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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 鍾國彪 | zh_TW |
| dc.contributor.advisor | Kuo-Piao Chung | en |
| dc.contributor.author | 金曉蕾 | zh_TW |
| dc.contributor.author | Hsiao-Lei Chin | en |
| dc.date.accessioned | 2023-03-01T17:08:41Z | - |
| dc.date.available | 2023-11-09 | - |
| dc.date.copyright | 2023-03-01 | - |
| dc.date.issued | 2022 | - |
| dc.date.submitted | 2002-01-01 | - |
| dc.identifier.citation | Agarwal, SK, Munjal M, Koul R, Agarwal R. (2014). Prospective evaluation of the QoL of oral tongue cancer patients before and after the treatment. Ann Palliat Med., 3, 238–243.
Ahmed Esmat Abdel Moneim,1 Ana Guerra-Librero, Javier Florido, Ying-Qiang Shen, Beatriz Fernández-Gil, Darío Acuña-Castroviejo, and Germaine Escames. (2017). Oral Mucositis: Melatonin Gel an Effective New Treatment. Int J Mol Sci. 18, 1003-23 Alison M Rose-Ped,, Lisa A Bellm, Joel B Epstein, Andy Trotti, Clement Gwede, Henry J Fuchs. (2002). Complications of radiation therapy for head and neck cancers. The patient's perspective. Cancer Nurs, 25, 461-7 Allison RR, Ambrad AA, Arshoun Y, Carmel RJ, Ciuba DF, Feldman E, Finkelstein SE, Gandhavadi R, Heron DE, Lane SC, Longo JM, Meakin C, Papadopoulos D, Pruitt DE, Steinbrenner LM, Taylor MA, Wisbeck WM, Yuh GE, Nowotnik DP, Sonis ST. (2014). Multi-institutional, randomized, double-blind, placebo- controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck. Cancer. 120(9),1433–1440. Ali Hatem Manfi Al-Rudayni, Divya Gopinath, Mari Kannan Maharajan, Rohit Kunnath Menon. (2020). Impact of oral mucositis on QoL in patients undergoing oncological treatment: a systematic review. Translational Cancer Research, 9(4), 3126-3134 Almas Binnal, Gururaghavendran Rajesh, PU Prakash Saxena, Sourjya Banerjee, Ceena Denny, Santosh Kumar Tadakamadla. (2022). Health-related QoL among oral and oropharyngeal cancer patients: An exploratory study. Oral Diseases, 28,585–599. Andreza Barkokebas, Igor H, Morais S. (2015). Impact of oral mucositis on oral‐health‐related QoL of patients diagnosed with cancer. J Oral Pathol Med., 44, 649-760. Antunes HS et al. (2013). Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation. Radiother Oncol., 109, 297–302. Barber C, Powell R, Ellis A, Hewett J. (2007). Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis. Support Care Cancer, 15(4), 427 Buchsel P.C. Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair®): A bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions. Expert Opin. Drug Metab. Toxicol. 2008;4:1449–54. Carvalho PA et al. (2011). Evaluation of low-level laser therapy in the prevention and treatment of radiation-induced mucositis: a double-blind randomized study in head and neck cancer patients. Oral Oncol, 47, 1176–81. Claudio Pulito, Antonio Cristaudo, Caterina La Porta, Stefano Zapperi, Giovanni Blandino1, Aldo Morrone and Sabrina Strano. (2020). Oral mucositis: the hidden side of cancer therapy. Pulito et al. Journal of Experimental & Clinical Cancer Research. 39, 210 Chattopadhyay S et al. (2014). Role of oral glutamine in alleviation and prevention of radiation-induced oral mucositis: a prospective randomized study. South Asian J Cancer, 3(1), 8–12 Correa M Elvira & Karis Kin Fong Cheng & Karen Chiang & Abhishek Kandwa & Charles L Loprinzi & Takehiko Mori & Carin Potting8 & Tanya Rouleau & Juan J Toro10 & Vinisha Ranna1 & Anusha Vaddi & Douglas E Peterson & Paolo Bossi14 & Rajesh V Lalla & Sharon Elad. (2020). Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer, 28, 2449–2456 C Scully, S Sonis, PD Diz. (2006). MUCOSAL DISEASES SERIES Oral mucositis. Oral Diseases, 12, 229–241 Debora Basile et al. (2019). Mucosal Injury during Anti-Cancer Treatment: From Pathobiology to Bedside. Cancers, 11, 857. doi:10.3390/cancers11060857 Devi S, Singh N. (2014) Dental care during and after radiotherapy in head and neck cancer. Natl J Maxillofac Surg. 5, 117–125. D'Hondt Lionel, Lonchay Christophe, André Marc, and Canon Jean-Luc. (2006). Oral mucositis induced by anticancer treatments: physiopathology and treatments. Ther Clin Risk Manag., 2(2), 159–168. Ernest A. Weymuller Jr; Bevan Yueh; Frederic W. B. Deleyiannis; et al. (2000). QoL in Patients With Head and Neck Cancer Lessons Learned From 549 Prospectively Evaluated Patients. Arch Otolaryngol Head Neck Surg. ,126(3), 329-335. Elâine Patrícia Alves de Araújo Gomes, Andreza Maria Fabio Aranha, Alvaro Henrique Borges, and Luiz Evaristo Ricci Volpato. (2020) ‘Head and Neck Cancer Patients’ QoL: Analysis of Three Instruments. J Dent (Shiraz), 21(1), 31–41. Elting LS, Cooksley CD, Chambers MS, Garden AS. (2007). Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and- neck malignancies. Int J Radiat Oncol Biol Phys., 68(4),1110-20. Ferreira Ana Sofia , Catarina Macedo , Ana Margarida Silva , Cristina Delerue-Matos , Paulo Costa and Francisca Rodrigues (2022). Natural Products for the Prevention and Treatment of Oral Mucositis - A Review. Int. J. Mol. Sci. 23, 4385 Fleta N. Bray, Brian J. Simmons, Aaron H. Wolfson & Keyvan Nouri. (2016). Acute and Chronic Cutaneous Reactions to Ionizing Radiation Therapy. Dermatology and Therapy., 6(2),185–206 Hammerlid E, Silander E, Hornestam L, Sullivan M. (2001). Health-related QoL three years after diagnosis of head and neck cancer-a longitudinal study. Head Neck 23(2), 113– 125. Han G et al. (2013). Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med.,19, 421–8. Hawley P. (2014). randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis. Supportive Care Cancer, 22, 751–61 Hoffman KE et al. (2014). The impact of concurrent granulocyte-macrophage colony- stimulating factor on QoL in head and neck cancer patients: results of the randomized, placebo-controlled Radiation Therapy Oncology Group 9901 trial. Qual Life Res., 23,1841–58. K.K.F. Cheng et al. (2004). Prevention of oral mucositis in paediatric patients treated withchemotherapy: a randomised crossover trial comparing two protocol of oral care. European Journal of Cancer. 40, 1208–121 Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, et al. (2014). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120, 1453-61. Leaper DJ (2006). Silver dressings: their role in wound management. Int Wound J, 3, 282–94. Lin YS et al. (2010). Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: subgroup analysis of a double-blind, randomized study. Nutr Cancerm 62, 682–91. Maddocks-Jennings W et al. (2009). Evaluating the effects of the essential oils Leptospermum scoparium (manuka) and Kunzea ericoides (kanuka) on radiotherapy induced mucositis: a randomized, placebo controlled feasibility study. Eur J Oncol Nurs., 13, 87–93. Maria Ines da Cruz Campos, Celso Neiva Campos, Fernando Monteiro Aarestrup and Beatriz Julião Vieira Aarestrup. (2014). Oral mucositis in cancer treatment: Natural history, prevention and treatment (Review). Molecular and Clinical Oncology, 2, 337-40. Masucci G et al. (2005). Therapeutic efficacy by recombinant human granulocyte/monocyte-colony stimulating factor on mucositis occurring in patients with oral and oropharynx tumors treated with curative radiotherapy: a multicenter open