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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 李克強(Eric Lee) | |
dc.contributor.advisor | 李克強(Eric Lee | ericlee@ntu.edu.tw | 0000-0002-6036-9403), | |
dc.contributor.author | Jung-Chun Lin | en |
dc.contributor.author | 林戎峻 | zh_TW |
dc.date.accessioned | 2023-03-19T21:13:29Z | - |
dc.date.copyright | 2022-08-22 | |
dc.date.issued | 2022 | |
dc.date.submitted | 2022-08-17 | |
dc.identifier.citation | 1. Shaw, D.J., Introduction to Colloid and Surface Chemistry. 4 ed. 1. Shaw, D.J., Introduction to Colloid and Surface Chemistry. 4 ed. 1992, Boston: Butterwirth Heinemann. 2. Hunter, R.J., Foundations of Colloid Science, vols I and II. 1989: Oxford: New York. 3. Park, K., Controlled Drug Delivery: Challenges and Strategies. 1997: American Chemical Society Washington, DC. 4. Donath, E. and V. Pastushenko, Electrophoretical study of cell surface properties. The influence of the surface coat on the electric potential distribution and on general electrokinetic properties of animal cells. Bioelectrochem. Bioenerg, 1979. 6: p. 543-554. 5. Hunter, R.J., Foundations of colloid science. 2001: Oxford university press. 6. Laidler, K., J. Meiser, and B. Sanctuary, Physical Chemistry. 2003. 7. Masliyah, J.H. and S. Bhattacharjee, Electrokinetic and colloid transport phenomena. 2006: John Wiley & Sons. 8. Derjaguin, B.v. and L. Landau, Theory of the stability of strongly charged lyophobic sols and of the adhesion of strongly charged particles in solutions of electrolytes. Progress in Surface Science, 1993. 43(1-4): p. 30-59. 9. Verwey, E.J.W., Theory of the stability of lyophobic colloids: the interaction of sol particles having an electric double layer. 1962. 10. Derjaguin, B. and L. Landau, Theory of the stability of strongly charged lyophobic sols and of the adhesion of strongly charged particles in solutions of electrolytes. Acta Physicochim URSS, 1941. 14(6): p. 633-662. 11. Verwey, E.J.W., J.T.G. Overbeek, and K. Van Nes, Theory of the Stability of Lyophobic Colloids: the Interaction of Sol Particles Having an Electric Double Layer. 1948: Elsevier New York. 12. Akbar, M.U., et al., Pluronic-Based Mixed Polymeric Micelles Enhance the Therapeutic Potential of Curcumin. Aaps Pharmscitech, 2018. 19(6): p. 2719-2739. 13. Del Gaudio, P., et al., Novel co-axial prilling technique for the development of core–shell particles as delayed drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics, 2014. 87(3): p. 541-547. 14. Smoluchowski, M., Versuch einer mathematischen Theorie der Koagulationskinetik kolloider Losungen. Zeitschrift fur Physikalische Chemie–Stochiometrie und Verwandtschaftslehre, 1917. 92: p. 129-168. 15. Huckel, E., The electrophoresis of spherical colloid. Physikalische Zeitschrift, 1924. 25: p. 204-210. 16. Henry, D.C., The Cataphoresis of Suspended Particles. Part I. The Equation of Cataphoresis. Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character, 1931. 133(821): p. 106-129. 17. Ballauff, M., Spherical polyelectrolyte brushes. Progress in Polymer Science, 2007. 32(10): p. 1135-1151. 18. Levine, S., et al., Theory of the electrokinetic behavior of human erythrocytes. Biophysical Journal, 1983. 42(2): p. 127-135. 