請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/85954完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 梁庚辰(Keng-Chen Liang) | |
| dc.contributor.author | Tsun-Kai Chang | en |
| dc.contributor.author | 張存凱 | zh_TW |
| dc.date.accessioned | 2023-03-19T23:30:19Z | - |
| dc.date.copyright | 2022-09-26 | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022-09-21 | |
| dc.identifier.citation | 陳德祐（2002）：《安非他命之驚跳反應致敏效果與情緒迴路之關係》。（未出版之博士論文）國立臺灣大學，台北市。https://hdl.handle.net/11296/5x56dq Alvarez, J. d. N., Fukushiro, D. F., Tatsu, J. A. O., de Carvalho, E. P., Gandolfi, A. C. d. C., Tsuchiya, J. B., . . . Frussa-Filho, R. (2006). Amphetamine-induced rapid-onset sensitization: role of novelty, conditioning and behavioral parameters. Pharmacology Biochemistry and Behavior, 83(4), 500-507. doi:10.1016/j.pbb.2006.03.010 Arduino.cc. (2015). Arduino - AboutUs. Retrieved from http://www.arduino.cc/en/Main/AboutUs Badiani, A., Anagnostaras, S. G., & Robinson, T. E. (1995). The development of sensitization to the psychomotor stimulant effects of amphetamine is enhanced in a novel environment. Psychopharmacology, 117(4), 443-452. doi:10.1007/BF02246217 Badiani, A., & Robinson, T. E. (2004). Drug-induced neurobehavioral plasticity: The role of environmental context. Behavioural Pharmacology, 15(5), 327-339. doi:10.1097/00008877-200409000-00004 Barnes, C. D. (1988). Sensitization in the nervous system (Vol. 1). CRC Press. Battisti, J. J., Chang, C.-H., Uretsky, N. J., & Wallace, L. J. (1999). Sensitization of stereotyped behavior to amphetamine is context and response dependent. Pharmacology Biochemistry and Behavior, 63(2), 263-269. doi:10.1016/S0091-3057(98)00259-7 Bell, K., & Kalivas, P. W. (1996). Context-specific cross-sensitization between systemic cocaine and intra-accumbens AMPA infusion in the rat. Psychopharmacology, 127(1), 377-383. doi:10.1007/s002130050101 Berman, S. M., Kuczenski, R., McCracken, J. T., & London, E. D. (2009). Potential adverse effects of amphetamine treatment on brain and behavior: A review. Molecular Psychiatry, 14(2), 123-142. doi:10.1038/mp.2008.90 Berridge, K. C. (2017). Incentive motivation and incentive salience. In Reference Module in Neuroscience and Biobehavioral Psychology: Elsevier. doi:10.1016/B978-0-12-809324-5.00342-4 Berridge, K. C., & Robinson, T. E. (2016). Liking, wanting, and the incentive-sensitization theory of addiction. The American Psychologist, 71(8), 670-679. doi:10.1037/amp0000059 Bjijou, Y., De Deurwaerdere, P., Spampinato, U., Stinus, L., & Cador, M. (2002). D-Amphetamine-induced behavioral sensitization: Effect of lesioning dopaminergic terminals in the medial prefrontal cortex, the amygdala and the entorhinal cortex. Neuroscience, 109(3), 499-516. doi:10.1016/S0306-4522(01)00508-5 Bloise, E., Carey, R. J., & Carrera, M. P. (2007). Behavioral sensitization produced by a single administration of apomorphine: implications for the role of Pavlovian conditioning in the mediation of context-specific sensitization. Pharmacology Biochemistry and Behavior, 86(3), 449-457. doi:10.1016/j.pbb.2007.01.002 Boileau, I., Dagher, A., Leyton, M., Gunn, R. N., Baker, G. B., Diksic, M., & Benkelfat, C. (2006). Modeling sensitization to stimulants in humans: An [11C]raclopride/positron emission tomography study in healthy men. Archives of General Psychiatry, 63(12), 1386-1395. doi:10.1001/archpsyc.63.12.1386 Bonate, P. L., Swann, A., & Silverman, P. B. (1996). Context-dependent cross-sensitization between cocaine and amphetamine. Life Sciences, 60(1), PL1-PL7. doi:10.1016/S0024-3205(96)00591-7 Booze, R. M., Welch, M. A., Wood, M. L., Billings, K. A., Apple, S. R., & Mactutus, C. F. (1999). Behavioral sensitization following repeated intravenous nicotine administration: Gender differences and gonadal hormones. Pharmacology Biochemistry and Behavior, 64(4), 827-839. doi:10.1016/S0091-3057(99)00169-0 Borowski, T. B., & Kokkinidis, L. (1992). Long-term influence of d-amphetamine on mesolimbic brain-stimulation reward: Comparison to chronic haloperidol and naloxone effects. Pharmacology Biochemistry and Behavior, 43(1), 1-15. doi:10.1016/0091-3057(92)90634-r Bradley, M. M., Cuthbert, B. N., & Lang, P. J. (1990). Startle reflex modification: Emotion or attention? Psychophysiology, 27(5), 513-522. doi:10.1111/j.1469-8986.1990.tb01966.x Browne, R. G., & Segal, D. S. (1977). Metabolic and experiential factors in the behavioral response to repeated amphetamine. Pharmacology