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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/84559完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 徐善慧(Shan-hui Hsu) | |
| dc.contributor.author | Li-Ting Juan | en |
| dc.contributor.author | 阮俐庭 | zh_TW |
| dc.date.accessioned | 2023-03-19T22:15:38Z | - |
| dc.date.copyright | 2022-09-23 | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022-09-20 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/84559 | - |
| dc.description.abstract | 水凝膠是能夠吸收和保留大量水的聚合物網絡。冷凍凝膠是由單體或聚合物前體在適度冷凍的溶液中化學或物理交聯製成的大孔結構，具有高吸水性、結構耐久性和可壓縮性。關於形狀記憶冷凍凝膠的研究很少，也沒有冷凍凝膠基於纖維素交聯劑的研究。在這裡我們合成了具有醛基作為交聯劑的多功能奈米纖維 (MCNF)，以生產殼聚醣水凝膠和冷凍凝膠。水凝膠（固含量 < 2%）具有自癒合+（損傷後約 100% 癒合）和剪切稀化特性，已通過流變學驗證。通過動態力學分析，冷凍凝膠顯示出高吸水率 (> 4300%) 和良好的可壓縮性。水凝膠和冷凍凝膠都是可注射的（分別通過 27 號和 18 號針頭）。特別是，冷凍凝膠（奈米纖維素：殼聚醣 1:6）揭示了熱誘導的形狀記憶，其機制通過原位小角 X 射線散射 (SAXS) 和廣角 X 射線散射 (WAXS) 闡明在形狀記憶程序期間冷凍凝膠的誘導晶體結構的取向變化解釋了其形狀記憶特性。形狀記憶允許大尺寸（15 mm × 10 mm × 1.1 mm）的冷凍凝膠片材通過 16G 針頭注射，並在 37°C 水中恢復其原始形狀。奈米纖維素殼聚醣形狀記憶冷凍凝膠顯示出細胞相容性和促進細胞生長的能力。奈米纖維素-殼聚醣水凝膠和冷凍凝膠是可注射和可降解的生物材料，具備可調節的機械性能，未來有應用於精準醫療及微創手術之潛力。 | zh_TW |
| dc.description.abstract | Hydrogels are polymeric networks capable of absorbing and retaining large amounts of water. Cryogels are macroporous structures made of monomers or polymeric precursors chemically or physically crosslinked in moderately frozen solutions, and have high water absorption, structural durability, and compressibility. There are few studies on shape memory cryogel, and none is based on cellulose crosslinker. Here we synthesized multifunctional cellulose nanofibers (MCNFs) with aldehyde group as crosslinker to produce chitosan hydrogel and cryogel. The hydrogel (solid content < 2%) had self-healing (~100% healing after injury) and shear thinning properties, verified by rheology. The cryogel showed high water absorption (> 4300%) and good compressibility through dynamic mechanical analyses. The hydrogel and cryogel were both injectable (via 27-gauge and 18-gauge needles, respectively). In particular, the cryogel (nanocellulose:chitosan 1:6) revealed thermally-induced shape memory, of which the mechanism was elucidated by in situ small-angle X-ray scattering (SAXS) and wide-angle