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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 孫秀卿(Shiow-Ching Shun) | |
| dc.contributor.author | Ling-Fang Hsu | en |
| dc.contributor.author | 許齡方 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:12:48Z | - |
| dc.date.available | 2022-02-15 | |
| dc.date.available | 2022-11-24T03:12:48Z | - |
| dc.date.copyright | 2022-02-15 | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022-02-09 | |
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HPB. https://doi.org/10.1016/j.hpb.2021.04.012 Lelond, S., Ward, J., Lambert, P. J., Kim, C. A. (2021). Symptom Burden of Patients with Advanced Pancreas Cancer (APC): A Provincial Cancer Institute Observational Study. Current Oncology (Toronto, Ont.), 28(4), 2789-2800. https://doi.org/10.3390/curroncol28040244 Leung, P. S. (2010a). Overview of the Pancreas. In The Renin-Angiotensin System: Current Research Progress in The Pancreas: The RAS in the Pancreas (pp. 3-12). Springer Netherlands. https://doi.org/10.1007/978-90-481-9060-7_1 Leung, P. S. (2010b). Physiology of the Pancreas. In The Renin-Angiotensin System: Current Research Progress in The Pancreas: The RAS in the Pancreas (pp. 13-27). Springer Netherlands. https://doi.org/10.1007/978-90-481-9060-7_2 Li, C. C., Chou, Y. J., Shun, S. C. (2021). The Relationship Between Muscle Strength and Body Composition Measures and Cancer-Related Fatigue: A Systematic Review and Meta-Analysis. Oncology Nursing Forum, 48(5), 558-576. https://doi.org/10.1188/21.Onf.558-576 Lindkvist, B., Phillips, M. E., Domínguez-Muñoz, J. E. (2015). Clinical, anthropometric and laboratory nutritional markers of pancreatic exocrine insufficiency: Prevalence and diagnostic use. Pancreatology, 15(6), 589-597. https://doi.org/10.1016/j.pan.2015.07.001 Litwin, M. (2007). Health-Related Quality of Life. In (pp. 237-251). https://doi.org/10.1007/978-1-59745-230-4_13 Müller-Nordhorn, J., Roll, S., Böhmig, M., Nocon, M., Reich, A., Braun, C., Noesselt, L., Wiedenmann, B., Willich, S. N., Brüggenjürgen, B. (2006). Health-related quality of life in patients with pancreatic cancer. Digestion, 74(2), 118-125. https://doi.org/10.1159/000098177 Mackay, T. M., Latenstein, A. E. J., Sprangers, M. A. G., van der Geest, L. G., Creemers, G. J., van Dieren, S., de Groot, J. B., Groot Koerkamp, B., de Hingh, I. H., Homs, M. Y. V., de Jong, E. J. M., Molenaar, I. Q., Patijn, G. A., van de Poll-Franse, L. V., van Santvoort, H. C., de Vos-Geelen, J., Wilmink, J. W., van Eijck, C. H., Besselink, M. G., van Laarhoven, H. W. M. (2020). Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis. Journal of the National Comprehensive Cancer Network, 18(10), 1354-1363. https://doi.org/10.6004/jnccn.2020.7579 Mackay, T. M., Latenstein, A. E. J., Sprangers, M. A. G., van der Geest, L. G. M., Creemers, G.-J. M., van Dieren, S., de Groot, J. W. B., Groot Koerkamp, B., de Hingh, I. H. J. T., Homs, M. Y. V., de Jong, E. J. M., Molenaar, I. Q., Patijn, G. A., van de Poll-Franse, L. V., van Santvoort, H. C., de Vos-Geelen, J., Wilmink, J. W., van Eijck, C. H. J., Besselink, M. G., van Laarhoven, H. W. M. (2020). Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis. Journal of the National Comprehensive Cancer Network : JNCCN, 18 10, 1354-1363. MacKinnon, D. (2008). An Introduction to Statistical Mediation Analysis. 245. https://doi.org/10.4324/9780203809556 Maeda, H., Hanazaki, K. (2011). Pancreatogenic diabetes after pancreatic resection. Pan……… | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80683 | - |
| dc.description.abstract | "背景：胰臟腫瘤切除手術是唯一能使胰臟癌治癒的治療方法，過去研究多著重於探討胰臟癌術後營養狀態、疲憊程度及生活品質之變化。然而，術後12個月胰臟癌術後疲憊對於病患之營養狀態與生活品質之改變所扮演的角色其相關機轉仍不甚明瞭，其三者之相關性亟待探討。 目的：瞭解胰臟切除術後十二個月內胰臟癌病患營養狀態、疲憊和生活品質之改變，並探討影響胰臟切除術後胰臟癌病患生活品質之影響因子中，疲憊在營養狀態及生活品質間所扮演的角色。 方法：本文為次級資料分析，採縱貫性、相關性研究設計。原研究採立意取樣，於北部某醫學中心之胰臟外科門診追蹤之胰臟癌術後病患為收案對象，本研究擷取其部分資料，樣本數共為89人。資料收集時間為術前、術後3、6、12個月共4次，以測量身體組成成分、上下肢肌力及迷你營養量表（Mini Nutritional Assessment, MNA）評估受試者之營養狀態。使用疲倦症狀量表（Fatigue Symptom Inventory, FSI）評估其疲憊程度及癌症治療功能性評估一般量表（The Functional Assessment of Cancer Therapy-General, FACT-G）評估其生活品質，並以自擬之基本人口學與疾病治療資料表收集受試者之基本資料。以IBM SPSS Statistics 26.0版進行資料分析，統計方式包含描述性統計、無母數檢定、Spearman等級相關、廣義估計方程式與Sobel中介效果檢定。 結果：胰臟癌病患之營養狀態術前至術後12個月之改變具有顯著差異。其中術前體重（60.45±11.44公斤，p<0.01）及手部平均握力（26.07±9.18公斤重，p=0.02）術前顯著高於術後3、6、12個月；30秒坐站平均次數最低為術前18.55±6.56次，術後6、12個月分別為20.72±8.90次、20.67±7.20次，顯示術前至術後為上升趨勢，但在統計上並無顯著差異；迷你營養量表平均總分術後3個月顯著低於術前、術後6、12個月（23.27±3.34分，p<0.01）。在疲憊方面，術後3個月之疲憊總分（平均21.91±23.88分，p=0.35）、最疲憊的程度（平均3.50±2.88分，p=0.49）、平均的疲憊程度（平均2.21±1.96分，p=0.25）、疲憊干擾（平均1.25±1.95分，p=0.19）、一星期疲憊天數（平均2.8±2.66天，p=0.12）、一天中疲憊時間（平均2.54±2.68，p=0.12）皆高於術前、術後6、12個月之分數，然而在統計上無顯著差異。在生活品質方面，術前生理健全（平均3.23±0.76分，p=0.18）、情緒健全（平均2.59±0.95分，p<0.01）與生活品質總分（平均77.19±14.12分，p=0.42）與術後3、6、12個月相比為最低分，術後3個月至12個月呈現上升趨勢；在社交／家庭健全部分，在術後6個月（平均3.18±0.77分）高於術前（平均3.14±0.78分）、術後3個月（平均3.14±0.74分），然而在統計上並無顯著差異（χ2=3.58、p=0.31）。在功能健全方面，最高分為術前（平均2.89±0.86分）、最低分為術後3個月（平均2.50±0.81分），術後12個月（平均2.84±0.91分）大致恢復至術前水準，但在統計上未有顯著差異（χ2=7.92、p=0.05）。胰臟癌病患術後12個月內手部平均握力及迷你營養量表評估之整體營養狀態與疲憊呈現負相關；體重、手部平均握力及迷你營養量表評估之整體營養狀態與生活品質呈現正相關；疲憊與生活品質呈現負相關。