randomized phase III study. Med Oncol., 22, 247–56. McCartan BE. (1995). Psychological factors associated with oral lichen planus. J Oral Pathol Med., 24, 273– 275. M J Dodd, S L Dibble, C Miaskowski, L MacPhail, D Greenspan, S M Paul, G Shiba, P Larson. (2000). Randomized clinical trial of the effectiveness of 3 commonly used mouthwashes to treat chemotherapy-induced mucositis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 90, 39-47. Nadarajah Vigneswaran, Michelle D. Williams. (2014). Epidemiological Trends in Head and Neck Cancer and Aids in Diagnosis. Oral Maxillofac Surg Clin North Am., 26(2), 123–141. doi:10.1016/j.coms.2014.01.001 M Knöös, M Ostman. (2010)Oral Assessment Guide--test of reliability and validity for patients receiving radiotherapy to the head and neck region. Eur J Cancer Care (Engl), 191, 53-60 Osama Muhammad Maria, Nicoletta Eliopoulos and Thierry Muanza. (2017). Radiation-Induced Oral Mucositis. Front. Oncol., 22, 7 . https://doi.org/10.3389/fonc.2017.00089 Pacheco,R., Cavacas,M.A.; Mascarenhas, P., Oliveira, P., Zagalo, C. (2021). Incidence of Oral Mucositis in Patients Undergoing Head and Neck Cancer Treatment: Systematic Review and Meta-Analysis. Med. Sci. Forum., 5, 23. Paolo Pisani et al. (2020). Metastatic disease in head & neck oncology. ACTA OTORHINOLARYNGOLOGICA ITALICA., 40(SUPPL.1), S1-S86; doi: 10.14639/0392-100X-suppl.1-40-2020 Park Y, Kim YH. (2009). Chemotherapy related oral and gastrointestinal mucositis. J Korean Med Assoc., 52, 897–906. Paulo S.S. Santos, Adrielle L. Cremonesi, Reyna A. Quispe, Cássia M. F. Rubira. (2017). The impact of oral health on QoL in individuals with head and neck cancer after radiotherapy: the importance of dentistry in psychosocial issues. Acta Odontol. Latinoam., 30, 62-67 Parliament MB et al. (2004). Preservation of oral health-related QoL and salivary flow rates after inverse-planned intensity- modulated radiotherapy (IMRT) for head-and-neck cancer. Int J Radiat Oncol Biol Phys., 58, 663–73. Porta C, Moroni M and Nastasi G. (1994). Allopurinol mouthwashes in the treatment of 5‑fluorouracil‑induced stomatitis. Am J Clin Oncol., 17, 246-7. Quinn B. (2013). Efficacy of a supersaturated calcium phosphate oral rinse for the prevention and treatment of oral mucositis in patients receiving high-dose cancer therapy: A review of current data. Eur. J. Cancer Care. 22, 564–79. Rajesh V. Lalla, Stephen T. Sonis and Douglas E. Peterson. (2008). Management of Oral Mucositis in Patients with Cancer. Dent Clin North Am., 52(1), 61-78 Raphael M.F., den Boer A.M., Kollen W.J., Mekelenkamp H., Abbink F.C., Kaspers G.J., Zomer-Kooijker K., Molmans B.H., Tissing W.J. (2014). Caphosol, a therapeutic option in case of cancer therapy-induced oral mucositis in children? Results from a prospective multicenter double blind randomized controlled trial. Support. Care Cancer. 22, 3–6. Rozier RG, Pahel BT. (2008). Patient and population reported outcomes in public health dentistry: Oral health related QoL. Dent Clin N Am., 52, 345-65. Sali Al-Ansari, Judith A. E. M. Zecha, Andrei Barasch, Jan de Lang , Fred R. Rozema and Judith E. Raber-Durlacher. (2015). Oral Mucositis Induced By Anticancer Therapies. Curr Oral Health Rep, 2:202-11. Santos PS, Cremonesi AL, Quispe RA, Rubira CM. (2017). The impact of oral health on QoL in individuals with head and neck cancer after radiotherapy: the importance of dentistry in psychosocial issues. Acta Odontol Latinoam., 30,62–7. Saunders Deborah P. & Tanya Rouleau & Karis Cheng & Noam Yarom & Abhishek Kandwal4 & Jamie Joy &Kivanc Bektas Kayhan & Marianne