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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/83800完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張煥宗(Huan-Tsung Chang) | |
| dc.contributor.author | Hui-Ling Yu | en |
| dc.contributor.author | 余慧玲 | zh_TW |
| dc.date.accessioned | 2023-03-19T21:18:33Z | - |
| dc.date.copyright | 2022-08-10 | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022-08-02 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/83800 | - |
| dc.description.abstract | 急性腎損傷 (Acute kidney injury, AKI) 是一種常見的臨床疾病，具有高發病率、高死亡率和高醫療成本無幾的特點，每年至少導致170萬人死亡，平均每百萬人就有將近五千人患此疾病，在美國每年與AKI相關的醫療支出高達240億美元。AKI的臨床特徵包含代謝功能障礙、腎小管損傷、嚴重發炎反應及氧化壓力積累；其中發炎反應過程中會產生一系列的生物事件，如活性氧類 (reactive oxygen species, ROS) 的過量產生、組織缺氧及巨噬細胞促發炎極化；因而引發一系列病理過程，包括細胞凋亡和腎纖維化，從而導致腎臟排泄功能迅速下降、尿量減少和氮代謝累積增加。目前，在腎功能完全喪失的情況下，除了腎臟替代療法，如血液透析、腹膜透析及腎臟移植三種方法外尚無有效的臨床治療方法。鑒於前述事實，本研究中致力於開發具有抗氧化和抗發炎特性的人工奈米?，作為AKI的有效治療策略。本研究將磷酸鐵及二氧化鈦組成的異質結構藉由一步法修飾於Ti3C2Tx (MXene) 奈米片上，形成複合材料FeP-Ti/MXene；該複合材料具有廣譜 ROS 清除能力和仿過氧化氫?的活性，可用於治療由橫紋肌溶解引起AKI的白化小鼠。在體外試驗中，我們發現FeP-Ti/MXene可有效避免人胚胎腎細胞 (HEK-293T) 氧化壓力積累及緩解由脂多醣誘發引起巨噬細胞 (Raw 264.7) 的發炎反應。在動物實驗中，FeP-Ti/MXene顯著改善了 AKI小鼠的存活率，同時尿素氮 (BUN)、肌酸酐 (CRE)、發炎因子及腎組織切片評估得知FeP-Ti/MXene對AKI具有顯著的治療效果。總的來說，將廣譜抗氧化劑結合仿過氧化氫?能有效減緩AKI導致的臨床病徵，並為開發AKI治療手段提供一個新穎的研究方向。 | zh_TW |
| dc.description.abstract | Acute kidney injury (AKI) is a common syndrome with very high morbidity, mortality and cost, involving more than 5000 cases per million people and causing at least 1.7 million deaths per year. The cost is as high as $24 billion. AKI features as metabolism dysfunction, tubular damage, inflammatory events, and oxidative stress. Moreover, a series of biological events would generate during the inflammatory response process, such as the excessive production of reactive oxygen species (ROS), the absence of oxygen situation, and the regulation of macrophages, triggering a series of pathological processes, including cellular apoptosis and renal fibrosis. Herein, we reported a FePO4/TiO2 heterostructure decorated Ti3C2Tx (FeP-Ti/MXene) nanocomposites that has broad-spectrum ROS scavenging activity and catalase-mimic activity for the treatment of AKI in mice. FeP-Ti/MXene showed anti-inflammatory properties in reducing the accumulation of ROS in human embryonic kidney cells (HEK-293T) and the inflammation of LPS induced macrophage (Raw264.7). Most importantly, we found that FeP-Ti/MXene alleviated oxidative stress-induced cellular apoptosis and significantly improved the treatment outcomes of AKI. Meanwhile, which was evaluated by the expression of blood urea nitrogen, creatinine, inflammatory factors, and tissue analyses showed that FeP-Ti/MXene is effective and efficient for the treatment of AKI. These findings open an avenue to the use of FeP-Ti/MXene as a novel nanodrug to treat AKI. | en |
