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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80981完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 段維新(Wei-Hsing Tuan) | |
| dc.contributor.author | Yan-Kai Huang | en |
| dc.contributor.author | 黃彥凱 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:24:41Z | - |
| dc.date.available | 2021-09-11 | |
| dc.date.available | 2022-11-24T03:24:41Z | - |
| dc.date.copyright | 2021-09-11 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-06 | |
| dc.identifier.citation | [1] Pietrzak, W. S., Ronk, R. (2000). Calcium sulfate bone void filler: a review and a look ahead. The Journal of craniofacial surgery, 11(4), 327-33. [2] Wang, J. L., Zin, Y. T., Tzeng, C. C., Lin, C. I., Lin, S. W., Chang, G. L. (2003). The assay of bone reaction after implantation of calcium sulfate and a composite of calcium sulfate and calcium phosphate. Journal of Medical and biological Engineering, 23(4), 205-212. [3] Chen, W. J., Tsai, T. T., Chen, L. H., Niu, C. C., Lai, P. L., Fu, T. S., McCarthy, K. (2005). The fusion rate of calcium sulfate with local autograft bone compared with autologous iliac bone graft for instrumented short-segment spinal fusion. Spine, 30(20), 2293-2297. [4] Thomas, M. V., Puleo, D. A., Al-Sabbagh, M. (2005). Calcium sulfate: a review. Journal of long-term effects of medical implants, 15(6). [5] Zhou, Z., Mitchell, C. A., Buchanan, F. J., Dunne, N. J. (2013). Effects of heat treatment on the mechanical and degradation properties of 3D-printed calcium-sulphate-based scaffolds. International Scholarly Research Notices, 2013. [6] Hench, L. L. (1991). Bioceramics: from concept to clinic. Journal of the american ceramic society, 74(7), 1487-1510. [7] Cortez, P. P., Silva, M. A., Santos, M., Armada-da-Silva, P., Afonso, A., Lopes, M. A.. Maurício, A. C. (2012). A glass-reinforced hydroxyapatite and surgical-grade calcium sulfate for bone regeneration: In vivo biological behavior in a sheep model. Journal of biomaterials applications, 27(2), 201-217. [8] Bucholz, R. W. (2002). Nonallograft osteoconductive bone graft substitutes. Clinical Orthopaedics and Related Research®, 395, 44-52. [9] Liu, Y., Luo, D., Wang, T. (2016). Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering. Small, 12(34), 4611–4632. [10] Venkatesan, J., Lowe, B., Kim, S.-K. (2015). Bone tissue engineering using functional marine biomaterials. Functional Marine Biomaterials, 53–61. [11] Amini, A. R., Laurencin, C. T., Nukavarapu, S. P. (2012). Bone Tissue Engineering: Recent Advances and Challenges. Critical Reviews™ in Biomedical Engineering, 40(5), 363–408. [12] Itkin, T., Gur-Cohen, S., Spencer, J. A., Schajnovitz, A., Ramasamy, S. K., Kusumbe, A. P., ... Lapidot, T. (2016). Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature, 532(7599), 323-328. [13] Manzoor, K., Ahmad, M., Ahmad, S., Ikram, S. (2019). Resorbable biomaterials: role of chitosan as a graft in bone tissue engineering. In Materials for Biomedical Engineering (pp. 23-44). Elsevier. [14] Boskey, A. L. (2013). Bone composition: relationship to bone fragility and antiosteoporotic drug effects. BoneKEy reports, 2. [15] Moore, W. R., Graves, S. E., Bain, G. I. (2001). Synthetic bone graft substitutes. ANZ journal of surgery, 71(6), 354-361. [16] Palma, G., Mannacio, V. A., Mastrogiovanni, G., Russolillo, V., Cioffi, S., Mucerino, M., Vosa, C. (2011). Bovine valved venous xenograft in pulmonary position: medium term evaluation of risk factors for dysfunction and failure after 156 implants. The Journal of cardiovascular surgery, 52(2), 285-291. [17] Miller, F. R. (2000). Xenograft models of premalignant breast disease. Journal of mammary gland biology and neoplasia, 5(4), 379-391. [18] Hutmacher, D. W., Sittinger, M., Risbud, M. V. (2004). Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems. TRENDS in Biotechnology, 22(7), 354-362. [19] https://www.thekneejoint.com/blog/what-type-of-graft-should-i-choose-for-my-acl- rconstruction. [20] Stevens, M. M. (2008). Biomaterials for bone tissue engineering. Materials today, 11(5), 18-25. [21] Kelly, C. M., Wilkins, R. M., Gitelis, S., Hartjen, C., Watson, J. T., Kim, P. T. (2001). The use of a surgical grade calcium sulfate as a bone graft substitute: results of a multicenter trial. Clinical Orthopaedics and Related Research®, 382, 42-50. [22] Zhang, J., Liu, W., Schnitzler, V., Tancret, F., Bouler, J.-M. (2014). Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties. Acta Biomaterialia, 10(3), 1035–1049. [23] Bohner, M., Baroud, G. (2005). Injectability of calcium phosphate pastes. Biomaterials, 26(13), 1553–1563 [24] Rungseevijitprapa, W., Bodmeier, R. (2009). Injectability of biodegradable in situ forming microparticle systems (ISM). European Journal of Pharmaceutical Sciences, 36(4-5), 524–531. [25] Xu, H. H. K., Simon, C. G. (2004). Self-hardening calcium phosphate cement-mesh composite: Reinforcement, macropores, and cell response. Journal of Biomedical Materials Research, 69A(2), 267–278. [26] Kim, S. B., Kim, Y. J., Yoon, T. L., Park, S. A., Cho, I. H., Kim, E. J., … Shin, J.-W. (2004). The characteristics of a hydroxyapatite–chitosan–PMMA bone cement. Biomaterials, 25(26), 5715–5723. [27] Orsini, G., Ricci, J., Scarano, A., Pecora, G., Petrone, G., Iezzi, G., Piattelli, A. (2004). Bone-defect healing with calcium-sulfate particles and cement: An experimental study in rabbit. Journal of Biomedical Materials Research, 68B(2), 199–208. [28] Wang, J. L., Zin, Y. T., Tzeng, C. C., Lin, C. I., Lin, S. W., Chang, G. L. (2003). The assay of bone reaction after implantation of calcium sulfate and a composite of calcium sulfate and calcium phosphate. Journal of Medical and biological Engineering, 23(4), 205-212. [29] Intini, G., Andreana, S., Margarone Iii, J. E., Bush, P. J., Dziak, R. (2002). Engineering a bioactive matrix by modifications of calcium sulfate. Tissue engineering, 8(6), 997-1008. [30] Pietrzak, W. S., Ronk, R. (2000). Calcium sulfate bone void filler: a review and a look ahead. The Journal of craniofacial surgery, 11(4), 327-33. [31] Lewis, K. N., Thomas, M. V., Puleo, D. A. (2006). Mechanical and degradation behavior of polymer-calcium sulfate composites. Journal of Materials Science: Materials in Medicine, 17(6), 531-537. [32] Tovar, N., Lee, P., Mamidwar, S., Alexander, H., Ricci, J. (2010, March). In vitro degradation of calcium sulfate polymer composites for the reconstruction of bone. In Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference (NEBEC) (pp. 1-2). IEEE. [33] Modulevsky, D. J., Cuerrier, C. M., Pelling, A. E. (2016). Biocompatibility of subcutaneously implanted plant-derived cellulose biomaterials. PloS one, 11(6), e0157894. [34] Manzello, S. L., Gann, R. G., Kukuck, S. R., Lenhert, D. B. (2007). Influence of gypsum board type (X or C) on real fire performance of partition assemblies. Fire and Materials: An International Journal, 31(7), 425-442. [35] Thomas, M. V., Puleo, D. A., Al-Sabbagh, M. (2005). Calcium sulfate: a review. Journal of long-term effects of medical implants, 15(6). [36] Mandal, P. K., Mandal, T. K. (2002). Anion water in gypsum (CaSO4• 2H2O) and