van de Wetering & Norman Brito-Dellan & Tomoko Kataoka9 & Karen Chiang10 & Vinisha Ranna & Anusha Vaddi12 & Joel Epstein & Rajesh V. Lalla & Paolo Bossi & Sharon Elad (2020). On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer, 28,2473–248 Scully C, Soni S, Diz PD. (2014). Oral mucositis. Oral Dis 2006;12:229–41. Hawley P. randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis. Supportive Care Cancer 22,751–61. Sheibani KM et al. (2015). Efficacy of benzydamine oral rinse in prevention and management of radiation-induced oral mucositis: a double-blind placebo- controlled randomized clinical trial. Asia Pac J Clin Oncol ,11,22–7. Sischo L. and H.L. Broder. (2011). Oral Health-related QoL What, Why, How, and Future Implications. J Dent Res., 90(11), 1264–1270. Silverman, S. Jr. (2007). Diagnosis and management of oral mucositis. The Journal of Supportive Oncology., 5(2 Suppl 1), 13-21. Slade GD, Spencer AJ. (1994). Development and evaluation of the oral health impact profile. Community Dent Health. 11, 03–11. Slade GD. (1997). Derivation and validation of a short-form oral health impact profile. Community Dent Oral Epidetniol., 25,284-90. Stoica Alexandra Elena , Cristina Chircov and Alexandru Mihai Grumezescu. (2020). Nanomaterials for Wound Dressings: An Up-to-Date Overview. Molecules, 25, 2699. Stone, R., Fliedner, M. C.,&Smiet, A. C. (2005). Management of oral mucositis in patients with cancer. European Journal of Oncology Nursing, 9(l), S24-S32. Su CK et al. (2004). Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head- and-neck neoplasms. Int J Radiat Oncol., 60, 171–7. Tabolli S, Bergamo F, Alessandroni L, Di Pietro C, Sampogna F, Abeni D. (2009). QoL and psychological problems of patients with oral mucosal disease in dermatological practice. Dermatology, 218(4),314–320. Talaipour AR et al. (2000). Chamomile mouth rinse effects on mucositis reduction after radiotherapy. J Dent,1,13. Tesic M, Cankovic M, Jevtic M, D Stevanovic. (2020). “Validation of the oral health impact profile - 14 in patients with head and neck cancer”. Med Oral Patol Oral Cir Bucal. 25(6),737-744. The World Oral Health Report 2003: continuous improvement of oral health in the 21st Century: the approach of the WHO Global Oral Health Programme. WHO. Geneva, Switzerland 2003. Trotti A, Byhardt R, Stetz J, et al. (2000). Common toxicity criteria: version 2.0. An improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int JRadiat Oncol Biol Phys.,47,13– 47. Trotti, A., Bellm, L. A., Epstein, J. B., Frame, D., Fuchs, H. J,, Gwede, C. K., Zilberberg, MD.. (2003). Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiotherapy and Oncology, 66(3), 253-262. Vanita Noronha et al. (2021). Post hoc analysis of a randomized controlled trial comparing concurrent chemoradiation with cisplatin versus nimotuzumab-cisplatin, focusing on acute oral mucositis. J. of the Egyptian National Cancer, 33,12-9. Vera-Llonch M, Oster G, Hagiwara M, Sonis S. (2006). Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer,106, 329-36. Villa A., Sonis S.T. (2015). Mucositis: Pathobiology and management. Curr. Opin. Oncol. 27, 159–64. Wu HG et al. (2009). Therapeutic effect of recombinant human epidermal growth factor (RhEGF) on mucositis in patients undergoing radiotherapy, with or without chemotherapy, for head and neck cancer: a double-blind placebo-controlled prospective phase 2 multi-institutional clinical trial. Cancer 115, 3699–708. Yang Y, Hu H. (2005). A Review on Antimicrobial Silver Absorbent Wound Dressings Applied to Exuding Wounds. J Microb. Biochem. Technol,. 7, 228-33. Ucuncu H et al. (2006). Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced oral mucositis and myelosuppression: a controlled study in a rat model. J Radiat Res, 47,91–102. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/83292 | - |