| dc.description.provenance | Made available in DSpace on 2023-03-19T21:18:33Z (GMT). No. of bitstreams: 1 U0001-0208202214031500.pdf: 4074788 bytes, checksum: 25c6155e265604ce9bf7a974192881e1 (MD5) Previous issue date: 2022 | en |
| dc.description.tableofcontents | 目錄 國立臺灣大學碩士學位論文口試委員審定書 I 致謝 II 中文摘要 IV Abstract V 目錄 VI 圖目錄 IX 表目錄 XIII 第一章 緒論 1 1.1 急性腎損傷 (Acute kidney injury, AKI) 1 1.2 清除ROS及抗發炎治療策略 2 1.3 MXene 4 1.4 研究動機 5 第二章 實驗部分 6 2.1實驗材料 6 2.2層狀 MXene (Ti3C2Tx) 奈米片的製備 6 2.3 FeP-Ti/MXene 的製備 7 2.4 材料鑑定 7 2.5 仿過氧化氫?活性測試 8 2.6 仿過氧化物?活性測試 9 2.7 仿氧化?活性測試 9 2.8 仿超氧化物歧化?活性測試 9 2.9 FeP-Ti/MXene抗氧化活性測試 9 2.10 FeP-Ti/MXene去除自由基能力測試 10 2.11 FeP-Ti/MXene酵素動力學分析 10 2.12 細胞培養 10 2.13 生物相容性測試 11 2.14 溶血性試驗 11 2.15 小鼠急性腎損傷 (AKI) 模型 12 2.16 FeP-Ti/MXene對於 AKI 小鼠的治療 12 2.17 腎功能測試 12 2.18 腎臟組織學 12 第三章 結果與討論 13 3.1 FeP-Ti/MXene的型態與光學性質 13 3.2 FeP-Ti/MXene的表徵鑑定 14 3.3 FeP-Ti/MXene的仿過氧化氫?能力 15 3.4 FeP-Ti/MXene 與天然過氧化氫?對於環境活性之探討 15 3.5 FeP-Ti/MXene 的ROS/RNS清除活性 16 3.6 FeP-Ti/MXene 的穩態動力學分析 16 3.7 FeP-Ti/MXene仿過氧化氫?活性機制 17 3.8 FeP-Ti/MXene的生物相容性 17 3.8.1 FeP-Ti/MXene的細胞毒性 18 3.8.2 FeP-Ti/MXene的溶血活性 18 3.9 FeP-Ti/MXene 細胞內清除ROS能力 18 3.10 FeP-Ti/MXene 於甘油誘導的 AKI 小鼠體內的治療效果 19 第四章 結論 20 References 21 Figures 34 Table 65 | |
| dc.language.iso | zh-TW | |
| dc.subject | 仿過氧化氫? | zh_TW |
| dc.subject | 急性腎損傷 | zh_TW |
| dc.subject | 抗氧化劑 | zh_TW |
| dc.subject | 抗發炎 | zh_TW |
| dc.subject | 活性氧類 | zh_TW |
| dc.subject | Acute kidney injury | en |
| dc.subject | catalase-like activity | en |
| dc.subject | ROS scavenging activity | en |
| dc.subject | FeP-Ti/MXene | en |
| dc.subject | Reactive oxygen species | en |
| dc.title | 一鍋法製備具有抗氧化和抗發炎活性的 FeP-Ti/MXene 奈米複合材料以減輕小鼠急性腎損傷 | zh_TW |
| dc.title | One-pot Preparation of FeP-Ti/MXene Nanocomposites with Anti-oxidant and Anti-inflammatory Activities to Alleviate Acute Kidney Injury in Mice | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 110-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 黃志清(Chih-Ching Huang),黃郁棻(Yu-Fen Huang),胡焯淳(Cho-Chun Hu) | |
| dc.subject.keyword | 急性腎損傷,活性氧類,抗氧化劑,仿過氧化氫?,抗發炎, | zh_TW |
| dc.subject.keyword | Acute kidney injury,Reactive oxygen species,FeP-Ti/MXene,ROS scavenging activity,catalase-like activity, | en |
| dc.relation.page | 65 | |
| dc.identifier.doi | 10.6342/NTU202201969 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2022-08-02 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 化學研究所 | zh_TW |
| 顯示於系所單位： | 化學系 | |
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