hemihydrate (CaSO4• 1/2H2O). Cement and Concrete Research, 32(2), 313-316. [37] Standard Test Methods for Time of Setting of Hydraulic Cement by Vicat Needle. [38] Soroka I. (1979) Setting and hardening. In: Portland Cement Paste and Concrete. Palgrave, London. [39] Şahin, E. (2018). Calcium Phosphate Bone Cements. Cement Based Materials. [40] Barinov, S. M., Komlev, V. S. (2011). Calcium phosphate bone cements. Inorganic Materials, 47(13), 1470–1485. [41] Cabañas, M. V., Rodríguez-Lorenzo, L. M., Vallet-Regí, M. (2002). Setting Behavior and in Vitro Bioactivity of Hydroxyapatite/Calcium Sulfate Cements. Chemistry of Materials, 14(8), 3550–3555 [42] Huan, Z., Chang, J. (2007). Self-setting properties and in vitro bioactivity of calcium sulfate hemihydrate–tricalcium silicate composite bone cements. Acta Biomaterialia, 3(6), 952–960. [43] O’Hara, R. M., Dunne, N. J., Orr, J. F., Buchanan, F. J., Wilcox, R. K., Barton, D. C. (2010). Optimisation of the mechanical and handling properties of an injectable calcium phosphate cement. Journal of Materials Science: Materials in Medicine, 21(8), 2299–2305 [44] Chen, Z., Liu, H., Liu, X., Lian, X., Guo, Z., Jiang, H.-J., Cui, F.-Z. (2013). Improved workability of injectable calcium sulfate bone cement by regulation of self-setting properties. Materials Science and Engineering: C, 33(3), 1048–1053. [45] Nilsson, M., Wielanek, L., Wang, J. S., Tanner, K. E., Lidgren, L. (2003). Factors influencing the compressive strength of an injectable calcium sulfate–hydroxyapatite cement. Journal of Materials Science: materials in medicine, 14(5), 399-404. [46] Koh, I., López, A., Helgason, B., Ferguson, S. J. (2014). The compressive modulus and strength of saturated calcium sulphate dihydrate cements: Implications for testing standards. Journal of the Mechanical Behavior of Biomedical Materials, 34, 187–198 [47] Bohner, M. (2004). New hydraulic cements based on α-tricalcium phosphate–calcium sulfate dihydrate mixtures. Biomaterials, 25(4), 741–749. [48] Chen, C.-C., Wang, C.-W., Hsueh, N.-S., Ding, S.-J. (2014). Improvement of in vitro physicochemical properties and osteogenic activity of calcium sulfate cement for bone repair by dicalcium silicate. Journal of Alloys and Compounds, 585, 25–31. [49] Wang, P., Lee, E.-J., Park, C.-S., Yoon, B.-H., Shin, D.-S., Kim, H.-E., … Park, S.-H. (2008). Calcium Sulfate Hemihydrate Powders with a Controlled Morphology for Use as Bone Cement. Journal of the American Ceramic Society, 91(6), 2039–2042. [50] Cavelier, S., Tanzer, M., Barthelat, F. (2020). Maximizing the strength of calcium sulfate for structural bone grafts. Journal of Biomedical Materials Research Part A, 108(4), 963-971. [51] Pina, S., Olhero, S. M., Gheduzzi, S., Miles, A. W., Ferreira, J. M. F. (2009). Influence of setting liquid composition and liquid-to-powder ratio on properties of a Mg-substituted calcium phosphate cement. Acta Biomaterialia, 5(4), 1233–1240. [52] Singh, N. B., Middendorf, B. (2007). Calcium sulfate hemihydrate hydration leading to gypsum crystallization. Progress In Crystal Growth and Characterization of Materials, 53(1), 53-77. [53] S. Hiromoto and T. Yamazaki, “Micromorphological effect of calcium phosphate coating on compatibility of magnesium alloy with osteoblast, “Sci Technol Adv Mater,” 18[1] 96-109 (2017). [54] K. Onuma and M, Iijima, “Nanoparticles in β-tricalcium phosphate substrate enhance modulation of structure and composition of an octacalcium phosphate grown layer”, CrystEngComm, 19[44] 6660-72 (2017). [55] C.Göbel, P. Simon, J.Buder, H. Tlatlik, and R. Kniep, “Phase formation and morphology of calcium phosphate-gelatine-composites grown by double diffusion technique: the fluoride,” J. Mater. Chem., 14[14] 2225-30 (2004). [56] M.M. Choy, W.R. Cook, R.F.S. Hearmon, J. Jaffe, J. Jerphagnon, S.K. Kurtz, S.T. Liu, D.F. Nelson, Landolt-Bornstein: numerical data and functional relationships in science and technology new series, in: K.