| dc.description.abstract | 背景/目的：口腔健康不僅是維持最佳整體健康的基本要素，而且在維持最佳整體健康方面也發揮著重要作用。口腔黏膜炎 (OM) 是同步放化療 (CCRT) 的一種極其痛苦且不可避免的併併發症。這種嚴重的不良症狀不僅會降低患者的生活品質，還會增加醫療費用。本研究的目的是探討使用聚丙烯酸酯銀鹽（PSS）/聚乙烯吡咯烷酮液體口腔敷料是否可以改善頭頸部癌症患者的口腔黏膜和口腔功能受損狀況, 進而在口腔黏膜口腔黏膜炎的改善下是否可以促進病人的健康生活品質。
方法：本實驗設計被設計為分層隨機對照試驗（stratified randomized control trial, stratified RCT）。首先按“口腔癌類型”和“其他頭頸類型”對符合條件的頭頸癌患者進行分層分派，然後在分層內將符合資格的參加者隨機分配實驗組或對照組。符合條件的受試者必須正在接受 CCRT 治療並已有 1 級以上粘膜炎症狀的頭頸癌患者。最終符合條件並完成整個試驗程序的患者人數為 55。所有患者均遵循多國癌症支持治療協會和國際口腔腫瘤學會 (MASCC/ISOO) 處置 OM 的臨床指引，但實驗組的病人會再加上15g PSS液體口腔敷料漱口的步驟。每週評估臨床 OM 和口腔功能連續 4 週直至放療完成後 5-10 天。每兩週對口腔健康相關的生活品質進行評分。評價口腔評估指引（oral assessment guide, OAG）收集口腔粘膜與功能評分數據；口腔健康衝擊量表 (OHIP-14) 用於評估患者的口腔健康相關生活品質 (OHRQoL)。 結果：PSS液體口腔敷料對改善CCRT誘導的頭頸部（H&N）患者的OM和生活品質皆有顯著性改善的效果。試驗組和對照組之間個統計結果比較為： OAG 分數（15.07 對 20.37 p<0.0001）和 OHIP-14 評分（23.85 對 34.2，p<0.0001）。 結論：綜上所述，使用PSS 液體口腔敷料作為改善OM嚴重度，是對需要進行放、化療治療的頭頸癌病人一個可以考慮的選擇。試驗證實在PSS液體口腔敷料的使用介入治療下，患者的口腔健康生活品質也得到顯著改善。 | zh_TW |
| dc.description.abstract | Background/Purpose: Oral health is not only an essential element of and also plays an important role in maintaining optimal overall health. Oral mucositis (OM) is an extremely painful and unavoidable complication of concurrent chemoradiotherapy (CCRT). This severe adverse symptom not only does it reduce the patient’s QoL and it also increases healthcare cost. The purpose of this study is to investigate whether the use of polyacrylate silver salt named as (polyacrylate silver salt, PSS)/Polyvinylpyrrolidone-based liquid oral dressing can improve the condition of OM and oral incapacitation in patients with head and neck cancer (HNC), and then promote their healthy QoL under the improvement of OM.
Methods: The design was designed as a stratified RCT. This study first stratified eligible HNC patients by "oral cancer type" and "other HNC type", and then randomly assigned patients to an experimental or control group within each stratum. The subjects must meet the symptoms of head and neck cancer patients who are undergoing CCRT treatment and have more than one grade of OM. The number of eligible patients who ultimately completed the entire trial was 55. All patients followed Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) clinical practice guidelines for the management of OM, but adding gargling with 15g PSS liquid oral dressing right after oral hygiene treaded for the experiment group. Clinical OM and oral function were assessed weekly for 4 consecutive weeks till 5-10 days after the completion of radiotherapy. Oral health related QoL was scored every two weeks. For evaluation, oral assessment guide (OAG) were used for collecting the data of OM status; oral health impact profile-14 (OHIP-14) was used to evaluate patients’ oral health-related QoL (OHRQoL). Results: The results showed that PSS liquid oral dressing a had positive effect on the improvement of CCRT-induced OM and QoL for head and neck cancer patients and all these data all had statistically significant improvement. OAG scores (15.07 vs. 20.37 p<0.0001) and OHIP-14 scores (23.85 vs. 34.2, p<0.0001) between the test group and the control group. Conclusions: In conclusion, oral care using PSS liquid oral dressing for the treatment of head and neck malignancies undergoing CCRT is an effective interventional option for improving the severity of OM. Under the intervention of PSS liquid oral dressing, patients' oral health QoL is also significantly improved. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-03-01T17:08:40Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2023-03-01T17:08:41Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員會審定書 I
