasound Simulation | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 111-1 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 邱錫彥;龍震宇;李正匡 | zh_TW |
| dc.contributor.oralexamcommittee | Shin-Yan Chiou;Chen-Yu Lung;Cheng-Kuang Lee | en |
| dc.subject.keyword | 聚焦式超音波聲場模擬,超音波治療,角譜法, | zh_TW |
| dc.subject.keyword | Focused ultrasound simulation,Ultrasonic therapy,Angular spectrum method, | en |
| dc.relation.page | 75 | - |
| dc.identifier.doi | 10.6342/NTU202300356 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2023-02-13 | - |
| dc.contributor.author-college | 電機資訊學院 | - |
| dc.contributor.author-dept | 電機工程學系 | - |
| dc.date.embargo-lift | 2026-02-08 | - |
| 顯示於系所單位： | 電機工程學系 | |
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