X-ray scattering (WAXS). Changes in the orientation of the induced crystalline structure of the cryogel during the shape memory program accounted for its shape memory property. The shape memory allowed the cryogel sheet with a large size (15 mm × 10 mm × 1.1 mm) to be injected through a 16G needle and return to its original shape in 37 °C water. The nanocellulose-chitosan shape memory cryogel showed cytocompatibility and the ability to promote cell growth. The nanocellulose-chitosan hydrogel and cryogel are injectable and degradable biomaterials with adjustable mechanical properties for precision medicine and minimally invasive surgery. | en |
| dc.description.provenance | Made available in DSpace on 2023-03-19T22:15:38Z (GMT). No. of bitstreams: 1 U0001-1209202216465900.pdf: 2395963 bytes, checksum: f7198d08b22f7d8b9e6fa76943790f8e (MD5) Previous issue date: 2022 | en |
| dc.description.tableofcontents | 目錄 致謝 II 摘要 III 圖目錄 IX 表目錄 X 第一章 文獻回顧 1 1.1. 水凝膠介紹 1 1.2. 自癒合水凝膠 2 1.3. 冷凍凝膠的介紹 3 1.4. 殼聚醣自癒合水凝膠及冷凍凝膠 3 1.5. 席夫鹼(schiff base)交聯劑 4 1.6. 奈米纖維素 6 1.6.1. TEMPO-氧化奈米纖維素 6 1.7. 形狀記憶聚合物 8 1.7.1. 形狀記憶冷凍凝膠 9 1.8. 研究目的 10 第二章 研究方法 12 2.1. 研究架構 12 2.2. 合成奈米纖維素 14 2.3. 合成Multifunctional cellulose nanofiber (MCNFs) 14 2.4. 鑑定MCNF交聯劑 14 2.4.1. 傅立葉變換紅外光譜 14 2.4.2. 穿透式電子顯微鏡 15 2.4.3. 動態光散射及Zeta電位分析 15 2.4.4. 醛基含量測定 15 2.5. 奈米纖維素交聯劑性質分析(MCNF crosslinker) 16 2.5.1. 熱性質分析 16 2.5.2. X光繞射分析 16 2.5.3. 廣角度X光散射分析 16 2.6. 奈米纖維素殼聚醣水凝膠和冷凍凝膠的製備 17 2.7. 奈米纖維素殼聚醣自修復水凝膠的表徵 17 2.8. 奈米纖維素殼聚醣冷凍凝膠的表徵及壓縮性質 18 2.8.1. 掃描式電子顯微鏡 18 2.8.2. 冷凍凝膠的孔隙度及膨脹率 18 2.8.3. 動態力學分析儀 19 2.8.4 冷凍凝膠的注射性質 19 2.9. 奈米纖維素殼聚醣水凝膠和冷凍凝膠的體外降解和凝膠分數 19 2.10. 奈米纖維素殼聚醣冷凍凝膠的形狀記憶評估 20 2.10.1. 熱性質及結晶度 20 2.10.2. U型彎曲試驗 20 2.11. 細胞實驗 21 第三章 實驗結果 23 3.1. 鑑定多官能奈米纖維素(MCNFs) 23 3.1.1. MCNF之官能基分析 23 3.1.2. MCNF之長度分析 23 3.1.3. MCNF之PDI、電位及醛含量分析 24 3.1.4. MCNF之小角X散射分析 24 3.2. 奈米纖維素交聯劑性質分析 24 3.2.1.熱性質及分析 24 3.2.2. 奈米纖維素交聯劑之X光繞射分析 25 3.3. 奈米纖維素殼具糖水凝膠和冷凍凝膠的製備 25 3.4.表徵奈米纖維素殼聚醣自修復水凝膠 26 3.4.1. 流變學性質分析 26 3.4.2.小角度X光散射分析 27 3.5. 表徵奈米纖維素殼聚醣冷凍凝膠和其壓縮性質 28 3.5.1. 觀察冷凍凝膠的孔洞大小、孔隙度及膨脹率 28 3.5.2. 不同冷凍凝膠的壓縮模量及注射性 28 3.6. 奈米纖維素殼聚醣冷凍凝膠的體外降解和凝膠率 29 3.7. 奈米纖維素殼聚醣冷凍凝膠的形狀記憶評估 29 3.7.1. 熱性質及結晶度 29 3.7.2. U型彎曲試驗 30 3.7.3. In situ SAXS/WAXS 30 3.8. 細胞實驗 31 第四章 討論 52 4.1. 