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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 席行正(Hsing-Cheng Hsi) | |
| dc.contributor.author | Tsu-Hsin Lin | en |
| dc.contributor.author | 林子歆 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:39:02Z | - |
| dc.date.available | 2021-08-04 | |
| dc.date.available | 2022-11-24T03:39:02Z | - |
| dc.date.copyright | 2021-08-04 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-07-28 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81256 | - |
| dc.description.abstract | "評估地下水污染場址之健康風險時，淋浴時的吸入暴露是重要的揮發性有機物暴露途徑。在計算淋浴時的吸入暴露時，呼吸速率是一項重要的影響參數，然而，現今環保署提供的「土壤及地下水污染場址健康風險評估方法」中，暴露參數大多參考美國環保署所建置的數據，國內目前尚缺乏本土化的呼吸速率參數。本研究使用COSMED K5攜帶式能量代謝系統，實際量測臺灣20-40歲成人的淋浴時呼吸速率，同時亦量測基本身體組成和肺功能，探討影響呼吸速率的因子，並建置本土化的呼吸速率預估公式；另外，再估算全台受含氯揮發性有機物污染的場址周邊成人之健康風險，探討淋浴呼吸速率參數於風險評估中的重要性。 本研究受試者平均淋浴時呼吸速率為14.7 m3/day，低於現今環保署土壤及地下水資訊管理系統(SGM系統)中的預設值(24 m3/day)；另外，成人淋浴呼吸速率在性別比較中呈顯著差異，且由相關性分析結果可知，淋浴呼吸速率與體重、體質量指數、骨骼肌、腰臀圍比、基礎代謝率呈顯著相關，表示淋浴呼吸速率受到各項生理指標影響。此外，比較本研究實測值與使用Layton (1993)預估公式預測值，結果顯示使用Layton (1993)預估公式會有低估的情形，建議未來應針對本國人的換氧當量(Ventilatory Quotient, VQ)進行調整。 由健康風險的結果顯示，淋浴時吸入暴露為成人暴露到地下水中含氯揮發性有機物的主要暴露途徑，且使用SGM系統預設值所計算出的風險大於使用本研究呼吸速率最大值所算出來的風險，表示若使用SGM系統預設淋浴呼吸速率值計算風險可能會有高估的狀況。 本研究利用人體實驗實際量測成人淋浴時呼吸速率，相較於過去的公式預估方式，能夠獲得更準確的成人呼吸速率值，建議未來在污染場址的健康風險評估中，能夠採用本研究實測值進行地下水揮發性有機物的估算，提供受體族群更完整的風險描述。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:39:02Z (GMT). No. of bitstreams: 1 U0001-2707202114484900.pdf: 4413648 bytes, checksum: ccb5f6ec62fba9cdd09851cf5cb8cf5d (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | Acknowledgement I 中文摘要 III Abstract IV Contents VI List of Figure X List of Table XIII List of Abbreviations XIV Chapter 1. Introduction 1 1.1. Motivation 1 1.2. Research objectives 3 Chapter 2. Literature review 5 2.1. Respiratory system 5 2.1.1. Lung structure 5 2.1.2. Gas exchange 6 2.1.3. Pulmonary ventilation 7 2.2. Influence factors on inhalation rate and respiratory pattern 9 2.2.1. Physiology 9 2.2.2. Physical activity level 11 2.2.3. Race/ethnicity 12 2.3. Inhalation rate prediction and measurement 13 2.3.1. Predictive equation by Layton (1993) 13 2.3.2. Calorimetry 16 2.4. Volatile chlorinated hydrocarbons 18 Chapter 3. Subjects and methods 20 3.1. Research design 20 3.2. Subjects 22 3.3. Experimental procedures 23 3.3.1. Anthropometric measurements 23 3.3.2. Lung function 23 3.3.3. Measure inhalation rate during showering 24 3.4. Health risk assessment 28 3.4.1. Hazard identification 28 3.4.2. Dose-response assessment 30 3.4.3. Exposure assessment 32 3.4.4. Risk characterization 39 3.5. Statistical analysis 42 Chapter 4. Results and discussion 43 4.1. Subjects’ information 43 4.1.1. Anthropometric measurement 43 4.1.2. Lung function analysis 46 4.2. Local inhalation rate during showering 49 4.2.1. Gender difference 49 4.2.2. Age difference 52 4.2.3. Correlation with body composition 55 4.3. Repeated measurement 60 4.3.1. Anthropometric measurement 60 4.3.2. Lung function analysis 62 4.3.3. Inhalation rate measurement during showering 63 4.4. Predictive equation of IR during showering 65 4.4.1. Layton (1993) 65 4.4.2. Linear regression with other factors 68 4.5. Health risk assessment 70 4.5.1. Non-carcinogenic health risk assessment 70 4.5.2. Carcinogenic risk assessment 76 4.5.3. Exposure factor of inhalation rate during showering 81 Chapter 5. Conclusions and suggestions 84 5.1. Conclusions 84 5.2. Suggestions 86 Reference 88 Appendix 1. Concentration of VCHs in the groundwater sites 96 Appendix 2. Parameters of health risk assessment 98 Appendix 3. The results of local inhalation rate measurement during showering 104 | |
| dc.language.iso | en | |
| dc.subject | 健康風險 | zh_TW |
| dc.subject | COSMED K5攜帶式能量代謝系統 | zh_TW |
| dc.subject | 淋浴呼吸速率 | zh_TW |
| dc.subject | inhalation rate during showering | en |
| dc.subject | COSMED K5 | en |
| dc.subject | health risk assessment | en |
| dc.title | 使用COSMED K5建置本土化成人淋浴呼吸速率評估台灣成人暴露地下水揮發性含氯有機物之健康風險評估 | zh_TW |
| dc.title | Health Risk Assessment of Volatile Chlorinated Hydrocarbons Exposure for Adults in Taiwan By Developing Local Inhalation Rate of Adult During Showering Using COSMED K5 | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 簡伶朱(Hsin-Tsai Liu),趙馨(Chih-Yang Tseng),陳永盛 | |
| dc.subject.keyword | COSMED K5攜帶式能量代謝系統,淋浴呼吸速率,健康風險, | zh_TW |
| dc.subject.keyword | COSMED K5,inhalation rate during showering,health risk assessment, | en |
| dc.relation.page | 105 | |
| dc.identifier.doi | 10.6342/NTU202101805 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-07-28 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 環境工程學研究所 | zh_TW |
| 顯示於系所單位： | 環境工程學研究所 | |
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