19. Ballauff, M. and O. Borisov, Polyelectrolyte brushes. Current Opinion in Colloid & Interface Science, 2006. 11(6): p. 316-323. 20. Balazs, A.C., et al., Theory of polymer chains tethered at interfaces. Progress in surface science, 1997. 55(3): p. 181-269. 21. Whitaker, S., Flow in porous media I: A theoretical derivation of Darcy's law. Transport in porous media, 1986. 1(1): p. 3-25. 22. Brinkman, H., A calculation of the viscous force exerted by a flowing fluid on a dense swarm of particles. Applied Scientific Research, 1949. 1(1): p. 27-34. 23. Debye, P. and A.M. Bueche, Intrinsic viscosity, diffusion, and sedimentation rate of polymers in solution. The Journal of Chemical Physics, 1948. 16(6): p. 573-579. 24. Felderhof, B. and J. Deutch, Frictional properties of dilute polymer solutions. I. Rotational friction coefficient. The Journal of Chemical Physics, 1975. 62: p. 2391. 25. Tehrani-Bagha, A.R., et al., An Ouzo emulsion of toluene in water characterized by NMR diffusometry and static multiple light scattering. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2016. 494: p. 81-86. 26. Shui, L., J.C. Eijkel, and A. van den Berg, Multiphase flow in microfluidic systems–Control and applications of droplets and interfaces. Advances in colloid and interface science, 2007. 133(1): p. 35-49. 27. Happel, J. and H. Brenner, Low Reynolds number hydrodynamics: with special applications to particulate media. Vol. 1. 2012: Springer Science & Business Media. 28. Taylor, T. and A. Acrivos, On the deformation and drag of a falling viscous drop at low Reynolds number. Journal of Fluid Mechanics, 1964. 18(3): p. 466-476. 29. Eow, J.S., M. Ghadiri, and A. Sharif, Experimental studies of deformation and break-up of aqueous drops in high electric fields. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2003. 225(1-3): p. 193-210. 30. Wu, B., et al., Active encapsulation in biocompatible nanocapsules. Small, 2020. 16(30): p. 2002716. 31. Drozdek, S. and U. Bazylinska, Biocompatible oil core nanocapsules as potential co-carriers of paclitaxel and fluorescent markers: preparation, characterization, and bioimaging. Colloid and Polymer Science, 2016. 294(1): p. 225-237. 32. Zhang, X.-p., et al., Porous microcapsules with tunable pore sizes provide easily controllable release and bioactivity. Journal of colloid and interface science, 2018. 517: p. 86-92. 33. Rahman, M.M., et al., Highly temperature responsive core–shell magnetic particles: Synthesis, characterization and colloidal properties. Journal of Colloid and Interface Science, 2011. 360(2): p. 556-564. 34. Hunter, R.J., Zeta potential in colloid science: principles and applications. Vol. 2. 2013: Academic press. 35. Nori, M.P., et al., Microencapsulation of propolis extract by complex coacervation. LWT-Food Science and Technology, 2011. 44(2): p. 429-435. 36. Li, J., et al., Engineered Near?Infrared Fluorescent Protein Assemblies for Robust Bioimaging and Therapeutic Applications. Advanced Materials, 2020. 32(17): p. 2000964. 37. Luo, Y. and X. Zhou, Nanoencapsulation of a hydrophobic compound by a miniemulsion polymerization process. Journal of Polymer Science Part A: Polymer Chemistry, 2004. 42(9): p. 2145-2154. 38. Kim, B., et al., Microfluidic production of semipermeable microcapsules by polymerization-induced phase separation. Langmuir, 2015. 