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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 丁詩同(Shih-Torng Ding),林原佑(Yuan-Yu Lin) | |
| dc.contributor.author | Pei-Xin Liao | en |
| dc.contributor.author | 廖珮馨 | zh_TW |
| dc.date.accessioned | 2022-11-25T05:33:55Z | - |
| dc.date.available | 2026-08-19 | |
| dc.date.copyright | 2021-11-09 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-08-19 | |
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Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol. Scand J Gastroenterol 44, 471-477. Yu, S.H., Chen, S.Y., Li, W.S., Dubey, N.K., Chen, W.H., Chuu, J.J., Leu, S.J., and Deng, W.P. (2015). Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice. J Diabetes Res 2015, 723190. Zaefarian, F., Abdollahi, M.R., Cowieson, A., and Ravindran, V. (2019). Avian Liver: The Forgotten Organ. Animals (Basel) 9. Zhang, J.W., Chen, D.W., Yu, B., and Wang, Y.M. (2011). Effect of dietary energy source on deposition and fatty acid synthesis in the liver of the laying hen. Br Poult Sci 52, 704-710. Zhang, X., Coker, O.O., Chu, E.S., Fu, K., Lau, H.C.H., Wang, Y.-X., Chan, A.W.H., Wei, H., Yang, X., Sung, J.J.Y., et al. (2021). Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites. Gut 70, 761-774. Zhang, Y., Liu, Z., Liu, R., Wang, J., Zheng, M., Li, Q., Cui, H., Zhao, G., and Wen, J. (2018). Alteration of Hepatic Gene Expression along with the Inherited Phenotype of Acquired Fatty Liver in Chicken. Genes (Basel) 9. Zhang, Y., Ma, K.L., Ruan, X.Z., and Liu, B.C. (2016). Dysregulation of the Low-Density Lipoprotein Receptor Pathway Is Involved in Lipid Disorder-Mediated Organ Injury. Int J Biol Sci 12, 569-579. Zhao, H., Lai, Q., Zhang, J., Huang, C., and Jia, L. (2018). Antioxidant and Hypoglycemic Effects of Acidic-Extractable Polysaccharides from Cordyceps militaris on Type 2 Diabetes Mice. Oxid Med Cell Longev 2018, 9150807. Zhong, D., Xie, Z., Huang, B., Zhu, S., Wang, G., Zhou, H., Lin, S., Lin, Z., and Yang, B. (2018). Ganoderma Lucidum Polysaccharide Peptide Alleviates Hepatoteatosis via Modulating Bile Acid Metabolism Dependent on FXR-SHP/FGF. Cell Physiol Biochem 49, 1163-1179. Zhou, Q., Zhang, Z., Wang, P., Zhang, B., Chen, C., Zhang, C., and