致謝 II 摘要 IV ABSTRACT VI TABLE OF CONTENTS VIII LIST OF TABLES XI LIST OF FIGURES XII CHAPTER I INTRODUCTION 1 1-1 BACKGROUND 1 1-2 PURPOSES 3 CHAPTER II LITERTURE DISCUSSION 5 2-1 ORAL-RELATED QOL 5 2-2 HEAD AND NECK (H&N) CANCER 6 2-2-1 Causes 7 2-2-2 Treatment 7 2-3 ORAL MUCOSITIS 8 2-3-1 Incidence of Oral Mucositis in Patients Undergoing HNC Treatment 8 2-3-2 Pathobiology 9 2-3-3 Adverse Impact Caused by OM 10 2-3-4 OM Management 11 . CHAPTER III METHODS 14 3-1 STUDY DESIGN 14 3-2 STRUCTURE & HYPOTHESIS 14 3-2-1 Research Structure 14 3-2-2 Hypothesis 15 3-3 PARTICIPANTS AND DATA COLLECTION 16 3-3-1 Participants 16 3-3-2 Data Collection 16 3-3-3 Polyacrylate silver salt liquid oral dressing 18 3-4 ASSESSMENT TOOLS AND VARIABLE DEFINITION 19 3-4-1 Assessment tools 19 3-4-2 Variable Operational Definition 21 3-5 STATISTICAL ANALYSIS 24 CHAPTER IV RESULTS 26 4-1 DESCRIPTIVE STATISTICAL ANALYSIS 26 4-1-1 Patients 26 4-1-2 Basic information 27 4-2 HOMOGENEITY TEST 29 4-2-1 independent sample t-test and Chi-square test for demographic characteristics and disease characteristics between two groups 29 4-3 COVARIANCE ANALYSIS 31 4-3-1 Difference comparison within control variable's stratification 31 4-4 INTERVENTION EFFECT ANALYSIS 34 4-4-1 Repeated Measurement Analysis for Intervention Effect 34 4-4-2 Regression Analysis for PSS Dressing Effect Identification 40 CHAPTER V DISCUSSION 43 5-1 RESEARCH DESIGN 43 5-2 RELATION BETWEEN ORAL FUNCTION AND OHQOL 45 5-3 CLINICAL FIND OUT 46 5-4 VERIFICATION OF HYPOTHESIS 49 5-4-1 The effect of oral dressings on oral function and OM 49 5-4-2 The effect of oral dressings on oral related-QoL 50 5-5 LIMITATION 52 CHAPTER VI CONCLUSION 54 6-1 CONCLUSION 54 6-2 RECOMMENDATION 55 REFERENCES 57 APPENDIX 68 APPENDIX 1 IRB Approval Document 68 APPENDIX 2 OHIP-14 69 APPENDIX 3 OM Evaluation Form – “CTCAE” 71 APPENDIX 4 Oral Assessment Guide, OAG 72 | - |
| dc.language.iso | en | - |
| dc.title | 探討PSS液體口腔敷料干預下CCRT誘導的OM改善對頭頸癌患者健康生活品質的影響：分層隨機對照試驗 | zh_TW |
| dc.title | To investigate the effect of CCRT-induced OM improvement on the healthy QoL in head and neck cancer patients under the intervention of PSS liquid oral dressing: A stratified RCT | en |
| dc.title.alternative | To investigate the effect of CCRT-induced OM improvement on the healthy QoL in head and neck cancer patients under the intervention of PSS liquid oral dressing: A stratified RCT | - |
| dc.type | Thesis | - |
| dc.date.schoolyear | 111-1 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.coadvisor | 陳敏慧 | zh_TW |
| dc.contributor.coadvisor | Min-Huey Chen | en |
| dc.contributor.oralexamcommittee | 章浩宏;楊銘欽 | zh_TW |
| dc.contributor.oralexamcommittee | Hao-Hueng Chang;Ming-Chin Yang | en |
| dc.subject.keyword | 口腔黏膜炎 OM,同步放化療 CCRT,PSS 液體口腔敷料,頸頸癌,健康生活品質,隨機對照試驗,重複量測, | zh_TW |
| dc.subject.keyword | Oral Mucositis,concurrent chemoradiotherapy,polyacrylate silver salt oral dressing,head and neck cancer,QoL,randomized control trial,repeated measures, | en |
| dc.relation.page | 72 | - |
| dc.identifier.doi | 10.6342/NTU202204251 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2022-10-07 | - |
| dc.contributor.author-college | 公共衛生學院 | - |
| dc.contributor.author-dept | 健康政策與管理研究所 | - |
| 顯示於系所單位： | 健康政策與管理研究所 | |
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