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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81815完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳億乘(Yi-Chen Chen) | |
| dc.contributor.author | Samuel Yi-Hsieng Wu | en |
| dc.contributor.author | 吳奕賢 | zh_TW |
| dc.date.accessioned | 2022-11-25T03:04:14Z | - |
| dc.date.available | 2026-07-30 | |
| dc.date.copyright | 2021-08-20 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-08-03 | |
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(2018). Regulation of metabolic health by essential dieta……… | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81815 | - |
| dc.description.abstract | "我國政府近年來依照國際發展趨勢而大力提倡「農業循環經濟」，因此各種農業副產物的加值化利用受到重視。國內家禽肝臟因氣味濃厚不受消費者青睞而用途有限，然近十年因禽肉成為國人最主要的蛋白質來源，其中又以白肉雞為大宗，因此研究白肉雞產業之屠宰副產物的加值化利用具有其意義。敝研究團隊已經成功將此產業副產物開發成具生物活性之雞肝水解物(chicken-liver hydrolysate, CLH)。根據先前的動物實驗結果指出：補充CLHs具有抗氧化、抗發炎、抗肥胖、抗肝纖維化、減少脂質生成等功效。故此推測CLHs之補充應具減緩代謝症候群(Metabolic syndrome, MetS)之病理進程功效。此研究旨於釐清長期餵飼高脂飼糧之小鼠經補充CLH對於其心腎保護、脂質恆定和血糖恆定之影響。 在實驗一的部分，於長期餵飼高脂飼糧之小鼠補充CLHs，可以顯著地降低(p < 0.05)體重、血清膽固醇、腹部脂肪量，並透過Sirius red組織染色顯示其可以有效減緩(p < 0.05)腎臟及心臟的纖維化情形。若進一步將心肌組織均質後測定促發炎和纖維化相關之細胞激素，結果顯示CLHs之補充可以減緩(p < 0.05)其發炎和纖維化之程度。而其中心肌細胞中自噬作用(autophagy)也參與其中。CLHs補充降低(p < 0.05) LC3BII之累積、提升Rab7之表現量。由此可見CLHs補充可以於高脂飼糧長期誘導的狀況下，維持autophagy之進行，以利組織清除多餘之油脂和損壞之胞器。 在實驗二中，油酸誘導FL83B細胞之平台中，透過蛋白質表現量之測定，顯示CLHs添加於培養液中，於4 mg CLH/L之濃度可以有效降低(p < 0.05)細胞中油脂的累積。也證實CLHs添加可以活化(p < 0.05) AMPK，並進一步抑制(p < 0.05)脂肪酸合成路徑的關鍵酵素表現(ACC和FAS)，並且可以有效地促進(p < 0.05)脂肪酸氧化之效率(fatty-acid β-oxidation)，也可以增加(p < 0.05) UCP2的表現量，以利剩餘能量之代謝。並在實驗二的動物實驗中，以IHC確認關鍵酵素之表現(DGAT2和ACADM)能再次驗證細胞實驗中得到的結果。另外，於葡萄糖耐受性試驗中證實CLHs補充可以顯著增加(p < 0.05)葡萄糖吸收的速率，因此曲線下面積顯著小於(p < 0.05) 單純高脂飲食組(HFD組)。在肝臟、骨骼肌和腎周脂肪組織中，也發現CLHs補充可以恢復(p < 0.05)胰島素訊息主要因子IRβ和GLUT4蛋白質表現量。 綜合上述而言，本試驗證實CLHs可以有效改善長期餵飼高脂飼糧所產生的脂質代謝異常、胰島素阻抗等，這在MetS的應用上提供客觀的證據。除此以外，CLHs的開發不僅是循環農業上的應用，在商業開發上面具有實際的應用性，雖在商業生產前尚有挑戰，但此研究確實可以提供國內白肉雞產業做為一個副產物加值利用的可行方案。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T03:04:14Z (GMT). No. of bitstreams: 1 U0001-3007202117431600.pdf: 10626611 bytes, checksum: 14edb318f2d6b7805784c6bf4457caf9 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "LIST OF FIGURES/Ⅰ LIST OF TABLES/Ⅵ LIST OF APPENDIXES/Ⅷ ABBREVIATION LIST/Ⅸ ABSTRACT (Chinese Version.)/1 ABSTRACT (English Version)/3 I. INTRODUCTION/6 II. LITERATURE REVIEW/13 2.1 Utilization of food by-products/13 2.2 Food-protein hydrolysates and chicken-liver hydrolysates/17 2.2.1 Peptide transport and bioavailability/17 2.2.2 Trends and applications of food-protein hydrolysates/24 2.2.2.1 Additives in the food processing industry/24 2.2.2.2 Bioactive nutraceuticals/29 2.2.3 Bioactive peptides, amino acids, and their derivatives/32 2.2.3.1 Essential amino acids, branched-chain amino acids, taurine, and others/32 2.2.3.2 Bioactive peptides/33 2.2.4 Manufacture of functional chicken-liver hydrolysates/45 2.2.4.1 Chicken liver: feed additives and slaughterhouse waste/45 2.2.4.2 The potential of commercial exploitation/47 2.2.4.3 The development of chicken-liver hydrolysates/49 2.2.5 Functionalities of functional chicken-liver hydrolysates/54 2.3 Metabolic syndrome: a worldwide issue/62 2.3.1 Life style and nutritional factor/70 2.3.2 Lipid homeostasis in the metabolic syndrome/76 2.3.3 Hepatic insulin resistance in the metabolic syndrome/88 2.3.4 Hepatocyte steatotic model in vitro/93 2.3.5 Long-term high fat diet-induced model in vivo/95 III. MATERIALS AND METHODS/102 3.1 Experimental design/102 3.2 Materials and chemicals/106 3.3 Nutritional composition, free amino-acid profiles, and carnosine/anserine contents of the chicken liver hydrolysates/110 3.4 FL83B cell culture/110 3.5 Lipid accumulation model of the FL83B cell/112 3.6 