Su, Y. (2019). EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Mol Nutr Food Res 63, e1801157. Zhou, X., Gong, Z., Su, Y., Lin, J., and Tang, K. (2009). Cordyceps fungi: natural products, pharmacological functions and developmental products. J Pharm Pharmacol 61, 279-291. Zhuang, Y., Xing, C., Cao, H., Zhang, C., Luo, J., Guo, X., and Hu, G. (2019). Insulin resistance and metabonomics analysis of fatty liver haemorrhagic syndrome in laying hens induced by a high-energy low-protein diet. Sci Rep 9, 10141. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82003 | - |
| dc.description.abstract | "脂肪肝 (fatty liver) 為蛋雞進入產蛋高峰時，肝臟因脂質代謝異常，脂肪堆積增加，造成肝臟發炎甚至肝臟出血及破裂的現象，嚴重則使產蛋驟降，甚至死亡，進而造成農民經濟損失。家禽與人類之內源性脂質生成 (de novo lipogenesis) 皆主要位於肝臟，在人類中非酒精性脂肪肝疾病 (non-alcoholic fatty liver disease, NAFLD) 近年已成為人類最常見的肝臟疾病，病因為過多脂肪蓄積於肝臟且與代謝性疾病有高度相關性，如肥胖、糖尿病、高血脂等。因 NAFLD 與雞隻脂肪肝皆被認為因能量不平衡導致過多脂肪堆積於肝臟之中所引發之疾病，因此產蛋家禽被認為是良好的脂肪肝研究模式。靈芝及北蟲草為著名的藥用真菌，各具有多種有效成分，亦有許多研究團隊證實在齧齒類動物模式中其具調控葡萄糖代謝、降血脂、改善脂肪肝與免疫調節活性之功能。禽類與人類皆有 90% 以上脂質代謝於肝臟中，因此本試驗之目的為飼糧中添加靈芝及北蟲草，探討其對雞隻脂肪肝之影響，並更加了解雞隻脂肪肝之生理機制，同時以雞隻作為未來改善 NAFLD 之動物模式。 本試驗分為三部分，第一部分探討在飼糧中添加不同濃度之靈芝子實體是否能減緩肝臟中之脂質堆積，動物試驗一使用伊莎褐殼蛋母雞餵飼快速誘導脂肪肝飼糧 (高膽固醇低膽鹼組, CLC) 及 CLC 飼糧添加 0.25、0.5、0.75、1% 之靈芝子實體，共五組，餵飼期間為 6 週 (7-13 週齡)。結果顯示，飼糧中添加不同濃度之靈芝子實體並無抑制血中脂肪之效果，但添加 0.25%、0.75% 及 1% 靈芝子實體能有效抑制肝臟膽固醇含量。然而，因靈芝之細胞壁較為堅韌，雞隻採食無法有效吸收靈芝子實體内之有效物質，動物試驗二進一步探討飼糧中除添加靈芝子實體外，亦測試以酒精且熱水萃取後的靈芝 (EGL) 以及北蟲草評估其對於脂肪肝之影響。試驗使用伊莎褐殼蛋母雞試驗分組為：對照組、CLC及 CLC 飼糧添加 0.1、0.5、1% 之萃取靈芝 (EGL)、1% 之靈芝子實體及 1% 北蟲草，共七組，餵飼 6 週。實驗結果發現添加不同濃度靈芝子實體、靈芝萃取物及北蟲草對血脂無影響，但添加活性成分如 0.5% 靈芝萃取物及 1% 北蟲草具降低肝臟膽固醇含量趨勢。由於過去研究發現飼糧中添加 DHA 和 Betaine 四個月後能有效減緩 30 週齡蛋雞產蛋後自然發生之脂肪肝症狀，在最後一部份的試驗使用此兩組正對照組確認雞隻快速誘導脂肪肝模式是否能同樣達到減緩肝臟脂質累積之效果，並再次評估萃取後的靈芝對肝臟中脂質含量之影響。動物試驗三使用伊莎褐殼蛋母雞，組別分組為：對照組、CLC 及 CLC 飼糧添加 DHA、Betaine、0.5、1% 之萃取靈芝 (EGL) 及 1% 北蟲草，共七組，餵飼 6 週。試驗結果顯示，在飼糧中添加 Betaine、DHA、0.5% EGL 及北蟲草具降低血中之三酸甘油酯之效果，但肝臟脂質含量則不受靈芝和北蟲草的影響。 綜上所述，在以年輕雞隻快速誘導脂肪肝模式進行添加物之評估後，發現靈芝及北蟲草具降低血脂之潛力，但對肝臟內脂質堆積之影響則仍不明確，未來將進一步探討其可能之有效成分，以了解其功效。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T05:33:55Z (GMT). No. of bitstreams: 1 U0001-1708202102182400.pdf: 3978549 bytes, checksum: 3c19e57645d0da41dc5341f5b0564089 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "致謝 I 中文摘要 III Abstract V 圖目錄 IX 表目錄 X 壹、 文獻探討 1 一、 經產家禽的脂肪肝病 1 1. 肝臟的重要性 1 2. 