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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 劉嚞睿(Je-Ruei Liu) | |
| dc.contributor.author | Chia-Fang Tsai | en |
| dc.contributor.author | 蔡佳芳 | zh_TW |
| dc.date.accessioned | 2022-11-25T05:33:40Z | - |
| dc.date.available | 2023-09-01 | |
| dc.date.copyright | 2021-11-12 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-07 | |
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Effects of Bacillus velezensis FKM10 for promoting the growth of Malus hupehensis Rehd. and inhibiting Fusarium verticillioides. Front Microbiol 10:2889. Wang, J., H. F. Ji, S. X. Wang, D. Y. Zhang, H. Liu, D. C. Shan, and Y. M. Wang. 2012. Lactobacillus plantarum ZLP001: In vitro assessment of antioxidant capacity and effect on growth performance and antioxidant status in weaning piglets. Asian-Australas J Anim Sci 25:1153-1158. Wang, S., J. Wu, F. Wang, H. Wang, Z. Wu, S. Wu, and W. Bao. 2020. Expression pattern analysis of antiviral genes and inflammatory cytokines in PEDV-infected porcine intestinal epithelial cells. Front Vet Sci 7:75. Wang, X., W. Hu, L. Zhu, and Q. Yang. 2017. Bacillus subtilis and surfactin inhibit the transmissible gastroenteritis virus from entering the intestinal epithelial cells. Biosci Rep 37:BSR20170082. Wang, Y., Y. Wu, Y. Wang, H. Xu, X. Mei, D. Yu, Y. Wang, and W. Li. 2017. Antioxidant properties of probiotic bacteria. Nutrients 9:521. Wang, Z., W. Chai, M. Burwinkel, S. Twardziok, P. Wrede, C. Palissa, B. Esch, and M. F. G. Schmidt. 2013. Inhibitory influence of Enterococcus faecium on the propagation of swine influenza A virus in vitro. PLoS One 8:e53043. Warrington, R., W. Watson, H. Kim, and F. R. Antonetti. 2011. An introduction to immunology and immunopathology. Allergy Asthma Clin Immunol 7:S1. Wu, Y., W. Li, Q. Zhou, Q. Li, Z. Xu, H. Shen, and F. Chen. 2019. Characterization and pathogenicity of Vero cell-attenuated porcine epidemic diarrhea virus CT strain. Virol J 16:121. Yang, B., L. Xiao, S. Liu, X. Liu, Y. Luo, Q. Ji, P. Yang, and Z. Liu. 2017. Exploration of the effect of probiotics supplementation on intestinal microbiota of food allergic mice. Am J Transl Res 9:376-385. Yang, K. M., Z. Y. Jiang, C. T. Zheng, L. Wang, and X. F. Yang. 2014. Effect of Lactobacillus plantarum on diarrhea and intestinal barrier function of young piglets challenged with enterotoxigenic Escherichia coli K88. J Anim Sci 92:1496-1503. Yang, X., Y. Liu, X. Guo, Q. Bai, X. Zhu, H. Ren, Q. Chen, T. Yue, and F. Long. 2019. Antiallergic activity of Lactobacillus plantarum against peanut allergy in a Balb/c mouse model. Food Agric Immunol 30:762-773. Yang, Y., H. Song, L. Wang, W. Dong, Z. Yang, P. Yuan, K. Wang, and Z. Song. 2017. Antiviral effects of a probiotic