疲憊在手部平均握力與生活品質間存在完全中介效果（t=2.70，p<0.01），在迷你營養量表評估之整體營養狀態與生活品質間存在部分中介效果（t=4.40，p<0.01）。 結論：本研究結果顯示手部平均握力及整體營養狀態與疲憊呈現負相關、疲憊與生活品質呈現負相關，疲憊為手部平均握力、整體營養狀態之中介變項。建議未來在臨床照護及學術研究方面，可以提升手部肌力為介入措施，了解手部肌力於胰臟癌術後病患疲憊之緩解及生活品質之改善。目前國內外未有胰臟癌術後病患營養狀態、疲憊與生活品質之中介模型，本研究結果可提供臨床上照護相關族群之醫護人員參考。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:12:48Z (GMT). No. of bitstreams: 1 U0001-0802202207000800.pdf: 1898096 bytes, checksum: 2c144acedb992a80e739398e5ab9d8ec (MD5) Previous issue date: 2022 | en |
| dc.description.tableofcontents | 致謝 ii 中文摘要 iii 英文摘要 v 目錄 viii 表目錄 x 圖目錄 xi 第一章 緒論 1 第一節 動機與重要性 1 第二節 研究目的 3 第二章 文獻查證 4 第一節 胰臟癌與胰臟切除手術簡介 4 第二節 胰臟癌術後病患營養狀態相關研究 8 第三節 胰臟癌病患之疲憊相關研究 15 第四節 影響胰臟癌術後病患生活品質之相關因素及研究 17 第三章 研究方法 23 第一節 研究架構 23 第二節 研究設計 24 第三節 研究假設 25 第四節 名詞界定 26 第五節 研究場所及研究對象 28 第六節 研究工具 29 第七節 資料收集步驟 32 第八節 資料處理與分析 33 第九節 研究倫理考量 35 第四章 研究結果 36 第一節 胰臟癌病患術後之基本屬性與疾病特性 37 第二節 胰臟癌病患術後十二個月內之營養狀態、疲憊、生活品質 39 第三節 胰臟癌病患術後十二個月內之營養狀態、疲憊與生活品質之相關 45 第四節 胰臟癌病患術後十二個月內疲憊在營養與生活品質間之中介效果 49 第五章 討論 56 第一節 胰臟癌病患術後十二個月內營養狀態、疲憊與生活品質之現況 56 第二節 胰臟癌病患術後十二個月內營養狀態、疲憊與生活品質之相關性 60 第六章 結論與建議 63 第一節 結論 63 第二節 研究限制 65 第三節 建議 66 參考資料 68 | |
| dc.language.iso | zh-TW | |
| dc.subject | 胰臟癌 | zh_TW |
| dc.subject | 胰臟切除術 | zh_TW |
| dc.subject | 疲憊 | zh_TW |
| dc.subject | 中介效果 | zh_TW |
| dc.subject | 生活品質 | zh_TW |
| dc.subject | 營養狀態 | zh_TW |
| dc.subject | pancreatic cancer | en |
| dc.subject | mediation effect | en |
| dc.subject | quality of life | en |
| dc.subject | fatigue | en |
| dc.subject | nutritional status | en |
| dc.subject | pancreactectomy | en |
| dc.title | 胰臟癌病患術後十二個月內營養狀態、疲憊與生活品質之相關性探討 | zh_TW |
| dc.title | "Relationship among Nutritional Status, Fatigue and Quality of Life in Patients with Pancreatic Cancer Within Twelve Months after Pancreatectomy" | en |
| dc.date.schoolyear | 110-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李芸湘(Tsung-Yu Lee),田郁文(Cheh-Shyh Ting),劉介宇(Ming-Hsu Li),(Tsung-Ren Peng),(Ching-Huei Kuo),(Ching-Huei Kuo),(Ching-Huei Kuo) | |
| dc.subject.keyword | 胰臟癌,胰臟切除術,營養狀態,疲憊,生活品質,中介效果, | zh_TW |
| dc.subject.keyword | pancreatic cancer,pancreactectomy,nutritional status,fatigue,quality of life,mediation effect, | en |
| dc.relation.page | 96 | |
| dc.identifier.doi | 10.6342/NTU202200357 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2022-02-10 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 護理學研究所 | zh_TW |
| 顯示於系所單位： | 護理學系所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| U0001-0802202207000800.pdf 授權僅限NTU校內IP使用（校園外請利用VPN校外連線服務） | 1.85 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。