Biochemistry and Behavior, 6(5), 545-552. doi:10.1016/0091-3057(77)90115-0 Cador, M., Bjijou, Y., & Stinus, L. (1995). Evidence of a complete independence of the neurobiological substrates for the induction and expression of behavioral sensitization to amphetamine. Neuroscience, 65(2), 385-395. doi:10.1016/0306-4522(94)00524-9 Cador, M., Cole, B. J., Koob, G. F., Stinus, L., & Le Moal, M. (1993). Central administration of corticotropin releasing factor induces long-term sensitization to d-amphetamine. Brain Research, 606(2), 181-186. doi:10.1016/0006-8993(93)90982-S Calabrese, E. J. (2008). Addiction and dose response: The psychomotor stimulant theory of addiction reveals that hormetic dose responses are dominant. Critical Reviews in Toxicology, 38(7), 599-617. doi:10.1080/10408440802026315 Calipari, E. S., Ferris, M. J., & Jones, S. R. (2014). Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. Journal of Neurochemistry, 128(2), 224-232. doi:10.1111/jnc.12452 Carey, R. J., & Damianopoulos, E. N. (2006). Cocaine conditioning and sensitization: The habituation factor. Pharmacology Biochemistry and Behavior, 84(1), 128-133. doi:10.1016/j.pbb.2006.04.017 Carr, C. C., Ferrario, C. R., & Robinson, T. E. (2020). Intermittent access cocaine self-administration produces psychomotor sensitization: Effects of withdrawal, sex and cross-sensitization. Psychopharmacology (Berl), 237(6), 1795-1812. doi:10.1007/s00213-020-05500-4 Cassella, J. V., & Davis, M. (1986). The design and calibration of a startle measurement system. Physiology & Behavior, 36(2), 377-383. doi:10.1016/0031-9384(86)90032-6 Chapman, H. C., Visser, K. F., Mittal, V. A., Gibb, B. E., Coles, M. E., & Strauss, G. P. (2020). Emotion regulation across the psychosis continuum. Development and Psychopathology, 32(1), 219-227. doi:10.1017/S0954579418001682 Chinen, C. C., Faria, R. R., & Frussa-Filho, R. (2006). Characterization of the rapid-onset type of behavioral sensitization to amphetamine in mice: Role of drug–environment conditioning. Neuropsychopharmacology, 31(1), 151-159. doi:10.1038/sj.npp.1300789 Cleck, J. N., & Blendy, J. A. (2008). Making a bad thing worse: Adverse effects of stress on drug addiction. The Journal of Clinical Investigation, 118(2), 454-461. doi:10.1172/JCI33946 Cole, B. J., Cador, M., Stinus, L., Rivier, J., Vale, W., Koob, G. F., & Le Moal, M. (1990). Central administration of a CRF antagonist blocks the development of stress-induced behavioral sensitization. Brain Research, 512(2), 343-346. doi:10.1016/0006-8993(90)90646-S Cook, E. W., Hawk, L. W., Davis, T. L., & Stevenson, V. E. (1991). Affective individual differences and startle reflex modulation. Journal of Abnormal Psychology, 100(1), 5. doi:10.1037/0021-843x.100.1.5 Crombag, H. S., Badiani, A., Chan, J., Dell'Orco, J., Dineen, S. P., & Robinson, T. E. (2001). The ability of environmental context to facilitate psychomotor sensitization to amphetamine can be dissociated from its effect on acute drug responsiveness and on conditioned responding. Neuropsychopharmacology, 24(6), 680-690. doi:10.1016/S0893-133X(00)00238-4 Cruz, F. C., Marin, M. T., Leão, R. M., & Planeta, C. S. (2012). Stress-induced cross-sensitization to amphetamine is related to changes in the dopaminergic system. Journal of Neural Transmission, 119(4), 415-424. doi:10.1007/s00702-011-0720-8 Cunningham, C. L., & Noble, D. (1992). Conditioned activation induced by ethanol: Role in sensitization and conditioned place preference. Pharmacology Biochemistry and Behavior, 43(1), 307-313. doi:10.1016/0091-3057(92)90673-4 Curran, C., Byrappa, N., & McBride, A. (2004). Stimulant psychosis: Systematic review. British Journal of Psychiatry, 185, 196-204. doi:10.1192/bjp.185.3.196 Damianopoulos, E. N., & Carey, R. J. (1992). Conditioning, habituation and behavioral reorganization factors in chronic cocaine effects. Behavioural Brain Research, 49(2), 149-157. doi:10.1016/s0166-4328(05)80159-7 Davis, M., & Astrachan, D. I. (1981). Spinal modulation of acoustic startle: Opposite effects of clonidine and d-amphetamine. Psychopharmacology, 75(3), 219-225. doi:10.1007/BF00432427 Davis, M., & Sheard, M. H. (1976). p-Chloroamphetamine (PCA): Acute and chronic effects on habituation and sensitization of the acoustic startle response in rats. European Journal of Pharmacology, 35(2), 261-273. doi:10.1016/0014-2999(76)90228-4 Davis, M., Svensson, T. H., & Aghajanian, G. K. (1975). Effects of d- and l-amphetamine on habituation