31(22): p. 6027-6034. 39. Hede, P.D., P. Bach, and A.D. Jensen, Two-fluid spray atomisation and pneumatic nozzles for fluid bed coating/agglomeration purposes: A review. Chemical Engineering Science, 2008. 63(14): p. 3821-3842. 40. Lee, H., et al., Encapsulation and enhanced retention of fragrance in polymer microcapsules. ACS applied materials & interfaces, 2016. 8(6): p. 4007-4013. 41. Park, S.J., Protein-Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020. 15: p. 5783-5802. 42. Mahmoudi, M., et al., Protein? nanoparticle interactions: opportunities and challenges. Chemical reviews, 2011. 111(9): p. 5610-5637. 43. M'Barek, K.B., et al., Phagocytosis of immunoglobulin-coated emulsion droplets. Biomaterials, 2015. 51: p. 270-277. 44. Ashaolu, T.J., Nanoemulsions for health, food, and cosmetics: a review. Environmental Chemistry Letters, 2021. 19(4): p. 3381-3395. 45. Plaza-Oliver, M., et al., The role of the intestinal-protein corona on the mucodiffusion behaviour of new nanoemulsions stabilised by ascorbyl derivatives. Colloids and Surfaces B: Biointerfaces, 2020. 186: p. 110740. 46. Singh, Y., et al., Nanoemulsion: Concepts, development and applications in drug delivery. Journal of Controlled Release, 2017. 252: p. 28-49. 47. Lai, S.K., et al., Micro- and macrorheology of mucus. Advanced Drug Delivery Reviews, 2009. 61(2): p. 86-100. 48. S?nchez-Moreno, P., et al., Balancing the effect of corona on therapeutic efficacy and macrophage uptake of lipid nanocapsules. Biomaterials, 2015. 61: p. 266-278. 49. Harnisch, S. and R.H. Muller, Adsorption kinetics of plasma proteins on oil-in-water emulsions for parenteral nutrition. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2000. 49(1): p. 41-46. 50. Harnisch, S. and R.H. Muller, Plasma protein adsorption patterns on emulsions for parenteral administration: Establishment of a protocol for two-dimensional polyacrylamide electrophoresis. ELECTROPHORESIS, 1998. 19(2): p. 349-354. 51. Torchilin, V.P., Recent advances with liposomes as pharmaceutical carriers. Nature reviews Drug discovery, 2005. 4(2): p. 145-160. 52. Akbarzadeh, A., et al., Liposome: classification, preparation, and applications. Nanoscale research letters, 2013. 8(1): p. 1-9. 53. Olusanya, T.O., et al., Liposomal drug delivery systems and anticancer drugs. Molecules, 2018. 23(4): p. 907. 54. Gao, W.W., et al., Liposome-like nanostructures for drug delivery. JOURNAL OF MATERIALS CHEMISTRY B, 2013. 1(48): p. 6569-6585. 55. Capriotti, A.L., et al., Do plasma proteins distinguish between liposomes of varying charge density? Journal of Proteomics, 2012. 75(6): p. 1924-1932. 56. Caracciolo, G., Liposome–protein corona in a physiological environment: Challenges and opportunities for targeted delivery of nanomedicines. Nanomedicine: Nanotechnology, Biology and Medicine, 2015. 11(3): p. 543-557. 57. Corbo, C., et al., Effects of the protein corona on liposome-liposome and liposome-cell interactions. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016. 11: p. 3049-3063. 58. Palchetti, S., et al., The protein corona of circulating PEGylated liposomes. Biochimica et Biophysica Acta (BBA)-Biomembranes, 2016. 1858(2): p. 189-196. 