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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 劉嚞睿(Je-Ruei Liu) | |
| dc.contributor.author | Jie-Hong Song | en |
| dc.contributor.author | 宋杰紘 | zh_TW |
| dc.date.accessioned | 2022-11-25T05:33:38Z | - |
| dc.date.available | 2023-09-01 | |
| dc.date.copyright | 2021-11-12 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-07 | |
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Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., Concha, H., Hassan, M., Rydén, M., Frisén, J., Arner, P. (2008). Dynamics of fat cell turnover in humans. Nature, 453(7196), 783-787. Stefanovski, D., Richey, J. M., Woolcott, O., Lottati, M., Zheng, D., Harrison, L. N., Ionut, V., Kim, S. P., Hsu, I., Bergman, R. N. (2011). Consistency of the disposition index in the face of diet induced insulin resistance: potential role of FFA. PLoS One, 6(3), e18134. Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C., Witztum, J. L. (1989). Beyond cholesterol. New England Journal of Medicine, 320(14), 915-924. Tak, Y. J., Lee, S. Y. (2021). Anti-obesity drugs: long-term efficacy and safety: an updated review. The World Journal of Men's Health, 39(2), 208. Takahashi, H., Sanada, K., Nagai, H., Li, Y., Aoki, Y., Ara, T., Seno, S., Matsuda, H., Yu, R., Kawada, T., Goto, T. (2017). 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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81987 | - |
| dc.description.abstract | "肥胖率在現代社會中逐漸攀升並且容易增加第二型糖尿病、心血管疾病以及非酒精性脂肪肝等疾病的患病機率，使肥胖現象儼然成為已開發社會的健康威脅之一。許多研究即以傳統中草藥為材料，測試其抗肥胖功能，企圖尋找出安全有效的抗肥胖藥物。眾多中草藥皆被發現具有抗肥胖功效，而北蟲草（Cordyceps militaris）便是其一。北蟲草可由人工培養在米培養基上，在北蟲草子實體收割後米培養基即被視為廢棄物並丟棄。然而，考慮到廢棄米培養基中含有北蟲草菌絲體，猜測其或許也具有些許藥用功效與利用價值。本論文之目的即在驗證此一說之可行性，以3T3-L1細胞與SD大鼠為試驗模型，測試北蟲草廢棄米培養基（Cordyceps militaris spent rice media, CMS）在抗肥胖方面的效果。由於蟲草素（Cordycepin）普遍被認為是北蟲草中的功效成分，故首先以高效液相層析（high performance liquid chromatography, HPLC）測定CMS中蟲草素含量，發現CMS的蟲草素含量約占其總重之0.4%，確認其含有功效成分。在細胞試驗結果中顯示北蟲草廢棄米培養基水萃物（Cordyceps militaris spent rice media water extract, CMSWE）可透過增加AMPK與Wnt10b訊號路徑相關蛋白的mRNA表現量而抑制C/EBPα與PPARγ的表現，從而阻礙3T3-L1前脂肪細胞的分化。此外，CMSWE亦可透過抑制脂肪合成與促進脂肪分解、β氧化相關基因表現而降低3T3-L1細胞中的脂肪累積。動物試驗結果進一步顯示餵食CMS的大鼠減輕由高脂飼料誘發的肥胖現象，具有較輕的體重、較少的脂肪量以及較低的血清三酸甘油酯與膽固醇含量，同時CMS亦可減輕由高脂飼料引起之肝脂肪變性程度。此外，由第三代定序技術分析大鼠腸道菌相結果指出，餵食CMS的大鼠腸道中Akkermansia muciniphila與Parabacteroides goldsteinii二個菌種的豐度有所增加，而前人研究曾指出此二菌種對宿主的代謝具有正面影響，可能在CMS減輕肥胖症狀的效果中具有一定的作用。上述試驗結果均顯示北蟲草廢棄米培養基具有抗肥胖的能力與潛在的應用價值。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T05:33:38Z (GMT). No. of bitstreams: 1 U0001-0309202117334400.pdf: 3904817 bytes, checksum: c7f9854cb56d0f0ceb4514a3a3027795 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 口試委員會審定書...i 誌謝...ii 中文摘要...iii Abstract...v 目錄...vii 圖目錄...xi 表目錄...xiii 第一章、文獻探討...1 第一節、肥胖...1 一、肥胖之定義與其普及狀況...1 二、肥胖對健康之影響...1 （一）慢性發炎...2 （二）第二型糖尿病...3 1. 