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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82069完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 曾宇鳳(Yu-Feng Jane Tseng) | |
| dc.contributor.author | Bo-Jhang Lin | en |
| dc.contributor.author | 林柏璋 | zh_TW |
| dc.date.accessioned | 2022-11-25T05:35:10Z | - |
| dc.date.available | 2026-12-28 | |
| dc.date.copyright | 2022-02-17 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-12-28 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82069 | - |
| dc.description.abstract | 質譜影像是能同時研究多種感興趣分子之空間分布的強大工具。質譜影像經常與其他成像技術結合使用進而擴展其適用性。對於多模態成像資料的資料融合，對準是關鍵的步驟。質譜影像與其他成像技術之間的對準經常是通過組織學間接達成的。目前，質譜影像與組織學之間的對準大多是通過手動或半自動操作來進行。本論文的第一部分，我們建構了一個用於在質譜影像和組織學之間自動對準的網頁服務。在使用來自五項不同研究的二十七個樣本資料進行的性能評估中，大多數對準是有效的且沒有明顯偏移。 思覺失調症是一種主要的精神性腦部疾病，在全球範圍內的終生患病率約為1%，但思覺失調症的神經生物學機制和病因錯綜複雜且仍然不明確。本論文的第二部分，以三維質譜影像的方式對思覺失調症風險小鼠模型的腦部和野生型小鼠的腦部進行了分析。在這裡，我們主要針對海馬迴進行分析。我們發現在思覺失調症風險小鼠模型的背側海馬迴區域中數種代謝物顯著增加，包含脂肪酸、溶血磷脂、磷脂。其中一些代謝物在以前的文獻中已被發現可能與炎症有關聯。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T05:35:10Z (GMT). No. of bitstreams: 1 U0001-2812202110393800.pdf: 5540845 bytes, checksum: 87b99b0c7e45bff7acd9abc32e4d323a (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 口試委員會審定書 # 誌謝 i 中文摘要 ii ABSTRACT iii CONTENTS v LIST OF FIGURES ix LIST OF TABLES xii Chapter 1 Introduction 1 1.1 Mass Spectrometry Imaging 1 1.1.1 Commonly Used Ionization Techniques in MSI 2 1.1.2 Mass Spectrometry Imaging Data Analysis 3 1.1.3 Mass Spectrometry Imaging Data Analysis Tools 5 1.2 Multimodal Imaging with Mass Spectrometry Imaging 7 1.2.1 Combinations of Multiple Ionization Techniques 7 1.2.2 Mass Spectrometry Imaging with Radiology 8 1.2.3 Mass Spectrometry Imaging with Vibrational Spectroscopies 9 1.2.4 Mass Spectrometry Imaging with Microscopy 9 1.3 Multimodal Imaging Data Fusion 10 Chapter 2 MSI Registrar: Automatic Registration Service for Mass Spectrometry Imaging and Histology 13 2.1 Introduction 13 2.1.1 Image Registration between Mass Spectrometry Imaging and Histology 14 2.1.2 Dimensionality Reduction 16 2.1.3 Motivation 18 2.2 Method and Materials 19 2.2.1 Experimental Datasets 19 2.2.2 Overview of MSI Registrar 21 2.2.3 Histological Image Processing 22 2.2.4 Mass Spectrometry Imaging Data Processing 23 2.2.5 Multimodal Registration 25 2.2.6 Spectral Index Extraction 27 2.2.7 Registration Evaluation 28 2.3 Results and Discussion 29 2.3.1 Histological Image Processing 29 2.3.2 On-tissue Spectra Extraction 32 2.3.3 Hyperspectral Visualization 34 2.3.4 Multimodal Registration 35 2.3.5 Limitations 39 2.3.6 Web Interface 40 2.4 Conclusion 42 Chapter 3 Three-Dimensional Mass Spectrometry Imaging Analysis in the Brain of Mouse Model of Schizophrenia Risk 44 3.1 Introduction 44 3.1.1 N-Methyl-D-aspartate (NMDA) Receptor 45 3.1.2 D-Serine and Serine Racemase 45 3.1.3 Lipids in Schizophrenia 46 3.1.4 Three-Dimensional Mass Spectrometry Imaging 48 3.2 Method and Materials 49 3.2.1 Tissue Preparation 50 3.2.2 DESI MSI 50 3.2.3 Image Registration and 3D Construction 51 3.2.4 Data Processing and Statistics Analysis 53 3.2.5 Metabolites Grouping based on Spatial Distribution 56 3.3 Results and Discussion 56 3.3.1 Metabolite Annotation 56 3.3.2 Metabolite Classification based on Spatial Distribution 58 3.3.3 Metabolites with Significant Intensity Difference in Hippocampus 76 3.3.4 Hypothesis Generated from Observations in Hippocampus 88 3.3.5 The Limitation of Differential Analysis through DESI MSI 92 3.4 Conclusion 94 REFERENCE 95 | |
| dc.language.iso | en | |
| dc.subject | 三維質譜影像 | zh_TW |
| dc.subject | 思覺失調症 | zh_TW |
| dc.subject | 自動影像對準 | zh_TW |
| dc.subject | 組織學 | zh_TW |
| dc.subject | 質譜影像 | zh_TW |
| dc.subject | schizophrenia | en |
| dc.subject | mass spectrometry imaging | en |
| dc.subject | histology | en |
| dc.subject | automatic image registration | en |
| dc.subject | three-dimensional mass spectrometry imaging | en |
| dc.title | 組織學影像與質譜影像之自動化對準網頁服務與應用 | zh_TW |
| dc.title | Web Service and Application for Automatic Registration with Mass Spectrometry Imaging and Histology | en |
| dc.date.schoolyear | 110-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 賴文崧(Hsin-Tsai Liu),徐丞志(Chih-Yang Tseng),陳志光,蘇柏翰 | |
| dc.subject.keyword | 質譜影像,組織學,自動影像對準,三維質譜影像,思覺失調症, | zh_TW |
| dc.subject.keyword | mass spectrometry imaging,histology,automatic image registration,three-dimensional mass spectrometry imaging,schizophrenia, | en |
| dc.relation.page | 101 | |
| dc.identifier.doi | 10.6342/NTU202104585 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-12-29 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
| dc.date.embargo-lift | 2026-12-28 | - |
| 顯示於系所單位： | 生醫電子與資訊學研究所 | |
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