and sensitization of the acoustic startle response in rats. Psychopharmacologia, 43(1), 1-11. doi:10.1007/BF00437607 Easton, N., Steward, C., Marshall, F., Fone, K., & Marsden, C. (2007). Effects of amphetamine isomers, methylphenidate and atomoxetine on synaptosomal and synaptic vesicle accumulation and release of dopamine and noradrenaline in vitro in the rat brain. Neuropharmacology, 52(2), 405-414. doi:10.1016/j.neuropharm.2006.07.035 Eaton, R. C. (1984). Neural mechanisms of startle behavior. Springer Science & Business Media. doi:10.1007/978-1-4899-2286-1 Falk, J. L., Ma, F., & Lau, C. E. (1991). Chronic oral cocaine self-administration: Pharmacokinetics and effects on spontaneous and discriminative motor functions. Journal of Pharmacology and Experimental Therapeutics, 257(1), 457-465. Fawcett, T. J., Cooper, C. S., Longenecker, R. J., & Walton, J. P. (2020). Automated classification of acoustic startle reflex waveforms in young CBA/CaJ mice using machine learning. Journal of Neuroscience Methods, 344, 108853. doi:10.1016/j.jneumeth.2020.108853 Garcia-Keller, C., Martinez, S. A., Esparza, M. A., Bollati, F., Kalivas, P. W., & Cancela, L. M. (2013). Cross-sensitization between cocaine and acute restraint stress is associated with sensitized dopamine but not glutamate release in the nucleus accumbens. European Journal of Neuroscience, 37(6), 982-995. doi:10.1111/ejn.12121 Gaytan, O., Lewis, C., Swann, A., & Dafny, N. (1999). Diurnal differences in amphetamine sensitization. European Journal of Pharmacology, 374(1), 1-9. doi:10.1016/s0014-2999(99)00243-5 George, S. (2003). An audit of the effectiveness of amphetamine isomer ratios as a marker of Dexedrine compliance in amphetamine abusers. Addiction Biology, 8(4), 439-443. doi:10.1080/13556210310001646411 George, S., & Braithwaite, R. A. (2000). Using amphetamine isomer ratios to determine the compliance of amphetamine abusers prescribed dexedrine. Journal of Analytical Toxicology, 24(3), 223-227. doi:10.1093/jat/24.3.223 Geyer, M. A., & Braff, D. L. (1987). Startle habituation and sensorimotor gating in schizophrenia and related animal models. Schizophrenia Bulletin, 13(4), 643-668. doi:10.1093/schbul/13.4.643 Geyer, M. A., Swerdlow, N. R., Mansbach, R. S., & Braff, D. L. (1990). Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Research Bulletin, 25(3), 485-498. doi:10.1016/0361-9230(90)90241-Q Glaser, P. E., Thomas, T. C., Joyce, B. M., Castellanos, F. X., & Gerhardt, G. A. (2005). Differential effects of amphetamine isomers on dopamine release in the rat striatum and nucleus accumbens core. Psychopharmacology, 178(2), 250-258. doi:10.1007/s00213-004-2012-6 Gómez-Nieto, R., Horta-Júnior, J. d. A. C., Castellano, O., Millian-Morell, L., Rubio, M. E., & López, D. E. (2014). Origin and function of short-latency inputs to the neural substrates underlying the acoustic startle reflex. Frontiers in Neuroscience, 8, 216. doi:10.3389/fnins.2014.00216 Griffith, J. (1966). A study of illicit amphetamine drug traffic in Oklahoma city. American Journal of Psychiatry, 123(5), 560-569. doi:10.1176/ajp.123.5.560 Groves, P. M., & Thompson, R. F. (1970). Habituation: a dual-process theory. Psychological Review, 77(5), 419. doi:10.1037/h0029810 Guillory, A. M., Herrera, S. H., Baker, L. K., Bubula, N., Forneris, J., You, Z.-B., . . . Singer, B. F. (2022). Conditioned inhibition of amphetamine sensitization. Neurobiology of Learning and Memory, 192, 107636. doi:10.1016/j.nlm.2022.107636 Heal, D. J., Smith, S. L., Gosden, J., & Nutt, D. J. (2013). Amphetamine, past and present--a pharmacological and clinical perspective. Journal of Psychopharmacology, 27(6), 479-496. doi:10.1177/0269881113482532 Horger, B. A., Shelton, K., & Schenk, S. (1990). Preexposure sensitizes rats to the rewarding effects of cocaine. Pharmacology Biochemistry and Behavior, 37(4), 707-711. doi:10.1016/0091-3057(90)90552-s Hu, M., & Becker, J. B. (2003). Effects of sex and estrogen on behavioral sensitization to cocaine in rats. Journal of Neuroscience, 23(2), 693. doi:10.1523/JNEUROSCI.23-02-00693.2003 Jing, L., Zhang, M., Li, J. X., Huang, P., Liu, Q., Li, Y. L., . . . Liang, J. H. (2014). Comparison of single versus repeated methamphetamine injection induced behavioral sensitization in mice. Neuroscience Letters, 560, 103-106. doi:10.1016/j.neulet.2013.12.024 Jones, C., Watson, D., & Fone, K. (2011). Animal models of schizophrenia. British Journal of Pharmacology, 164(4), 