-H. Kellwege, A.M. Hellwege (Eds.), Group III: Crystal and Solid State Physics, Elastic, Piezoelectric, Pyroelectric, Piezooptic, Electro optic Constants, and Nonlinear Dielectric Susceptibilities of Crystals, vol. 11, Springer-Verlag, Berlin, 1979. Revised and Extended Edition of Volumes III/1 and III/2. [57] A.S. Bhalla, W.R. Cook, R.F.S. Hearmon, J. Jerphagnon, S.K. Kurtz, S.T. Liu, D.F. Nelson, J.-L. Oudar, Landolt –Bornstein: numerical data and functional relationships in science and technology new series, in: K.-H. Kellwege, A.M. Hellwege (Eds.), Group III: Crystal and Solid State Physics, Elastic, Piezoelectric, Pyroelectric, Piezooptic, Electro optic Constants, and Nonlinear Dielectric Susceptibilities of Crystals, vol. 18, Springer-Verlag, Berlin, 1984. Supplement to Volume III/11. [58] Bell, F. G. (1994). A survey of the engineering properties of some anhydrite and gypsum from the north and midlands of England. Engineering Geology, 38(1-2), 1–23. [59] Robertson, E. C., Robie, R. A., Books, K. G. (1958). Physical properties of salt, anhydrite and gypsum: preliminary report (No. 1048). [60] Haecker, C. J., Garboczi, E. J., Bullard, J. W., Bohn, R. B., Sun, Z., Shah, S. P., Voigt, T. (2005). Modeling the linear elastic properties of Portland cement paste. Cement and Concrete Research, 35(10), 1948-1960. [61] Wu, H. C., Xia, Y. M., Hu, X. Y., Liu, X. (2014). Improvement on mechanical strength and water absorption of gypsum modeling material with synthetic polymers. Ceramics International, 40(9), 14899-14906. [62] Cramer, S. M., Friday, O. M., White, R. H., Sriprutkiat, G. (2003). Mechanical properties of gypsum board at elevated temperatures. In Fire and materials 2003: 8th International Conference, January 2003, San Francisco, CA, USA. London: Interscience Communications Limited, c2003: pages 33-42.. [63] M. Prakasam, J. Locs, K. Salma-Ancane, D. Loca, A. Largeteau, and L. Berzina-Cimdina, “Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review”, J Funct Biomater, 6[4] 1099-140 (2015). [64] Mitsionis, A. I., Vaimakis, T. C. (2010). A calorimetric study of the temperature effect on calcium phosphate precipitation. Journal of thermal analysis and calorimetry, 99(3), 785-789. [65] Wysocki, B., Dybała, B., Kurzydłowski, K. J., Leszczyńska, D., Święszkowski, W. (2015). CNTs as ion carriers in formation of calcium phosphate coatings. Surface Engineering, 31(10), 733-739. [66] Mekmene, O., Quillard, S., Rouillon, T., Bouler, J. M., Piot, M., Gaucheron, F. (2009). Effects of pH and Ca/P molar ratio on the quantity and crystalline structure of calcium phosphates obtained from aqueous solutions. Dairy science technology, 89(3), 301-316. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80981 | - |