59. Helmholtz, H.v., Ueber einige Gesetze der Vertheilung elektrischer Str?me in k?rperlichen Leitern, mit Anwendung auf die thierisch?elektrischen Versuche (Schluss.). Annalen der Physik, 1853. 165(7): p. 353-377. 60. Gouy, M., Sur la constitution de la charge ?lectrique ? la surface d'un ?lectrolyte. 1910. 61. Chapman, D.L., LI. A contribution to the theory of electrocapillarity. The London, Edinburgh, and Dublin philosophical magazine and journal of science, 1913. 25(148): p. 475-481. 62. Stern, O., The theory of the electrolytic double-layer. Z. Elektrochem, 1924. 30(508): p. 1014-1020. 63. Shaw, D., The colloidal state. 1992, Butterworth-Heinemann: Oxford. p. 1-20. 64. Cohen, A. and B. Karger, High-performance sodium dodecyl sulfate polyacrylamide gel capillary electrophoresis of peptides and proteins. Journal of Chromatography A, 1987. 397: p. 409-417. 65. Woolley, A.T. and R.A. Mathies, Ultra-high-speed DNA sequencing using capillary electrophoresis chips. Analytical chemistry, 1995. 67(20): p. 3676-3680. 66. Woolley, A.T., G.F. Sensabaugh, and R.A. Mathies, High-speed DNA genotyping using microfabricated capillary array electrophoresis chips. Analytical Chemistry, 1997. 69(11): p. 2181-2186. 67. Von Smoluchowski, M., Experiments on a mathematical theory of kinetic coagulation of colloid solutions. Zeitschrift fur Physikalische Chemie–Stochiometrie und Verwandtschaftslehre, 1917. 92(2): p. 129-168. 68. H?ckel, E., The cataphoresis of the sphere. Physikalische Zeitschrift, 1924. 25: p. 204-210. 69. Henry, D.C., The cataphoresis of suspended particles Part I - The equation of cataphoresis. Proceedings of the Royal Society of London Series a-Containing Papers of a Mathematical and Physical Character, 1931. 133(821): p. 106-129. 70. Overbeek, J.T.G., Quantitative interpretation of the electrophoretic velocity of colloids. Advances in Colloid Science, 1950. 3: p. 97-135. 71. Booth, F., The cataphoresis of spherical, solid non-conducting particles in a symmetrical electrolyte. Proceedings of the Royal Society of London Series a-Mathematical and Physical Sciences, 1950. 203(1075): p. 514-533. 72. Wiersema, P.H., A.L. Loeb, and J.T. Overbeek, Calculation of electrophoretic mobility of a spherical colloid particle. Journal of Colloid and Interface Science, 1966. 22(1): p. 78-&. 73. Obrien, R.W. and L.R. White, Electrophoretic Mobility of a Spherical Colloidal Particle. Journal of the Chemical Society-Faraday Transactions Ii, 1978. 74: p. 1607-1626. 74. Bird, R.B., W.E. Stewart, and E.N. Lightfoot, Transport Phenomena. 2006: John Wiley & Sons. 75. Kilic, M.S., M.Z. Bazant, and A. Ajdari, Steric effects in the dynamics of electrolytes at large applied voltages. I. Double-layer charging. Physical review E, 2007. 75(2): p. 021502. 76. Ohshima, H., Theory of colloid and interfacial electric phenomena. Vol. 12. 2006: Elsevier. 77. O'Brien, R.W. and L.R. White, Electrophoretic mobility of a spherical colloidal particle. Journal of the Chemical Society, Faraday Transactions 2: Molecular and Chemical Physics, 1978. 74: p. 1607-1626. 78. Viswanath, D.S., et al., Viscosity of liquids: theory, estimation, experiment, and data. 2007: Springer Science & Business Media. 79. Ahualli, S., et al., Electrophoresis and dielectric dispersion of spherical polyelectrolyte brushes. Langmuir, 2012. 