1162-1194. doi:10.1111/j.1476-5381.2011.01386.x Jones, C. N., Hill, H. F., & Harris, R. T. (1974). Discriminative response control by d-amphetamine and related compounds in the rat. Psychopharmacologia, 36(4), 347-356. doi:10.1007/bf00422566 Joyce, E. M., & Iversen, S. D. (1979). The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat. Neuroscience Letters, 14(2-3), 207-212. doi:10.1016/0304-3940(79)96149-4 Kabbaj, M., Isgor, C., Watson, S. J., & Akil, H. (2002). Stress during adolescence alters behavioral sensitization to amphetamine. Neuroscience, 113(2), 395-400. doi:10.1016/S0306-4522(02)00188-4 Kilts, C. D. (2001). Imaging the roles of the amygdala in drug addiction. Psychopharmacology Bulletin, 35(1), 84-94. Koch, M., & Schnitzler, H.-U. (1997). The acoustic startle response in rats—circuits mediating evocation, inhibition and potentiation. Behavioural Brain Research, 89(1), 35-49. doi:10.1016/S0166-4328(97)02296-1 Kokkinidis, L. (1984). Effects of chronic intermittent and continuous amphetamine administration on acoustic startle. Pharmacology Biochemistry and Behavior, 20(3), 367-371. doi:10.1016/0091-3057(84)90272-7 Kokkinidis, L., & Anisman, H. (1980). Amphetamine models of paranoid schizophrenia: an overview and elaboration of animal experimentation. Psychological Bulletin, 88(3), 551-579. doi:10.1037/0033-2909.88.3.551 Kokkinidis, L., & MacNeill, E. P. (1982). Potentiation of d-amphetamine and L-dopa-induced acoustic startle activity after long-term exposure to amphetamine. Psychopharmacology (Berl), 78(4), 331-335. doi:10.1007/bf00433736 Kolta, M., Scalzo, F., Ali, S., & Holson, R. (1990). Ontogeny of the enhanced behavioral response to amphetamine in amphetamine-pretreated rats. Psychopharmacology, 100(3), 377-382. doi:10.1007/BF02244610 Korn, H., & Faber, D. S. (1996). Escape behavior — brainstem and spinal cord circuitry and function. Current Opinion in Neurobiology, 6(6), 826-832. doi:10.1016/S0959-4388(96)80034-1 Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (1990). Emotion, attention, and the startle reflex. Psychological Review, 97(3), 377. doi:10.1037/0033-295X.97.3.377 Laviola, G., Wood, R. D., Kuhn, C., Francis, R., & Spear, L. P. (1995). Cocaine sensitization in periadolescent and adult rats. Journal of Pharmacology and Experimental Therapeutics, 275(1), 345-357. Leith, N. J., & Kuczenski, R. (1982). Two dissociable components of behavioral sensitization following repeated amphetamine administration. Psychopharmacology (Berl), 76(4), 310-315. doi:10.1007/bf00449116 Li, L., Du, Y., Li, N., Wu, X., & Wu, Y. (2009). Top–down modulation of prepulse inhibition of the startle reflex in humans and rats. Neuroscience & Biobehavioral Reviews, 33(8), 1157-1167. doi:10.1016/j.neubiorev.2009.02.001 Liu, Y., Morgan, D., & Roberts, D. C. S. (2007). Cross-sensitization of the reinforcing effects of cocaine and amphetamine in rats. Psychopharmacology, 195(3), 369-375. doi:10.1007/s00213-007-0909-6 Livingstone, K., Harper, S., & Gillanders, D. (2009). An exploration of emotion regulation in psychosis. Clinical Psychology & Psychotherapy: An International Journal of Theory & Practice, 16(5), 418-430. doi:10.1002/cpp.635 Mattingly, B. A., Koch, C., Osborne, F. H., & Gotsick, J. E. (1997). Stimulus and response factors affecting the development of behavioral sensitization to apomorphine. Psychopharmacology, 130(2), 109-116. doi:10.1007/s002130050217 Mattson, B. J., Koya, E., Simmons, D. E., Mitchell, T. B., Berkow, A., Crombag, H. S., & Hope, B. T. (2008). Context‐specific sensitization of cocaine‐induced locomotor activity and associated neuronal ensembles in rat nucleus accumbens. European Journal of Neuroscience, 27(1), 202-212. doi:10.1111/j.1460-9568.2007.05984.x McKerchar, T. L., Zarcone, T. J., & Fowler, S. C. (2006). Use of a force-plate actometer for detecting and quantifying vertical leaping induced by amphetamine in BALB/cJ mice, but not in C57BL/6J, DBA/2J, 129X1/SvJ, C3H/HeJ, and CD-1 mice. Journal of Neuroscience Methods, 153(1), 48-54. doi:10.1016/j.jneumeth.2005.10.002 McSweeney, F. K., Murphy, E. S., & Kowal, B. P. (2005). Regulation of drug taking by sensitization and habituation. Experimental and Clinical Psychopharmacology, 13(3), 163. doi:10.1037/1064-1297.13.3.163 Mueller, K., Kunko, P. M., Whiteside, D., & Haskett, C. (1989). Time course of amphetamine-induced locomotor stereotypy in an open field. Psychopharmacology (Berl), 99(4), 501-507. doi:10.1007/bf00589899 Neisewander, J. L., Baker, D. A., Fuchs, R. A., Tran-Nguyen, L. T., Palmer, A., & Marshall, J. F. (2000). Fos protein expression and cocaine-seeking behavior in rats after exposure to a cocaine self-administration environment. Journal of Neuroscience, 20(2), 798-805. doi:10.1523/jneurosci.20-02-00798.2000 Paulson, P. E., Camp, D. M., & Robinson, T. E. (1991). Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats. Psychopharmacology (Berl), 103(4), 480-492. doi:10.1007/bf02244248 Paulson, P. E., & Robinson, T. E. (1995). Amphetamine-induced time-dependent sensitization of dopamine neurotransmission in the dorsal and ventral striatum: A microdialysis study in behaving rats. Synapse, 19(1), 56-65. doi:10.1002/syn.890190108 Peleg-Raibstein, D., Knuesel, I., & Feldon, J. (2008). Amphetamine sensitization in rats as an animal model of schizophrenia. Behavioural Brain Research, 191(2), 190-201. doi:10.1016/j.bbr.2008.03.037 Phillips, A. G., Brooke, S. M., & Fibiger, H. C. (1975). Effects of amphetamine isomers and neuroleptics on self-stimulation from the nucleus accumbens and dorsal nor-adrenergenic bundle. Brain Research, 85(1), 13-22. doi:10.1016/0006-8993(75)90998-1 Phillips, A. G., & Di Ciano, P. (1996). Behavioral sensitization is induced by intravenous self-administration of cocaine by rats. Psychopharmacology, 124(3), 279-281. doi:10.1007/BF02246669 Phillips, T. J., Roberts, A. J., & Lessov, C. N. (1997). Behavioral sensitization to ethanol: Genetics and the effects of stress. Pharmacology Biochemistry and Behavior, 57(3), 487-493. doi:10.1016/S0091-3057(96)00448-0 Piazza, P. V., Deminière, J. M., le Moal, M., & Simon, H. (1989). Factors that predict individual vulnerability to amphetamine self-administration. Science, 245(4925), 1511-1513. doi:10.1126/science.2781295 Piazza, P. V., Deminière, J. M., le Moal, M., & Simon, H. (1990). Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration. Brain Research, 514(1), 22-26. doi:10.1016/0006-8993(90)90431-A Pierce, R. C., & Kalivas, P. W. (1997). A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Research Reviews, 25(2), 192-216. doi:10.1016/s0165-0173(97)00021-0 Pierce, R. C., Reeder, D., Hicks, J., Morgan, Z., & Kalivas, P. (1997). Ibotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaine. Neuroscience, 82(4), 1103-1114. doi:10.1016/s0306-4522(97)00366-7 Pilz, P. K., & Schnitzler, H.-U. (1996). Habituation and sensitization of the acoustic startle response in rats: Amplitude, threshold, and latency measures. Neurobiology of Learning and Memory, 66(1), 67-79. doi:10.1006/nlme.1996.0044 Pinel, J. P. J., Kim, C. K., & Mana, M. J. (1990). Contingent tolerance to the anticonvulsant effects of drugs on kindled convulsions. In J. A. Wada (Ed.), Kindling 4 (pp. 283-297). Boston, MA: Springer US. doi:10.1007/978-1-4684-5796-4_21 Pope, S. G., Dean, P., & Redgrave, P. (1980). Dissociation of d-amphetamine-induced locomotor activity and stereotyped behaviour by lesions of the superior colliculus. Psychopharmacology, 70(3), 297-302. doi:10.1007/BF00427890 Post, R. M., Lockfeld, A., Squillace, K. M., & Contel, N. R. (1981). Drug-environment interaction: Context dependency of cocaine-induced behavioral sensitization. Life Sciences, 28(7), 755-760. doi:10.1016/0024-3205(81)90157-0 Post, R. M., Weiss, S. R., & Pert, A. (1992). Sensitization and kindling effects of chronic cocaine administration. In (pp. 115-161): CRC Press: Boca Raton. Poulos, C. X., & Cappell, H. (1991). Homeostatic theory of drug tolerance: A general model of physiological adaptation. Psychological Review, 98(3), 390. doi:10.1037/0033-295x.98.3.390 Robinson, T. E. (1984). Behavioral sensitization: Characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats. Psychopharmacology (Berl), 84(4), 466-475. doi:10.1007/bf00431451 Robinson, T. E., & Becker, J. B. (1982). Behavioral sensitization is accompanied by an enhancement in amphetamine-stimulated dopamine release from striatal tissue in vitro. European Journal of Pharmacology, 85(2), 253-254. doi:10.1016/0014-2999(82)90478-2 Robinson, T. E., & Becker, J. B. (1986). Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis. Brain Research Reviews, 396(2), 157-198. doi:10.1016/s0006-8993(86)80193-7 Robinson, T. E., Becker, J. B., & Presty, S. K. (1982). Long-term facilitation of amphetamine-induced rotational behavior and striatal dopamine release produced by a single exposure to amphetamine: Sex differences. Brain Research, 253(1), 231-241. doi:10.1016/0006-8993(82)90690-4 Robinson, T. E., & Berridge, K. C. (1993). The neural basis of drug craving: An incentive-sensitization theory of addiction. Brain Research Reviews, 18(3), 247-291. doi:10.1016/0165-0173(93)90013-P Robinson, T. E., & Berridge, K. C. (2003). Addiction. Annual Review of Psychology, 54(1), 25-53. doi:10.1146/annurev.psych.54.101601.145237 Robinson, T. E., & Berridge, K. C. (2008). Review. The incentive sensitization theory of addiction: Some current issues. Philosophical Transactions of the Royal Society B, 363(1507), 3137-3146. doi:10.1098/rstb.2008.0093 Rosen, J. B., Hitchcock, J. M., Sananes, C. B., Miserendino, M. J., & Davis, M. (1991). A direct projection from the central nucleus of the amygdala to the acoustic startle pathway: Anterograde and retrograde tracing studies. Behavioral Neuroscience, 105(6), 817. doi:10.1037/0735-7044.105.6.817 Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003). Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron, 37(4), 577-582. doi:10.1016/s0896-6273(03)00021-7 Salazar-Juárez, A., Barbosa-Méndez, S., Jurado, N., Hernández-Miramontes, R., Leff, P., & Antón, B. (2016). Mirtazapine prevents induction and expression of cocaine-induced behavioral sensitization in rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 68, 15-24. doi:10.1016/j.pnpbp.2016.02.010 Sax, K. W., & Strakowski, S. M. (2001). Behavioral sensitization in humans. Journal of Addictive Diseases, 20(3), 55-65. doi:10.1300/J069v20n03_06 Segal, D. S., & Mandell, A. J. (1974). Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypy. Pharmacology Biochemistry and Behavior, 2(2), 249-255. doi:10.1016/0091-3057(74)90060-4 Smith, R. C., & Davis, J. M. (1977). Comparative effects of d-amphetamine, l-amphetamine, and methylphenidate on mood in man. Psychopharmacology (Berl), 53(1), 1-12. doi:10.1007/bf00426687 Steketee, J. D., & Kalivas, P. W. (2011). Drug wanting: Behavioral sensitization and relapse to drug-seeking behavior. Pharmacological Reviews, 63(2), 348-365. doi:10.1124/pr.109.001933 Stewart, J., & Vezina, P. (1991). Extinction procedures abolish conditioned stimulus control but spare sensitized responding to amphetamine. Behavioural Pharmacology, 2(1), 65-71. doi:10.1097/00008877-199102000-00009 Strakowski, S. M., Sax, K. W., Rosenberg, H. L., DelBello, M. P., & Adler, C. M. (2001). Human response to repeated low-dose d-amphetamine: Evidence for behavioral enhancement and tolerance. Neuropsychopharmacology, 25(4), 548-554. doi:10.1016/S0893-133X(01)00253-6 Taylor, K. M., & Snyder, S. H. (1970). Amphetamine: Differentiation by d and l isomers of behavior involving brain norepinephrine or dopamine. Science, 168(3938), 1487-1489. doi:10.1126/science.168.3938.1487 Tirelli, E., & Terry, P. (1998). Amphetamine-induced conditioned activity and sensitization: The role of habituation to the test context and the involvement of Pavlovian processes. Behavioural Pharmacology, 9(5-6), 409-419. doi:10.1097/00008877-199809000-00004 Tost, H., Alam, T., & Meyer-Lindenberg, A. (2010). Dopamine and psychosis: Theory, pathomechanisms and intermediate phenotypes. Neuroscience & Biobehavioral Reviews, 34(5), 689-700. doi:10.1016/j.neubiorev.2009.06.005 Trombin, T. F., Procópio-Souza, R., Kameda, S. R., Zanlorenci, L. H. F., Fukushiro, D. F., Calzavara, M. B., . . . Frussa-Filho, R. (2018). Environmental novelty modulates the induction and expression of single injection-induced behavioral sensitization to morphine. Pharmacology Biochemistry and Behavior, 173, 90-95. doi:10.1016/j.pbb.2018.07.006 Van Den Buuse, M., Garner, B., Gogos, A., & Kusljic, S. (2005). Importance of animal models in schizophrenia research. Australian & New Zealand Journal of Psychiatry, 39(7), 550-557. doi:10.1080/j.1440-1614.2005.01626.x Vanderschuren, L. J., Schmidt, E. D., De Vries, T. J., Van Moorsel, C. A., Tilders, F. J., & Schoffelmeer, A. N. (1999). A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats. Journal of Neuroscience, 19(21), 9579-9586. doi:10.1523/jneurosci.19-21-09579.1999 Vestin, E., Lagström, O., Domi, A., Ericson, M., Söderpalm, B., & Adermark, L. (2022). Differential and long-lasting changes in neurotransmission in the amygdala of male Wistar rats during extended amphetamine abstinence. Neuropharmacology, 210, 109041. doi:10.1016/j.neuropharm.2022.109041 Vezina, P., & Leyton, M. (2009). Conditioned cues and the expression of stimulant sensitization in animals and humans. Neuropharmacology, 56, 