| dc.description.abstract | "由於醫療發展越來越進步使得人口平均壽命增加，人口老化或是受傷導致的骨孔洞、骨質疏鬆越來越常見，所以對於骨替代材、骨移植和骨填充材的要求也隨之增加。本研究目的為研究半水硫酸鈣型骨水泥的硬化時間(setting time)以及其物理性質，並試著使其更適合為實際使用。 硫酸鈣主要具有三種型態，二水硫酸鈣 (CaSO4•2H2O)、半水硫酸鈣 (CaSO4•1/2H2O)以及無水硫酸鈣 (CaSO4)。半水硫酸鈣作為骨填充材已將近百年，而其與水進行水和反應的產物二水硫酸鈣有著良好的生物相容性、骨傳導和骨誘導性，以及刺激新骨細胞的生成。整體來說，半水硫酸鈣型骨水泥最大的優勢在於，非常容易塑型，只要加水就能變成二水硫酸鈣，而且可被生物體吸收並完全降解，不用進行二次手術。 本次研究，第一部分是將蒸餾水與半水硫酸鈣粉末以粉水比 (LPR value) = 0.6, 0.8, 1.0, 1.2, 1.4混合，用維克氏針 (Vicats needle) 測定其硬化時間的變化，並量測其物理性質包括密度、壓縮強度、彎取強度，最後再進行微結構分析以及相分析。 除了研究粉水比對骨水泥造成的影響，這次研究也會在半水硫酸鈣粉末中混入不同量的二水硫酸鈣粉末，起因是因為過去的研究指出，二水硫酸鈣可以加快半水硫酸鈣進行水合的時間，也就是降低硬化時間。最後會將溶劑從蒸餾水替換成高磷酸根溶劑 (high phosphate content solution, HPS) ，實驗結果顯示，磷酸根離子參與反應，會使產物的結構發生變化，並且使半水硫酸鈣型骨水泥的強度上升。 最終實驗結果顯示，隨著粉水比的下降會使硬化時間變短，密度和強度都會上升，可以藉此調整硫酸鈣的硬化時間，但要注意如果加入的水量太少會使材料無法和液體混合出均勻的漿料。而添加一定量的二水硫酸鈣雖可以使硬化時間下降，但是會使材料的密度、強度都下降，而使得原本強度就低的硫酸鈣骨水泥更難以被實際使用。如果將溶劑替換成高磷酸根溶劑酸雖然使得硬化時間上升，但是還是在可使用範圍，而其可以讓材料強度上升，因此本實驗認識添加磷酸根離子是使硫酸鈣骨水泥更接近實際使用的方法之一。 " | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:24:41Z (GMT). No. of bitstreams: 1 U0001-0309202119591500.pdf: 3327489 bytes, checksum: f1316c84241f99ac0803f9c5c8634496 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 口試委員會審定書 i 誌謝 ii 中文摘要 iii ABSTRACT iv CONTENTS vii LIST OF FIGURES ix LIST OF TABLES xii Chapter 1 Introduction 1 Chapter 2 Literature survey 3 2.1 Bone tissue 3 2.2 Bone graft substitutes and bone cement 6 2.3 Calcium sulfate hemihydrate type bone cement 10 2.3.1 Different type bone cement………………………………………………..10 2.3.2 Material properties …………………………………………………………12 Chapter 3 Experimental procedures 14 3.1 Calcium sulfate 14 3.1.1 Starting materials 14 3.1.2 Processing 15 3.2 Replacing starting powder 16 3.2.1 Adding CSD powder 16 3.3 High phosphate solution 17 3.3.1 Adding HPS solution 17 3.4 Characterization 19 3.4.1 Density 19 3.4.2 Microstructure observation 19 3.4.3 Phase identification 19 3.5 Mechanical properties 20 3.6 Setting time 21 Chapter 4 Results 22 4.1 Setting time 22 4.1.1 Effect of LPR values 22 4.1.2 Adding CSD powder 24 4.1.3 High phosphate content solution 26 4.2 Density 27 4.2.1 Effect of LPR values 27 4.2.2 Adding CSD powder 28 4.2.3 High phosphate content solution 29 4.3 Mechanical properties 30 4.3.1 Effect of LPR values 30 4.3.2 Adding CSD powder 32 4.3.3 High phosphate content solution 34 4.4 Microstructure 37 4.4.1 Effect of LPR values 37 4.4.2 Adding CSD powder 38 4.4.3 Process of drying 40 4.4.4 Effect of phosphate ions 41 4.5 Phase identification 43 Chapter 5 Discussion 48 5.1 Setting behavior 48 5.2 CSD accelerator 52 5.3 Precipitation 54 5.4 Phase identification 57 Chapter 6 Conclusions 59 Chapter 7 References 60 | |
| dc.language.iso | en | |
| dc.subject | 析出 | zh_TW |
| dc.subject | 硫酸鈣 | zh_TW |
| dc.subject | 水粉比 | zh_TW |
| dc.subject | 骨水泥 | zh_TW |
| dc.subject | 磷酸鈣 | zh_TW |
| dc.subject | 密度 | zh_TW |
| dc.subject | 壓縮強度 | zh_TW |
| dc.subject | 撓曲強度 | zh_TW |
| dc.subject | precipitation | en |
| dc.subject | calcium sulfate | en |
| dc.subject | liquid powder ratio | en |
| dc.subject | bone cement | en |
| dc.subject | calcium phosphate | en |
| dc.subject | density | en |
| dc.subject | compressive strength | en |
| dc.subject | flexural strength | en |
| dc.title | 硫酸鈣型骨水泥的硬化行為與物理特性探討 | zh_TW |
| dc.title | Setting behavior and physical properties of calcium sulfate cements | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 曾文甲(Hsin-Tsai Liu),許沛衣(Chih-Yang Tseng) | |
| dc.subject.keyword | 硫酸鈣,水粉比,骨水泥,磷酸鈣,密度,壓縮強度,撓曲強度,析出, | zh_TW |
| dc.subject.keyword | calcium sulfate,liquid powder ratio,bone cement,calcium phosphate,density,compressive strength,flexural strength,precipitation, | en |
| dc.relation.page | 67 | |
| dc.identifier.doi | 10.6342/NTU202102985 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-09-07 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 材料科學與工程學研究所 | zh_TW |
| 顯示於系所單位： | 材料科學與工程學系 | |
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| U0001-0309202119591500.pdf 授權僅限NTU校內IP使用（校園外請利用VPN校外連線服務） | 3.25 MB | Adobe PDF |
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