脂肪肝發現及症狀 1 3. 雞隻脂肪肝病發生原因 3 4. 雞隻肝臟脂質代謝與堆積途徑 4 5. 判斷禽體脂肪肝程度之方法診斷方式 8 二、 脂肪肝病 12 1. 非酒精性脂肪肝 12 2. 非酒精性脂肪肝病因與研究模式 13 三、 護肝物質 14 1. 靈芝 14 2. 北蟲草 17 貳、 研究方法及材料 19 一、 試驗設計 19 二、 雞隻飼養與管理 20 1. 動物試驗一、靈芝子實體添加於飼糧中對雞隻脂肪肝之影響 22 2. 動物試驗二、靈芝子實體、萃取靈芝及北蟲草添加於飼糧中對雞隻脂肪肝之影響 24 3. 動物試驗三、萃取靈芝子實體、北蟲草及DHA添加於飼糧中對雞隻脂肪肝之影響 26 三、 採樣處理 28 四、 生長性狀 28 五、 血液分析 28 六、 口服葡萄糖耐受性測驗 Oral glucose tolerance test, OGTT 29 七、 肝臟分析 29 1. 脂肪肝程度評分 29 2. 肝臟中總膽固醇與三酸甘油酯含量 29 八、 組織切片分析 30 1. 石蠟包埋、切片及蘇木素 - 伊紅染色 30 2. 冷凍切片及 Oil Red O 染色 30 九、 即時定量 PCR (real-time PCR) 分析 31 十、 統計分析 34 參、 試驗結果 35 一、 動物試驗一：飼糧中添加不同濃度靈芝子實體對雞隻脂肪肝之影響 35 1. 添加不同濃度靈芝子實體對雞隻生長表現之影響 35 2. 血漿中三酸甘油酯及膽固醇濃度 37 3. 額外添加不同濃度之靈芝子實體對雞隻肝臟脂肪堆積影響 38 4. 肝臟中脂肪肝生物標記、促發炎因子、脂質生合成及脂質氧化作用相關基因表現 43 二、 動物試驗二：飼糧中添加不同濃度靈芝子實體萃取物及北蟲草對雞隻脂肪肝之影響 45 1. 添加不同濃度靈芝及蟲草對於雞隻生長表現之影響 45 2. 血漿中三酸甘油酯及膽固醇濃度 47 3. 額外添加不同濃度之靈芝子實體、萃取物及蟲草對於雞隻肝臟脂肪堆積之影響 49 4. 肝臟中脂肪肝生物標記、促發炎因子、脂質生合成及脂質氧化作用相關基因表現 55 三、 動物試驗三：飼糧中添加萃取靈芝、北蟲草、Betaine 及 DHA 對雞隻脂肪肝之影響 57 1. 添加不同濃度靈芝及蟲草對於雞隻生長表現之影響 57 2. 血漿中三酸甘油酯及膽固醇濃度 59 3. 額外添加不同濃度之萃取靈芝及北蟲草對於雞隻血糖控制之效果 61 4. 額外添加不同濃度之萃取靈芝及北蟲草對於雞隻肝臟脂肪改善效果評估 63 5. 肝臟中脂肪肝生物標記、促發炎因子、脂質生合成及脂質氧化作用相關基因檢測結果 68 肆、 討論 72 伍、 結論 79 陸、 參考資料 80" | |
| dc.language.iso | zh-TW | |
| dc.subject | 蛋雞 | zh_TW |
| dc.subject | 血脂 | zh_TW |
| dc.subject | 靈芝 | zh_TW |
| dc.subject | 北蟲草 | zh_TW |
| dc.subject | 脂肪肝 | zh_TW |
| dc.subject | Cordyceps militaris | en |
| dc.subject | lipid profile | en |
| dc.subject | chicken | en |
| dc.subject | Ganoderma lucidum | en |
| dc.subject | fatty liver | en |
| dc.title | 飼糧中添加靈芝子實體及北蟲草對雞隻脂肪肝之影響 | zh_TW |
| dc.title | Effect of dietary supplementation with Ganoderma lucidum fruiting body and Cordyceps militaris on fatty liver in chickens | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳洵一(Hsin-Tsai Liu),林傳順(Chih-Yang Tseng),黃晁瑋 | |
| dc.subject.keyword | 脂肪肝,靈芝,北蟲草,蛋雞,血脂, | zh_TW |
| dc.subject.keyword | fatty liver,Ganoderma lucidum,Cordyceps militaris,chicken,lipid profile, | en |
| dc.relation.page | 90 | |
| dc.identifier.doi | 10.6342/NTU202102418 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-08-20 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 動物科學技術學研究所 | zh_TW |
| dc.date.embargo-lift | 2026-08-19 | - |
| 顯示於系所單位： | 動物科學技術學系 | |
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