160-168. doi:10.1016/j.neuropharm.2008.06.070 Wise, R. A., & Bozarth, M. A. (1987). A psychomotor stimulant theory of addiction. Psychological Review, 94(4), 469-492. doi:10.1037/0033-295X.94.4.469 Wise, R. A., Gingras, M. A., & Amit, Z. (1996). Influence of novel and habituated testing conditions on cocaine sensitization. European Journal of Pharmacology, 307(1), 15-19. doi:10.1016/0014-2999(96)00218-X Wise, R. A., & Koob, G. F. (2014). The development and maintenance of drug addiction. Neuropsychopharmacology, 39(2), 254-262. doi:10.1038/npp.2013.261 Wolf, M. E., Dahlin, S. L., Hu, X. T., Xue, C. J., & White, K. (1995). Effects of lesions of prefrontal cortex, amygdala, or fornix on behavioral sensitization to amphetamine: comparison with N-methyl-d-aspartate antagonists. Neuroscience, 69(2), 417-439. doi:10.1016/0306-4522(95)00248-H Wolf, M. E., White, F. J., Nassar, R., Brooderson, R. J., & Khansa, M. R. (1993). Differential development of autoreceptor subsensitivity and enhanced dopamine release during amphetamine sensitization. Journal of Pharmacology and Experimental Therapeutics, 264(1), 249-255. Yokel, R. A., & Pickens, R. (1973). Self-administration of optical isomers of amphetamine and methylamphetamine by rats. Journal of Pharmacology and Experimental Therapeutics, 187(1), 27-33. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/85954 | - |
| dc.description.abstract | 反覆使用精神興奮劑會增強藥物對行為的促進效果，稱為行為致敏化。行為致敏化的產生被認為是引發藥物成癮及藥物導致精神障礙的原因之一，因此透過致敏化相關的研究有助於了解行為異常的機制。本研究利用與實際濫用及醫療處置接近的消旋安非他命作為引發致敏化的藥物，探討其效果。在行為測試上，本研究採用大白鼠的聽覺驚跳反應(acoustic startle response)作為致敏化的指標，並透過自製的驚跳反應系統予以量測。該自製系統通過不同測試檢驗，證實其實用性。本研究應用其探討不同致敏化調節因素的影響，例如藥物注射程序、引發期情境、以及致敏表現期間杏仁核活性。研究結果顯示消旋安非他命如其他異構物同樣可引發行為致敏化，但其效價(potency)較右旋安非他命為低。注射單劑5.0 mg/kg的消旋安非他命，於一個月的戒斷後，可測得對同樣劑量消旋安非他命致敏化，若僅隔兩周測試則無效。然而此單次注射致敏化較不穩定，易受其他因素影響。連續七天重複注射5.0 mg/kg的消旋安非他命可引發立即致敏化，而其效果具有倒U型趨勢，消旋安非他命對驚跳反應的促進效果先隨著注射天數先增加，後續又降低，這現象暗示致敏效果可能同時受藥物引發習慣化作用的影響。經過一個月的戒斷後，重複注射派典下表現出延宕致敏化。透過比較單一與重複注射兩種典範，發現重複注射引發的致敏化效果較單一注射更為穩定。若改變引發期情境，使大白鼠於飼養籠接受消旋安非他命重複注射，仍可於一個月後展現行為致敏化；反之若大白鼠於飼養籠僅接受單次注射，則無法於一個月後展現致敏化。此外在致敏化表現上，以利多卡因抑制杏仁核活性不影響重複注射引發致敏化之表現。綜合以上結果，消旋安非他命如右旋安非他命一般可引發致敏化效果，但會受到各種因素所調節。本研究成果可作為藥物致敏化相關神經機制的研究基礎，同時也可提供實際醫療應用參考，降低消旋安非他命作為處方用藥的負向效果。 | zh_TW |
| dc.description.abstract | Repeated administration of psychostimulants such as amphetamine can lead to a progressive increase in the drug-activating behavior, which is noted as behavioral sensitization. It is considered to be a primary cause for drug addiction and stimulant-related psychosis. Therefore, understanding the mechanism of behavioral sensitization can improve our knowledge about the mechanism of these abnormal behaviors. The present study aimed to examine the behavioral sensitization effect of dl-amphetamine, as this mixed-isomer is widely used in the drug addicts and for the treatment of ADHD. We used it to investigate the phenomenon of behavioral sensitization and the various modulating factors of it, such as the administration protocol and the induction context; as well as the role of amygdala in expression of the sensitization effect. Acoustic startle responses were used to index behavioral sensitization in this study. We developed a complete open-source startle system to conduct the behavioral experiments. This home-made system was verified by empirical data to be reliable and valid for assessing the startle behavior. Results showed that dl-amphetamine could induce a dose-dependent enhancing effect on startle, just as the other forms of isomers, but it was less potent than that of d-amphetamine. A single injection of 5.0 mg/kg of dl-amphetamine could induce behavioral sensitization after one month of withdrawal, but not after two weeks. Yet the effect was not very robust and could be altered by certain modulating factors. Repeated administration of 5.0 mg/kg dl-amphetamine for 7 days induced an immediate form of sensitization with an inverted-U function, with startle augmented at the middle of the injection period but subsided at the end of it. A delayed form of sensitization to the repeated administration paradigm also developed after one month of drug withdrawal. By comparing the sensitization one month after the induction, the sensitization induced by the multiple-injection paradigm was more robust than that by the single-injection paradigm. For example, the effect of the multiple injections was persistent by injecting the drug at the home cage such that the context between induction and challenge was