metabolic products against transmissible gastroenteritis coronavirus. J Prob Health 5:3. Ye, M., C. Wei, A. Khalid, Q. Hu, R. Yang, B. Dai, H. Cheng, and Z. Wang. 2020. Effect of Bacillus velezensis to substitute in-feed antibiotics on the production, blood biochemistry and egg quality indices of laying hens. BMC Vet Res 16:400. Yi, P. J., C. K. Pai, and J. R. Liu. 2010. Isolation and characterization of a Bacillus licheniformis strain capable of degrading zearalenone. World J Microbiol Biotechnol 27:1035-1043. Yong, C. Y., H. K. Ong, S. K. Yeap, K. L. Ho, and W. S. Tan. 2019. Recent advances in the vaccine development against middle east respiratory syndrome-coronavirus. Front Microbiol 10:1781. Zhang, J., H. Su, Q. Li, H. Wu, M. Liu, J. Huang, M. Zeng, Y. Zheng, and X. Sun. 2017. Oral administration of Clostridium butyricum CGMCC0313-1 inhibits β-lactoglobulin-induced intestinal anaphylaxis in a mouse model of food allergy. Gut Pathog 9:11. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81989 | - |
| dc.description.abstract | "近年來許多研究表明益生菌可作為一種新策略來降低病毒或過敏性疾病發生的風險，而芽孢桿菌作為潛力益生菌具有獨特的內孢子結構，使在腸胃道或飼料加工的惡劣環境下表現出較好的生存能力，且適用於健康的促進劑。故本研究選用分離自實驗室且具益生菌潛力的液化澱粉芽孢桿菌LN（Bacillus amyloliquefaciens LN）、貝萊斯芽孢桿菌AC（B. velezensis AC）與地衣芽孢桿菌CK1（B. licheniformis CK1）作為研究對象，評估其抗病毒與抗過敏功效。在抗病毒試驗中，將LN、AC及CK1之胞內液及細胞壁預處理Vero細胞後測定抗豬流行性下痢病毒（porcine epidemic diarrhea virus, PEDV）的活性，可得LN及AC的菌株萃取物皆表現抗病毒能力且以LN效果最好；進一步探討抗病毒機制後，儘管兩菌株萃取物無法有效上調抗病毒基因的表現，但促發炎細胞激素及病毒核殼蛋白的RNA基因表現皆於感染後的48小時顯著下降；此外，菌株萃取物與PEDV之直接相互作用試驗結果則表明彼此不具影響性。在抗過敏試驗中，以注射花生蛋白萃取物的方式誘導C3H/HeOuJ小鼠致敏並在預防及治療模式下管餵CK1（10^10 CFU/kg體重），發現致敏小鼠在餵食CK1後可減輕過敏性症狀並抑制IgE介導的過敏反應；腸道組織學分析顯示CK1的餵食明顯減少腸黏膜肥大細胞的數量並恢復因致敏而造成的腸黏膜損傷；此外，致敏小鼠在餵食CK1後其腸道菌群中Clostridia的豐度明顯增加。總結來說，LN和AC具抗PEDV活性而有潛力作為抗病毒之飼料添加物，期望有效預防動物病毒性疾病的發生，而CK1具有減緩花生過敏之功效，未來希望能應用於食品或寵物食品添加劑。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T05:33:40Z (GMT). No. of bitstreams: 1 U0001-0309202116382600.pdf: 4551726 bytes, checksum: 4c2bec15ba2caf73463b986320cdcd44 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "致謝 i 中文摘要 ii Abstract iii 目錄 v 圖目錄 x 表目錄 xii 第一章、文獻探討 1 第一節、益生菌 1 一、益生菌之定義 1 二、益生菌具備之特性 1 三、益生菌之功能 2 （一）促進腸道屏障的保護 2 （二）抑制腸道病原菌的定植及生長 2 （三）調節免疫系統 3 （四）抗氧化功能 3 第二節、芽孢桿菌 6 一、芽孢桿菌（Bacillus）簡介及應用 6 二、液化澱粉芽孢桿菌（Bacillus amyloliquefaciens） 6 三、貝萊斯芽孢桿菌（Bacillus velezensis） 7 四、地衣芽孢桿菌（Bacillus licheniformis） 8 第三節、病毒 11 一、病毒簡介 11 二、常見的經濟動物病毒性疾病 11 （一）豬流感（swine influenza） 11 （二）傳染性胃腸炎（transmissible gastroenteritis, TGE） 12 （三）豬瘟（classical swine fever） 12 （四）豬生殖與呼吸道綜合症（porcine reproductive and respiratory syndrome, PRRS） 12 （五）口蹄疫（foot-and-mouth disease, FMD） 13 （六）豬流行性下痢（porcine epidemic diarrhea, PED） 13 三、豬流行性下痢病毒（porcine epidemic diarrhea virus, PEDV） 14 （一）豬流行性下痢病毒組成及結構 14 （二）感染週期 14 四、病毒防治 15 五、益生菌於抗病毒的應用 16 （一）益生菌與病毒之直接作用 16 （二）益生菌細胞成分及其胞外分泌物之抗病毒能力 