28(47): p. 16372-81. 80. Gopmandal, P.P., S. Bhattacharyya, and H. Ohshima, Effect of core charge density on the electrophoresis of a soft particle coated with polyelectrolyte layer. COLLOID AND POLYMER SCIENCE, 2016. 294(4): p. 727-733. 81. Ohshima, H., Approximate analytic expressions for the electrophoretic mobility of spherical soft particles. Electrophoresis, 2021. 82. Hermans, J., Sedimentation and electrophoresis of porous spheres. Journal of Polymer Science, 1955. 18(90): p. 527-534. 83. Wu, Y., et al., Electrophoresis of a Highly Charged Dielectric Fluid Droplet in Electrolyte Solutions. Journal of Colloid and Interface Science, 2021. 598. 84. Wu, Y., et al., Diffusiophoresis of a highly charged soft particle in electrolyte solutions induced by diffusion potential. Physics of Fluids, 2021. 33(1). 85. Ye, J., et al., A new hydrodynamic interpretation of liquid metal droplet motion induced by an electrocapillary phenomenon. Soft Matter, 2021. 17(34): p. 7835-7843. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/83664 | - |
dc.description.abstract | 本研究討論單一液滴核心之軟球於電解質溶液中之電泳行為,該粒子模型將傳統軟球模型結合介電液滴模型加以修正,為介電液滴與包覆於其表面的高分子多孔層組成的內核-外殼結構,可更加準確描述微膠囊、蛋白質冠奈米藥物等膠體粒子的電泳行為。 在液滴核心之軟球的電泳現象中,會有多種效應互相影響。分別為多孔層所造成的摩擦阻力與固定電荷,以及介電液滴造成的表面移動效應與表面上的額外電驅動力。本研究除了與硬球核、低表面帶電的軟球解析解做比較之外,亦比對了介電液滴與多孔球,其所含的多樣性非常值得探討。本研究藉由數值方法解除低電位的條件限制,並模擬液滴核心內外流體流動造成的流動力學與高帶電量下的電動力學行為,深入了解介電液滴吸附上高分子多孔層後改變的電泳行為。 研究結果顯示,介電液滴即使在包覆上多孔層後仍會在表面產生外部渦流,而多孔層的摩擦效應也因此在介電液滴不同的表面移動情況下,產生截然不同的效應。液滴內核流體的黏度非常高時,內核流體幾乎無法流動,表面移動效應極弱,液滴核心之軟球泳動行為接近軟球。除此之外,當液滴核心之軟球的液滴內核比例極大時,多孔層的影響極小,此時泳動行為接近介電液滴。反之,多孔層佔比極大時泳動行為會接近於多孔球,而與傳統軟球不同之處在於,液滴內核的表面移動效應較重要不可忽視。 液滴核心之軟球在離子濃度高的情況下,本身所帶的電荷會吸引過多的反離子進入電雙層,造成反離子遮蔽效應,甚至出現泳動度反轉,此現象亦與介電液滴表面與多孔層的帶電量高度相關,本研究亦針對此做深入探討。 | zh_TW |
dc.description.abstract | This thesis discusses the electrophoretic behavior of a core-shell droplet in electrolyte solution. The particle model combines the conventional soft particle and dielectric droplet model into a core-shell structure composed of internal dielectric droplet core and polymer porous layer coating on its surface, which can more accurately describe the electrophoretic behavior of colloidal particles such as microcapsules, protein corona nanodrugs and so on. The electrophoretic phenomenon of a core-shell droplet is affected by much influence, such as friction resistance and fixed charge caused by porous layer, or surface shifting effect and Maxwell stress tensor arose from dielectric droplet. In addition to the comparison with the analytical solutions of low surface charged soft particle, the study also compares with dielectric droplets and porous particles, and its diversity is worth discussing. In this study, numerical methods were used to remove the restrictions of low potential, simulating the flow mechanics caused by the fluid inside and outside the droplet core and the electrodynamic behavior under high charged condition, so as to have an in-depth understanding of the electrophoretic behavior of dielectric droplets after adsorption on the polymer porous layer. The results show that, even coated with the porous layer, the dielectric droplets still generate external vortices on the surface, and the friction resistance of the porous layer will induce different effects