different, while the effect of the single injection was abolished when the injection was given at the home cage. Further, the delayed sensitization induced by the multiple injections was impervious to suppression of the amygdala with lidocaine, while that induced by the single injection vanished by the intra-amygdala cannula implantation and drug infusion procedure. These findings suggest that several factors must be taken into consideration in analyzing dl-amphetamine-induced sensitization, for example, the induction paradigm and the context contingency. Further, a habituation process might be involved in the multiple-injection paradigm that resulted in an immediate form of sensitization during the induction period. These results could contribute to our understanding of the neural mechanisms underlying behavioral sensitization and be applied to clinical practices to minimize the potential negative effects of dl-amphetamine for its therapeutic use. | en |
| dc.description.provenance | Made available in DSpace on 2023-03-19T23:30:19Z (GMT). No. of bitstreams: 1 U0001-1609202202470600.pdf: 4880033 bytes, checksum: 39fb0b1b88b2f956e1ffff52862b906e (MD5) Previous issue date: 2022 | en |
| dc.description.tableofcontents | 誌謝 i 摘要 iv Abstract v 第一章 緒論 1 第一節 引言 1 第二節 心理刺激性藥物引發行為致敏化 2 第三節 消旋安非他命與行為致敏化 4 第四節 行為致敏化之調控因素 6 第五節 行為致敏化之神經機制 8 第六節 聽覺驚跳反應於行為致敏化之應用 9 第七節 驚跳反應系統建置 13 第八節 研究目的 15 第二章 聽覺驚跳反應系統建構 16 第一節 系統元件及架構 16 第二節 聽覺驚跳反應系統信效度測試 26 壹、驚跳系統穩定性測試 26 貳、驚跳系統效度測試 29 第三節 小結 31 第三章 安非他命引發之行為致敏化 33 第一節 一般材料與方法 33 第二節 安非他命引發之驚跳反應致敏化 38 第四章 實驗結果 41 第一節 實驗1安非他命與聽覺驚跳反應之劑量反應關係 41 第二節 實驗2單一注射安非他命引發驚跳反應致敏化 43 壹、實驗2-1戒斷期長度對於單一注射引發行為致敏化之影響 43 貳、實驗2-2單一注射安非他命引發行為致敏化 46 參、實驗2-3飼養籠單一注射對於行為致敏化之作用 47 肆、實驗2-4壓抑杏仁核對於單一注射引發行為致敏化的影響 49 伍、實驗2小結 51 第三節 實驗3重複注射安非他命引發驚跳反應致敏化 52 壹、實驗3-1重複注射安非他命引發行為致敏化 52 貳、實驗3-2飼養籠重複注射對於行為致敏化之作用 56 參、實驗3-3壓抑杏仁核對於重複注射引發行為致敏化的影響 58 肆、實驗3小結 61 第五章 綜合討論 62 第一節 研究成果綜述 62 第二節 驚跳反應測試系統 63 第三節 消旋安非他命於驚跳反應之效價 66 第四節 消旋安非他命引發聽覺驚跳反應致敏化之調節 66 第五節 重複注射消旋安非他命於驚跳反應之倒U型助長趨勢 73 第六節 研究總結 77 參考文獻 79 圖1-1 : 本實驗室市售驚跳反應系統於實驗前後穩定性表現 14 圖2-1 : 驚跳反應系統基礎架構 17 圖2-2 : 木製隔音箱 17 圖2-3：驚跳測試盒外觀 18 圖2-4：驚跳測試盒於隔音箱中 19 圖2-5：壓力感測器荷重元 20 圖2-6：荷重元測量之驚跳反應示意圖 20 圖2-7：類比數位轉換器ADS1256(左)及微控制器Arduino Uno(右) 21 圖2-8 : 單板微型電腦樹莓派4B+ 22 圖2-9 : 音頻撥放器WAV Trigger 23 圖2-10 : 自製聽覺驚跳系統架構圖 24 圖2-11 : 自製驚跳系統實驗控制時序流程 25 圖2-12 : 實驗時螢幕顯示大鼠的驚跳反應 26 圖2-13 : 靜止500克砝碼於驚跳嘗試下表現 28 圖2-14 : 以500克砝碼測試四組驚跳箱之穩定性 28 圖2-15 : 自製驚跳系統於不同砝碼重量下之平均誤差值 30 圖2-16 : 不同聲音強度引發大鼠驚跳反應示意圖 31 圖3-1 : 組織切片及針頭位置示意圖 36 圖3-2 : 驚跳反應行為測試流程 38 圖3-3 : 驚跳反應計算示意圖 40 圖4-1 : 單一安非他命注射對聽覺驚跳比例改變值之影響 42 圖4-2 : 無聲嘗試下，單一安非他命注射對曲線下面積差異之影響 43 圖4-3 : 實驗2-1流程 44 圖4-4 : 單次注射引發後兩周挑戰之結果 45 圖4-5 : 單次注射引發後一個月挑戰之結果 45 圖4-6 : 實驗2-2流程 46 圖4-7 : 單次注射一個月後挑戰之結果 47 圖4-8 : 實驗2-3流程 48 圖4-9 : 飼養籠單一注射引發下挑戰之結果 49 圖4-10 : 實驗2-4流程 50 圖4-11 : 單次注射安非他命5.0 mg/kg後一個月，顱內注射磷酸鹽緩衝生理鹽水或利多卡因對5.0 mg/kg安非他命挑戰之影響 51 圖4-12 : 實驗3-1流程 53 圖4-13 : 連續七天重複注射5.0 mg/kg安非他命對驚跳比例改變值之影響 55 圖4-14 : 連續七天重複注射5.0 mg/kg安非他命對無聲刺激下曲線下面積影響 55 圖4-15 : 引發期重複注射結束後兩天挑戰之結果 56 圖4-16 : 引發期重複注射結束後一個月挑戰之結果 56 圖4-17 : 實驗3-2流程 57 圖4-18 : 飼養籠連續七天重複注射後一個月挑戰之結果 58 圖4-19 : 實驗3-3流程 59 圖4-20 : 杏仁核顱內埋管連續七天重複注射5.0 mg/kg安非他命對驚跳反應之結果 60 圖4-21 : 杏仁核顱內注射對連續注射安非他命引發致敏化之影響 60 圖5-1 : 安非他命異構物對驚跳反應之劑量反應曲線受致敏化影響之示意圖 69 圖5-2 : 雙歷程理論於重複注射安非他命引發驚跳反應倒U型趨勢之示意圖 77 圖5-3 : 行為致敏化受藥物經驗及其他調節因素共同形塑 78 | |
| dc.language.iso | zh-TW | |
| dc.subject | 大白鼠 | zh_TW |
| dc.subject | 杏仁核 | zh_TW |
| dc.subject | 戒斷 | zh_TW |
| dc.subject | 情境一致性 | zh_TW |
| dc.subject | 成癮 | zh_TW |
| dc.subject | addiction | en |
| dc.subject | withdrawal | en |
| dc.subject | context consistency | en |
| dc.subject | rats | en |
| dc.subject | amygdala | en |
| dc.title | 消旋安非他命引發聽覺驚跳反應之致敏化效用 | zh_TW |
| dc.title | The Effect of DL-Amphetamine on Inducing Sensitization of the Acoustic Startle Response | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 110-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳德祐(Der-Yow Chen),蕭富仁(Fu-Zen Shaw),顏怡君(Yi-Chun Yen) | |
| dc.subject.keyword | 杏仁核,成癮,戒斷,情境一致性,大白鼠, | zh_TW |
| dc.subject.keyword | amygdala,addiction,withdrawal,context consistency,rats, | en |
| dc.relation.page | 91 | |
| dc.identifier.doi | 10.6342/NTU202203460 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2022-09-22 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 心理學研究所 | zh_TW |
| dc.date.embargo-lift | 2022-09-26 | - |
| 顯示於系所單位： | 心理學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| U0001-1609202202470600.pdf | 4.77 MB | Adobe PDF | 檢視/開啟 |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。