鑑定MCNF交聯劑 52 4.2 製備奈米纖維素殼聚醣水凝膠及冷凍凝膠 53 4.3. 奈米纖維素殼聚醣自修復水凝膠的表徵 54 4.4 奈米纖維素殼聚醣冷凍凝膠的表徵及壓縮性質 54 4.5. 奈米纖維素殼聚醣水凝膠和冷凍凝膠的體外降解和凝膠分數 55 4.6. 奈米纖維素殼聚醣冷凍凝膠的形狀記憶評估 56 4.7. 細胞實驗 58 第五章 結論 61 圖目錄 圖2.1. 研究架構圖 13 圖3.1. 多功能纖維素奈米纖維（MCNF）的合成和結構表徵 33 圖3.2. 通過 DSC表徵奈米纖維素交聯劑和冷凍凝膠 34 圖3.3. 透過XRD分析奈米纖維素交聯劑和冷凍凝膠 35 圖3.4. 從殼聚醣和MCNFs形成水凝膠或冷凍凝膠。 36 圖3.5. GC-MCNF自癒合水凝膠 37 圖3.6. GC-MCNF冷凍凝膠的宏觀行為和機械性能（由MCNFL 0.25 wt%和GC 1.5 wt%組成） 38 圖3.7. GC-MCNFL水凝膠和冷凍凝膠（1.5 wt% GC和0.25 wt% MCNFL）的物理化學特性 39 圖3.8. 使用原位 WAXS 表徵奈米纖維素交聯劑和冷凍凝膠 40 圖3.10. 原位SAXS/WAXS測量裝置示意圖 42 圖3.11. 原位SAXS/WAXS圖觀察冷凍凝膠的形狀記憶特性 43 圖3.12. 大尺寸形狀記憶冷凍凝膠的可注射性圖 44 圖3.13. hMSCs接種於奈米纖維素殼聚醣冷凍凝膠中的的細胞活力實驗 45 圖4.1. hMSCs接種於使用快速塗層溶液(Quick coating solution)奈米纖維素殼聚醣冷凍凝膠中的的細胞活力實驗。 60 表目錄 表3.1. TCNF 和各種 MCNF 的基本性質 46 表 3.2. 奈米纖維素殼聚醣水凝膠的組成（主鏈和不同含量的交聯劑）的優化和選擇。 47 表 3.3. 奈米纖維素殼聚醣冷凍凝膠的組成（主鏈和不同含量的交聯劑）的優化和選擇 48 表 3.4. 不同組分比例(GC : MCNFs)的水凝膠的基本性質 49 表 3.5. 不同組分比例(GC : MCNFs)的冷凍凝膠的基本性質。 50 表 3.6. 奈米纖維素殼聚醣冷凍凝膠（1.5 wt% GC/0.25 wt% MCNFL）在不同條件下變形和恢復的形狀固定率（Rf）和恢復率（Rr） 51 | |
| dc.language.iso | zh-TW | |
| dc.subject | 殼聚醣 | zh_TW |
| dc.subject | 冷凍凝膠 | zh_TW |
| dc.subject | 形狀記憶 | zh_TW |
| dc.subject | 自癒合水凝膠 | zh_TW |
| dc.subject | 纖維素奈米纖維 | zh_TW |
| dc.subject | chitosan | en |
| dc.subject | Cellulose nanofiber | en |
| dc.subject | self-healing hydrogel | en |
| dc.subject | shape memory | en |
| dc.subject | cryogel | en |
| dc.title | 官能化奈米纖維作為交聯劑製備殼聚醣自癒合水凝膠與形狀記憶冷凍凝膠 | zh_TW |
| dc.title | Functionalized cellulose nanofibers as crosslinker to produce chitosan self-healing hydrogel and shape memory cryogel | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 110-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張書瑋(Shu-Wei Chang),周佳靚(Chia-Ching Chou),莊偉綜(Wei-Tsung Chuang) | |
| dc.subject.keyword | 纖維素奈米纖維,自癒合水凝膠,形狀記憶,冷凍凝膠,殼聚醣, | zh_TW |
| dc.subject.keyword | Cellulose nanofiber,self-healing hydrogel,shape memory,cryogel,chitosan, | en |
| dc.relation.page | 70 | |
| dc.identifier.doi | 10.6342/NTU202203310 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2022-09-22 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
| dc.date.embargo-lift | 2022-09-23 | - |
| 顯示於系所單位： | 高分子科學與工程學研究所 | |
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