16 （三）益生菌可調節宿主免疫達到抗病毒效果 17 第四節、過敏 20 一、過敏（allergy）簡介 20 二、食物過敏（food allergy） 20 （一）急性食物過敏 20 （二）慢性食物過敏 21 三、過敏反應之控制 22 四、益生菌於抗過敏之應用 22 第五節、研究動機與目的 25 第二章、材料與方法 26 第一節、實驗架構 26 第二節、芽孢桿菌之抗豬流行性下痢病毒能力評估 27 一、芽孢桿菌之培養及保存 27 二、芽孢桿菌萃取物的製備 27 （一）胞內萃取物 27 （二）細胞壁 27 三、細胞株培養 28 （一）細胞株活化 28 （二）細胞株繼代 28 （三）細胞株冷凍保存 29 四、菌株萃取物之細胞毒性測試 29 五、豬流行性下痢病毒之培養 30 （一）病毒感染液配製 30 （二）病毒製備 30 （三）病毒效價測定 30 六、預防模式之抗病毒活性試驗 31 七、抗病毒及促發炎相關基因表現之分析 32 （一）抽取RNA 32 （二）製備cDNA 33 （三）即時定量聚合酶連鎖反應（real-time quantitative PCR, qPCR） 33 八、菌株萃取物與病毒顆粒之直接作用活性測試 34 （一）病毒直接抑制 34 （二）抑制病毒貼附 35 （三）抑制病毒進入 35 第三節、芽孢桿菌之抗花生食物過敏潛力評估 39 一、Bacillus licheniformis CK1菌株製備 39 二、花生萃取物製備 39 三、實驗動物 39 （一）飼養條件 39 （二）試驗設計與分析項目 39 （三）樣本採集 41 四、實驗方法 42 （一）過敏性症狀（anaphylactic symptoms）分析 42 （二）臟器重量比 42 （三）花生致敏之相關過敏指標分析 43 （四）腸道組織病理學分析 43 （五）腸道微生物組成分析 44 第四節、統計分析 45 第三章、實驗結果 46 第一節、芽孢桿菌之抗豬流行性下痢病毒能力評估 46 一、豬流行性下痢病毒效價測試 46 二、預防模式下具抗病毒活性之芽孢桿菌菌株篩選 46 （一）菌株萃取物之細胞毒性 46 （二）菌株萃取物之抗病毒活性 47 （三）基因表現量分析 47 三、菌株萃取物與病毒顆粒之直接作用活性測試 49 第二節、芽孢桿菌之抗花生致敏的潛力評估 61 一、過敏性症狀分析 61 二、生理數值測量 62 三、非特異性免疫球蛋白測定 63 四、Th2相關細胞激素之測定 63 五、肥大細胞脫粒作用之下游相關蛋白測定 64 六、腸黏膜肥大細胞數量計數 64 七、腸黏膜完整性評估 65 八、腸道微生物群組成變化之分析 65 第四章、討論 81 第一節、芽孢桿菌之抗豬流行性下痢病毒能力評估 81 一、預防模式下芽孢桿菌之抗病毒活性 81 二、基因表現量分析 82 三、菌株萃取物與病毒顆粒之直接作用 84 第二節、芽孢桿菌之抗花生致敏的潛力評估 85 一、 過敏性症狀與器官體重比的改善 86 二、 IgE介導之過敏反應的影響 86 三、 腸道組織學的探討 87 四、 腸道微生物群的變化 88 第五章、結論 92 第六章、參考文獻 93" | |
| dc.language.iso | zh-TW | |
| dc.subject | 花生 | zh_TW |
| dc.subject | 益生菌 | zh_TW |
| dc.subject | Bacillus amyloliquefacien | zh_TW |
| dc.subject | Bacillus velezensis | zh_TW |
| dc.subject | Bacillus licheniformis | zh_TW |
| dc.subject | 豬流行性下痢病毒 | zh_TW |
| dc.subject | 過敏 | zh_TW |
| dc.subject | Bacillus amyloliquefaciens | en |
| dc.subject | Bacillus velezensis | en |
| dc.subject | Probiotic | en |
| dc.subject | Peanut | en |
| dc.subject | Allergy | en |
| dc.subject | Porcine epidemic diarrhea virus | en |
| dc.subject | Bacillus licheniformis | en |
| dc.title | 具益生菌潛力之芽孢桿菌抗病毒與抗過敏功效評估 | zh_TW |
| dc.title | Evaluation of antiviral and antiallergic effects of Bacillus strains with probiotic potential | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 劉啟德(Hsin-Tsai Liu),張惠雯(Chih-Yang Tseng),鄭永祥,謝建元 | |
| dc.subject.keyword | 益生菌,Bacillus amyloliquefacien,Bacillus velezensis,Bacillus licheniformis,豬流行性下痢病毒,過敏,花生, | zh_TW |
| dc.subject.keyword | Probiotic,Bacillus amyloliquefaciens,Bacillus velezensis,Bacillus licheniformis,Porcine epidemic diarrhea virus,Allergy,Peanut, | en |
| dc.relation.page | 107 | |
| dc.identifier.doi | 10.6342/NTU202102981 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-09-08 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 生物科技研究所 | zh_TW |
| dc.date.embargo-lift | 2023-09-01 | - |
| 顯示於系所單位： | 生物科技研究所 | |
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