肥胖與胰島素阻抗...4 2. 肥胖與胰島β細胞功能失調...5 （三）心血管疾病...7 （四）非酒精性脂肪肝疾病...8 三、肥胖治療...9 （一）減重手術...9 （二）減肥藥物...10 第二節、北蟲草...11 一、北蟲草簡介與其藥用功效...11 二、北蟲草之抗肥胖功效...11 三、北蟲草廢棄米培養基之潛在應用價值...12 第三節、研究動機與目的...13 第二章、材料與方法...14 第一節、試驗架構...14 第二節、北蟲草廢棄米培養基與子實體蟲草素含量測定...15 一、樣品來源與樣品水萃物製備...15 二、高效液相層析...15 第三節、細胞試驗...16 一、細胞株與細胞培養...16 二、3T3-L1細胞誘導分化...16 三、細胞試驗設計...17 （一）毒性試驗...17 （二）細胞分組...17 （三）試驗分組與目的...18 四、油紅染色...18 五、RNA抽取純化與即時定量聚合酶連鎖反應...18 第四節、動物試驗...25 一、實驗動物...25 二、動物試驗設計...25 三、飼料製備...25 四、檢測項目...26 （一）身體數值與器官重量...26 （二）採食量與食物利用率...26 （三）血清生化分析...26 （四）肝臟脂肪萃取與定量...26 （五）肝臟組織切片HE染色...27 五、RNA抽取純化與即時定量聚合酶連鎖反應...27 六、腸道微生物菌相分析...28 第五節、統計分析...31 第三章、試驗結果...32 第一節、HPLC分析結果...32 一、北蟲草廢棄米培養基之蟲草素含量測定結果...32 第二節、細胞試驗結果...34 一、北蟲草廢棄米培養基水萃物細胞毒性測試結果...34 二、抑制3T3-L1前脂肪細胞分化試驗結果...34 （一）油紅染色與細胞活性...34 （二）成熟脂肪細胞指標蛋白之mRNA表現量...34 （三）細胞增生相關蛋白之mRNA表現量與分化後細胞數量變化...35 （四）前脂肪細胞分化路徑相關蛋白之mRNA表現量...35 （五）前脂肪細胞分化期間AMPKα之mRNA表現量...36 三、抑制3T3-L1細胞脂肪生成試驗結果...37 （一）油紅染色與細胞活性...37 （二）脂肪合成相關蛋白之mRNA表現量...37 四、促進3T3-L1細胞脂肪分解試驗結果...37 （一）油紅染色與細胞活性...37 （二）脂肪分解代謝相關蛋白之mRNA表現量...38 第三節、動物試驗結果...49 一、體重記錄...49 二、攝食記錄與食物利用率...49 三、身體數值...49 四、脂肪組織與器官重量...50 五、血清生化分析...50 六、肝臟脂肪含量與HE染色之組織切片...50 七、肝臟中與脂肪代謝相關蛋白之mRNA表現量...51 八、脂肪組織中與脂肪代謝相關蛋白之mRNA表現量...51 九、脂肪組織發炎相關蛋白之mRNA表現量...52 十、腸道菌相分析...52 （一）α多樣性...52 （二）β多樣性...53 （三）物種組成...53 第四章、討論...76 第一節、細胞試驗結果討論...76 一、北蟲草廢棄米培養基水萃物具有抑制3T3-L1前脂肪細胞分化為成熟脂肪細胞之能力...76 二、北蟲草廢棄米培養基水萃物對3T3-L1脂肪細胞的脂肪累積具有負面調控作用...80 三、北蟲草廢棄米培養基水萃物試驗組與蟲草素正對照組之比較...81 第二節、動物試驗結果討論...82 一、餵食北蟲草廢棄米培養基之大鼠減輕高脂飼料誘發之肥胖症狀...82 二、餵食北蟲草廢棄米培養基之大鼠減輕高脂飼料誘發之非酒精性脂肪肝症狀...83 三、餵食北蟲草廢棄米培養基對實驗大鼠腸道菌相之影響...84 第五章、結論...89 參考文獻...90 附錄一...105 | |
| dc.language.iso | zh-TW | |
| dc.subject | 非酒精性脂肪肝 | zh_TW |
| dc.subject | 肥胖 | zh_TW |
| dc.subject | 腸道菌相 | zh_TW |
| dc.subject | 北蟲草 | zh_TW |
| dc.subject | 3T3-L1 | zh_TW |
| dc.subject | 蟲草素 | zh_TW |
| dc.subject | hepatic steatosis | en |
| dc.subject | microbiota | en |
| dc.subject | 3T3-L1 | en |
| dc.subject | obesity | en |
| dc.subject | cordycepin | en |
| dc.subject | Cordycepes militaris | en |
| dc.title | 北蟲草廢棄米培養基之抗肥胖功效探討 | zh_TW |
| dc.title | Study of anti-obesity effects of Cordyceps militaris spent rice media | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 謝建元(Hsin-Tsai Liu),張惠雯(Chih-Yang Tseng),劉啟德,鄭永祥 | |
| dc.subject.keyword | 北蟲草,蟲草素,肥胖,非酒精性脂肪肝,3T3-L1,腸道菌相, | zh_TW |
| dc.subject.keyword | Cordycepes militaris,cordycepin,obesity,hepatic steatosis,3T3-L1,microbiota, | en |
| dc.relation.page | 106 | |
| dc.identifier.doi | 10.6342/NTU202102984 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-09-08 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 生物科技研究所 | zh_TW |
| dc.date.embargo-lift | 2023-09-01 | - |
| 顯示於系所單位： | 生物科技研究所 | |
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