Animal and diets/113 3.7 Intraperitoneal glucose tolerance test/116 3.8 Collection of serum, liver, abdominal fat, feces, and muscle of experimental mice/116 3.9 Serum biochemical values and lipid profiles of livers and feces/117 3.10 Serum lipid peroxidation level and anti-oxidant capacity/117 3.11 Hepatic lipid peroxidation and pro-inflammatory cytokine levels/118 3.12 Myocardial pro-inflammatory and fibrotic cytokines levels/118 3.13 Western blotting/118 3.14 Histological analyses and immunohistochemistry stain of livers, adipose tissue, kidney, and heart/121 3.15 Statistical analysis/122 IV. RESULTS/123 4.1 Experiment Ⅰ: Effects of chicken liver hydrolysates on growth performance, serum biochemical analyses, and organ weights in high-fat diet-induced mice/123 4.2 Experiment Ⅰ: Effects of chicken liver hydrolysates on obesity and renal morphology in high-fat diet-induced mice/125 4.3 Experiment Ⅰ: Effects of chicken liver hydrolysates on myocardial damage in high-fat diet-induced mice/126 4.4 Experiment Ⅱ: Effects of chicken liver hydrolysates on oleic acid-induced lipid accumulation in vitro/136 4.5 Experiment Ⅱ: Effects of chicken liver hydrolysates on physiological parameters, blood biochemical values, hepatic antioxidative capacities, and pro-inflammatory cytokines of experimental mice/137 4.6 Experiment Ⅱ: Effects of chicken liver hydrolysates on hepatic steatosis and insulin resistance of liver, adipose tissue, and skeletal muscle/138 V. DISCUSSION/154 5.1 Chicken liver hydrolysate is rich in bioactive amino acids and peptides, which may attenuate metabolic disorders/154 5.2 The cardio-renal protective effects of chicken liver hydrolysate are attributed to its free amino acid composition/155 5.3 Chicken liver hydrolysate supplementation reduced the weight gain, which releases the impacts to cardiovascular system/158 5.4 Chicken liver hydrolysate supplementation modulated lipid homeostasis against lipid deposition in vitro and in vivo/161 5.5 Chicken liver hydrolysate supplementation promoted whole-body insulin sensitivities and hepatic energy expenditure/166 VI. CONCLUSION/169 REFERENCES/173 APPENDIXES/245" | |
| dc.language.iso | en | |
| dc.subject | 血糖恆定 | zh_TW |
| dc.subject | 肝臟保護 | zh_TW |
| dc.subject | 自噬作用 | zh_TW |
| dc.subject | 白肉雞肝水解物 | zh_TW |
| dc.subject | 脂質恆定 | zh_TW |
| dc.subject | 心腎保護 | zh_TW |
| dc.subject | glucose homeostasis | en |
| dc.subject | autophagy | en |
| dc.subject | lipid homeostasis | en |
| dc.subject | hepatoprotection | en |
| dc.subject | cardio-renoprotection | en |
| dc.subject | broiler liver hydrolysate | en |
| dc.title | 白肉雞副產物加值化利用：以小鼠模式探討機能性雞肝水解物於慢性高脂飲食下對心腎保護、肝臟保護及血糖恆定之影響 | zh_TW |
| dc.title | "Value-added Utilization of Broilers’ Byproducts: Effects of Functional Chicken-liver Hydrolysates on Cardio-renoprotection, Hepatoprotection, and Glucose Homeostasis in a Long-term High-fat Dietary Habit via a Mouse Model" | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 邱智賢(Hsin-Tsai Liu),徐慶琳(Chih-Yang Tseng),謝淑貞,黃惠君,謝昌衛,曾榮凱,楊登傑 | |
| dc.subject.keyword | 白肉雞肝水解物,心腎保護,肝臟保護,血糖恆定,脂質恆定,自噬作用, | zh_TW |
| dc.subject.keyword | broiler liver hydrolysate,cardio-renoprotection,hepatoprotection,glucose homeostasis,lipid homeostasis,autophagy, | en |
| dc.relation.page | 254 | |
| dc.identifier.doi | 10.6342/NTU202101948 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-08-03 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 動物科學技術學研究所 | zh_TW |
| dc.date.embargo-lift | 2026-07-30 | - |
| 顯示於系所單位： | 動物科學技術學系 | |
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| U0001-3007202117431600.pdf 此日期後於網路公開 2026-07-30 | 10.38 MB | Adobe PDF |
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