under different surface shifting conditions of the dielectric droplets. When the viscosity of the droplet core fluid is very high, the core fluid can hardly flow, the surface shifting effect is very weak, and the electrophoretic behavior of the core-shell droplet is close to the corresponding soft particle. In addition, when the proportion of droplet core is very large in core-shell droplet, the influence of the porous layer is very small, and the electrophoretic behavior is close to that of the dielectric droplet. On the contrary, when the porous layer accounts for a large proportion, its electrophoretic behavior will be similar to the porous particle. However, different from the soft particle, the surface shifting effect of the droplet core still exists and cannot be ignored. When the concentration of solution is high, the core-shell droplet will attract counterion into its electric double layer, causing counterion condensation, or even reversing its mobility This phenomena is highly related to electric charge of dielectric droplet and porous layer, and we also makes a thorough discussion. | en |
dc.description.provenance | Made available in DSpace on 2023-03-19T21:13:29Z (GMT). No. of bitstreams: 1 U0001-1608202212071500.pdf: 3671571 bytes, checksum: 19a143085a7409ca7dd62a40b86033ac (MD5) Previous issue date: 2022 | en |
dc.description.tableofcontents | 致謝 ii 摘要 iv Abstract v 目錄 vii 圖目錄 x 表目錄 xii Chapter 1 緒論 1 1.1 膠體粒子簡介 1 1.2 液滴核心之軟球模型簡介 2 1.2.1 軟球模型簡介 2 1.2.2 多孔層之性質 4 1.2.3 液滴內核之性質 5 1.3 液滴核心之軟球模型應用 8 1.3.1 奈米膠囊 (nanoparticle) 8 1.3.2 蛋白質冠(protein corona)奈米藥物 10 1.4 電動力學現象 18 1.4.1 電雙層理論 18 1.4.2 電動力學理論文獻回顧 19 Chapter 2 理論 22 2.1 系統描述 22 2.2 主控電動力學方程組 23 2.2.1 電位方程式 24 2.2.2 離子守恆式 25 2.2.3 流場方程式 26 2.3 擾動法分析(perturbation analysis) 29 2.3.1 擾動法原理 29 2.3.2 平衡態 30 2.3.3 擾動態 31 2.4 無因次化分析 34 2.5 邊界條件 37 2.5.1 液滴內核表面 37 2.5.2 多孔層交界面 39 2.5.3 無窮遠(r*→ ∞): 40 2.6 方程式與邊界條件一維化 43 2.7 數值計算之邊界條件前處理 47 2.7.1 液滴內部處理方法 47 2.7.2 無窮遠邊界處理方法 47 2.8 泳動度之計算 49 Chapter 3 數值方法 51 3.1 正交配位法 (orthogonal collocation method) 51 3.2 空間映射 55 3.3 多區聯解問題 56 3.4 牛頓-拉福森 (Newton-Raphson) 迭代法 58 Chapter 4 結果與討論 60 4.1 系統參數設定 60 4.1.1 格點配置 60 4.1.2 選用之參數量值 60 4.2 程式正確性驗證 63 4.3 不同λa對泳動度之影響 66 4.4 不同帶電量對泳動度之影響 77 4.5 不同內核半徑比r_c^*對泳動度之影響 84 4.6 不同σ_H對泳動度之影響 90 Chapter 5 結論 94 符號說明 96 附錄 100 A. 電解質水溶液參數值 100 B. 液滴內核解析解與相關之表面邊界條件推導細節 101 C. Ohshima低電位解析解細節 108 D. 液滴內核相關無因次參數計算細節 110 E. 表面電荷密度與表面電位換算表 112 參考文獻 114 | |
dc.language.iso | zh-TW | |
dc.title | 單一液滴核心之軟球於電解質溶液之電泳現象探討 | zh_TW |
dc.title | Electrophoresis Phenomena of a Core-Shell Droplet in Electrolyte Solutions | en |
dc.type | Thesis | |
dc.date.schoolyear | 110-2 | |
dc.description.degree | 碩士 | |
dc.contributor.advisor-orcid | 李克強(0000-0002-6036-9403) | |
dc.contributor.oralexamcommittee | 朱智瑋(Jhih-Wei Chu),唐于博(Yu-Po Tang),游佳欣(Jiashing Yu),陳賢燁(Hsien-Yeh Chen) | |
dc.subject.keyword | 電泳,電雙層極化效應,液滴核心之軟球,數值解, | zh_TW |
dc.subject.keyword | electrophoresis,electric double layer polarization,core-shell droplet,numerical solution, | en |
dc.relation.page | 124 | |
dc.identifier.doi | 10.6342/NTU202202443 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2022-08-17 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
顯示於系所單位: | 化學工程學系 |
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